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Tytuł:
Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: A systems biology approach.
Autorzy:
Meyer-Hermann M
Figge MT
Straub RH
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Źródło:
Arthritis & Rheumatism; Sep2009, Vol. 60 Issue 9, p2585-2594, 10p
Czasopismo naukowe
Tytuł:
Quantitative analysis of peroxisome tracks using a Hidden Markov Model.
Autorzy:
Svensson CM; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Reglinski K; Leibniz-Institute of Photonic Technologies, Jena, Germany.; Institute of Applied Optics and Biophysics, Friedrich-Schiller University Jena, Jena, Germany.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; University Hospital Jena, Jena, Germany.
Schliebs W; Institute of Biochemistry and Pathobiochemistry, Systems Biochemistry, Ruhr-University Bochum, Bochum, Germany.
Erdmann R; Institute of Biochemistry and Pathobiochemistry, Systems Biochemistry, Ruhr-University Bochum, Bochum, Germany.
Eggeling C; Leibniz-Institute of Photonic Technologies, Jena, Germany. .; Institute of Applied Optics and Biophysics, Friedrich-Schiller University Jena, Jena, Germany. .; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. .; Jena Center for Soft Matter (JCSM), Jena, Germany. .
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany. thilo.figge@leibniz-hki.de.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich-Schiller University Jena, Jena, Germany. thilo.figge@leibniz-hki.de.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 11; Vol. 13 (1), pp. 19694. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peroxisomes*/metabolism
Microtubules*/metabolism
Humans ; HEK293 Cells ; Intracellular Membranes/metabolism ; Microscopy, Fluorescence
Czasopismo naukowe
Tytuł:
Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections.
Autorzy:
Saffer C; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Timme S; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Rudolph P; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Figge MT; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany. thilo.figge@leibniz-hki.de.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. thilo.figge@leibniz-hki.de.
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Źródło:
NPJ systems biology and applications [NPJ Syst Biol Appl] 2023 Apr 10; Vol. 9 (1), pp. 12. Date of Electronic Publication: 2023 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Macrophages, Alveolar*
Aspergillosis*/microbiology
Mice ; Humans ; Animals ; Aspergillus fumigatus ; Pulmonary Alveoli/microbiology
Czasopismo naukowe
Tytuł:
Guided-deconvolution for correlative light and electron microscopy.
Autorzy:
Ma F; Institute of Physical Chemistry and Abbe Center of Photonics, University of Jena, Jena, Thuringia, Germany.; Leibniz Institute of Photonic Technology, Jena, Thuringia, Germany.; Jena Center for Soft Matter, University of Jena, Jena, Thuringia, Germany.
Kaufmann R; Centre for Structural Systems Biology, Hamburg, Germany.; Department of Physics, University of Hamburg, Hamburg, Germany.
Sedzicki J; Biozentrum, University of Basel, Basel, Switzerland.
Cseresnyés Z; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Thuringia, Germany.
Dehio C; Biozentrum, University of Basel, Basel, Switzerland.
Hoeppener S; Jena Center for Soft Matter, University of Jena, Jena, Thuringia, Germany.; Laboratory of Organic Chemistry and Macromolecular Chemistry, University of Jena, Jena, Thuringia, Germany.
Figge MT; Jena Center for Soft Matter, University of Jena, Jena, Thuringia, Germany.; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Thuringia, Germany.; Institute of Microbiology, Faculty of Biological Sciences, University of Jena, Jena, Thuringia, Germany.
Heintzmann R; Institute of Physical Chemistry and Abbe Center of Photonics, University of Jena, Jena, Thuringia, Germany.; Leibniz Institute of Photonic Technology, Jena, Thuringia, Germany.; Jena Center for Soft Matter, University of Jena, Jena, Thuringia, Germany.
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Źródło:
PloS one [PLoS One] 2023 Mar 09; Vol. 18 (3), pp. e0282803. Date of Electronic Publication: 2023 Mar 09 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Organelles*
Humans ; Microscopy, Electron ; HeLa Cells
Czasopismo naukowe
Tytuł:
Targeting of phagolysosomes containing conidia of the fungus Aspergillus fumigatus with polymeric particles.
Autorzy:
González K; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.; Institute of Microbiology, Friedrich Schiller University Jena, Neugasse 25, 07745, Jena, Germany.
Gangapurwala G; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Alex J; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Vollrath A; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Cseresnyés Z; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
Weber C; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Czaplewska JA; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Hoeppener S; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Svensson CM; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
Orasch T; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
Heinekamp T; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
Guerrero-Sánchez C; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Figge MT; Institute of Microbiology, Friedrich Schiller University Jena, Neugasse 25, 07745, Jena, Germany.; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
Schubert US; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Brakhage AA; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Adolf-Reichwein-Straße 23, 07745, Jena, Germany. .; Institute of Microbiology, Friedrich Schiller University Jena, Neugasse 25, 07745, Jena, Germany. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Feb; Vol. 107 (2-3), pp. 819-834. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Aspergillus fumigatus*
Phagosomes*
Humans ; Spores, Fungal ; Macrophages/microbiology ; Phagocytosis
Czasopismo naukowe
Tytuł:
Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions.
Autorzy:
Lehnert T; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Leonhardt I; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Research Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Timme S; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Thomas-Rüddel D; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Bloos F; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Sponholz C; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Kurzai O; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Research Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Figge MT; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany. thilo.figge@leibniz-hki.de.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. thilo.figge@leibniz-hki.de.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. thilo.figge@leibniz-hki.de.
Hünniger K; Research Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany. .; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 08; Vol. 11 (1), pp. 12039. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunity, Innate*
Phagocytosis*
Candida albicans/*immunology
Neutrophils/*immunology
Staphylococcus aureus/*immunology
Candidiasis/immunology ; Humans ; Staphylococcal Infections/immunology
Czasopismo naukowe
Tytuł:
Expression Patterns in Reductive Iron Assimilation and Functional Consequences during Phagocytosis of Lichtheimia corymbifera , an Emerging Cause of Mucormycosis.
Autorzy:
Stanford FA; Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute (HKI), 07745 Jena, Germany.; Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.
Matthies N; Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute (HKI), 07745 Jena, Germany.; Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.
Cseresnyés Z; Applied Systems Biology, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute, 12622 Jena, Germany.
Figge MT; Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.; Applied Systems Biology, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute, 12622 Jena, Germany.
Hassan MIA; Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute (HKI), 07745 Jena, Germany.; Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.; National Research Centre, Pests & Plant Protection Department, 33rd El Buhouth St., Dokki, Giza 12622, Egypt.
Voigt K; Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute (HKI), 07745 Jena, Germany.; Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany.
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Źródło:
Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2021 Apr 03; Vol. 7 (4). Date of Electronic Publication: 2021 Apr 03.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Comparative assessment of immune evasion mechanisms in human whole-blood infection assays by a systems biology approach.
Autorzy:
Lehnert T; Applied Systems Biology, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Prauße MTE; Applied Systems Biology, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Hünniger K; Fungal Septomics, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Praetorius JP; Applied Systems Biology, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Kurzai O; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Fungal Septomics, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
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Źródło:
PloS one [PLoS One] 2021 Apr 01; Vol. 16 (4), pp. e0249372. Date of Electronic Publication: 2021 Apr 01 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Theoretical*
Candidiasis/*pathology
Immune Evasion/*physiology
Staphylococcal Infections/*pathology
Candida albicans/pathogenicity ; Candida glabrata/pathogenicity ; Candidiasis/immunology ; Humans ; Staphylococcal Infections/immunology ; Staphylococcus aureus/pathogenicity ; Systems Biology/methods
Czasopismo naukowe
Tytuł:
Dynamic spherical harmonics approach for shape classification of migrating cells.
Autorzy:
Medyukhina A; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.; Center for Bioimage Informatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Blickensdorf M; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.
Cseresnyés Z; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.
Ruef N; Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland.
Stein JV; Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany. thilo.figge@leibniz-hki.de.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. thilo.figge@leibniz-hki.de.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. thilo.figge@leibniz-hki.de.
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 08; Vol. 10 (1), pp. 6072. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Cell Shape*
Computer Simulation*
Humans ; Support Vector Machine ; T-Lymphocytes/classification ; T-Lymphocytes/cytology ; T-Lymphocytes/physiology
Czasopismo naukowe
Tytuł:
Automated tracking of label-free cells with enhanced recognition of whole tracks.
Autorzy:
Al-Zaben N; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Medyukhina A; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.
Dietrich S; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.
Marolda A; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.; Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.
Hünniger K; Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.; Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Kurzai O; Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany.; Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena, Germany. thilo.figge@leibniz-hki.de.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. thilo.figge@leibniz-hki.de.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. thilo.figge@leibniz-hki.de.
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 01; Vol. 9 (1), pp. 3317. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Algorithms*
Cell Movement*
Cell Tracking*
Image Processing, Computer-Assisted*
Microscopy*
Humans
Czasopismo naukowe
Tytuł:
Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.
Autorzy:
Svensson CM; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.
Hoffmann B; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.; Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.; Friedrich Schiller University Jena, Germany.
Irmler IM; Institute of Immunology, University Hospital Jena, Leutragraben 3, 07743 Jena, Germany.
Straßburger M; Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.; Friedrich Schiller University Jena, Germany.
Saluz HP; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.; Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 14; Vol. 7, pp. 44434. Date of Electronic Publication: 2017 Mar 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Experimental/*diagnostic imaging
Arthritis, Rheumatoid/*diagnostic imaging
Bone and Bones/*diagnostic imaging
Animals ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/physiopathology ; Arthritis, Rheumatoid/physiopathology ; Bone and Bones/physiopathology ; Disease Models, Animal ; Glucose-6-Phosphate Isomerase/toxicity ; Humans ; Mice ; Models, Theoretical ; X-Ray Microtomography
Czasopismo naukowe
Tytuł:
Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs.
Autorzy:
Pollmächer J; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.
Timme S; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.
Schuster S; Department of Bioinformatics, Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.
Brakhage AA; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Zipfel PF; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Figge MT; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Germany.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 13; Vol. 6, pp. 27807. Date of Electronic Publication: 2016 Jun 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspergillus fumigatus/*physiology
Inflammation/*pathology
Pulmonary Aspergillosis/*pathology
Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Macrophages, Alveolar/immunology ; Models, Biological ; Neutrophils/immunology ; Phagocytosis ; Pulmonary Alveoli/microbiology ; Pulmonary Aspergillosis/immunology ; Pulmonary Aspergillosis/microbiology ; Spores, Fungal/physiology
Czasopismo naukowe
Tytuł:
Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.
Autorzy:
Mattern DJ; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Schoeler H; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Weber J; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Novohradská S; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Kraibooj K; Friedrich Schiller University Jena, Jena, Germany.; Department of Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Dahse HM; Department of Infection Biology, Leibniz Institute for Infection Biology and Natural Product Research (HKI), Jena, Germany.
Hillmann F; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany.
Valiante V; Leibniz Junior Research Group - Biobricks of Microbial Natural Product Syntheses, Jena, Germany.
Figge MT; Friedrich Schiller University Jena, Jena, Germany.; Department of Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Brakhage AA; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Beutenbergstrasse 11a, 07745, Jena, Germany. .; Friedrich Schiller University Jena, Jena, Germany. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2015 Dec; Vol. 99 (23), pp. 10151-61. Date of Electronic Publication: 2015 Aug 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multigene Family*
Aspergillus fumigatus/*genetics
Aspergillus fumigatus/*metabolism
Biological Products/*metabolism
Immunologic Factors/*metabolism
Macrophages, Alveolar/*drug effects
Phagocytosis/*drug effects
Animals ; Cells, Cultured ; Dictyostelium/drug effects ; Dictyostelium/physiology ; Gene Deletion ; Genetic Complementation Test ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/microbiology ; Mice
Czasopismo naukowe
Tytuł:
Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes.
Autorzy:
Duggan S; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Essig F; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany.
Hünniger K; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Mokhtari Z; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Bauer L; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Lehnert T; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Brandes S; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Häder A; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Jacobsen ID; Friedrich Schiller University Jena, Jena, Germany.; Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Martin R; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.
Kurzai O; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany.; Friedrich Schiller University Jena, Jena, Germany.; German National Reference Center for Invasive Fungal Infections, Hans Knoell Institute, Jena, Germany.
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Źródło:
Cellular microbiology [Cell Microbiol] 2015 Sep; Vol. 17 (9), pp. 1259-76. Date of Electronic Publication: 2015 May 05.
Typ publikacji:
Journal Article
MeSH Terms:
Neutrophil Activation*
Phagocytosis*
Candida albicans/*immunology
Candida glabrata/*immunology
Candidiasis/*immunology
Monocytes/*immunology
Monocytes/*microbiology
Animals ; Candidiasis/microbiology ; Candidiasis/pathology ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Histocytochemistry ; Humans ; Kidney/microbiology ; Kidney/pathology ; Mice
Czasopismo naukowe
Tytuł:
Automated Classification of Circulating Tumor Cells and the Impact of Interobsever Variability on Classifier Training and Performance.
Autorzy:
Svensson CM; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany.
Hübler R; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany ; Friedrich Schiller University Jena, Fürstengraben 1, 07743 Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany ; Friedrich Schiller University Jena, Fürstengraben 1, 07743 Jena, Germany.
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Źródło:
Journal of immunology research [J Immunol Res] 2015; Vol. 2015, pp. 573165. Date of Electronic Publication: 2015 Oct 04.
Typ publikacji:
Journal Article
MeSH Terms:
Support Vector Machine*
Neoplasms/*diagnosis
Neoplastic Cells, Circulating/*pathology
Algorithms ; Antigens, Surface/metabolism ; Bayes Theorem ; Biomarkers ; Humans ; Microscopy, Fluorescence/methods ; Microscopy, Fluorescence/standards ; Neoplasms/metabolism ; Neoplastic Cells, Circulating/metabolism ; Observer Variation ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis.
Autorzy:
Kraibooj K; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany; Friedrich Schiller University Jena, Jena, Germany.
Park HR
Dahse HM
Skerka C
Voigt K
Figge MT
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Źródło:
Mycoses [Mycoses] 2014 Dec; Vol. 57 Suppl 3, pp. 56-66. Date of Electronic Publication: 2014 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Macrophages/*immunology
Mucorales/*pathogenicity
Mucormycosis/*immunology
Phagocytosis/*immunology
Animals ; Cell Adhesion ; Host-Pathogen Interactions ; Humans ; Image Processing, Computer-Assisted ; Macrophages/microbiology ; Mice ; Microscopy, Fluorescence ; Mucormycosis/microbiology ; Spores, Fungal/immunology
Czasopismo naukowe
Tytuł:
Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection.
Autorzy:
Pollmächer J; Applied Systems Biology, Leibniz-Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany; Friedrich Schiller University, Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz-Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany; Friedrich Schiller University, Jena, Germany.
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Źródło:
PloS one [PLoS One] 2014 Oct 31; Vol. 9 (10), pp. e111630. Date of Electronic Publication: 2014 Oct 31 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemotaxis*
Signal Transduction*
Systems Analysis*
Aspergillus fumigatus/*physiology
Epithelial Cells/*microbiology
Epithelial Cells/*pathology
Pulmonary Alveoli/*pathology
Aspergillosis/microbiology ; Aspergillosis/pathology ; Computer Simulation ; Humans ; Imaging, Three-Dimensional ; Macrophages/metabolism ; Respiration ; Spores, Fungal ; Time Factors
Czasopismo naukowe
Tytuł:
A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood.
Autorzy:
Hünniger K; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany.
Lehnert T; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany.
Bieber K; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany.
Martin R; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany.
Figge MT; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany.
Kurzai O; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2014 Feb 20; Vol. 10 (2), pp. e1003479. Date of Electronic Publication: 2014 Feb 20 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunity, Innate*
Models, Immunological*
Candidemia/*immunology
Candida albicans/immunology ; Candida albicans/pathogenicity ; Candidemia/blood ; Candidemia/microbiology ; Computational Biology ; Computer Simulation ; Cross Infection/blood ; Cross Infection/immunology ; Cross Infection/microbiology ; Host-Pathogen Interactions/immunology ; Humans ; Mathematical Concepts ; Monocytes/immunology ; Monte Carlo Method ; Neutrophils/immunology ; Phagocytosis ; User-Computer Interface
Czasopismo naukowe
Tytuł:
Automated characterization and parameter-free classification of cell tracks based on local migration behavior.
Autorzy:
Mokhtari Z; Applied Systems Biology, HKI-Center for Systems Biology of Infection, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Germany.
Mech F
Zitzmann C
Hasenberg M
Gunzer M
Figge MT
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Źródło:
PloS one [PLoS One] 2013 Dec 06; Vol. 8 (12), pp. e80808. Date of Electronic Publication: 2013 Dec 06 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Image Interpretation, Computer-Assisted*
Spatio-Temporal Analysis*
Cell Tracking/*statistics & numerical data
Neutrophils/*cytology
Single-Cell Analysis/*statistics & numerical data
Animals ; Cell Movement ; Cell Tracking/methods ; Mice ; Microscopy ; Primary Cell Culture ; Single-Cell Analysis/methods
Czasopismo naukowe

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