Autor: "Fang, EF" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Alzheimer's disease diagnostic accuracy by fluid and neuroimaging ATN framework.
Autorzy:: Xiong X; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
He H; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ye Q; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qian S; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhou S; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Feng F; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Fang EF; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Xie C; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory Of Alzheimer's Disease Of Zhejiang Province, Wenzhou, China.; Institute of Aging, Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province, Wenzhou, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14357. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/diagnostic imaging
Cognitive Dysfunction*/diagnostic imaging
Humans ; Fluorodeoxyglucose F18 ; Neuroimaging ; Positron-Emission Tomography/methods ; Biomarkers ; tau Proteins ; Amyloid beta-Peptides

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome.
Autorzy:: Tian Y; Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR.; Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR.
Lautrup S; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Law PWN; Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR.
Dinh ND; Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Chan WY; Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. .; Hong Kong Branch CAS Center of Excellence for Animal Evolution and Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. .; CUHK-SDU University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. .; MOE Key Laboratory of Regenerative Medicine (CUHK-Jinan University), The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. .; Pokaż więcej
Źródło:: Cell & bioscience [Cell Biosci] 2024 Jan 06; Vol. 14 (1), pp. 7. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:: Journal Article

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Autorzy:: Pun FW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Leung GHD; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Leung HW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Rice J; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Schmauck-Medina T; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Lautrup S; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Long X; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Liu BHM; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Wong CW; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Ozerov IV; Insilico Medicine Hong Kong Ltd., Hong Kong, China.
Aliper A; Insilico Medicine AI Ltd., Masdar City, United Arab Emirates.
Ren F; Insilico Medicine Shanghai Ltd., Shanghai, China.
Rosenberg AJ; Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Illinois, USA.
Agrawal N; Department of Surgery, University of Chicago, Chicago, Illinois, USA.
Izumchenko E; Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, Illinois, USA.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre On Healthy Ageing (NO-Age), Oslo, Norway.
Zhavoronkov A; Insilico Medicine Hong Kong Ltd., Hong Kong, China.; Insilico Medicine AI Ltd., Masdar City, United Arab Emirates.; Buck Institute for Research on Aging, Novato, California, USA.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2023 Dec; Vol. 22 (12), pp. e14017. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:: Journal Article
MeSH Terms:: Caenorhabditis elegans Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/genetics
Animals ; Humans ; Aging/genetics ; Longevity/genetics ; Caenorhabditis elegans/metabolism ; Artificial Intelligence ; Histone Demethylases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Roles of NAD in Acute and Chronic Kidney Diseases.
Autorzy:: Morevati M; Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Mace ML; Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Kanbay M; Division of Nephrology, Department of Medicine, Koç University School of Medicine, Istanbul 34010, Turkey.
Gravesen E; Department of Pathology, Herlev Hospital, University of Copenhagen, 2730 Copenhagen, Denmark.
Nordholm A; Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Egstrand S; Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Hornum M; Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 21; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Acute Kidney Injury*
Renal Insufficiency, Chronic*
Sirtuins*/metabolism
Humans ; Energy Metabolism ; NAD/metabolism ; Poly(ADP-ribose) Polymerases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Design, Synthesis, Molecular Docking Analysis and Biological Evaluations of 4-[(Quinolin-4-yl)amino]benzamide Derivatives as Novel Anti-Influenza Virus Agents.
Autorzy:: Zhang C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tang YS; School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Meng CR; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xu J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang DL; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Huang EF; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shaw PC; School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Hu C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 04; Vol. 23 (11). Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:: Journal Article
MeSH Terms:: Influenza A Virus, H1N1 Subtype*
Influenza A Virus, H3N2 Subtype*
Antiviral Agents/pharmacology ; Benzamides/pharmacology ; DNA Viruses ; Molecular Docking Simulation ; Ribonucleoproteins ; Virus Replication

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: PharmKG: a dedicated knowledge graph benchmark for bomedical data mining.
Autorzy:: Zheng S; School of Data and Computer Science at the Sun Yat-Sen University.
Rao J; School of Data and Computer Science at the Sun Yat-Sen University.
Song Y; School of Systems Science and Engineering at the Sun Yat-Sen University.
Zhang J; Aladdin Healthcare Technologies Ltd.
Xiao X; Aladdin Healthcare Technologies Ltd.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Yang Y; School of Data and Computer Science and the National Super Computer Center at Guangzhou, Sun Yat-sen University, China.
Niu Z; Aladdin Healthcare Technologies Ltd.; Pokaż więcej
Źródło:: Briefings in bioinformatics [Brief Bioinform] 2021 Jul 20; Vol. 22 (4).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Biomedical Research*
Data Mining*
Neural Networks, Computer*
Semantics*
Software*
Benchmarking ; Humans

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer's Disease.
Autorzy:: Wang H; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway.
Lautrup S; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway.
Caponio D; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway.
Zhang J; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway.; Xiangya School of Stomatology, Central South University, Changsha 410083, China.
Fang EF; Department of Clinical Molecular Biology, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age), 0010 Oslo, Norway.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 23; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Damage*
Genomic Instability*
Aging/*pathology
Alzheimer Disease/*complications
Neurodegenerative Diseases/*pathology
Animals ; DNA Repair ; Humans ; Mutation ; Neurodegenerative Diseases/etiology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling.
Autorzy:: Okur MN; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Department of Clinical Molecular Biology, University of Oslo and The Akershus University Hospital, Lørenskog, Norway.
Fivenson EM; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Tiwari V; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Croteau DL; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Danish Center for Healthy Aging, University of Copenhagen, Copenhagen N, Denmark.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2020 Dec; Vol. 19 (12), pp. e13268. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cockayne Syndrome/*metabolism
DNA Helicases/*metabolism
DNA Repair Enzymes/*metabolism
Mitochondria/*metabolism
NAD/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Transcription Factors/*metabolism
AMP-Activated Protein Kinases/metabolism ; Aging, Premature/genetics ; Aging, Premature/metabolism ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cerebellum/metabolism ; Cockayne Syndrome/genetics ; Cockayne Syndrome/pathology ; DNA Helicases/deficiency ; DNA Helicases/genetics ; DNA Repair Enzymes/deficiency ; DNA Repair Enzymes/genetics ; Disease Models, Animal ; Humans ; Longevity/genetics ; Longevity/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mitochondria/pathology ; Oligonucleotide Array Sequence Analysis ; Poly-ADP-Ribose Binding Proteins/deficiency ; Poly-ADP-Ribose Binding Proteins/genetics ; Signal Transduction ; Transcription Factors/deficiency ; Transcription Factors/genetics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis.
Autorzy:: Ianevski A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Kulesskiy E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Krpina K; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Lou G; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Aman Y; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Bugai A; Department of Biochemistry and Developmental Biology, University of Helsinki, 00014 Helsinki, Finland.
Aasumets K; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
Akimov Y; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Bulanova D; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Gildemann K; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
Arutyunyan AF; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Susova OY; Institute of Carcinogenesis, FSBI 'N.N. Blokhin National Medical Research Center of Oncology', The Ministry of Health of the Russian Federation, 119991 Moscow, Russia.
Zhuze AL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ji P; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Wang W; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Holien T; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.; Department of Hematology, St. Olav's University Hospital, 7030 Trondheim, Norway.
Bugge M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Zusinaite E; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
Oksenych V; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Lysvand H; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Gerhold JM; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.
Bjørås M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.
Johansen P; Department of Dermatology, University of Zurich, 8006 Zurich, Switzerland.
Waage A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.; Department of Hematology, St. Olav's University Hospital, 7030 Trondheim, Norway.
Heckman CA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Kainov DE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Institute of Technology, University of Tartu, 50090 Tartu, Estonia.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2020 Jun 25; Vol. 12 (6). Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:: Journal Article

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.
Autorzy:: Wong JH; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .
Ng TB; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. .; The Chinese University of Hong Kong (CUHK) Shenzhen Research Institute, Shenzhen, China. .
Chan HHL; Vita Green Pharmaceuticals (Hong Kong) Limited, Hong Kong, China. .
Liu Q; Institute of Plant Nutrition, Agricultural Resources and Environmental Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Man GCW; Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
Zhang CZ; State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center and Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Guan S; Department of Social Medicine, College of Public Health, Xinjiang Medical University, Urumqi, China.
Ng CCW; School of Medicine, King's College London, London, UK.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Wang H; Department of Microbiology, China Agricultural University, Beijing, China.
Liu F; Department of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, China.
Ye X; Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, Fujian, China.
Rolka K; Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, Gdańsk, Poland.
Naude R; Department of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, 6031, South Africa.
Zhao S; Key Laboratory of Vegetable Postharvest Processing, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, and Beijing Key Laboratory of Fruits and Vegetable Storage and Processing, Ministry of Agriculture, Beijing, China.
Sha O; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.
Li C; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .
Xia L; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2020 Jun; Vol. 104 (11), pp. 4675-4703. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Agaricales/*chemistry
Agaricales/*classification
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Animals ; Cell Line, Tumor ; Clinical Trials as Topic ; Complex Mixtures/chemistry ; Complex Mixtures/pharmacology ; Disease Models, Animal ; Female ; Humans ; Mice ; Rats

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 11.

Tytuł:: New ribosome-inactivating proteins and other proteins with protein synthesis-inhibiting activities.
Autorzy:: Wong JH; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University, Shenzhen, China. .; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .
Bao H; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.
Ng TB; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. .
Chan HHL; Vita Green Pharmaceuticals (Hong Kong) Limited, Hong Kong, China. .
Ng CCW; School of Medicine, King's College London, London, UK.
Man GCW; Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
Wang H; Department of Microbiology, China Agricultural University, Beijing, China.
Guan S; Department of Social Medicine, College of Public Health, Xinjiang Medical University, Urumqi, China.
Zhao S; Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, and Beijing Key Laboratory of Fruits and Vegetable Storage and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture, Beijing, China.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Rolka K; Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, Gdańsk, Poland.
Liu Q; Institute of Plant Nutrition, Agricultural Resources and Environmental Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Li C; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.
Sha O; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.
Xia L; State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. .; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2020 May; Vol. 104 (10), pp. 4211-4226. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein Biosynthesis/*drug effects
Ribosome Inactivating Proteins/*metabolism
Amino Acid Sequence ; Animals ; Culicidae/chemistry ; Insect Proteins/metabolism ; Plant Proteins/metabolism ; Ribosome Inactivating Proteins/classification ; Ribosome Inactivating Proteins/pharmacology ; Seeds/chemistry

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 12.

Tytuł:: Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.
Autorzy:: Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Waltz TB; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Kassahun H; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Institute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Lu Q; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Kerr JS; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Morevati M; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Fivenson EM; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Wollman BN; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Marosi K; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Wilson MA; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Iser WB; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Eckley DM; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Zhang Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Lehrmann E; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Goldberg IG; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Scheibye-Knudsen M; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Mattson MP; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Nilsen H; Institute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Becker KG; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Apr 11; Vol. 7, pp. 46208. Date of Electronic Publication: 2017 Apr 11.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Caenorhabditis elegans/*physiology
Caenorhabditis elegans Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Longevity/*physiology
Mitophagy/*drug effects
NF-E2-Related Factor 2/*metabolism
Signal Transduction/*drug effects
Tomatine/*analogs & derivatives
Transcription Factors/*metabolism
Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Gene Expression Regulation/drug effects ; Longevity/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Muscles/drug effects ; Muscles/physiology ; Organelle Biogenesis ; Reactive Oxygen Species/metabolism ; Stress, Physiological/drug effects ; Tomatine/pharmacology ; Transcriptome/genetics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 13.

Tytuł:: DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.
Autorzy:: Misiak M; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Vergara Greeno R; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Baptiste BA; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Sykora P; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Liu D; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Cordonnier S; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Croteau DL; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Mattson MP; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD, 21224, USA.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2017 Feb; Vol. 16 (1), pp. 162-172. Date of Electronic Publication: 2016 Sep 30.
Typ publikacji:: Journal Article
MeSH Terms:: Smell*
Alzheimer Disease/*enzymology
Alzheimer Disease/*pathology
DNA Polymerase beta/*metabolism
Olfactory Bulb/*enzymology
Olfactory Bulb/*pathology
Amyloid beta-Peptides/metabolism ; Animals ; Apoptosis ; Cell Death ; Cell Differentiation ; Cell Respiration ; DNA Damage ; Disease Models, Animal ; Embryo, Mammalian/metabolism ; Haploinsufficiency ; Heterozygote ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitochondria/metabolism ; Neurogenesis ; Neurons/metabolism ; Neurons/pathology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis.
Autorzy:: Li X; 1] School of Public Health, Fudan University, Shanghai, 200032, China [2] Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China [3].
Fang EF; 1] Laboratory of Molecular Gerontology, National Institute on Ageing, National Institutes of Health, Baltimore, MD USA [2] School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Shatin, New Territories, Hong Kong [3].
Scheibye-Knudsen M; Laboratory of Molecular Gerontology, National Institute on Ageing, National Institutes of Health, Baltimore, MD USA.
Cui H; Shanghai Stomatological Disease Centre. Shanghai, 200001, PR China.
Qiu L; Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China.
Li J; Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China.
He Y; Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China.
Huang J; Laboratory of Molecular Gerontology, National Institute on Ageing, National Institutes of Health, Baltimore, MD USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Ageing, National Institutes of Health, Baltimore, MD USA.
Ng TB; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Shatin, New Territories, Hong Kong.
Guo H; School of Public Health, Fudan University, Shanghai, 200032, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2014 Sep 22; Vol. 4, pp. 6434. Date of Electronic Publication: 2014 Sep 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Replication/*drug effects
Mitochondria/*drug effects
Sirtuin 1/*biosynthesis
Spermatogenesis/*drug effects
Animals ; DNA Replication/genetics ; Humans ; Male ; Mitochondria/pathology ; Rats ; Reproduction/drug effects ; Reproduction/genetics ; Spermatogenesis/genetics ; Testis/drug effects