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Wyświetlanie 1-15 z 15
Tytuł :
Associations between Polymorphisms in the Solute Carrier Family 6 Member 3 and the Myelin Basic Protein Gene and Posttraumatic Stress Disorder.
Autorzy :
Muminovic Umihanic M; Community Health Center Zivinice, Alije Izetbegovica 17, 75270 Zivinice, Bosnia & Herzegovina, .
Babic R
Kravic N
Avdibegovic E
Dzubur Kulenovic A
Agani F
Jakovljevic M
Babic D
Kucukalic A
Kucukalic S
Sabic Dzananovic E
Bravo Mehmedbasic A
Goci Uka A
Haxhibeqiri S
Hoxha B
Haxhibeqiri V
Aukst Margetic B
Jaksic N
Cima Franc A
Rudan D
Pavlović M
Feric Bojic E
Marjanovic D
Bozina N
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Sinanovic O
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 235-240.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Polymorphism, Single Nucleotide*
Dopamine Plasma Membrane Transport Proteins/*genetics
Myelin Basic Protein/*genetics
Stress Disorders, Post-Traumatic/*genetics
Alleles ; Female ; Genotype ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Association Analysis of Maoa and Slc6a4 Gene Variation in South East European War Related Posttraumatic Stress Disorder.
Autorzy :
Kravić N; Department of Psychiatry, University Clinical Centre Tuzla, Rate Dugonjića bb, 75000 Tuzla, Bosnia and Herzegovina, .
Šabić Džananović E
Muminović Umihanić M
Džubur Kulenović A
Sinanović O
Jakovljević M
Babić D
Kučukalić A
Agani F
Kučukalić S
Bravo Mehmedbašić A
Goci Uka A
Haxhibeqiri S
Haxhibeqiri V
Hoxha B
Aukst Margetić B
Jakšić N
Cima Franc A
Rudan D
Pavlović M
Babić R
Ferić Bojić E
Marjanović D
Božina N
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Avdibegović E
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 211-218.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Polymorphism, Genetic*
Armed Conflicts/*psychology
Monoamine Oxidase/*genetics
Serotonin Plasma Membrane Transport Proteins/*genetics
Stress Disorders, Post-Traumatic/*genetics
Alleles ; Europe, Eastern ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Associations of Gene Variations in Neuropeptide Y and Brain Derived Neurotrophic Factor Genes with Posttraumatic Stress Disorder.
Autorzy :
Ferić Bojić E; International Burch University, Department of Genetics and Bioengineering, Francuske revolucije bb, 71000 Sarajevo, Bosnia and Herzegovina, elma.feric@gmail.com.
Kučukalić S
Džubur Kulenović A
Avdibegović E
Babić D
Agani F
Jakovljević M
Kučukalić A
Bravo Mehmedbašić A
Šabić Džananović E
Kravic N
Babić R
Pavlović M
Aukst Margetic B
Jaksic N
Cima Franc A
Rudan D
Haxhibeqiri S
Goci Uka A
Hoxha B
Haxhibeqiri V
Muminović Umihanić M
Sinanović O
Božina N
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Marjanović D
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 227-234.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Polymorphism, Single Nucleotide*
Brain-Derived Neurotrophic Factor/*genetics
Neuropeptide Y/*genetics
Stress Disorders, Post-Traumatic/*genetics
Armed Conflicts/psychology ; Europe, Eastern ; Female ; Genotype ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Genetic Susceptibility to Posttraumatic Stress Disorder: Analyses of the Oxytocin Receptor, Retinoic Acid Receptor-Related Orphan Receptor A and Cannabinoid Receptor 1 Genes.
Autorzy :
Kučukalić S; Department of Psychiatry, Clinical Center University Sarajevo, Bolnička 25, 71000 Sarajevo, Bosnia and Herzegovina, .
Ferić Bojić E
Babić R
Avdibegović E
Babić D
Agani F
Jakovljević M
Kučukalić A
Bravo Mehmedbašić A
Šabić Džananović E
Marjanović D
Kravic N
Pavlović M
Aukst Margetic B
Jaksic N
Cima Franc A
Rudan D
Haxhibeqiri S
Goci Uka A
Hoxha B
Haxhibeqiri V
Muminović Umihanić M
Sinanović O
Božina N
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Džubur Kulenović A
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 219-226.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Genetic Predisposition to Disease*
Receptor, Cannabinoid, CB1/*genetics
Receptors, Oxytocin/*genetics
Receptors, Retinoic Acid/*genetics
Stress Disorders, Post-Traumatic/*genetics
Armed Conflicts/psychology ; Bosnia and Herzegovina ; Croatia ; Female ; Humans ; Kosovo ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
A Candidate Gene Association Study of FKBP5 and CRHR1 Polymorphisms in Relation to War-Related Posttraumatic Stress Disorder.
Autorzy :
Jaksic N; Department of Psychiatry, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia, .
Šabić Džananović E
Aukst Margetic B
Rudan D
Cima Franc A
Bozina N
Ferić Bojić E
Kučukalić S
Džubur Kulenović A
Marjanović D
Avdibegović E
Babić D
Agani F
Kučukalić A
Bravo Mehmedbašić A
Kravic N
Muminović Umihanić M
Sinanović O
Babić R
Pavlović M
Haxhibeqiri S
Goci Uka A
Hoxha B
Haxhibeqiri V
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Jakovljevic M
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 269-275.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Genetic Association Studies*
Polymorphism, Single Nucleotide*
Armed Conflicts/*psychology
Receptors, Corticotropin-Releasing Hormone/*genetics
Stress Disorders, Post-Traumatic/*genetics
Tacrolimus Binding Proteins/*genetics
Europe, Eastern ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
The Association of Catechol-O-Methyl-Transferase and Interleukin 6 Gene Polymorphisms with Posttraumatic Stress Disorder.
Autorzy :
Haxhibeqiri V; Department of Clinical Biochemistry, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Haxhibeqiri S
Topciu-Shufta V
Agani F
Goci Uka A
Hoxha B
Dzubur Kulenovic A
Jakovljević M
Avdibegović E
Kravić N
Muminović Umihanić M
Sinanović O
Šabić Džananović E
Kučukalić A
Kučukalić S
Bravo Mehmedbašić A
Aukst Margetić B
Jakšić N
Cima Franc A
Rudan D
Pavlović M
Babić R
Ferić Bojić E
Marjanović D
Božina N
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Babić D
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 241-248.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Catechol O-Methyltransferase/*genetics
Interleukin-6/*genetics
Stress Disorders, Post-Traumatic/*genetics
Alleles ; Armed Conflicts/psychology ; Europe, Eastern ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Association of Neuropeptide S Receptor 1 and Glutamate Decarboxylase 1 Gene Polymorphisms with Posttraumatic Stress Disorder.
Autorzy :
Haxhibeqiri S; Institute of Kosovo Forensic Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo.
Haxhibeqiri V
Agani F
Goci Uka A
Hoxha B
Dzubur Kulenovic A
Kučukalić A
Avdibegović E
Sinanović O
Babic D
Jakovljevic M
Kučukalić S
Bravo Mehmedbašić A
Kravić N
Muminović-Umihanić M
Babić R
Pavlović M
Jakšić N
Aukst Margetić B
Rudan D
Ferić Bojić E
Marjanović D
Ziegler C
Wolf C
Warrings B
Domschke K
Deckert J
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 249-255.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Glutamate Decarboxylase/*genetics
Polymorphism, Single Nucleotide/*genetics
Receptors, G-Protein-Coupled/*genetics
Stress Disorders, Post-Traumatic/*genetics
Alleles ; Armed Conflicts/psychology ; Europe, Eastern ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD.
Autorzy :
Goçi Uka A; Department of Psychiatry, University Clinical Centre of Kosovo, Str, Hile Mosi, nr 11, 10000 Prishtina, Kosovo, .
Agani F
Blyta A
Hoxha B
Haxhibeqiri S
Haxhibeqiri V
Sabic Dzananovic E
Kucukalic S
Bravo Mehmedbasic A
Kucukalic A
Dzubur-Kulenovic A
Feric Bojic E
Marjanovic D
Kravic N
Avdibegovic E
Muminovic Umihanic M
Jaksic N
Cima Franc A
Rudan D
Jakovljevic M
Babic R
Pavlovic M
Babic D
Aukst Margetic B
Bozina N
Sinanovic O
Ziegler C
Warrings B
Domschke K
Deckert J
Wolf C
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 256-262.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Alleles*
Receptor, Serotonin, 5-HT1A/*genetics
Stress Disorders, Post-Traumatic/*genetics
Tryptophan Hydroxylase/*genetics
Armed Conflicts/psychology ; Bosnia and Herzegovina ; Croatia ; Female ; Humans ; Kosovo ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
The Role of TaqI DRD2 (rs1800497) and DRD4 VNTR Polymorphisms in Posttraumatic Stress Disorder (PTSD).
Autorzy :
Hoxha B; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo, .
Goçi Uka A
Agani F
Haxhibeqiri S
Haxhibeqiri V
Sabic Dzananovic E
Kucukalic S
Bravo Mehmedbasic A
Kucukalic A
Dzubur Kulenovic A
Feric Bojic E
Marjanovic D
Kravic N
Avdibegovic E
Muminovic Umihanić M
Jaksic N
Cima Franc A
Rudan D
Jakovljevic M
Babic R
Pavlovic M
Babic D
Aukst Margetic B
Bozina N
Sinanovic O
Ziegler C
Warrings B
Domschke K
Deckert J
Wolf C
Vyshka G
Pokaż więcej
Źródło :
Psychiatria Danubina [Psychiatr Danub] 2019 Jun; Vol. 31 (2), pp. 263-268.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry Country of Publication: Croatia NLM ID: 9424753 Publication Model: Print Cited Medium: Print ISSN: 0353-5053 (Print) Linking ISSN: 03535053 NLM ISO Abbreviation: Psychiatr Danub Subsets: MEDLINE
MeSH Terms :
Minisatellite Repeats*
Polymorphism, Genetic*
Receptors, Dopamine D2/*genetics
Receptors, Dopamine D4/*genetics
Stress Disorders, Post-Traumatic/*genetics
Armed Conflicts/psychology ; Bosnia and Herzegovina ; Croatia ; Exons/genetics ; Female ; Humans ; Kosovo ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)-PTSD Study.
Autorzy :
Ziegler C; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Wolf C; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Schiele MA; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Feric Bojic E; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina.
Kucukalic S; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Sabic Dzananovic E; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Goci Uka A; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo.
Hoxha B; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo.
Haxhibeqiri V; Department of Medical Biochemistry, University Clinical Center of Kosovo, Prishtina, Kosovo.; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo.
Haxhibeqiri S
Kravic N; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina.
Muminovic Umihanic M; Community Health Center, Zivinice, Bosnia and Herzegovina.
Cima Franc A; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia.
Jaksic N; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia.
Babic R; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina.
Pavlovic M; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina.
Warrings B; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Bravo Mehmedbasic A; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Rudan D; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia.
Aukst-Margetic B; Department of Psychiatry, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
Kucukalic A; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Marjanovic D; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina.; Institute for Anthropological Researches, Zagreb, Croatia.
Babic D; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina.
Bozina N; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia.
Jakovljevic M; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia.
Sinanovic O; Department of Neurology, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina.
Avdibegovic E; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina.
Agani F; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo.
Dzubur-Kulenovic A; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Domschke K; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Pokaż więcej
Źródło :
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2018 May 01; Vol. 21 (5), pp. 423-432.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int. J. Neuropsychopharmacol. Subsets: MEDLINE
MeSH Terms :
DNA Methylation/*genetics
Epigenesis, Genetic/*genetics
Monoamine Oxidase/*genetics
Stress Disorders, Post-Traumatic/*genetics
Stress Disorders, Post-Traumatic/*physiopathology
Adult ; Bosnia and Herzegovina ; Croatia ; Female ; Humans ; Kosovo ; Male ; Middle Aged ; Severity of Illness Index ; Sex Factors
Czasopismo naukowe
Tytuł :
Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
Autorzy :
Graceffa RF
Boezio AA
Able J; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Altmann S
Berry LM
Boezio C
Butler JR
Chu-Moyer M
Cooke M
DiMauro EF
Dineen TA
Feric Bojic E
Foti RS
Fremeau RT Jr
Guzman-Perez A
Gao H
Gunaydin H
Huang H
Huang L
Ilch C
Jarosh M
Kornecook T; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Kreiman CR
La DS
Ligutti J; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Milgram BC
Lin MJ
Marx IE
Nguyen HN
Peterson EA
Rescourio G
Roberts J
Schenkel L
Shimanovich R
Sparling BA
Stellwagen J
Taborn K
Vaida KR
Wang J
Yeoman J
Yu V
Zhu D
Moyer BD; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Weiss MM
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2017 Jul 27; Vol. 60 (14), pp. 5990-6017. Date of Electronic Publication: 2017 Apr 20.
Typ publikacji :
Journal Article
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J. Med. Chem. Subsets: MEDLINE
MeSH Terms :
NAV1.7 Voltage-Gated Sodium Channel/*metabolism
Quinolones/*chemistry
Sulfonamides/*chemistry
Voltage-Gated Sodium Channel Blockers/*chemistry
Analgesics/chemistry ; Analgesics/pharmacokinetics ; Analgesics/pharmacology ; Animals ; Capsaicin ; Cell Line ; Dogs ; Histamine ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Pain/chemically induced ; Pain/prevention & control ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Pruritus/chemically induced ; Pruritus/prevention & control ; Quinolones/administration & dosage ; Quinolones/chemical synthesis ; Quinolones/pharmacokinetics ; Quinolones/pharmacology ; Rats ; Structure-Activity Relationship ; Sulfonamides/administration & dosage ; Sulfonamides/chemical synthesis ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Voltage-Gated Sodium Channel Blockers/pharmacokinetics ; Voltage-Gated Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Tytuł :
Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
Autorzy :
Weiss MM
Dineen TA
Marx IE
Altmann S
Boezio A
Bregman H
Chu-Moyer M
DiMauro EF
Feric Bojic E
Foti RS
Gao H
Graceffa R
Gunaydin H
Guzman-Perez A
Huang H
Huang L
Jarosh M
Kornecook T; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Kreiman CR
Ligutti J; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
La DS
Lin MJ
Liu D; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Moyer BD; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Nguyen HN
Peterson EA
Rose PE
Taborn K
Youngblood BD
Yu V
Fremeau RT Jr
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2017 Jul 27; Vol. 60 (14), pp. 5969-5989. Date of Electronic Publication: 2017 Apr 20.
Typ publikacji :
Journal Article
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J. Med. Chem. Subsets: MEDLINE
MeSH Terms :
Isoquinolines/*chemistry
NAV1.7 Voltage-Gated Sodium Channel/*metabolism
Sulfonamides/*chemistry
Voltage-Gated Sodium Channel Blockers/*chemistry
Animals ; Cell Line ; Cytochrome P-450 CYP3A/biosynthesis ; Cytochrome P-450 CYP3A Inhibitors/chemistry ; Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Dogs ; Enzyme Induction ; Histamine ; Humans ; Isoquinolines/administration & dosage ; Isoquinolines/pharmacokinetics ; Male ; Mice, Inbred C57BL ; Pregnane X Receptor ; Pruritus/chemically induced ; Pruritus/prevention & control ; Rats ; Receptors, Steroid/agonists ; Structure-Activity Relationship ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Voltage-Gated Sodium Channel Blockers/pharmacokinetics ; Voltage-Gated Sodium Channel Blockers/pharmacology
Czasopismo naukowe
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