Temat: "Floxuridine" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: High OXPHOS efficiency in RA-FUdr-differentiated SH-SY5Y cells: involvement of cAMP signalling and respiratory supercomplexes.
Autorzy:: Matrella ML; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Valletti A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.; MASMEC Biomed S.p.A, 70026, Modugno, Italy.
Gigante I; National Institute of Gastroenterology- IRCCS 'Saverio De Bellis', Via Turi 27, Castellana Grotte, 70013, Bari, Italy.
De Rasmo D; Bioenergetics and Molecular Biotechnologies, CNR-Institute of Biomembranes, 70124, Bari, Italy.
Signorile A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Russo S; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Lobasso S; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Lobraico D; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Dibattista M; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
Pacelli C; Department of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy. .
Cocco T; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 28; Vol. 14 (1), pp. 7411. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:: Journal Article
MeSH Terms:: Tretinoin*/pharmacology
Tretinoin*/metabolism
Neuroblastoma*/metabolism
Humans ; Floxuridine ; Oxidative Phosphorylation ; Cell Line, Tumor ; Cell Differentiation

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
Autorzy:: Harpel Z; Department of Biology, Hamilton College, Clinton, NY, United States of America.
Chang WJ; Department of Biology, Hamilton College, Clinton, NY, United States of America.
Circelli J; Department of Biology, Hamilton College, Clinton, NY, United States of America.
Chen R; College of Literature, Science, and Arts, University of Michigan, Ann Arbor, MI, United States of America.
Chang I; Clinton Senior High School, Clinton, NY, United States of America.
Rivera J; Clinton Senior High School, Clinton, NY, United States of America.
Wu S; Department of Biology, Hamilton College, Clinton, NY, United States of America.
Wei R; Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Applications, School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, Henan, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Sep 14; Vol. 18 (9), pp. e0284309. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tetrahymena thermophila*
Floxuridine/pharmacology ; Nucleosides ; Thymine/pharmacology ; Antimetabolites ; Gemcitabine ; Pyrimidines/pharmacology ; Uracil/pharmacology ; Fluorouracil/pharmacology ; Cytarabine

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake.
Autorzy:: Aviñó A; Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.; Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.
Clua A; Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.; Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.
Bleda MJ; Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.
Eritja R; Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.; Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.
Fàbrega C; Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.; Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 26; Vol. 22 (11). Date of Electronic Publication: 2021 May 26.
Typ publikacji:: Journal Article
MeSH Terms:: Cytotoxins*/chemistry
Cytotoxins*/pharmacokinetics
Cytotoxins*/pharmacology
Floxuridine*/chemistry
Floxuridine*/pharmacokinetics
Floxuridine*/pharmacology
Oligonucleotides*/chemistry
Oligonucleotides*/pharmacokinetics
Oligonucleotides*/pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
HeLa Cells ; Hep G2 Cells ; Humans

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Effects of FUdR on gene expression in the C. elegans bacterial diet OP50.
Autorzy:: McIntyre G; Department of Biology, Marian University, 3200 Cold Spring Rd, Indianapolis, IN, 46222, USA.
Wright J; Department of Biology, Juniata College, 1700 Moore St, Huntingdon, PA, 16652, USA.
Wong HT; Department of Biology, Juniata College, 1700 Moore St, Huntingdon, PA, 16652, USA.
Lamendella R; Department of Biology, Juniata College, 1700 Moore St, Huntingdon, PA, 16652, USA.
Chan J; Department of Biology, Marian University, 3200 Cold Spring Rd, Indianapolis, IN, 46222, USA. .; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2021 May 28; Vol. 14 (1), pp. 207. Date of Electronic Publication: 2021 May 28.
Typ publikacji:: Journal Article
MeSH Terms:: Caenorhabditis elegans*/genetics
Floxuridine*
Animals ; Diet ; Escherichia coli/genetics ; Gene Expression

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Co-delivery of 5-fluorodeoxyuridine and doxorubicin via gold nanoparticle equipped with affibody-DNA hybrid strands for targeted synergistic chemotherapy of HER2 overexpressing breast cancer.
Autorzy:: Zhang C; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China.
Zhang F; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China.
Han M; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China.
Wang X; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China.
Du J; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China.
Zhang H; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China. .
Li W; College of Chemistry and Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Dec 16; Vol. 10 (1), pp. 22015. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Breast Neoplasms/*drug therapy
DNA/*chemistry
Doxorubicin/*therapeutic use
Floxuridine/*therapeutic use
Gold/*chemistry
Metal Nanoparticles/*chemistry
Receptor, ErbB-2/*metabolism
Recombinant Fusion Proteins/*chemistry
Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Doxorubicin/administration & dosage ; Doxorubicin/pharmacology ; Drug Delivery Systems ; Drug Liberation ; Drug Synergism ; Endocytosis/drug effects ; Female ; Floxuridine/administration & dosage ; Floxuridine/pharmacology ; Humans ; Metal Nanoparticles/ultrastructure

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis.
Autorzy:: Sato A; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Hiramoto A; Division of International Infectious Disease Control, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
Kim HS; Division of International Infectious Disease Control, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
Wataya Y; Division of International Infectious Disease Control, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 16; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antimetabolites, Antineoplastic/*pharmacology
Apoptosis/*drug effects
Floxuridine/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Neoplasms/*drug therapy
Animals ; Antimetabolites, Antineoplastic/therapeutic use ; Floxuridine/therapeutic use ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of DPYD Exon Sequencing and the Role of Phenotyping Assays.
Autorzy:: De Luca O; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Salerno G; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
De Bernardini D; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Torre MS; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Simmaco M; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Lionetto L; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Gentile G; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Borro M; Laboratory of Clinical Biochemistry, Advanced Molecular Diagnostic Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy.; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 11; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 11.
Typ publikacji:: Journal Article
MeSH Terms:: Dihydrouracil Dehydrogenase (NADP)*/genetics
Dihydrouracil Dehydrogenase (NADP)*/metabolism
Dihydropyrimidine Dehydrogenase Deficiency*/diagnosis
Dihydropyrimidine Dehydrogenase Deficiency*/genetics
Humans ; Fluorouracil/adverse effects ; Fluorouracil/metabolism ; Floxuridine ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/metabolism ; Exons

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2'-deoxyuridine (FUdR).
Autorzy:: Lesslich HM; Department of Biochemistry II, Ruhr-Universität Bochum, Bochum, Germany.
Klapal L; Department of Biochemistry II, Ruhr-Universität Bochum, Bochum, Germany.
Wilke J; Department of Biochemistry II, Ruhr-Universität Bochum, Bochum, Germany.
Haak A; Nanoscopy Group, RUBION, Ruhr-Universität Bochum, Bochum, Germany.
Dietzel ID; Department of Biochemistry II, Ruhr-Universität Bochum, Bochum, Germany.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Mar 09; Vol. 17 (3), pp. e0265084. Date of Electronic Publication: 2022 Mar 09 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Astrocytes*/metabolism
Cytostatic Agents*/pharmacology
Animals ; Cell Culture Techniques ; Cells, Cultured ; Deoxyuridine/analogs & derivatives ; Floxuridine/pharmacology ; Hippocampus ; Neurons/metabolism ; Rats

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Supramolecular Amphiphiles Based on Pillar[5]arene and Meroterpenoids: Synthesis, Self-Association and Interaction with Floxuridine.
Autorzy:: Akhmedov AA; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Shurpik DN; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Padnya PL; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Khadieva AI; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Gamirov RR; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Panina YV; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Gazizova AF; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Grishaev DY; Scientific and Educational Center of Pharmaceutics, Kazan Federal University, 420008 Kazan, Russia.
Plemenkov VV; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.
Stoikov II; A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji:: Journal Article
MeSH Terms:: Membranes, Artificial*
Calixarenes/*chemistry
Floxuridine/*chemistry
Terpenes/*chemistry

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells.
Autorzy:: Kurasaka C; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Ogino Y; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.; Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Sato A; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji:: Journal Article
MeSH Terms:: Antimetabolites, Antineoplastic/*pharmacology
Drug Resistance, Neoplasm/*genetics
Fluorouracil/*pharmacology
Thymidylate Synthase/*genetics
Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Floxuridine/pharmacology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Irinotecan/pharmacology ; Platinum Compounds/pharmacology ; Thymidylate Synthase/metabolism ; Exome Sequencing

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 11.

Tytuł:: 3'-O- and 5'-O-Propargyl Derivatives of 5-Fluoro-2'-Deoxyuridine: Synthesis, Cytotoxic Evaluation and Conformational Analysis.
Autorzy:: Baraniak D; a Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego St 12/14, 61-704 Poznań , Poland.
Baranowski D; a Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego St 12/14, 61-704 Poznań , Poland.; b Department of Pharmacology , Faculty of Pharmacy, Poznań University of Medical Sciences , Rokietnicka St 5a, 60-806 Poznań , Poland.
Ruszkowski P; b Department of Pharmacology , Faculty of Pharmacy, Poznań University of Medical Sciences , Rokietnicka St 5a, 60-806 Poznań , Poland.
Boryski J; a Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego St 12/14, 61-704 Poznań , Poland.; Pokaż więcej
Źródło:: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2016; Vol. 35 (4), pp. 178-94. Date of Electronic Publication: 2016 Feb 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*chemical synthesis
Floxuridine/*analogs & derivatives
Neoplasms/*drug therapy
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Female ; Floxuridine/chemical synthesis ; Floxuridine/chemistry ; Floxuridine/pharmacology ; Humans ; Molecular Conformation

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 12.

Tytuł:: Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy.
Autorzy:: Xu L; National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, 266237, People's Republic of China.
Liu X; State Key Lab of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Li Y; National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, 266237, People's Republic of China.
Yin Z; State Key Lab of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Jin L; National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, 266237, People's Republic of China.
Lu L; National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, 266237, People's Republic of China.
Qu J; State Key Lab of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Xiao M; National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, 266237, People's Republic of China. .; State Key Lab of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China. .; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Oct; Vol. 103 (19), pp. 7997-8008. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji:: Journal Article
MeSH Terms:: Alternaria/*enzymology
Antineoplastic Agents/*metabolism
Glycoside Hydrolases/*metabolism
Molecular Targeted Therapy/*methods
Neoplasms/*drug therapy
Prodrugs/*metabolism
Rhamnose/*metabolism
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cytarabine/metabolism ; Cytarabine/pharmacology ; Floxuridine/metabolism ; Floxuridine/pharmacology ; Humans ; Hydroxyurea/metabolism ; Hydroxyurea/pharmacology ; Prodrugs/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 13.

Tytuł:: Nucleoside dimers analogues with a 1,2,3-triazole linkage: conjugation of floxuridine and thymidine provides novel tools for cancer treatment. Part II.
Autorzy:: Baraniak D; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.
Baranowski D; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.
Ruszkowski P; Department of Pharmacology, Faculty of Pharmacy, Poznań University of Medical Sciences , Poznań , Poland.
Boryski J; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.; Pokaż więcej
Źródło:: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2019; Vol. 38 (11), pp. 807-835. Date of Electronic Publication: 2019 Jun 08.
Typ publikacji:: Journal Article; Video-Audio Media
MeSH Terms:: Antineoplastic Agents/*pharmacology
Nucleosides/*pharmacology
Triazoles/*pharmacology
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Click Chemistry ; Cycloaddition Reaction ; Dimerization ; Floxuridine/analogs & derivatives ; Floxuridine/pharmacology ; Humans ; Molecular Conformation ; Nucleosides/chemistry ; Thymidine/analogs & derivatives ; Thymidine/pharmacology ; Triazoles/chemistry

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.
Autorzy:: Jacobs BAW; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Deenen MJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.; Department of Clinical Pharmacology and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
Joerger M; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Rosing H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
de Vries N; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Meulendijks D; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Dutch Medicines Evaluation Board, Utrecht, The Netherlands.
Cats A; Department of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Division of Pharmaco-epidemiology & Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Schellens JHM; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Division of Pharmaco-epidemiology & Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Dec; Vol. 8 (12), pp. 940-950. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji:: Journal Article
MeSH Terms:: Antimetabolites, Antineoplastic/*pharmacokinetics
Capecitabine/*pharmacokinetics
Dihydrouracil Dehydrogenase (NADP)/*genetics
Neoplasms/*drug therapy
Adult ; Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Capecitabine/administration & dosage ; Capecitabine/chemistry ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacokinetics ; Female ; Floxuridine/pharmacokinetics ; Gastrectomy ; Humans ; Male ; Middle Aged ; Neoplasms/blood ; Neoplasms/genetics ; Pharmacogenomic Variants ; Prodrugs

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.
Autorzy:: Damaraju VL; a Department of Oncology, University of Alberta, Edmonton, Alta., Canada.
Mowles D
Wilson M
Kuzma M
Cass CE
Sawyer MB; Pokaż więcej
Źródło:: Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2013 Dec; Vol. 91 (6), pp. 419-27. Date of Electronic Publication: 2013 Jun 17.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antimetabolites, Antineoplastic/*pharmacology
Deoxycytidine/*analogs & derivatives
Floxuridine/*pharmacology
Fluorouracil/*analogs & derivatives
Gene Expression Regulation, Neoplastic/*drug effects
Kidney Tubules, Proximal/*drug effects
Antimetabolites, Antineoplastic/metabolism ; Biological Transport/drug effects ; Biotransformation ; Capecitabine ; Cell Line, Tumor ; Deoxycytidine/metabolism ; Deoxycytidine/pharmacology ; Equilibrative Nucleoside Transporter 1/genetics ; Equilibrative Nucleoside Transporter 1/metabolism ; Equilibrative-Nucleoside Transporter 2 ; Floxuridine/metabolism ; Fluorouracil/metabolism ; Fluorouracil/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Interferon-alpha/pharmacology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Kinetics ; Nucleosides/metabolism ; Signal Transduction ; Thymidine Phosphorylase/genetics ; Thymidine Phosphorylase/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.
Autorzy:: Tsume Y; Department of Pharmaceutical Science, University of Michigan, Ann Arbor, MI 48109, USA.
Amidon GL; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2012 Mar 26; Vol. 17 (4), pp. 3672-89. Date of Electronic Publication: 2012 Mar 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Antimetabolites, Antineoplastic/*metabolism
Cathepsin D/*metabolism
Floxuridine/*metabolism
Prodrugs/*metabolism
Amino Acids/metabolism ; Antimetabolites, Antineoplastic/pharmacology ; Cathepsin B/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dipeptides/metabolism ; Drug Stability ; Enzyme Activation/drug effects ; Floxuridine/pharmacology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/enzymology ; Pancreatic Neoplasms/genetics ; Prodrugs/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.
Autorzy:: Honeywell RJ; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Giovannetti E
Peters GJ; Pokaż więcej
Źródło:: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2011 Dec; Vol. 30 (12), pp. 1203-13.
Typ publikacji:: Journal Article
MeSH Terms:: Antimetabolites, Antineoplastic/*metabolism
Deoxycytidine/*analogs & derivatives
Floxuridine/*analogs & derivatives
Mass Spectrometry/*methods
Cell Line, Tumor ; Chromatography, Liquid ; Cytosol/metabolism ; Deoxycytidine/metabolism ; Floxuridine/metabolism ; Humans ; Nucleotides/metabolism ; Phosphorylation/drug effects ; Gemcitabine

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 18.

Tytuł:: Prognostic significance of miR-181b and miR-21 in gastric cancer patients treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin.
Autorzy:: Jiang J; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People's Republic of China.
Zheng X
Xu X
Zhou Q
Yan H
Zhang X
Lu B
Wu C
Ju J; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011; Vol. 6 (8), pp. e23271. Date of Electronic Publication: 2011 Aug 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Floxuridine/*therapeutic use
MicroRNAs/*genetics
Organoplatinum Compounds/*therapeutic use
Oxonic Acid/*therapeutic use
Stomach Neoplasms/*drug therapy
Stomach Neoplasms/*genetics
Tegafur/*therapeutic use
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Combinations ; Female ; Floxuridine/pharmacology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Male ; MicroRNAs/metabolism ; Middle Aged ; Organoplatinum Compounds/pharmacology ; Oxaliplatin ; Oxonic Acid/pharmacology ; Prognosis ; Stomach Neoplasms/diagnosis ; Tegafur/pharmacology ; Treatment Outcome

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 19.

Tytuł:: Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial.
Autorzy:: Buisman FE; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands. .
Homs MYV; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.
Grünhagen DJ; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.
Filipe WF; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.
Bennink RJ; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Rotterdam, The Netherlands.
Besselink MGH; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Borel Rinkes IHM; Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Bruijnen RCG; Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Cercek A; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
D'Angelica MI; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
van Delden OM; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Rotterdam, The Netherlands.
Donswijk ML; Department of Nuclear Medicine, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
van Doorn L; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.
Doornebosch PG; Department of Surgery, IJsselland Hospital, Capelle aan den IJssel, The Netherlands.
Emmering J; Department of Radiology and Nuclear Medicine, Erasmus MC, Erasmus University, Rotterdam, The Netherlands.
Erdmann JI; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
IJzerman NS; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.; Department of Medical Oncology, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Grootscholten C; Department of Medical Oncology, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Hagendoorn J; Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Kemeny NE; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
Kingham TP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Klompenhouwer EG; Department of Radiology, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Kok NFM; Department of Surgery, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Koolen S; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.
Kuhlmann KFD; Department of Surgery, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Kuiper MC; Department of Medical Oncology, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Lam MGE; Department of Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.
Moelker A; Department of Radiology and Nuclear Medicine, Erasmus MC, Erasmus University, Rotterdam, The Netherlands.
Oomen-de Hoop E; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University, Rotterdam, The Netherlands.
Punt CJA; Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Te Riele WW; Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Roodhart JML; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Swijnenburg RJ; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Prevoo W; Department of Radiology, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Tanis PJ; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Vermaas M; Department of Surgery, IJsselland Hospital, Capelle aan den IJssel, The Netherlands.
Versleijen MWJ; Department of Nuclear Medicine, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Veuger FP; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Weterman MJ; Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Verhoef C; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.
Groot Koerkamp B; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2019 Apr 05; Vol. 19 (1), pp. 327. Date of Electronic Publication: 2019 Apr 05.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Hepatectomy*
Antimetabolites, Antineoplastic/*administration & dosage
Colorectal Neoplasms/*pathology
Floxuridine/*administration & dosage
Liver Neoplasms/*therapy
Neoplasm Recurrence, Local/*prevention & control
Adult ; Chemotherapy, Adjuvant/instrumentation ; Chemotherapy, Adjuvant/methods ; Clinical Trials, Phase III as Topic ; Colorectal Neoplasms/mortality ; Humans ; Infusion Pumps, Implantable ; Infusions, Intra-Arterial/instrumentation ; Infusions, Intra-Arterial/methods ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Multicenter Studies as Topic ; Netherlands ; Progression-Free Survival ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Young Adult

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 20.

Tytuł:: Nucleoside dimers analogs containing floxuridine and thymidine with unnatural linker groups: synthesis and cancer line studies. Part III.
Autorzy:: Baraniak D; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.
Ruszkowski P; Department of Pharmacology, Faculty of Pharmacy, Poznań University of Medical Sciences , Poznań , Poland.
Baranowski D; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.
Framski G; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.
Boryski J; Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań , Poland.; Pokaż więcej
Źródło:: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2019; Vol. 38 (12), pp. 980-1005. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*chemical synthesis
Floxuridine/*chemistry
Nucleosides/*chemical synthesis
Thymidine/*chemistry
Triazoles/*chemistry
Antineoplastic Agents/pharmacology ; Cell Survival/drug effects ; Click Chemistry/methods ; Cycloaddition Reaction/methods ; Dimerization ; HeLa Cells ; Humans ; KB Cells ; MCF-7 Cells ; Neoplasms/drug therapy ; Neoplasms/pathology ; Nucleosides/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Informacja

Wyszukujesz frazę ""Floxuridine"" wg kryterium: Temat

Źródło danych

Ogranicz do:

Ogranicz do bazy

Typ dokumentu

Temat

Wydawca

Publikacja

Język