PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.
Autorzy:
Zhao Z; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Kurimchak A; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Nikonova AS; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. FeiserF; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Wasserman JS; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Fowle H; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Varughese T; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Connors M; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Johnson K; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Makhov P; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Lindskog C; Department of Immunology, Genetics and Pathology, Uppsala University, 752 36, Uppsala, Sweden. Kolenko VM; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Golemis EA; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Duncan JS; Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Graña X; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. .
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Źródło:
Oncogenesis [Oncogenesis] 2019 Dec 10; Vol. 8 (12), pp. 72. Date of Electronic Publication: 2019 Dec 10.
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