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Tytuł:
Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR mice.
Autorzy:
Thompson D; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK. .
Mahmood S; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Morrice N; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Kamli-Salino S; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Dekeryte R; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Hoffmann PA; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Doherty MK; Lipidomics Research Facility, Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, IV2 3JH, UK.
Whitfield PD; Lipidomics Research Facility, Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, IV2 3JH, UK.; Glasgow Polyomics, University of Glasgow, Garscube Campus, Glasgow, G61 1QH, UK.
Delibegović M; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Mody N; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 09; Vol. 13 (1), pp. 3937. Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis*/drug therapy
Atherosclerosis*/etiology
Atherosclerosis*/prevention & control
Fenretinide*/pharmacology
Insulin Resistance*
Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/etiology
Non-alcoholic Fatty Liver Disease*/metabolism
Animals ; Mice ; Ceramides/metabolism ; Diet, High-Fat ; Liver/metabolism ; Mice, Inbred C57BL ; Obesity/complications ; Obesity/drug therapy ; Obesity/metabolism ; Sphingomyelin Phosphodiesterase/metabolism ; Tretinoin/pharmacology ; Receptors, LDL/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule.
Autorzy:
Potenza RL; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.
Lodeserto P; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.
Orienti I; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 04; Vol. 23 (13). Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Fenretinide*/pharmacology
Fenretinide*/therapeutic use
Neoplasms*/drug therapy
Apoptosis ; Humans ; Tretinoin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure N -(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up.
Autorzy:
Alfei S; Department of Pharmacy (DIFAR), University of Genoa, Viale Cembrano, 16148 Genoa, Italy.
Zuccari G; Department of Pharmacy (DIFAR), University of Genoa, Viale Cembrano, 16148 Genoa, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 06; Vol. 27 (11). Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Fenretinide*/metabolism
Fenretinide*/pharmacology
Animals ; Mice ; Rats ; Tretinoin/analogs & derivatives ; Tretinoin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide.
Autorzy:
Plucińska K; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.; The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Integrative Physiology and Environmental Influences, University of Copenhagen, Copenhagen, Denmark.
Mody N; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Dekeryte R; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Shearer K; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Mcilroy GD; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.; The Rowett Institute, University of Aberdeen, Aberdeen, UK.
Delibegovic M; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Platt B; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2022 Apr; Vol. 25 (4), pp. 719-736. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Fenretinide*
Amyloid Precursor Protein Secretases/metabolism ; Animals ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Cognition ; Diet, High-Fat/adverse effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mixed micelles of TPGS and Soluplus for co-delivery of paclitaxel and fenretinide: in vitro and in vivo anticancer study.
Autorzy:
Wang Y; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ding Y; School of Basic Medicine, Dalian Medical University, Dalian, P.R. China.
Xu Y; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Wang C; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ding Y; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Gao M; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ma C; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ma X; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Li L; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.; Key Laboratory for Basic and Applied Research on Pharmacodynamic Substances of Traditional Chinese Medicine of Liaoning Province, Dalian Medical University, Dalian, P.R. China.
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Źródło:
Pharmaceutical development and technology [Pharm Dev Technol] 2020 Sep; Vol. 25 (7), pp. 865-873. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji:
Journal Article
MeSH Terms:
Micelles*
Antineoplastic Agents/*administration & dosage
Drug Delivery Systems/*methods
Fenretinide/*administration & dosage
Paclitaxel/*administration & dosage
Polyethylene Glycols/*administration & dosage
Polyvinyls/*administration & dosage
Vitamin E/*administration & dosage
Animals ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Drug Carriers/administration & dosage ; Drug Carriers/pharmacokinetics ; Female ; Fenretinide/pharmacokinetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Paclitaxel/pharmacokinetics ; Polyethylene Glycols/pharmacokinetics ; Polyvinyls/pharmacokinetics ; Rats ; Rats, Wistar ; Tumor Burden/drug effects ; Tumor Burden/physiology ; Vitamin E/pharmacokinetics ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19.
Autorzy:
Orienti I; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.
Gentilomi GA; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.; Unit of Microbiology, Alma Mater Studiorum-University of Bologna, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy.
Farruggia G; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.; Biostructures and Biosystems National Institute (BBNI), 00136 Roma, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 May 27; Vol. 21 (11). Date of Electronic Publication: 2020 May 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Anti-Inflammatory Agents/*therapeutic use
Coronavirus Infections/*drug therapy
Fenretinide/*therapeutic use
Pneumonia, Viral/*drug therapy
Animals ; Anti-Inflammatory Agents/pharmacology ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cytokines ; Fenretinide/pharmacology ; Humans ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Respiratory System/drug effects ; Respiratory System/metabolism ; SARS-CoV-2 ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells.
Autorzy:
Orienti I; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Salvati V; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.; Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.
Sette G; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.; Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.
Zucchetti M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Bongiorno-Borbone L; Department of Experimental Medicine, TOR, University of Rome 'Tor Vergata', Rome, Italy.
Peschiaroli A; National Research Council of Italy (CNR), Institute of Translational Pharmacology IFT, Rome, Italy.
Zolla L; Department of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.
Francescangeli F; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Ferrari M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Matteo C; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Bello E; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Di Virgilio A; Service for Biotechnology and Animal Welfare, Istituto Superiore di Sanità, Rome, Italy.
Falchi M; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
De Angelis ML; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Baiocchi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Melino G; Department of Experimental Medicine, TOR, University of Rome 'Tor Vergata', Rome, Italy.
De Maria R; Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy.; Fondazione Policlinico Universitario 'A. Gemelli' - I.R.C.C.S, Rome, Italy.
Zeuner A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Eramo A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Aug 22; Vol. 38 (1), pp. 373. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Micelles*
Colonic Neoplasms/*drug therapy
Fenretinide/*administration & dosage
Lung Neoplasms/*drug therapy
Melanoma/*drug therapy
Neoplastic Stem Cells/*drug effects
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Apoptosis ; Biological Availability ; Cell Proliferation ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Female ; Fenretinide/chemistry ; Fenretinide/pharmacokinetics ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Melanoma/metabolism ; Melanoma/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tissue Distribution ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Water-soluble derivatives of 4-oxo-N-(4-hydroxyphenyl) retinamide: synthesis and biological activity.
Autorzy:
Musso L; Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università degli Studi di Milano, Milano, Italy. .
Tiberio P; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Italy.
Appierto V; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Italy.
Cincinelli R; Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università degli Studi di Milano, Milano, Italy.
Cavadini E; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Italy.
Cleris L; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Italy.
Daidone MG; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Italy.
Dallavalle S; Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università degli Studi di Milano, Milano, Italy.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2016 Oct; Vol. 88 (4), pp. 608-14. Date of Electronic Publication: 2016 Jun 06.
Typ publikacji:
Letter
MeSH Terms:
Apoptosis/*drug effects
Fenretinide/*chemical synthesis
Fenretinide/*pharmacology
Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Fenretinide/analogs & derivatives ; Fenretinide/chemistry ; Humans ; Solubility ; Water/chemistry
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lipid nano-bubble combined with ultrasound for anti-keloids therapy.
Autorzy:
Wang XQ; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.; b Yanbian University Hospital , Yanji , China , and.; c Jining No.1 People's Hospital , Jining , China.
Li ZN; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.; b Yanbian University Hospital , Yanji , China , and.
Wang QM; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Jin HY; b Yanbian University Hospital , Yanji , China , and.
Gao Z; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Jin ZH; b Yanbian University Hospital , Yanji , China , and.
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Źródło:
Journal of liposome research [J Liposome Res] 2018 Mar; Vol. 28 (1), pp. 5-13. Date of Electronic Publication: 2016 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Liposomes*
Nanoparticles*
Ultrasonic Waves*
Fenretinide/*pharmacology
Keloid/*therapy
Lipids/*chemistry
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Fenretinide/chemistry ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Particle Size ; Surface Properties
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1.
Autorzy:
Poliakov E; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Samuel W; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Duncan T; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Gutierrez DB; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Mata NL; Acucela Inc., Seattle, Washington, United States of America.
Redmond TM; Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Apr 27; Vol. 12 (4), pp. e0176487. Date of Electronic Publication: 2017 Apr 27 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Targeted Therapy*
Fenretinide/*analogs & derivatives
Fenretinide/*metabolism
Membrane Proteins/*antagonists & inhibitors
Oxidoreductases/*antagonists & inhibitors
Stearoyl-CoA Desaturase/*antagonists & inhibitors
Tretinoin/*analogs & derivatives
beta-Carotene 15,15'-Monooxygenase/*antagonists & inhibitors
Animals ; Cell Line ; Fenretinide/pharmacology ; Humans ; Mice ; Receptors, Retinoic Acid/metabolism ; Tretinoin/metabolism ; Tretinoin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Fenretinide-polyethylene glycol (PEG) conjugate with improved solubility enhanced cytotoxicity to cancer cell and potent in vivo efficacy.
Autorzy:
Wang Y; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ding Y; School of Basic Medicine, Dalian Medical University, Dalian, P.R. China.
Wang C; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Gao M; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Xu Y; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ma X; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Ma X; The Second Hospital of Dalian Medical University, Dalian, P.R. China.
Cui H; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.
Li L; School of Pharmacy, Dalian Medical University, Dalian, P.R. China.; Key Laboratory for Basic and Applied Research on Pharmacodynamic Substances of Traditional Chinese Medicine of Liaoning Province, Dalian Medical University, Dalian, P.R. China.
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Źródło:
Pharmaceutical development and technology [Pharm Dev Technol] 2020 Oct; Vol. 25 (8), pp. 962-970. Date of Electronic Publication: 2020 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Fenretinide/*pharmacology
Polyethylene Glycols/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Humans ; MCF-7 Cells ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Rats, Sprague-Dawley ; Solubility/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fenretinide: a novel treatment for endometrial cancer.
Autorzy:
Mittal N; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Malpani S; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Dyson M; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Ono M; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Coon JS; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Kim JJ; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Schink JC; Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America; Department of Obstetrics and Gynecology, Spectrum Health Medical Group, Grand Rapids, Michigan, United States of America.
Bulun SE; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
Pavone ME; Division of Reproductive Biology, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America; Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Oct 23; Vol. 9 (10), pp. e110410. Date of Electronic Publication: 2014 Oct 23 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endometrial Neoplasms/*drug therapy
Fenretinide/*therapeutic use
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Survival/genetics ; Disease Progression ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Female ; Fenretinide/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Megestrol Acetate/pharmacology ; Membrane Proteins/metabolism ; Mice, Nude ; Vitamin A/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: a case report from a New Approaches to Neuroblastoma (NANT) Phase I study.
Autorzy:
Kang MH; Cancer Center and Departments of Cell Biology and Biochemistry, Pharmacology and Neuroscience, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 9445 79430 Lubbock, TX, USA. .
Villablanca JG
Glade Bender JL
Matthay KK
Groshen S
Sposto R
Czarnecki S
Ames MM
Reynolds CP
Marachelian A
Maurer BJ
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Źródło:
BMC research notes [BMC Res Notes] 2014 Apr 23; Vol. 7, pp. 256. Date of Electronic Publication: 2014 Apr 23.
Typ publikacji:
Case Reports; Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetaminophen/*adverse effects
Ceftriaxone/*adverse effects
Fenretinide/*adverse effects
Neuroblastoma/*drug therapy
Acetaminophen/administration & dosage ; Acetaminophen/therapeutic use ; Ceftriaxone/administration & dosage ; Ceftriaxone/therapeutic use ; Child ; Dose-Response Relationship, Drug ; Drug Interactions ; Fatal Outcome ; Fenretinide/administration & dosage ; Fenretinide/therapeutic use ; Humans ; Injections, Intravenous ; Male ; Neuroblastoma/diagnostic imaging ; Radiography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel PLA microspheres with hydrophilic and bioadhesive surfaces for the controlled delivery of fenretinide.
Autorzy:
Falconi M; Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Unit of Human Anatomy, University of Bologna , Via Irnerio 48, 40126 Bologna , Italy and.
Focaroli S
Teti G
Salvatore V
Durante S
Nicolini B
Orienti I
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Źródło:
Journal of microencapsulation [J Microencapsul] 2014; Vol. 31 (1), pp. 41-8. Date of Electronic Publication: 2013 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Fenretinide*/chemistry
Fenretinide*/pharmacology
Microspheres*
Neoplasms/*drug therapy
Animals ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Cattle ; Cell Line, Tumor ; Delayed-Action Preparations ; Gelatin/chemistry ; Gelatin/pharmacology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Microscopy, Electrochemical, Scanning ; Neoplasms/metabolism ; Neoplasms/pathology ; Particle Size ; Phosphatidylcholines/chemistry ; Phosphatidylcholines/pharmacology ; Polyesters/chemistry ; Polyesters/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fenretinide treatment accelerates atherosclerosis development in apoE-deficient mice in spite of beneficial metabolic effects.
Autorzy:
Busnelli M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Manzini S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Bonacina F; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Soldati S; Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
Barbieri SS; IRCCS, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Amadio P; IRCCS, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Sandrini L; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.; IRCCS, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Arnaboldi F; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
Donetti E; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
Laaksonen R; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Paltrinieri S; Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
Scanziani E; Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione UniMi, Milan, Italy.
Chiesa G; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Jan; Vol. 177 (2), pp. 328-345. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*toxicity
Aorta/*drug effects
Aortic Diseases/*chemically induced
Atherosclerosis/*chemically induced
Energy Metabolism/*drug effects
Fenretinide/*toxicity
Animals ; Aorta/metabolism ; Aorta/pathology ; Aortic Diseases/genetics ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diet, Western ; Disease Models, Animal ; Disease Progression ; Female ; Lipids/blood ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Plaque, Atherosclerotic ; Spleen/drug effects ; Spleen/metabolism ; Spleen/pathology ; Weight Loss/drug effects
Czasopismo naukowe
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Tytuł:
Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment.
Autorzy:
Britt EL; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Raman S; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Leek K; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Sheehy CH; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Kim SW; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Harada H; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Jul 05; Vol. 14 (7), pp. e0219398. Date of Electronic Publication: 2019 Jul 05 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Fenretinide/*pharmacology
NADPH Oxidase 2/*genetics
Squamous Cell Carcinoma of Head and Neck/*genetics
Sulfonamides/*pharmacology
Cell Line, Tumor ; Ectopic Gene Expression/genetics ; Humans ; NADPH Oxidase 2/metabolism ; Squamous Cell Carcinoma of Head and Neck/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
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Tytuł:
Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers.
Autorzy:
Dobrotkova V; Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Pekarska, Czech Republic.
Chlapek P; Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Pekarska, Czech Republic.
Jezova M; Department of Pathology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska, Czech Republic.
Adamkova K; Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska, Czech Republic.
Mazanek P; Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Cernopolni, Czech Republic.
Sterba J; International Clinical Research Center, St. Anne's University Hospital, Pekarska, Czech Republic.; Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Cernopolni, Czech Republic.
Veselska R; Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Pekarska, Czech Republic.; Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Cernopolni, Czech Republic.
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Źródło:
PloS one [PLoS One] 2019 Jun 12; Vol. 14 (6), pp. e0218269. Date of Electronic Publication: 2019 Jun 12 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Biomarkers, Pharmacological/*metabolism
Drug Resistance, Neoplasm/*drug effects
Isotretinoin/*pharmacology
Neuroblastoma/*genetics
Tretinoin/*analogs & derivatives
Tretinoin/*pharmacology
Adolescent ; Bexarotene/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Drug Resistance, Neoplasm/genetics ; Female ; Fenretinide/pharmacology ; HMGA1a Protein/genetics ; HMGA1a Protein/metabolism ; HMGA2 Protein/genetics ; HMGA2 Protein/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Infant ; Infant, Newborn ; Male ; Nervous System Neoplasms/genetics ; Nervous System Neoplasms/metabolism ; Nervous System Neoplasms/pathology ; Nervous System Neoplasms/surgery ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Neuroblastoma/surgery ; Paraffin Embedding ; Pre-B-Cell Leukemia Transcription Factor 1/genetics ; Pre-B-Cell Leukemia Transcription Factor 1/metabolism ; Tissue Fixation ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide
Autorzy:
Cristina Matteo
Isabella Orienti
Adriana Eramo
Ann Zeuner
Mariella Ferrari
Alice Passoni
Renzo Bagnati
Marianna Ponzo
Ezia Bello
Massimo Zucchetti
Roberta Frapolli
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Temat:
fenretinide
4-HPR
oral formulation
pharmacokinetics
tumor distribution
analytical chemistry
Pharmacy and materia medica
RS1-441
Źródło:
Pharmaceutics, Vol 16, Iss 3, p 387 (2024)
Opis pliku:
electronic resource
Relacje:
https://www.mdpi.com/1999-4923/16/3/387; https://doaj.org/toc/1999-4923
Dostęp URL:
https://doaj.org/article/27825a3d5a704a958b9781168ea195db  Link otwiera się w nowym oknie
Czasopismo naukowe
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Wyświetlanie 1-20 z 696

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