Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer.
Autorzy:
Ramos INF; Oncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil. da Silva MF; Oncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil. Lopes JMS; Department of Physics, Federal University of Roraima, Boa Vista 69310-000, RR, Brazil. Cruz JN; Institute of Technology, Federal University of Pará, Belém 66075-110, PA, Brazil. Alves FS; Graduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém 66075-110, PA, Brazil. do Rego JAR; Graduate Program in Science and Environment, Federal University of Pará, Belém 66075-110, PA, Brazil. Costa MLD; Institute of Geosciences, Federal University of Pará, Belém 66075-110, PA, Brazil. Assumpção PP; Oncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil. Barros Brasil DDS; Institute of Technology, Federal University of Pará, Belém 66075-110, PA, Brazil.; Graduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém 66075-110, PA, Brazil.; Graduate Program in Science and Environment, Federal University of Pará, Belém 66075-110, PA, Brazil. Khayat AS; Oncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil.; Institute of Biological Science, Federal University of Pará, Belém 66075-110, PA, Brazil.
APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.
Autorzy:
Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Jain-Washburn E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Philipp I; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Loika Y; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Loiko E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Bagley O; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Ukraintseva S; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Yashin A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Arbeev K; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. Stallard E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA. FeitosaMF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA. Schupf N; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, New York, USA. Christensen K; Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark. Culminskaya I; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
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Źródło:
Aging cell [Aging Cell] 2022 Dec; Vol. 21 (12), pp. e13730. Date of Electronic Publication: 2022 Nov 03.
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Autorzy:
Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. . Rasheed H; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway. Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Rowan BX; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. Stanzick KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Thomas LF; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore-Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway. Tin A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Hoppmann A; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. Chu AY; Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. Tayo B; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. Thio CHL; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Cusi D; Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy.; Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy. Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. Sieber KB; Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. Horn K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Li M; Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, UT, USA. Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Cocca M; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Wuttke M; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.; Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Ghasemi S; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. Li Y; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. Pontali G; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.; University of Trento, Department of Cellular, Computational and Integrative Biology-CIBIO, Trento, Italy. Günther F; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, Munich, Germany. Dehghan A; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Dementia Research Institute, Imperial College London, London, UK. Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. Parsa A; Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; University of Maryland School of Medicine, Baltimore, MD, USA. Feresin A; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. de Vries APJ; Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA. Smith AV; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. Oldehinkel AJ; Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. De Grandi A; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Rosenkranz AR; Department of Internal Medicine, Division of Nephrology, Medical University Graz, Graz, Austria. Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. Teren A; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Heart Center Leipzig, Leipzig, Germany. Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Hicks AA; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Morris AP; Department of Health Data Science, University of Liverpool, Liverpool, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK. Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany. Morgan A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Podgornaia AI; Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. Peters A; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Chair of Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany. Körner A; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.; Center for Pediatric Research, University of Leipzig, Leipzig, Germany. Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK. Campbell A; Center for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Freedman BI; Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Spedicati B; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. Ponte B; Service de Néphrologie et Hypertension, Medicine Department, Geneva University Hospitals, Geneva, Switzerland. Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Network Aging Research, University of Heidelberg, Heidelberg, Germany. Brumpton B; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway. Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Krämer BK; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Jung B; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. Åsvold BO; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. Ning B; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Penninx BWJH; Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands. Vanderwerff BR; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA. Kammerer CM; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Langefeld CD; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA. Robinson-Cohen C; Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.; Vanderbilt University Medical Center, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Injury Research, and Vanderbilt Precision Nephrology Program Nashville, Nashville, TN, USA. Hartman CA; Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Lindgren CM; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7LF, UK. Wang C; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore. Lanzani C; Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Cheng CY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. Fuchsberger C; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Gieger C; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Shaffer CM; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Schulz CA; Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA. Gudbjartsson DF; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy. Toniolo D; San Raffaele Research Institute, Milan, Italy. Czamara D; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. Porteous DJ; Center for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Waterworth DM; Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. Mascalzoni D; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.; Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Mook-Kanamori DO; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Reilly DF; Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. Boerwinkle E; Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA. Salvi E; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy. Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany. Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke - NUS Medical School, Singapore, Singapore. Catamo E; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Rizzi F; Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy.; ePhood Scientific Unit, ePhood SRL, Milano, Italy. Guo F; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Rivadeneira F; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Guilianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. Sveinbjornsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Ehret G; Cardiology, Geneva University Hospitals, Geneva, Switzerland. Waeber G; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Biino G; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council of Italy, Pavia, Italy. Girotto G; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. Pistis G; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. Nadkarni GN; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Montgomery GW; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia. Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Campbell H; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. White HD; Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. Gao H; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK. Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Schmidt H; Research Unit Genetic Epidemiology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. Li H; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Network Aging Research, University of Heidelberg, Heidelberg, Germany. Holm H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Kramer H; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.; Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. Rudan I; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Tzoulaki I; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Dementia Research Institute, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. Olafsson I; Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. Martins J; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK. Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. Halbritter J; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany. Felix JF; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Divers J; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK. Lee JJ; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. O'Connell J; University of Maryland School of Medicine, Baltimore, MD, USA. Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institutefor Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. Liu J; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. Xu J; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Thiery J; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. Ärnlöv J; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Studies, Dalarna University, Stockholm, Sweden. Kuusisto J; University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland. Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland.; The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland. Tremblay J; Montreal University Hospital Research Center, CHUM, Montreal, QC, Canada.; CRCHUM, Montreal, QC, Canada. Chambers JC; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Gaziano JM; Department of Internal Medicine, Harvard Medical School, Boston, MA, USA.; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Jonas JB; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.; Instituteof Molecular and Clinical Ophthalmology, Basel, Switzerland.; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany. Mychaleckyj JC; Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA. Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark. Eckardt KU; Intensive Care Medicine, Charité, Berlin, Germany.; Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Endlich K; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. Dittrich K; Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.; Center for Pediatric Research, University of Leipzig, Leipzig, Germany. Ryan KA; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA. Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institutefor Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. Ho K; Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.; Department of Nephrology, Geisinger, Danville, PA, USA. Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Matsuda K; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany. Miliku K; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Hveem K; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. Lind L; Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Wallentin L; Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Yerges-Armstrong LM; Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Phillips LS; Atlanta VA Health Care System, Decatur, GA, USA.; Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Lange LA; Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. Citterio L; Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Klaric L; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Ising M; Max Planck Institute of Psychiatry, Munich, Germany. Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany. Francescatto M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. Concas MP; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy. Piratsu M; Institute of Genetic and Biomedical Research, National Research Council of Italy, Cagliari, Italy. Orho-Melander M; Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. Laakso M; University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland. Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Perola M; Finnish Institute for Health and Welfare, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. de Borst MH; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Gögele M; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Bianca M; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Lukas MA; Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA. FeitosaMF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Biggs ML; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA. Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Kanai M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Yasuda M; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan. Nauck M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Waldenberger M; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Chee ML; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Chee ML; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany. Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA. O'Donoghue ML; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.; TIMI Study Group, Boston, MA, USA. Kubo M; RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan. Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Kastarinen M; Kuopio University Hospital, Kuopio, Finland. Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA. Kuokkanen M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; The Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Bochud M; Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1010, Lausanne, Switzerland. Josyula NS; Department of Population Health Sciences, Geisinger Health, 100 N. Academy Ave., Danville, PA, USA. Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. Pirastu N; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA. Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Hutri-Kähönen N; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Bansal N; Division of Nephrology, University of Washington, Seattle, WA, USA.; Kidney Research Institute, University of Washington, Seattle, WA, USA. Devuyst O; Institute of Physiology, University of Zurich, Zurich, Switzerland. Melander O; Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. Polasek O; Faculty of Medicine, University of Split, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia. Manunta P; Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Gasparini P; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Sulem P; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Elliott P; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Dementia Research Institute, Imperial College London, London, UK.; Imperial College NIHR Biomedical Research Center, Imperial College London, London, UK.; Health Data Research UK-London, London, UK. Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA. Hamet P; Montreal University Hospital Research Center, CHUM, Montreal, QC, Canada.; Medpharmgene, Montreal, QC, Canada. Svensson PO; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Department of Cardiology, Södersjukhuset, Stockholm, Sweden. Joshi PK; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. Pramstaller PP; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Rossing P; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Sim RZH; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Burkhardt R; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA. Carroll RJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Gansevoort RT; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Felicita SC; San Raffaele Research Institute, Milan, Italy. Sedaghat S; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. Pendergrass SA; Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA. Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Hwang SJ; NHLBI's Framingham Heart Study, Framingham, MA, USA.; The Center for Population Studies, NHLBI, Framingham, MA, USA. Kerr SM; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, Cagliari, Italy. Patil SB; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. Hallan S; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Nephrology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Bakker SJL; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Lim SC; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore. Lucae S; Max Planck Institute of Psychiatry, Munich, Germany. Vogelezang S; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. Corre T; Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1010, Lausanne, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; The Bioinformatics Center, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Boutin TS; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Meitinger T; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany. Wong TY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. Bergler T; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Rabelink TJ; Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, The Netherlands. Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. Haller T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Thorsteinsdottir U; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. Foo VHX; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland. Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Giedraitis V; Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Gudnason V; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland. Jaddoe VWV; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China.; Shanghai Industrial Technology Institute, Shanghai, China. Zhang W; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UK. Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Kiess W; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.; Center for Pediatric Research, University of Leipzig, Leipzig, Germany. März W; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Koenig W; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany. Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. Gao X; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Friedlander Y; School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Tham YC; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. Milaneschi Y; Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands. Yu Z; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA. Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Stefansson K; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Böger CA; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. Hung AM; Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.; Vanderbilt University Medical Center, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Injury Research, and Vanderbilt Precision Nephrology Program Nashville, Nashville, TN, USA. Kronenberg F; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Köttgen A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. Pattaro C; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. .
The experience of teaching introductory programming skills to bioscientists in Brazil.
Autorzy:
Zuvanov L; São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil. Basso Garcia AL; Department of Genetics, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil. Correr FH; Department of Genetics, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil. Bizarria R Jr; Department of General and Applied Biology, São Paulo State University, Rio Claro, Brazil.; Center of the Study of Social Insects, Department of General and Applied Biology, Institute of Biosciences of Rio Claro, São Paulo State University, Rio Claro, Brazil. Filho APDC; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. da Costa AH; Department of Computer Science, Federal University of São Carlos, São Carlos, Brazil. Thomaz AT; School of Natural Sciences, Universidad del Rosario, Bogotá, Colombia. Pinheiro ALM; Department of Genetics, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil. Riaño-Pachón DM; Computational, Evolutionary and Systems Biology Lab, Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil. Winck FV; Regulatory Systems Biology Lab, Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil. Esteves FG; Center of the Study of Social Insects, Department of General and Applied Biology, Institute of Biosciences of Rio Claro, São Paulo State University, Rio Claro, Brazil. Margarido GRA; Department of Genetics, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil. Casagrande GMS; Barretos Cancer Hospital, Barretos, Brazil. Frajacomo HC; Department of Computer Science, Federal University of São Carlos, São Carlos, Brazil. Martins L; Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil. Cavalheiro MF; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Genomics for Climate Change Research Center, University of Campinas, Campinas, Brazil. Grachet NG; Roche Sequencing Solutions, Pleasanton, California, United States of America. da Silva RGC; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China. Cerri R; Department of Computer Science, Federal University of São Carlos, São Carlos, Brazil. Ramos RTJ; Institute of Biological Sciences, Federal University of Pará, Belém, Brazil. Medeiros SDS; Department of Informatics and Statistics, Federal University of Santa Catarina, Florianópolis, Brazil. Tavares TV; Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, Brazil. Corrêa Dos Santos RA; School of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.; Institute of Biology, State University of Campinas, Campinas, Brazil.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Nov 11; Vol. 17 (11), pp. e1009534. Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2021).
Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Autorzy:
Hahn J; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Fu YP; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America. Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America. de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. FeitosaMF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Weiss S; Interfaculty Institute for Genetics and Functional Genomics, The University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. Smith AV; Icelandic Heart Association, Kovapvogur, Iceland.; Faculty of Medicine, University of Iceland, Reykajvik, Iceland. Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America. Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Biostatistics, The University of Washington, Seattle, Washington, United States of America. Becker DM; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America. Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America. Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America. Franco OH; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Grove M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Harris TB; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America. Hofman A; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. Hwang SJ; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America. Kral BG; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Launer LJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Markus MRP; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, The University Medicine Greifswald, Greifswald, Germany. Rice KM; Department of Biostatistics, The University of Washington, Seattle, Washington, United States of America. Rich SS; Department of Medicine and Epidemiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America. Rivadeneira F; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America. Sotoodehnia N; Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, United States of America. Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America. Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. Völker U; Interfaculty Institute for Genetics and Functional Genomics, The University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Völzke H; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America. Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America. Dörr M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, The University Medicine Greifswald, Greifswald, Germany. Gudnason V; Icelandic Heart Association, Kovapvogur, Iceland.; Faculty of Medicine, University of Iceland, Reykajvik, Iceland. Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Post W; Department of Medicine and Epidemiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Epidemiology, The University of Washington, Seattle, Washington, United States of America.; Department of Health Services, The University of Washington, Seattle, Washington, United States of America.; Kaiser Permanente Research Institute, Seattle, Washington, United States of America. Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. O'Donnell CJ; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America.; VA Boston Healthcare System, Veteran's Affair, Boston, Massachusetts, United States of America.; Cardiovascular Medicine Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Nov 13; Vol. 15 (11), pp. e0230035. Date of Electronic Publication: 2020 Nov 13 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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