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Wyświetlanie 1-12 z 12
Tytuł :
Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na in ion-coupled drug efflux.
Autorzy :
Castellano S; National Institutes of Health, United States.
Claxton DP; Vanderbilt University, United States.
Ficici E; National Institutes of Health, United States.
Kusakizako T; University of Tokyo, Japan.
Stix R; National Institutes of Health, United States.
Zhou W; National Institutes of Health, United States.
Nureki O; University of Tokyo, Japan.
Mchaourab HS; Dept of Molecular Physiology and Biophysics, Vanderbilt University, United States.
Faraldo-Gómez JD; National Institutes of Health, United States.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan 05. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.
Autorzy :
Debruycker V; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Hutchin A; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Masureel M; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA.
Ficici E; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Martens C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Legrand P; Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin 91192, Gif sur Yvette, France.
Stein RA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Remaut H; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; Structural and Molecular Microbiology, VIB-VUB Center for Structural Biology, Brussels, Belgium.
Govaerts C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 829-835. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*metabolism
Bacterial Proteins/*metabolism
Lactococcus lactis/*metabolism
Membrane Transport Proteins/*metabolism
Phosphatidylglycerols/*metabolism
Bacterial Proteins/chemistry ; Binding Sites ; Biological Transport ; Crystallography, X-Ray ; Lactococcus lactis/chemistry ; Ligands ; Membrane Transport Proteins/chemistry ; Molecular Dynamics Simulation ; Phosphatidylglycerols/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Broadly conserved Na -binding site in the N-lobe of prokaryotic multidrug MATE transporters.
Autorzy :
Ficici E; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Zhou W; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Castellano S; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 03; Vol. 115 (27), pp. E6172-E6181. Date of Electronic Publication: 2018 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Archaeal Proteins/*chemistry
Carrier Proteins/*chemistry
Pyrococcus furiosus/*chemistry
Amino Acid Motifs ; Archaeal Proteins/genetics ; Archaeal Proteins/metabolism ; Binding Sites ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Pyrococcus furiosus/genetics ; Pyrococcus furiosus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism.
Autorzy :
Ficici E; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Jennings ML; Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR .
Forrest LR; Computational Structural Biology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD .
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Źródło :
The Journal of general physiology [J Gen Physiol] 2017 Dec 04; Vol. 149 (12), pp. 1149-1164. Date of Electronic Publication: 2017 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Ion Channel Gating*
Anion Exchange Protein 1, Erythrocyte/*chemistry
Amino Acid Motifs ; Anion Exchange Protein 1, Erythrocyte/metabolism ; Humans ; Protein Domains ; Protein Multimerization
Czasopismo naukowe
Tytuł :
Electric-Field-Induced Protein Translocation via a Conformational Transition in SecDF: An MD Study.
Autorzy :
Ficici E; Department of Chemistry, University of California, Irvine, Irvine, California.
Jeong D; Department of Chemistry, University of California, Irvine, Irvine, California.
Andricioaei I; Department of Chemistry, University of California, Irvine, Irvine, California. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2017 Jun 20; Vol. 112 (12), pp. 2520-2528.
Typ publikacji :
Journal Article
MeSH Terms :
Electromagnetic Fields*
Bacterial Proteins/*chemistry
Bacterial Proteins/*radiation effects
Membrane Transport Proteins/*chemistry
Membrane Transport Proteins/*radiation effects
Bacterial Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Molecular Dynamics Simulation ; Protein Conformation ; Protons ; Static Electricity
Czasopismo naukowe
Tytuł :
Dendrimers in Nanoscale Confinement: The Interplay between Conformational Change and Nanopore Entrance.
Autorzy :
Ficici E; †Department of Chemistry, University of California Irvine, Irvine, California 92697, United States.
Andricioaei I; †Department of Chemistry, University of California Irvine, Irvine, California 92697, United States.
Howorka S; ‡Department of Chemistry, Institute for Structural and Molecular Biology, University College London, London WC1H0AJ, England, United Kingdom.
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Źródło :
Nano letters [Nano Lett] 2015 Jul 08; Vol. 15 (7), pp. 4822-8. Date of Electronic Publication: 2015 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Tytuł :
On the Possibility of Facilitated Diffusion of Dendrimers Along DNA.
Autorzy :
Ficici E; Department of Chemistry, University of California, Irvine, California 92697, United States.
Andricioaei I; Department of Chemistry, University of California, Irvine, California 92697, United States.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2015 Jun 11; Vol. 119 (23), pp. 6894-904. Date of Electronic Publication: 2015 Jun 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA/*chemistry
Dendrimers/*chemistry
Computer Simulation ; Models, Chemical ; Models, Genetic ; Molecular Dynamics Simulation ; Static Electricity
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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