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Wyświetlanie 1-17 z 17
Tytuł:
Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model.
Autorzy:
O'Geen H; Genome Center, UC Davis, Davis, CA, USA.
Beitnere U; Genome Center, UC Davis, Davis, CA, USA.
Garcia MS; Genome Center, UC Davis, Davis, CA, USA.
Adhikari A; MIND Institute, UC Davis Health System, Sacramento, CA, USA; Department of Psychiatry and Behavioral Sciences, UC Davis Health System, Sacramento, CA, USA.
Cameron DL; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Fenton TA; MIND Institute, UC Davis Health System, Sacramento, CA, USA; Department of Psychiatry and Behavioral Sciences, UC Davis Health System, Sacramento, CA, USA.
Copping NA; MIND Institute, UC Davis Health System, Sacramento, CA, USA; Department of Psychiatry and Behavioral Sciences, UC Davis Health System, Sacramento, CA, USA.
Deng P; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Lock S; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Halmai JANM; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Villegas IJ; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Liu J; Genome Editing and Novel Modalities (GENM), MilliporeSigma, St. Louis, MO, USA.
Wang D; Genome Editing and Novel Modalities (GENM), MilliporeSigma, St. Louis, MO, USA.
Fink KD; Neurology Department, Stem Cell Program and Gene Therapy Center, UC Davis Health System, Sacramento, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA.
Silverman JL; MIND Institute, UC Davis Health System, Sacramento, CA, USA; Department of Psychiatry and Behavioral Sciences, UC Davis Health System, Sacramento, CA, USA.
Segal DJ; Genome Center, UC Davis, Davis, CA, USA; Department of Biochemistry and Molecular Medicine, UC Davis, Davis, CA, USA; MIND Institute, UC Davis Health System, Sacramento, CA, USA. Electronic address: .
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Apr 05; Vol. 31 (4), pp. 1088-1105. Date of Electronic Publication: 2023 Jan 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Angelman Syndrome*/genetics
Angelman Syndrome*/therapy
Angelman Syndrome*/metabolism
Animals ; Mice ; Brain/metabolism ; Gene Expression Regulation ; Transcription Factors/genetics ; Phenotype ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł:
Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids.
Autorzy:
DeFelice BC; West Coast Metabolomics Center, University of California, Davis, CA 95616, USA.
Fiehn O; West Coast Metabolomics Center, University of California, Davis, CA 95616, USA.
Belafsky P; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Ditterich C; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Moore M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Abouyared M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Beliveau AM; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Farwell DG; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Bewley AF; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Clayton SM; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Archard JA; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Pavlic J; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Rao S; Department of Radiation Oncology, University of California, Davis, CA 95616, USA.
Kuhn M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Deng P; Department of Neurology, University of California, Davis, CA 95616, USA.
Halmai J; Department of Neurology, University of California, Davis, CA 95616, USA.
Fink KD; Department of Neurology, University of California, Davis, CA 95616, USA.
Birkeland AC; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Anderson JD; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
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Źródło:
Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2022 Mar 24; Vol. 12 (4). Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models.
Autorzy:
Deng P; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Biochemistry and Molecular Medicine, Genome Center, University of California, Davis, Davis, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Halmai JANM; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Beitnere U; Department of Biochemistry and Molecular Medicine, Genome Center, University of California, Davis, Davis, CA, United States.
Cameron D; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Martinez ML; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, Gene Therapy Center, and California National Primate Research Center, University of California, Davis, Davis, CA, United States.
Lee CC; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, Gene Therapy Center, and California National Primate Research Center, University of California, Davis, Davis, CA, United States.
Waldo JJ; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Thongphanh K; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.
Adhikari A; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Copping N; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Petkova SP; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Lee RD; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Lock S; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Palomares M; Department of Biochemistry and Molecular Medicine, Genome Center, University of California, Davis, Davis, CA, United States.
O'Geen H; Department of Biochemistry and Molecular Medicine, Genome Center, University of California, Davis, Davis, CA, United States.
Carter J; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Gonzalez CE; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Buchanan FKB; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Anderson JD; Department of Otolaryngology, University of California, Davis, Davis, CA, United States.
Fierro FA; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.
Nolta JA; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.
Tarantal AF; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, Gene Therapy Center, and California National Primate Research Center, University of California, Davis, Davis, CA, United States.
Silverman JL; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
Segal DJ; Department of Biochemistry and Molecular Medicine, Genome Center, University of California, Davis, Davis, CA, United States.
Fink KD; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, United States.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, United States.; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States.
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Źródło:
Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Jan 27; Vol. 14, pp. 789913. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2021).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome.
Autorzy:
Copping NA; School of Medicine, Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Research II Building 96, 4625 2nd Avenue, Suite 1001B, Davis, Sacramento, CA, 95817, USA.; Stem Cell Program and Gene Therapy Center, Department of Neurology, MIND Institute, University of California, Davis, Sacramento, CA, USA.
McTighe SM; Arkuda Therapeutics, 200 Arsenal Yards Blvd, Suite 220 , Watertown, MA, USA.
Fink KD; Stem Cell Program and Gene Therapy Center, Department of Neurology, MIND Institute, University of California, Davis, Sacramento, CA, USA.
Silverman JL; School of Medicine, Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Research II Building 96, 4625 2nd Avenue, Suite 1001B, Davis, Sacramento, CA, 95817, USA. .
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Źródło:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2021 Jul; Vol. 18 (3), pp. 1535-1547. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Angelman Syndrome/*genetics
Angelman Syndrome/*therapy
Anticonvulsants/*therapeutic use
Genetic Therapy/*methods
Animals ; Biological Products/therapeutic use ; Humans ; Isoxazoles/therapeutic use ; Neurodevelopmental Disorders/genetics ; Neurodevelopmental Disorders/therapy ; RNA, Antisense/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł:
The iNs and Outs of Direct Reprogramming to Induced Neurons.
Autorzy:
Carter JL; Gene Therapy Center, Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California, Davis, Sacramento, CA, United States.
Halmai JANM; Gene Therapy Center, Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California, Davis, Sacramento, CA, United States.
Fink KD; Gene Therapy Center, Stem Cell Program, Department of Neurology, Institute for Regenerative Cures, University of California, Davis, Sacramento, CA, United States.
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Źródło:
Frontiers in genome editing [Front Genome Ed] 2020 Sep 04; Vol. 2, pp. 7. Date of Electronic Publication: 2020 Sep 04 (Print Publication: 2020).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.
Autorzy:
Halmai JANM; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Deng P; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Gonzalez CE; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Coggins NB; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Cameron D; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Carter JL; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Buchanan FKB; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Waldo JJ; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Lock SR; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Anderson JD; Department of Otolaryngology, University of California, Davis, Davis, CA, USA.
O'Geen H; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Segal DJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.
Nolta J; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
Fink KD; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.; Stem Cell Program and Gene Therapy Center, University of California, Davis, Sacramento, CA, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2020 Mar 18; Vol. 48 (5), pp. 2372-2387.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Promoter Regions, Genetic*
X Chromosome Inactivation*
Chromosomes, Human, X/*chemistry
Protein Serine-Threonine Kinases/*genetics
RNA, Messenger/*genetics
Alleles ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Chromosomes, Human, X/metabolism ; CpG Islands ; Gene Editing ; Gene Silencing ; Humans ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Neurons/cytology ; Neurons/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Messenger/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; RNA, Guide, CRISPR-Cas Systems
Czasopismo naukowe
Tytuł:
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome.
Autorzy:
Berg EL; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Pride MC; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Petkova SP; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Lee RD; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Copping NA; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Shen Y; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Adhikari A; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Fenton TA; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Pedersen LR; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Noakes LS; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Nieman BJ; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Lerch JP; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
Harris S; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Born HA; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Peters MM; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Deng P; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Cameron DL; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Fink KD; Stem Cell Program, Institute for Regenerative Cures, and Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA.
Beitnere U; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
O'Geen H; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
Anderson AE; Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, USA.
Dindot SV; Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Nash KR; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Weeber EJ; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Wöhr M; Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.
Ellegood J; Mouse Imaging Centre, Toronto Centre for Phenogenomics, The Hospital for Sick Children, Toronto, ON, Canada.
Segal DJ; MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.
Silverman JL; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, USA. .
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Źródło:
Translational psychiatry [Transl Psychiatry] 2020 Jan 27; Vol. 10 (1), pp. 39. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Angelman Syndrome*/genetics
Intellectual Disability*/genetics
Animals ; Gene Deletion ; Memory ; Rats ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł:
Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation.
Autorzy:
Showalter MR; West Coast Metabolomics Center, University of California Davis, USA.
Wancewicz B; West Coast Metabolomics Center, University of California Davis, USA.
Fiehn O; West Coast Metabolomics Center, University of California Davis, USA.
Archard JA; Department of Otolaryngology, University of California Davis, USA.
Clayton S; Department of Otolaryngology, University of California Davis, USA.
Wagner J; Drug Discovery Consortium, University of California, USA.
Deng P; Department of Neurology, University of California Davis, USA.
Halmai J; Department of Neurology, University of California Davis, USA.
Fink KD; Department of Neurology, University of California Davis, USA.
Bauer G; Good Manufacturing Practice Facility, University of California Davis, USA.
Fury B; Good Manufacturing Practice Facility, University of California Davis, USA.
Perotti NH; Good Manufacturing Practice Facility, University of California Davis, USA.
Apperson M; Department of Neurology, University of California Davis, USA.
Butters J; Department of Neurology, University of California Davis, USA.
Belafsky P; Department of Otolaryngology, University of California Davis, USA.
Farwell G; Department of Otolaryngology, University of California Davis, USA.
Kuhn M; Department of Otolaryngology, University of California Davis, USA.
Nolta JA; Stem Cell Program, University of California Davis, USA.
Anderson JD; Department of Otolaryngology, University of California Davis, USA. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 May 14; Vol. 512 (4), pp. 729-735. Date of Electronic Publication: 2019 Mar 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Exosomes/*immunology
Mesenchymal Stem Cells/*immunology
Cell Line ; Exosomes/metabolism ; Glycolysis ; Humans ; Immunomodulation ; Macrophage Activation ; Mesenchymal Stem Cells/metabolism ; Metabolome ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł:
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.
Autorzy:
O'Geen H; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA. .
Bates SL; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
Carter SS; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
Nisson KA; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Halmai J; Department of Neurology and Stem Cell Program, University of California, Sacramento, CA, 95817, USA.
Fink KD; Department of Neurology and Stem Cell Program, University of California, Sacramento, CA, 95817, USA.
Rhie SK; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Farnham PJ; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Segal DJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.
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Źródło:
Epigenetics & chromatin [Epigenetics Chromatin] 2019 May 03; Vol. 12 (1), pp. 26. Date of Electronic Publication: 2019 May 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein/*genetics
Repressor Proteins/*genetics
Animals ; CRISPR-Cas Systems ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; DNA Methyltransferase 3A ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Gene Editing ; Genetic Engineering/methods ; HCT116 Cells ; Histone Methyltransferases/genetics ; Histone Methyltransferases/metabolism ; Histones/metabolism ; Humans ; Mice ; Promoter Regions, Genetic ; RNA, Guide, CRISPR-Cas Systems/genetics ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Repressor Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models.
Autorzy:
Pollock K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Dahlenburg H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Nelson H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Fink KD; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Cary W; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Hendrix K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Annett G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Torrest A; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Deng P; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Gutierrez J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Nacey C; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Pepper K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Kalomoiris S; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
D Anderson J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
McGee J; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Gruenloh W; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Fury B; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Bauer G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
Duffy A; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Tempkin T; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Wheelock V; Department of Neurology, University of California Davis Health System, Sacramento, California, USA.
Nolta JA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, California, USA.
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2016 May; Vol. 24 (5), pp. 965-77. Date of Electronic Publication: 2016 Jan 14.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł:
Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells.
Autorzy:
Deng P; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Torrest A; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Pollock K; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Dahlenburg H; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Annett G; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Nolta JA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
Fink KD; Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health System, Sacramento, CA, USA.
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Źródło:
Neural regeneration research [Neural Regen Res] 2016 May; Vol. 11 (5), pp. 702-5.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number.
Autorzy:
Rossignol J; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; College of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA. .
Fink KD; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; Faculté des Science et des Techniques, Université de Nantes, 44300, Nantes, France. .; INSERM U1064, ITUN, 44093, Nantes, France. .
Crane AT; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Davis KK; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Bombard MC; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Clerc S; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Bavar AM; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Lowrance SA; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Song C; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Witte S; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .
Lescaudron L; Faculté des Science et des Techniques, Université de Nantes, 44300, Nantes, France. .; INSERM U791, Laboratoire d'Ingenierie Osteo-Articulaire et Dentaire (LIOAD), 44042, Nantes, France. .
Dunbar GL; Field Neurosciences Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, 1280 East Campus Drive, HP Building Room 2336, Mount Pleasant, MI, 48859, USA. .; Field Neurosciences Institute, Saginaw, MI, 48604, USA. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2015 Feb 19; Vol. 6, pp. 9. Date of Electronic Publication: 2015 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*
Bone Marrow Cells/*cytology
Huntington Disease/*therapy
Mesenchymal Stem Cells/*cytology
Animals ; Behavior, Animal ; Brain/metabolism ; Brain/pathology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Male ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Transgenic ; Motor Activity ; Nerve Growth Factor/genetics ; Nerve Growth Factor/metabolism ; Nerve Tissue Proteins/genetics ; Receptor, trkB/genetics ; Receptor, trkB/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł:
Bone-marrow-derived mesenchymal stem cells attenuate cognitive deficits in an endothelin-1 rat model of stroke.
Autorzy:
Lowrance SA; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Fink KD; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Crane A; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Matyas J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Dey ND; Field Neurosciences Institute, Saginaw, MI, USA.
Matchynski JJ; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Thibo T; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Reinke T; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Kippe J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Hoffman C; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Sandstrom M; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.
Rossignol J; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.; Central Michigan University College of Medicine, Mount Pleasant, MI, USA.
Dunbar GL; Field Neurosciences Institute Laboratory for Restorative Neurology, Mount Pleasant, MI, USA.; Central Michigan University Program in Neuroscience, Mount Pleasant, MI, USA.; Field Neurosciences Institute, Saginaw, MI, USA.
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2015; Vol. 33 (4), pp. 579-88.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*/methods
Cognition Disorders/*therapy
Stroke/*therapy
Animals ; Body Weight ; Brain/pathology ; Chronic Disease ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Cognition Disorders/physiopathology ; Conditioning, Operant ; Disease Models, Animal ; Endothelin-1 ; Female ; Male ; Psychological Tests ; Rats, Sprague-Dawley ; Stroke/pathology ; Stroke/physiopathology ; Stroke/psychology ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Intrastriatal transplantation of adenovirus-generated induced pluripotent stem cells for treating neuropathological and functional deficits in a rodent model of Huntington's disease.
Autorzy:
Fink KD; Field Neurosciences Institute Laboratory for Restorative Neurology, Brain Research and Integrative Neuroscience Center, Program in Neuroscience, and College of Medicine, Central Michigan University, Mount Pleasant, Michigan, USA; Faculté des Sciences et des Techniques, Faculté de Médecine, and Faculté d'Odontologie, Université de Nantes, Nantes, France; INSERM U1064, ITUN, Nantes, France; INSERM U791, Laboratoire d'Ingenierie Osteo-Articulaire et Dentaire, Nantes, France; INSERM UMR 643, Nantes, France; Field Neurosciences Institute, Saginaw, Michigan, USA; Centre Hospitalier-Universitaire Hotel Dieu de Nantes, Nantes, France.
Crane AT
Lévêque X
Dues DJ
Huffman LD
Moore AC
Story DT
Dejonge RE
Antcliff A
Starski PA
Lu M
Lescaudron L
Rossignol J
Dunbar GL
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Źródło:
Stem cells translational medicine [Stem Cells Transl Med] 2014 May; Vol. 3 (5), pp. 620-31. Date of Electronic Publication: 2014 Mar 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenoviridae*
Corpus Striatum*
Huntington Disease*/chemically induced
Huntington Disease*/metabolism
Huntington Disease*/pathology
Huntington Disease*/therapy
Induced Pluripotent Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/transplantation
Stem Cell Transplantation*
Transduction, Genetic*
Animals ; Behavior, Animal ; Convulsants/adverse effects ; Convulsants/pharmacology ; Disease Models, Animal ; Female ; Male ; Nitro Compounds/adverse effects ; Nitro Compounds/pharmacology ; Propionates/adverse effects ; Propionates/pharmacology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis.
Autorzy:
Fink KD
Rossignol J
Crane AT
Davis KK
Bombard MC
Bavar AM
Clerc S
Lowrance SA
Song C
Lescaudron L
Dunbar GL
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2013 Oct 24; Vol. 4 (5), pp. 130. Date of Electronic Publication: 2013 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal*/physiology
Mesenchymal Stem Cell Transplantation*
Motor Activity*/physiology
Huntington Disease/*surgery
Mesenchymal Stem Cells/*cytology
Umbilical Cord/*cytology
Animals ; Brain/pathology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Female ; Huntington Disease/pathology ; Male ; Memory ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
The effects of acute voluntary wheel running on recovery of function following medial frontal cortical contusions in rats.
Autorzy:
Crane AT; Neuroscience Graduate Program, Central Michigan University, MI, USA.
Fink KD
Smith JS
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2012; Vol. 30 (4), pp. 325-33.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Recovery of Function*
Brain Injuries/*physiopathology
Cerebral Cortex/*physiopathology
Motor Activity/*physiology
Animals ; Brain Injuries/pathology ; Cerebral Cortex/injuries ; Male ; Physical Conditioning, Animal ; Rats ; Rats, Long-Evans ; Reaction Time
Czasopismo naukowe
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