Autor: "Fallacara AL" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line.
Autorzy:: Cammarata FP; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Torrisi F; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .; Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy. .
Forte GI; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Minafra L; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Bravatà V; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Pisciotta P; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .; Departments of Physics and Astronomy, University of Catania, 95123 Catania, Italy. .
Savoca G; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .
Calvaruso M; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Petringa G; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .; Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy. .
Cirrone GAP; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Fallacara AL; Lead Discovery Siena s.r.l. (LDS), 53100 Siena, Italy. al.fallacara@gmail.com.; Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, 53100 Siena, Italy. al.fallacara@gmail.com.
Maccari L; Lead Discovery Siena s.r.l. (LDS), 53100 Siena, Italy. .
Botta M; Lead Discovery Siena s.r.l. (LDS), 53100 Siena, Italy. .; Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, 53100 Siena, Italy. .
Schenone S; Department of Pharmacy, Università degli Studi di Genova, 16126 Genova, Italy. .
Parenti R; Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy. .
Cuttone G; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .
Russo G; Institute of Molecular Bioimaging and Physiology, National Research Council, IBFM-CNR, 90015 Cefalù, Italy. .; National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Sep 24; Vol. 20 (19). Date of Electronic Publication: 2019 Sep 24.
Typ publikacji:: Journal Article
MeSH Terms:: Proton Therapy*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
src-Family Kinases/*antagonists & inhibitors
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/therapy ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Gene Expression Profiling ; Glioblastoma/metabolism ; Glioblastoma/therapy ; Humans ; Inhibitory Concentration 50 ; Mice ; Radiation Tolerance/drug effects ; Xenograft Model Antitumor Assays

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Tytuł:: A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4- d ]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
Autorzy:: Fallacara AL; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. al.fallacara@gmail.com.
Zamperini C; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. .
Podolski-Renić A; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. .
Dinić J; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. .
Stanković T; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. .
Stepanović M; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. .
Mancini A; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. .
Rango E; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .
Iovenitti G; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .
Molinari A; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .
Bugli F; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. .; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. .
Sanguinetti M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. .; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. .
Torelli R; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. .; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. .
Martini M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. .; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. .
Maccari L; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. .
Valoti M; Dipartimento Scienze della Vita, Università degli Studi di Siena, 53100 Siena, Italy. .
Dreassi E; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .
Botta M; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. .; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. .
Pešić M; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. .
Schenone S; Department of Pharmacy, Università degli Studi di Genova, 16132 Genova, Italy. .; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2019 Jun 19; Vol. 11 (6). Date of Electronic Publication: 2019 Jun 19.
Typ publikacji:: Journal Article

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Tytuł:: Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors.
Autorzy:: Francini CM; Rottapharm Biotech S.r.l. Valosa di Sopra N9Street, 20900 Monza, Italy. .
Musumeci F; Department of Pharmacy, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy. .
Fallacara AL; Department of Biotechnology, Chemistry and Pharmacy, Via Aldo Moro 2, 53100 Siena, Italy. al.fallacara@gmail.com.
Botta L; Department of Biological and Ecological Science, University of Tuscia, 01100 Viterbo, Italy. .
Molinari A; Department of Biotechnology, Chemistry and Pharmacy, Via Aldo Moro 2, 53100 Siena, Italy. .
Artusi R; Rottapharm Biotech S.r.l. Valosa di Sopra N9Street, 20900 Monza, Italy. .
Mennuni L; Rottapharm Biotech S.r.l. Valosa di Sopra N9Street, 20900 Monza, Italy. .
Angelucci A; Department of Applied Clinical Science and Biotechnology, University of L'Aquila, Via Vetoio Coppito, 67100 L'Aquila, Italy. .
Schenone S; Department of Pharmacy, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Sep 17; Vol. 23 (9). Date of Electronic Publication: 2018 Sep 17.
Typ publikacji:: Journal Article
MeSH Terms:: Imidazoles/*chemistry
Imidazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
src-Family Kinases/*antagonists & inhibitors
Adenosine Triphosphate/metabolism ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry ; src-Family Kinases/metabolism

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