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    Tytuł:
    Budget Impact Analysis of Utilization of Sacubitril/Valsartan for the Treatment of Heart Failure With Reduced Ejection Fraction in the Philippines
    Autorzy:
    Leong, Robert Neil
    Caesar delos Trinos, John Paul
    Gerodias, Ferdinand, Jr.
    Mojica, Vio Jianu
    Alconera, Christelle Jhan
    Tamayo, Reiner Lorenzo
    Alacapa, Jason
    Almirol, Bernadette Joy
    Paredes, Karlo Paolo
    Lim, Sheila
    Tumanan-Mendoza, Bernadette
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    Źródło:
    In Value in Health Regional Issues July 2023 36:105-116
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs.
    Autorzy:
    Ferdinand JR; Molecular Immunity Unit, University of Cambridge, Department of Medicine, Cambridge, UK.
    Morrison MI; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK.
    Andreasson A; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK.
    Charlton C; Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
    Chhatwal AK; Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
    Scott WE 3rd; Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
    Borthwick LA; Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
    Clatworthy MR; Molecular Immunity Unit, University of Cambridge, Department of Medicine, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK.
    Fisher AJ; Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK.
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    Źródło:
    Clinical transplantation [Clin Transplant] 2022 Apr; Vol. 36 (4), pp. e14570. Date of Electronic Publication: 2022 Jan 10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Lung Transplantation*
    Biomarkers/metabolism ; Humans ; Lung ; Perfusion ; Tissue Donors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
    Autorzy:
    Douthwaite JA; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. .
    Brown CA; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK. .
    Ferdinand JR; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
    Sharma R; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
    Elliott J; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Taylor MA; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Malintan NT; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Duvoisin H; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Hill T; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Delpuech O; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Orton AL; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Pitt H; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Kuenzi F; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Fish S; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.; GSK R&D Tech, Stevenage, UK.
    Nicholls DJ; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Cuthbert A; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Richards I; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Ratcliffe G; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Upadhyay A; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Marklew A; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Hewitt C; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Ross-Thriepland D; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Brankin C; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Chodorge M; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Browne G; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Mander PK; GSK R&D, Stevenage, UK.
    DeWildt RM; GSK R&D, Stevenage, UK.
    Weaver S; GSK R&D Tech, Stevenage, UK.
    Smee PA; GSK R&D Tech, Stevenage, UK.
    van Kempen J; GSK R&D, Stevenage, UK.
    Bartlett JG; GSK R&D, Stevenage, UK.
    Allen PM; GSK R&D, Stevenage, UK.
    Koppe EL; GSK R&D, Stevenage, UK.
    Ashby CA; GSK R&D, Stevenage, UK.
    Phipps JD; GSK R&D, Stevenage, UK.
    Mehta N; GSK R&D, Stevenage, UK.
    Brierley DJ; GSK R&D, Stevenage, UK.
    Tew DG; GSK R&D, Stevenage, UK.
    Leveridge MV; GSK R&D, Stevenage, UK.
    Baddeley SM; GSK R&D, Stevenage, UK.
    Goodfellow IG; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
    Green C; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Abell C; Vice Chancellor's Office, University of Cambridge, Cambridge, UK.
    Neely A; Vice Chancellor's Office, University of Cambridge, Cambridge, UK.
    Waddell I; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
    Rees S; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Maxwell PH; School of Clinical Medicine, University of Cambridge, Cambridge, UK.
    Pangalos MN; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Howes R; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Clark R; Charles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2022 Feb 24; Vol. 12 (1), pp. 3114. Date of Electronic Publication: 2022 Feb 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    SARS-CoV-2*
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing.
    Autorzy:
    Delpuech O; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
    Douthwaite JA; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. .; In Vivo Expressed Biologics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. .
    Hill T; Charles River Laboratories, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
    Niranjan D; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Malintan NT; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Duvoisin H; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Elliott J; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Goodfellow I; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge, UK.
    Hosmillo M; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge, UK.
    Orton AL; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
    Taylor MA; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
    Brankin C; Biologics Engineering, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
    Pitt H; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Animal Science and Technologies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Ross-Thriepland D; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Siek M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Facilities Management, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Cuthbert A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Clinical Operations, Late-Stage Development, Oncology R&D, AstraZeneca, Cambridge, UK.
    Richards I; Charles River Laboratories, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
    Ferdinand JR; Charles River Laboratories, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
    Barker C; BiologIC Technologies Ltd., Soham, UK.
    Shaw R; Oral Product Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield, UK.
    Ariani C; Wellcome Sanger Institute, Hinxton, UK.
    Waddell I; Charles River Laboratories, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
    Rees S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Green C; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
    Clark R; Charles River Laboratories, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
    Upadhyay A; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
    Howes R; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2022 Feb 21; Vol. 12 (1), pp. 2883. Date of Electronic Publication: 2022 Feb 21.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Validation Study
    MeSH Terms:
    Hot Temperature*
    Virus Inactivation*
    COVID-19/*diagnosis
    COVID-19 Nucleic Acid Testing/*methods
    Containment of Biohazards/*methods
    Real-Time Polymerase Chain Reaction/*methods
    SARS-CoV-2/*genetics
    Specimen Handling/*methods
    Animals ; COVID-19/virology ; Cell Line ; Humans ; Mice ; Murine hepatitis virus/genetics ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Sensitivity and Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A cell atlas of human thymic development defines T cell repertoire formation.
    Autorzy:
    Park JE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Botting RA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Domínguez Conde C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Popescu DM; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Lavaert M; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
    Kunz DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
    Goh I; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Stephenson E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Ragazzini R; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.
    Tuck E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Roberts K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Kedlian VR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    He X; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.
    Webb S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Maunder D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Vandamme N; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
    Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Crossland D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    de Rita F; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    Fuller A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Filby A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Reynolds G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Dixon D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Lisgo S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Henderson D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Barker RA; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.; WT-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus, Cambridge CB2 0AW, UK.
    Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Saeys Y; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
    Bonfanti P; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; Institute of Immunity and Transplantation, University College London, London, UK.
    Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK.
    Clatworthy MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Taghon T; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium. .; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
    Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. .; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. .; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.
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    Źródło:
    Science (New York, N.Y.) [Science] 2020 Feb 21; Vol. 367 (6480).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Atlases as Topic*
    Cell Differentiation*
    CD8-Positive T-Lymphocytes/*immunology
    Thymus Gland/*growth & development
    Thymus Gland/*immunology
    CD8-Positive T-Lymphocytes/cytology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Fibroblasts/cytology ; Fibroblasts/immunology ; Humans ; RNA-Seq/methods ; Receptors, Antigen, T-Cell/metabolism ; Single-Cell Analysis/methods ; Thymus Gland/cytology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Spatiotemporal immune zonation of the human kidney.
    Autorzy:
    Stewart BJ; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
    Young MD; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Mitchell TJ; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Loudon KW; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Riding AM; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Richoz N; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
    Frazer GL; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
    Staniforth JUL; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
    Vieira Braga FA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Botting RA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Popescu DM; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Stephenson E; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Cagan A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Farndon SJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.
    Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Efremova M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Green K; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Del Castillo Velasco-Herrera M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Guzzo C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Collord G; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
    Aho T; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Armitage JN; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Riddick ACP; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Mushtaq I; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
    Farrell S; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
    Nicholson J; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Filby A; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Burge J; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Lisgo S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
    Lindsay S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
    Bajenoff M; Centre d'Immunologie de Marseille-Luminy, 13009 Marseille, France.
    Warren AY; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Stewart GD; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Sebire N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.
    Coleman N; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
    Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. .; Theory of Condensed Matter Group, Cavendish Laboratory-Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.
    Behjati S; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
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    Źródło:
    Science (New York, N.Y.) [Science] 2019 Sep 27; Vol. 365 (6460), pp. 1461-1466.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Kidney/*immunology
    Macrophages/*cytology
    Neutrophils/*cytology
    Adult ; Animals ; Epithelial Cells/cytology ; Female ; Fetus ; Gene Expression Regulation, Developmental ; Humans ; Kidney/anatomy & histology ; Kidney/cytology ; Lymphocytes/cytology ; Mice, Inbred C57BL ; Mice, Transgenic ; Myeloid Cells/cytology ; RNA-Seq ; Single-Cell Analysis ; Urinary Tract Infections/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
    Autorzy:
    Young MD; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Mitchell TJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Vieira Braga FA; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Tran MGB; UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK.; Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK.
    Stewart BJ; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    Collord G; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Botting RA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Popescu DM; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Loudon KW; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    Vento-Tormo R; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Stephenson E; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Cagan A; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Farndon SJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.
    Del Castillo Velasco-Herrera M; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Guzzo C; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Richoz N; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    Mamanova L; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Aho T; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Armitage JN; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Riddick ACP; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Mushtaq I; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
    Farrell S; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
    Nicholson J; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Filby A; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Burge J; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Lisgo S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
    Maxwell PH; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
    Lindsay S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
    Warren AY; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Stewart GD; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
    Sebire N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.
    Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
    Haniffa M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. .; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.
    Teichmann SA; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. .
    Clatworthy M; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. .; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    Behjati S; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. .; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2018 Aug 10; Vol. 361 (6402), pp. 594-599.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Transcriptome*
    Kidney/*metabolism
    Kidney Neoplasms/*genetics
    Kidney Neoplasms/*pathology
    Adult ; Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Child ; Genetic Variation ; Humans ; Kidney/embryology ; Kidney Neoplasms/classification ; Single-Cell Analysis ; Wilms Tumor/classification ; Wilms Tumor/genetics ; Wilms Tumor/pathology
    Czasopismo naukowe
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