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Tytuł :
Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells.
Autorzy :
Adhikari A; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Copping NA; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Beegle J; Stem Cell Program, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Cameron DL; Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Deng P; Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
O'Geen H; Department of Biochemistry and Medical Microbiology, UC Davis Genome Center, University of California Davis School of Medicine, Davis, CA 95616, USA.
Segal DJ; Department of Biochemistry and Medical Microbiology, UC Davis Genome Center, University of California Davis School of Medicine, Davis, CA 95616, USA.
Fink KD; Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Silverman JL; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Anderson JS; Stem Cell Program, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2021 Jun 09; Vol. 30 (12), pp. 1067-1083.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cell-Based Delivery Approaches for DNA-Binding Domains into the Central Nervous System.
Autorzy :
Deng P; UC Davis Medical Center, Department of Neurology. United States.
Halmai J; UC Davis Medical Center, Department of Neurology. United States.
Waldo JJ; UC Davis Medical Center, Department of Neurology. United States.
Fink KD; UC Davis Medical Center, Department of Neurology. United States.
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Źródło :
Current neuropharmacology [Curr Neuropharmacol] 2021 May 17. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.
Autorzy :
Halmai JANM; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Deng P; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Gonzalez CE; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Coggins NB; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Cameron D; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Carter JL; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Buchanan FKB; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Waldo JJ; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Lock SR; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Anderson JD; Department of Otolaryngology, University of California, Davis, Davis, CA, USA.
O'Geen H; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Segal DJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Nolta J; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Fink KD; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Mar 18; Vol. 48 (5), pp. 2372-2387.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Promoter Regions, Genetic*
X Chromosome Inactivation*
Chromosomes, Human, X/*chemistry
Protein-Serine-Threonine Kinases/*genetics
RNA, Messenger/*genetics
Alleles ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Chromosomes, Human, X/metabolism ; CpG Islands ; Gene Editing ; Gene Silencing ; Humans ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Neurons/cytology ; Neurons/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Guide/genetics ; RNA, Guide/metabolism ; RNA, Messenger/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome.
Autorzy :
Berg EL; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Pride MC; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Petkova SP; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Lee RD; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Copping NA; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Shen Y; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Adhikari A; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Fenton TA; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Pedersen LR; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Noakes LS; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Nieman BJ; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Lerch JP; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
Harris S; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Born HA; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Peters MM; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Deng P; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Cameron DL; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Fink KD; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Beitnere U; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
O'Geen H; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
Anderson AE; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Dindot SV; Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Nash KR; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Weeber EJ; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Wöhr M; Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.
Ellegood J; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Segal DJ; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
Silverman JL; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2020 Jan 27; Vol. 10 (1), pp. 39. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation.
Autorzy :
Showalter MR; West Coast Metabolomics Center, University of California Davis, USA.
Wancewicz B; West Coast Metabolomics Center, University of California Davis, USA.
Fiehn O; West Coast Metabolomics Center, University of California Davis, USA.
Archard JA; Department of Otolaryngology, University of California Davis, USA.
Clayton S; Department of Otolaryngology, University of California Davis, USA.
Wagner J; Drug Discovery Consortium, University of California, USA.
Deng P; Department of Neurology, University of California Davis, USA.
Halmai J; Department of Neurology, University of California Davis, USA.
Fink KD; Department of Neurology, University of California Davis, USA.
Bauer G; Good Manufacturing Practice Facility, University of California Davis, USA.
Fury B; Good Manufacturing Practice Facility, University of California Davis, USA.
Perotti NH; Good Manufacturing Practice Facility, University of California Davis, USA.
Apperson M; Department of Neurology, University of California Davis, USA.
Butters J; Department of Neurology, University of California Davis, USA.
Belafsky P; Department of Otolaryngology, University of California Davis, USA.
Farwell G; Department of Otolaryngology, University of California Davis, USA.
Kuhn M; Department of Otolaryngology, University of California Davis, USA.
Nolta JA; Stem Cell Program, University of California Davis, USA.
Anderson JD; Department of Otolaryngology, University of California Davis, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 May 14; Vol. 512 (4), pp. 729-735. Date of Electronic Publication: 2019 Mar 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Exosomes/*immunology
Mesenchymal Stem Cells/*immunology
Cell Line ; Exosomes/metabolism ; Glycolysis ; Humans ; Immunomodulation ; Macrophage Activation ; Mesenchymal Stem Cells/metabolism ; Metabolome ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.
Autorzy :
O'Geen H; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA. .
Bates SL; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
Carter SS; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
Nisson KA; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Halmai J; Department of Neurology and Stem Cell Program, University of California, Sacramento, CA, 95817, USA.
Fink KD; Department of Neurology and Stem Cell Program, University of California, Sacramento, CA, 95817, USA.
Rhie SK; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Farnham PJ; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Segal DJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
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Źródło :
Epigenetics & chromatin [Epigenetics Chromatin] 2019 May 03; Vol. 12 (1), pp. 26. Date of Electronic Publication: 2019 May 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer of Zeste Homolog 2 Protein/*genetics
Repressor Proteins/*genetics
Animals ; CRISPR-Cas Systems ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Gene Editing ; Genetic Engineering/methods ; HCT116 Cells ; Histone Methyltransferases/genetics ; Histone Methyltransferases/metabolism ; Histones/metabolism ; Humans ; Mice ; Promoter Regions, Genetic ; RNA, Guide/genetics ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Repressor Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion.
Autorzy :
Yuan O; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Lin C; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Wagner J; 2 Drug Discovery Consortium, University of California, San Francisco, San Francisco, California.
Archard JA; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Deng P; 3 Department of Neurology, University of California, Davis, Davis, California.
Halmai J; 3 Department of Neurology, University of California, Davis, Davis, California.
Bauer G; 4 Good Manufacturing Practice Facility, University of California, Davis, Davis, California.
Fink KD; 3 Department of Neurology, University of California, Davis, Davis, California.
Fury B; 4 Good Manufacturing Practice Facility, University of California, Davis, Davis, California.
Perotti NH; 4 Good Manufacturing Practice Facility, University of California, Davis, Davis, California.
Walker JE; 5 Stem Cell Program, University of California, Davis, Davis, California.
Pollock K; 5 Stem Cell Program, University of California, Davis, Davis, California.
Apperson M; 3 Department of Neurology, University of California, Davis, Davis, California.
Butters J; 3 Department of Neurology, University of California, Davis, Davis, California.
Belafsky P; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Farwell DG; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Kuhn M; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
Nolta J; 5 Stem Cell Program, University of California, Davis, Davis, California.
Anderson JD; 1 Department of Otolaryngology, University of California, Davis, Davis, California.
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Źródło :
Stem cells and development [Stem Cells Dev] 2019 Mar 15; Vol. 28 (6), pp. 398-409. Date of Electronic Publication: 2019 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mitosis*
Exosomes/*metabolism
Intercellular Signaling Peptides and Proteins/*metabolism
Mesenchymal Stem Cells/*metabolism
Adolescent ; Adult ; Cell Line, Tumor ; Female ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Middle Aged
Czasopismo naukowe
Tytuł :
Spatial memory in Huntington's disease: A comparative review of human and animal data.
Autorzy :
Glikmann-Johnston Y; Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. Electronic address: .
Fink KD; Department of Neurology, Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd, Sacramento, CA, 95817, USA.
Deng P; Department of Neurology, Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd, Sacramento, CA, 95817, USA.
Torrest A; Department of Neurology, Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd, Sacramento, CA, 95817, USA.
Stout JC; Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
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Źródło :
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2019 Mar; Vol. 98, pp. 194-207. Date of Electronic Publication: 2019 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cognition Disorders/*pathology
Hippocampus/*pathology
Huntington Disease/*pathology
Neurogenesis/*physiology
Spatial Memory/*physiology
Animals ; Disease Models, Animal ; Humans
Czasopismo naukowe
Tytuł :
Engineered BDNF producing cells as a potential treatment for neurologic disease.
Autorzy :
Deng P; a Stem Cell Program and Institute for Regenerative Cures , University of California Davis Health Systems , Sacramento , CA , USA.; b Genome Center, MIND Institute, and Biochemistry and Molecular Medicine , University of California , Davis , CA , USA.
Anderson JD; a Stem Cell Program and Institute for Regenerative Cures , University of California Davis Health Systems , Sacramento , CA , USA.
Yu AS; b Genome Center, MIND Institute, and Biochemistry and Molecular Medicine , University of California , Davis , CA , USA.
Annett G; a Stem Cell Program and Institute for Regenerative Cures , University of California Davis Health Systems , Sacramento , CA , USA.
Fink KD; a Stem Cell Program and Institute for Regenerative Cures , University of California Davis Health Systems , Sacramento , CA , USA.
Nolta JA; a Stem Cell Program and Institute for Regenerative Cures , University of California Davis Health Systems , Sacramento , CA , USA.
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Źródło :
Expert opinion on biological therapy [Expert Opin Biol Ther] 2016 Aug; Vol. 16 (8), pp. 1025-33. Date of Electronic Publication: 2016 May 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain-Derived Neurotrophic Factor/*therapeutic use
Nervous System Diseases/*drug therapy
Animals ; Brain-Derived Neurotrophic Factor/administration & dosage ; Humans ; Neurodegenerative Diseases/drug therapy ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Tytuł :
Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells.
Autorzy :
Deng P; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Torrest A; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Pollock K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Dahlenburg H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Annett G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Nolta JA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Fink KD; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
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Źródło :
Neural regeneration research [Neural Regen Res] 2016 May; Vol. 11 (5), pp. 702-5.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.
Autorzy :
Pollock K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Dahlenburg H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Nelson H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Fink KD; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Cary W; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Hendrix K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Annett G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Torrest A; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Deng P; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Gutierrez J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Nacey C; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Pepper K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Kalomoiris S; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
D Anderson J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
McGee J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Gruenloh W; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Fury B; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Bauer G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Duffy A; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Tempkin T; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Wheelock V; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Nolta JA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2016 May; Vol. 24 (5), pp. 965-77. Date of Electronic Publication: 2016 Jan 14.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling.
Autorzy :
Anderson JD; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Johansson HJ; Cancer Proteomics, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Graham CS; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Vesterlund M; Cancer Proteomics, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Pham MT; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Bramlett CS; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Montgomery EN; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Mellema MS; Surgical and Radiological Sciences, Department of Veterinary Medicine, University of California Davis, Davis, California, USA.
Bardini RL; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Contreras Z; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Hoon M; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Bauer G; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Fink KD; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Fury B; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Hendrix KJ; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Chedin F; Department of Molecular and Cellular Biology, University of California Davis, Davis, California, USA.
El-Andaloussi S; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Hwang B; Department of Surgery, University of Washington, Seattle, Washington, USA.
Mulligan MS; Department of Surgery, University of Washington, Seattle, Washington, USA.
Lehtiö J; Cancer Proteomics, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Nolta JA; Stem Cell Program, Department of Internal Medicine, University of California Davis, Davis, California, USA.
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Źródło :
Stem cells (Dayton, Ohio) [Stem Cells] 2016 Mar; Vol. 34 (3), pp. 601-13. Date of Electronic Publication: 2016 Feb 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Exosomes/*genetics
Mesenchymal Stem Cells/*metabolism
NF-kappa B/*genetics
Neovascularization, Physiologic/*genetics
Bone Marrow Cells/metabolism ; Gene Expression Regulation, Developmental ; Humans ; Male ; Paracrine Communication/genetics ; Proteome/genetics ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.
Autorzy :
Fink KD; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health Systems, Sacramento, CA, USA.
Deng P
Gutierrez J
Anderson JS
Torrest A
Komarla A
Kalomoiris S
Cary W
Anderson JD
Gruenloh W
Duffy A
Tempkin T
Annett G
Wheelock V
Segal DJ
Nolta JA
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Źródło :
Cell transplantation [Cell Transplant] 2016; Vol. 25 (4), pp. 677-86. Date of Electronic Publication: 2016 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alleles*
Huntingtin Protein*/biosynthesis
Huntingtin Protein*/genetics
Huntington Disease*/genetics
Huntington Disease*/metabolism
Polymorphism, Single Nucleotide*
Transcriptional Activation*
Fibroblasts/*metabolism
Female ; Gene Knockdown Techniques ; Humans ; Male
Czasopismo naukowe
Tytuł :
Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number.
Autorzy :
Rossignol J; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; College of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA. .
Fink KD; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; Faculté des Science et des Techniques, Université de Nantes, 44300, Nantes, France. .; INSERM U1064, ITUN, 44093, Nantes, France. .
Crane AT; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Davis KK; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Bombard MC; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Clerc S; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Bavar AM; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Lowrance SA; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Song C; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Witte S; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Lescaudron L; Faculté des Science et des Techniques, Université de Nantes, 44300, Nantes, France. .; INSERM U791, Laboratoire d'Ingenierie Osteo-Articulaire et Dentaire (LIOAD), 44042, Nantes, France. .
Dunbar GL; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; Field Neurosciences Institute, Saginaw, MI, 48604, USA. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2015 Feb 19; Vol. 6, pp. 9. Date of Electronic Publication: 2015 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mesenchymal Stem Cell Transplantation*
Bone Marrow Cells/*cytology
Huntington Disease/*therapy
Mesenchymal Stem Cells/*cytology
Animals ; Behavior, Animal ; Brain/metabolism ; Brain/pathology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Male ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Transgenic ; Motor Activity ; Nerve Growth Factor/genetics ; Nerve Growth Factor/metabolism ; Nerve Tissue Proteins/genetics ; Receptor, trkB/genetics ; Receptor, trkB/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Bone-marrow-derived mesenchymal stem cells attenuate cognitive deficits in an endothelin-1 rat model of stroke.
Autorzy :
Lowrance SA; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Fink KD; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Crane A; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Matyas J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Dey ND; Field Neurosciences Institute, Saginaw, MI, USA.
Matchynski JJ; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Thibo T; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Reinke T; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Kippe J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Hoffman C; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Sandstrom M; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Rossignol J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.; Central Michigan University College of Medicine, Mount Pleasant, MI, USA.
Dunbar GL; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.; Field Neurosciences Institute, Saginaw, MI, USA.
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Źródło :
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2015; Vol. 33 (4), pp. 579-88.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mesenchymal Stem Cell Transplantation*/methods
Cognition Disorders/*therapy
Stroke/*therapy
Animals ; Body Weight ; Brain/pathology ; Chronic Disease ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Cognition Disorders/physiopathology ; Conditioning, Operant ; Disease Models, Animal ; Endothelin-1 ; Female ; Male ; Psychological Tests ; Rats, Sprague-Dawley ; Stroke/pathology ; Stroke/physiopathology ; Stroke/psychology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Developing stem cell therapies for juvenile and adult-onset Huntington's disease.
Autorzy :
Fink KD; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Deng P; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Torrest A; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Stewart H; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Pollock K; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Gruenloh W; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Annett G; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
Tempkin T; GenomeCenter, Biochemistry & Molecular Medicine, University of California, 451 Health Sciences Dr. Davis, CA 95616 USA.
Wheelock V; Department of Neurology, University of California Davis Health Systems, 4860 Y Street Sacramento, CA, 95817 USA.
Nolta JA; Stem Cell Program & Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd. Sacramento, CA, USA 95817.
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Źródło :
Regenerative medicine [Regen Med] 2015; Vol. 10 (5), pp. 623-46.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Stem Cell Transplantation*
Huntington Disease/*therapy
Adult ; Animals ; Animals, Genetically Modified ; Cell Differentiation ; Cell Transplantation/methods ; Central Nervous System/pathology ; Child ; Clinical Trials as Topic ; Disease Progression ; Embryonic Stem Cells/cytology ; Humans ; Immune System ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/metabolism ; Nerve Growth Factors/chemistry ; Neurons/metabolism ; Neuroprotection
Czasopismo naukowe
Tytuł :
Intrastriatal transplantation of adenovirus-generated induced pluripotent stem cells for treating neuropathological and functional deficits in a rodent model of Huntington's disease.
Autorzy :
Fink KD; Field Neurosciences Institute Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, and College of Medicine, Central Michigan University, Mount Pleasant, Michigan, USA; Faculté des Sciences et des Techniques, Faculté de Médecine, and Faculté d'Odontologie, Université de Nantes, Nantes, France; INSERM U1064, ITUN, Nantes, France; INSERM U791, Laboratoire d'Ingenierie Osteo-Articulaire et Dentaire, Nantes, France; INSERM UMR 643, Nantes, France; Field Neurosciences Institute, Saginaw, Michigan, USA; Centre Hospitalier-Universitaire Hotel Dieu de Nantes, Nantes, France.
Crane AT
Lévêque X
Dues DJ
Huffman LD
Moore AC
Story DT
Dejonge RE
Antcliff A
Starski PA
Lu M
Lescaudron L
Rossignol J
Dunbar GL
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Źródło :
Stem cells translational medicine [Stem Cells Transl Med] 2014 May; Vol. 3 (5), pp. 620-31. Date of Electronic Publication: 2014 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoviridae*
Corpus Striatum*
Huntington Disease*/chemically induced
Huntington Disease*/metabolism
Huntington Disease*/pathology
Huntington Disease*/therapy
Induced Pluripotent Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/transplantation
Stem Cell Transplantation*
Transduction, Genetic*
Animals ; Behavior, Animal ; Convulsants/adverse effects ; Convulsants/pharmacology ; Disease Models, Animal ; Female ; Male ; Nitro Compounds/adverse effects ; Nitro Compounds/pharmacology ; Propionates/adverse effects ; Propionates/pharmacology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum.
Autorzy :
Fink KD; Program in Neuroscience, Field Neurosciences Laboratory for Restorative Neurology Brain Research and Integrative Neuroscience Center, Central Michigan University, Mount Pleasant, MI, USA.
Rossignol J
Lu M
Lévêque X
Hulse TD
Crane AT
Nerriere-Daguin V
Wyse RD
Starski PA
Schloop MT
Dues DJ
Witte SJ
Song C
Vallier L
Nguyen TH
Naveilhan P
Anegon I
Lescaudron L
Dunbar GL
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Źródło :
Cell transplantation [Cell Transplant] 2014; Vol. 23 (11), pp. 1407-23. Date of Electronic Publication: 2013 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoviridae/*physiology
Cellular Reprogramming/*physiology
Corpus Striatum/*surgery
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*virology
Stem Cell Transplantation/*methods
Animals ; Cell Differentiation/physiology ; Cell Survival/physiology ; Corpus Striatum/cytology ; Male ; Rats ; Rats, Sprague-Dawley ; Transfection
Czasopismo naukowe

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