Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases.
Autorzy:
Canning AJ; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, 4261 Weiskotten Hall, Syracuse, NY, 13210, USA. Viggiano S; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, 4261 Weiskotten Hall, Syracuse, NY, 13210, USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. Cosgrove MS; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, 4261 Weiskotten Hall, Syracuse, NY, 13210, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Nov 02; Vol. 12 (1), pp. 18487. Date of Electronic Publication: 2022 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials.
Autorzy:
Allenspach K; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Borcherding DC; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Iennarella-Servantez CA; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA.; Royal Veterinary College, University of London, London, UK. Mosichuk AP; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Atherly T; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Sahoo DK; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Kathrani A; Royal Veterinary College, University of London, London, UK. Suchodolski JS; Gastrointestinal Laboratory, Texas A&M University, College of Veterinary Medicine & Biomedical Sciences, College Station, Texas, USA. Bourgois-Mochel A; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Serao MR; Department of Animal Science, Iowa State University, Ames, Iowa, USA. Serao NV; Department of Animal Science, Iowa State University, Ames, Iowa, USA. Willette A; Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA. Perez BA; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Gabriel V; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Mao S; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Kilburn L; Department of Animal Science, Iowa State University, Ames, Iowa, USA. Dang V; Veterinary Diagnostics Laboratory, Iowa State University, Ames, Iowa, USA. Borts D; Veterinary Diagnostics Laboratory, Iowa State University, Ames, Iowa, USA. Almada LL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA. Phillips GJ; Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, USA. Jergens AE; Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA. Mochel JP; Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA.
Nuclear Dynamics and Chromatin Structure: Implications for Pancreatic Cancer.
Autorzy:
Flores LF; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Tader BR; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Tolosa EJ; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Sigafoos AN; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Marks DL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło:
Cells [Cells] 2021 Oct 01; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease.
Autorzy:
Sigafoos AN; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Paradise BD; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Jul 07; Vol. 13 (14). Date of Electronic Publication: 2021 Jul 07.
LPCAT1-TERT fusions are uniquely recurrent in epithelioid trophoblastic tumors and positively regulate cell growth.
Autorzy:
Oliver GR; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Marcano-Bonilla S; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Quist J; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Tolosa EJ; Division of Oncology Research, Schulze Center for Novel Therapeutics, Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America. Iguchi E; Division of Oncology Research, Schulze Center for Novel Therapeutics, Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America. Swanson AA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Hoppman NL; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Schwab T; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America. Sigafoos A; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America. Prodduturi N; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Voss JS; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Knight SM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Zhang J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Fadra N; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Urrutia R; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Zimmerman M; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America. Egan JB; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America. Bilyeu AG; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Jen J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Veras E; Sibley Memorial Hospital, Johns Hopkins Medicine, Washington, DC, United States of America. Al-Safi R; Gynecologic Pathology, Histopathology and Cytology Units, Maternity Hospital, Kuwait City, Kuwait. Block M; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America. Kerr S; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Fernandez-ZapicoME; Division of Oncology Research, Schulze Center for Novel Therapeutics, Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America. Schoolmeester JK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America. Klee EW; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.; Division of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
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Źródło:
PloS one [PLoS One] 2021 May 25; Vol. 16 (5), pp. e0250518. Date of Electronic Publication: 2021 May 25 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer.
Autorzy:
Xie H; Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA. . Paradise BD; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.. . Ma WW; Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA. . Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.. .
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Źródło:
Cells [Cells] 2019 Apr 29; Vol. 8 (5). Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
Derivation of adult canine intestinal organoids for translational research in gastroenterology.
Autorzy:
Chandra L; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. Borcherding DC; Biomedical Sciences, Iowa State University, Ames, IA, USA. Kingsbury D; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. Atherly T; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. Ambrosini YM; Biomedical Sciences, Iowa State University, Ames, IA, USA. Bourgois-Mochel A; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. Yuan W; Biomedical Sciences, Iowa State University, Ames, IA, USA. Kimber M; Biomedical Sciences, Iowa State University, Ames, IA, USA. Qi Y; Departments of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA. Wang Q; Departments of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA. Wannemuehler M; Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA. Ellinwood NM; Animal Science, Iowa State University, Ames, IA, USA. Snella E; Animal Science, Iowa State University, Ames, IA, USA. Martin M; UCLA School of Medicine, Los Angeles, CA, USA. Skala M; Biomedical Engineering, University of Wisconsin, Madison, WI, USA. Meyerholz D; Division of Comparative Pathology, University of Iowa Carver College of Medicine, Iowa City, USA. Estes M; Baylor College of Medicine, Houston, TX, USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. Jergens AE; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. Mochel JP; Biomedical Sciences, Iowa State University, Ames, IA, USA. . Allenspach K; Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA. .
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Źródło:
BMC biology [BMC Biol] 2019 Apr 11; Vol. 17 (1), pp. 33. Date of Electronic Publication: 2019 Apr 11.
Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?
Autorzy:
Paradise BD; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. .; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA. . Barham W; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. .; Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA. . Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. .
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Źródło:
Cancers [Cancers (Basel)] 2018 Apr 28; Vol. 10 (5). Date of Electronic Publication: 2018 Apr 28.
Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion.
Autorzy:
Jalan-Sakrikar N; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America. De Assuncao TM; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America. Lu J; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America. Almada LL; Schultze Center for Novel Therapeutics, Mayo Clinic and Foundation, Rochester, MN, United States of America. Lomberk G; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America. Fernandez-ZapicoME; Schultze Center for Novel Therapeutics, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America. Urrutia R; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America. Huebert RC; Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America.; Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Dec 09; Vol. 11 (12), pp. e0168266. Date of Electronic Publication: 2016 Dec 09 (Print Publication: 2016).
Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials.
Autorzy:
Yun S; Department of Medicine, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85721 USA ; Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 12902 USA. Vincelette ND; Molecular Pharmacology and Experimental Therapeutics, Department of Medicine, Mayo Clinic, Rochester, MN 55905 USA. Abraham I; Center for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ 85721 USA ; Arizona Cancer Center, University of Arizona, Tucson, AZ 85721 USA. Robertson KD; Pharmacology, Department of Medicine, Mayo Clinic, Rochester, MN 55905 USA. Fernandez-ZapicoME; Schulze Center for Novel Therapeutics, Department of Medicine, Mayo Clinic, Rochester, MN 55905 USA. Patnaik MM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905 USA.
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2016 Jun 14; Vol. 8, pp. 68. Date of Electronic Publication: 2016 Jun 14 (Print Publication: 2016).
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