Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Fluorenes"" wg kryterium: Temat


Tytuł :
Sofosbuvir plus ribavirin and sofosbuvir plus ledipasvir in patients with genotype 1 or 3 hepatitis C virus and severe renal impairment: a multicentre, phase 2b, non-randomised, open-label study.
Autorzy :
Lawitz E; Texas Liver Institute, University of Texas Health San Antonio, San Antonio, TX, USA.
Landis CS; Department of Medicine, University of Washington, Seattle, WA, USA.
Flamm SL; Northwestern University, Chicago, IL, USA.
Bonacini M; Mission Gastroenterology and Hepatology, University of California, San Francisco, CA, USA.
Ortiz-Lasanta G; Fundación de Investigación, San Juan, Puerto Rico.
Huang J; University of Rochester, Rochester, NY, USA.
Zhang J; Gilead Sciences, Foster City, CA, USA.
Kirby BJ; Gilead Sciences, Foster City, CA, USA.
De-Oertel S; Gilead Sciences, Foster City, CA, USA.
Hyland RH; Gilead Sciences, Foster City, CA, USA.
Osinusi AO; Gilead Sciences, Foster City, CA, USA.
Brainard DM; Gilead Sciences, Foster City, CA, USA.
Robson R; Christchurch Clinical Studies Trust, Christchurch, New Zealand.
Maliakkal BJ; University of Rochester, Rochester, NY, USA.
Gordon SC; Henry Ford Health System, Detroit, MI, USA.
Gane EJ; Auckland Clinical Studies, Auckland, New Zealand. Electronic address: .
Pokaż więcej
Źródło :
The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2020 Oct; Vol. 5 (10), pp. 918-926. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Fluorenes/*therapeutic use
Hepatitis C/*drug therapy
Non-Randomized Controlled Trials as Topic/*methods
Renal Insufficiency, Chronic/*complications
Ribavirin/*therapeutic use
Sofosbuvir/*therapeutic use
Uridine Monophosphate/*analogs & derivatives
Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Antiviral Agents/pharmacokinetics ; Benzimidazoles/administration & dosage ; Benzimidazoles/adverse effects ; Benzimidazoles/pharmacokinetics ; Drug Therapy, Combination/methods ; Female ; Fluorenes/administration & dosage ; Fluorenes/adverse effects ; Fluorenes/pharmacokinetics ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/complications ; Humans ; Male ; Middle Aged ; New Zealand/epidemiology ; Renal Insufficiency, Chronic/classification ; Renal Insufficiency, Chronic/physiopathology ; Ribavirin/administration & dosage ; Ribavirin/adverse effects ; Ribavirin/pharmacokinetics ; Safety ; Sofosbuvir/administration & dosage ; Sofosbuvir/adverse effects ; Sofosbuvir/pharmacokinetics ; Treatment Outcome ; United States/epidemiology ; Uridine Monophosphate/administration & dosage ; Uridine Monophosphate/adverse effects ; Uridine Monophosphate/pharmacokinetics ; Uridine Monophosphate/therapeutic use ; Viral Load/drug effects
Czasopismo naukowe
Tytuł :
Clinical effectiveness of pharmacist-led versus conventionally delivered antiviral treatment for hepatitis C virus in patients receiving opioid substitution therapy: a pragmatic, cluster-randomised trial.
Autorzy :
Radley A; NHS Tayside, Directorate of Public Health, Kings Cross Hospital, Dundee, UK; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK. Electronic address: .
de Bruin M; Radboud University Medical Center, Radboud Institute of Health Sciences, Nijmegen, Netherlands; University of Aberdeen, Institute of Applied Health Sciences, Aberdeen, UK.
Inglis SK; University of Dundee, Tayside Clinical Trials Unit, Dundee, UK.
Donnan PT; University of Dundee, Tayside Clinical Trials Unit, Dundee, UK.
Hapca A; University of Dundee, Tayside Clinical Trials Unit, Dundee, UK.
Barclay ST; NHS Greater Glasgow and Clyde, Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK; Glasgow Caledonian University, Department of Life Sciences, Glasgow, UK.
Fraser A; NHS Grampian, Aberdeen Royal Infirmary, Foresterhill Health Campus, Aberdeen, UK.
Dillon JF; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Pokaż więcej
Źródło :
The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2020 Sep; Vol. 5 (9), pp. 809-818. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Fluorenes/*therapeutic use
Hepatitis C/*drug therapy
Opiate Substitution Treatment/*methods
Uridine Monophosphate/*analogs & derivatives
Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Benzimidazoles/administration & dosage ; Benzimidazoles/adverse effects ; Drug Therapy, Combination ; Female ; Fluorenes/administration & dosage ; Fluorenes/adverse effects ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/blood ; Hepatitis C/epidemiology ; Humans ; Imidazoles/administration & dosage ; Imidazoles/adverse effects ; Imidazoles/therapeutic use ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pharmacists/standards ; Scotland/epidemiology ; Sofosbuvir/administration & dosage ; Sofosbuvir/adverse effects ; Sofosbuvir/therapeutic use ; Sustained Virologic Response ; Treatment Outcome ; Uridine Monophosphate/administration & dosage ; Uridine Monophosphate/adverse effects ; Uridine Monophosphate/therapeutic use
Czasopismo naukowe
Tytuł :
Differential responses in the biotransformation systems of the oyster Crassostrea gigas (Thunberg, 1789) elicited by pyrene and fluorene: Molecular, biochemical and histological approach - Part II.
Autorzy :
Dos Reis IMM; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil.
Siebert MN; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil.
Zacchi FL; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil.
Mattos JJ; Aquaculture Pathology Research Center - NEPAQ, Federal University of Santa Catarina, UFSC, Florianópolis, Brazil.
Flores-Nunes F; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil.
Toledo-Silva G; Bioinformatics Laboratory, Cell Biology, Embryology and Genetics Department, Federal University of Santa Catarina, Florianópolis, Brazil.
Piazza CE; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil.
Bícego MC; Laboratory of Marine Organic Chemistry - LABQOM, Oceanographic Institute, University of São Paulo, USP, São Paulo, SP, Brazil.
Taniguchi S; Laboratory of Marine Organic Chemistry - LABQOM, Oceanographic Institute, University of São Paulo, USP, São Paulo, SP, Brazil.
Melo CMR; Laboratory of Marine Mollusks (LMM), Department of Aquaculture, Center of Agricultural Science, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Bainy ACD; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry - LABCAI, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2020 Sep; Vol. 226, pp. 105565. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Crassostrea/*drug effects
Fluorenes/*toxicity
Pyrenes/*toxicity
Water Pollutants, Chemical/*toxicity
Animals ; Biotransformation/drug effects ; Crassostrea/metabolism ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Fluorenes/metabolism ; Gills/drug effects ; Gills/metabolism ; Glutathione Transferase/metabolism ; Oxidative Stress/drug effects ; Pyrenes/metabolism ; Water Pollutants, Chemical/metabolism
Czasopismo naukowe
Tytuł :
Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer.
Autorzy :
Alhamdow A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Essig YJ; Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Krais AM; Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Gustavsson P; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Region Stockholm, Centre for Occupational and Environmental Medicine, Stockholm, Sweden.
Tinnerberg H; School of Public Health and Community Medicine, Section of Occupational and Environmental Medicine, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden.
Lindh CH; Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Hagberg J; MTM Research Centre, Örebro universitet Akademin för Naturvetenskap och Teknik, Orebro, Sweden.; Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Graff P; Department of Chemical and Biological Work Environment, STAMI, Oslo, Norway.
Albin M; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.; Region Stockholm, Centre for Occupational and Environmental Medicine, Stockholm, Sweden.
Broberg K; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden .; Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Pokaż więcej
Źródło :
Occupational and environmental medicine [Occup Environ Med] 2020 Jul; Vol. 77 (7), pp. 488-495. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Fluorenes/*adverse effects
Occupational Exposure/*adverse effects
Polycyclic Aromatic Hydrocarbons/*adverse effects
Adult ; Aged ; Biomarkers, Tumor/blood ; Creosote/adverse effects ; Cross-Sectional Studies ; DNA Methylation ; DNA, Mitochondrial ; Fluorenes/metabolism ; Fluorenes/urine ; Humans ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Occupational Exposure/analysis ; Phenanthrenes/metabolism ; Phenanthrenes/urine ; Polycyclic Aromatic Hydrocarbons/metabolism ; Telomere Homeostasis
Czasopismo naukowe
Tytuł :
Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid.
Autorzy :
Kim YC; School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.
Lee SR; Department of Biological and Environmental Science, Dongguk University, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
Jeon HJ; School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.
Kim K; School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.
Kim MJ; School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.
Choi SD; School of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Lee SE; School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2020 Dec; Vol. 260, pp. 127622. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorenes/*toxicity
Water Pollutants, Chemical/*toxicity
Animals ; Carboxylic Acids/metabolism ; Embryo, Nonmammalian/drug effects ; Fluorenes/metabolism ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
Generic Ledipasvir-Sofosbuvir Treatment for Adolescents With Chronic Hepatitis C Virus Infection.
Autorzy :
Fouad HM; Department of Pediatrics, Faculty of Medicine, Helwan University, Cairo, Egypt.; Department of Pediatrics, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Sabry MA; Department of Pediatrics, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Ahmed A; Department of Biochemistry, and Molecular Biology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Hassany M; Department of Hepatology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Al Soda MF; Pediatric and Neonatology Department, Ahmed Maher Teaching Hospital, Cairo, Egypt.
Abdel Aziz H; Hepatology Department, Ain Shams University, Cairo, Egypt.
Pokaż więcej
Źródło :
Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2020 Jul 13; Vol. 9 (3), pp. 386-389.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Fluorenes/*therapeutic use
Hepatitis C, Chronic/*drug therapy
Uridine Monophosphate/*analogs & derivatives
Adolescent ; Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Blood Transfusion ; Child ; Drug Combinations ; Drugs, Generic/adverse effects ; Drugs, Generic/therapeutic use ; Egypt ; Female ; Fluorenes/adverse effects ; Hepatitis C, Chronic/therapy ; Humans ; Male ; Prospective Studies ; Uridine Monophosphate/adverse effects ; Uridine Monophosphate/therapeutic use
Czasopismo naukowe
Tytuł :
Pharmacokinetics, Safety, and Tolerability of Ledipasvir/Sofosbuvir and Sofosbuvir/Velpatasvir in Healthy Chinese Subjects.
Autorzy :
Li C; Phase 1 Clinical Trial Unit, First Hospital, Jilin University, Changchun, Jilin, China.
Li X; Phase 1 Clinical Trial Unit, First Hospital, Jilin University, Changchun, Jilin, China.
Zhu X; Phase 1 Clinical Trial Unit, First Hospital, Jilin University, Changchun, Jilin, China.
Zhang H; Phase 1 Clinical Trial Unit, First Hospital, Jilin University, Changchun, Jilin, China.
Shen G; Gilead Sciences Inc, Foster City, CA, USA.
Kersey K; Gilead Sciences Inc, Foster City, CA, USA.
Ding Y; Phase 1 Clinical Trial Unit, First Hospital, Jilin University, Changchun, Jilin, China. Electronic address: .
Pokaż więcej
Źródło :
Clinical therapeutics [Clin Ther] 2020 Mar; Vol. 42 (3), pp. 448-457. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/adverse effects
Antiviral Agents*/blood
Antiviral Agents*/pharmacokinetics
Benzimidazoles*/adverse effects
Benzimidazoles*/blood
Benzimidazoles*/pharmacokinetics
Carbamates*/adverse effects
Carbamates*/blood
Carbamates*/pharmacokinetics
Fluorenes*/adverse effects
Fluorenes*/blood
Fluorenes*/pharmacokinetics
Heterocyclic Compounds, 4 or More Rings*/adverse effects
Heterocyclic Compounds, 4 or More Rings*/blood
Heterocyclic Compounds, 4 or More Rings*/pharmacokinetics
Sofosbuvir*/adverse effects
Sofosbuvir*/blood
Sofosbuvir*/pharmacokinetics
Adult ; China ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Safety and Efficacy of 8 Weeks Ledipasvir/Sofosbuvir for Chronic Hepatitis C Genotype 4 in Children Aged 4-10 Years.
Autorzy :
Behairy BE; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
El-Araby HA; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
El-Guindi MA; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
Basiouny HM; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
Fouad OA; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
Ayoub BA; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.
Marei AM; Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, El-Sharkiya, Egypt.
Sira MM; Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt. Electronic address: .
Pokaż więcej
Źródło :
The Journal of pediatrics [J Pediatr] 2020 Apr; Vol. 219, pp. 106-110. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*administration & dosage
Benzimidazoles/*administration & dosage
Fluorenes/*administration & dosage
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Uridine Monophosphate/*analogs & derivatives
Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Child ; Child, Preschool ; Female ; Fluorenes/adverse effects ; Genotype ; Hepacivirus/drug effects ; Hepatitis C, Chronic/virology ; Humans ; Male ; Prospective Studies ; Time Factors ; Treatment Outcome ; Uridine Monophosphate/administration & dosage ; Uridine Monophosphate/adverse effects
Czasopismo naukowe
Tytuł :
Synthesis, experimental and in silico studies of N-fluorenylmethoxycarbonyl-O-tert-butyl-N-methyltyrosine, coupled with CSD data: a survey of interactions in the crystal structures of Fmoc-amino acids.
Autorzy :
Bojarska J; Institute of General and Ecological Chemistry, Lodz University of Technology, Faculty of Chemistry, Żeromskiego 116, Lodz 90-924, Poland.
Remko M; Remedika, Sustekova 1, 85104 Bratislava, Slovakia.
Madura ID; Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warszawa, Poland.
Kaczmarek K; Institute of Organic Chemistry, Lodz University of Technology, Faculty of Chemistry, Żeromskiego 116, Lodz 90-924, Poland.
Zabrocki J; Institute of Organic Chemistry, Lodz University of Technology, Faculty of Chemistry, Żeromskiego 116, Lodz 90-924, Poland.
Wolf WM; Institute of General and Ecological Chemistry, Lodz University of Technology, Faculty of Chemistry, Żeromskiego 116, Lodz 90-924, Poland.
Pokaż więcej
Źródło :
Acta crystallographica. Section C, Structural chemistry [Acta Crystallogr C Struct Chem] 2020 Apr 01; Vol. 76 (Pt 4), pp. 328-345. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acids/*chemistry
Fluorenes/*chemical synthesis
Methyltyrosines/*chemistry
Phenylalanine/*chemistry
Amino Acids/chemical synthesis ; Computer Simulation ; Crystallography, X-Ray ; Fluorenes/chemistry ; Hydrogen Bonding ; Molecular Conformation ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Hepatitis C virus treatment response to ledipasvir/sofosbuvir among patients coinfected with HIV and HCV: Real world data in a black population.
Autorzy :
Banga J; Rutgers New Jersey Medical School.
Nizami S; Rutgers New Jersey Medical School.
Slim J; Saint Michael's Medical Center.
Nagarakanti S; Newark Beth Israel Medical Center, Newark, NJ.
Portilla M; Rutgers New Jersey Medical School.
Swaminathan S; Rutgers New Jersey Medical School.
Pokaż więcej
Źródło :
Medicine [Medicine (Baltimore)] 2020 Mar; Vol. 99 (11), pp. e19140.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Coinfection/*drug therapy
Fluorenes/*therapeutic use
HIV Infections/*complications
Hepacivirus/*drug effects
Hepatitis C/*complications
Uridine Monophosphate/*analogs & derivatives
African Americans/statistics & numerical data ; Antiviral Agents/administration & dosage ; Benzimidazoles/administration & dosage ; Coinfection/virology ; Female ; Fluorenes/administration & dosage ; HIV Infections/drug therapy ; HIV Infections/virology ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Male ; Middle Aged ; New Jersey ; Retrospective Studies ; Treatment Outcome ; Uridine Monophosphate/administration & dosage ; Uridine Monophosphate/therapeutic use
Czasopismo naukowe
Tytuł :
Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.
Autorzy :
Baldauf KJ; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
Salazar-González RA; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
Doll MA; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
Pierce WM Jr; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
States JC; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
Hein DW; Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, Louisville, Kentucky.
Pokaż więcej
Źródło :
Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Feb; Vol. 61 (2), pp. 235-245. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Polymorphism, Genetic*
Aminobiphenyl Compounds/*metabolism
Arylamine N-Acetyltransferase/*genetics
Carcinogens/*metabolism
Fluorenes/*metabolism
Acetylation ; Aminobiphenyl Compounds/toxicity ; Animals ; Arylamine N-Acetyltransferase/metabolism ; CHO Cells ; Carcinogens/toxicity ; Cricetinae ; Cricetulus ; DNA Damage/drug effects ; Fluorenes/toxicity ; Humans ; Mutagenesis/drug effects ; Mutagenicity Tests
Czasopismo naukowe
Tytuł :
Ledipasvir-Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C.
Autorzy :
Schwarz KB; Johns Hopkins Hospital, Baltimore, MD.
Rosenthal P; University of California San Francisco, San Francisco, CA.
Murray KF; University of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA.
Honegger JR; The Ohio State University and Nationwide Children's Hospital, Columbus, OH.
Hardikar W; The Royal Children's Hospital, Melbourne, VIC, Australia.
Hague R; Royal Hospital for Children, Glasgow, United Kingdom.
Mittal N; Texas Liver Institute, San Antonio, TX.
Massetto B; Gilead Sciences Inc., Foster City, CA.
Brainard DM; Gilead Sciences Inc., Foster City, CA.
Hsueh CH; Gilead Sciences Inc., Foster City, CA.
Shao J; Gilead Sciences Inc., Foster City, CA.
Parhy B; Gilead Sciences Inc., Foster City, CA.
Narkewicz MR; Digestive Health Institute, Children's Hospital of Colorado and Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO.
Rao GS; Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
Whitworth S; Cook Children's Health Care System, Fort Worth, TX.
Bansal S; King's College Hospital, London, United Kingdom.
Balistreri WF; Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.
Pokaż więcej
Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2020 Feb; Vol. 71 (2), pp. 422-430. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*administration & dosage
Benzimidazoles/*administration & dosage
Fluorenes/*administration & dosage
Hepatitis C, Chronic/*drug therapy
Uridine Monophosphate/*analogs & derivatives
Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Child ; Child, Preschool ; Female ; Fluorenes/adverse effects ; Humans ; Male ; Sustained Virologic Response ; Time Factors ; Treatment Outcome ; Uridine Monophosphate/administration & dosage ; Uridine Monophosphate/adverse effects
Czasopismo naukowe
Tytuł :
Chemometrically Assisted Development of Ultra-High-Performance Liquid Chromatography Method for the Simultaneous Quantification of Sofosbuvir, Daclatasvir and Ledipasvir in Pharmaceutical Dosage Forms.
Autorzy :
Labidi A; Faculté des Sciences de Tunis, Laboratoire de Chimie Analytique et Electrochimie, Université de Tunis El Manar, Campus Universitaire Farhat Hached, 2092 Tunis, Tunisia.; Laboratoire National de Contrôle des Médicaments, 11 bis Rue Jebel Lakhdar Bab Saadoun, 1006 Tunis, Tunisia.
El Atrache LL; Faculté des Sciences de Tunis, Laboratoire de Chimie Analytique et Electrochimie, Université de Tunis El Manar, Campus Universitaire Farhat Hached, 2092 Tunis, Tunisia.; Institut Préparatoire aux Etudes d'Ingénieurs d'El Manar, Université de Tunis El Manar, B.P. 244 El Manar II, 2092 Tunis, Tunisia.
Pokaż więcej
Źródło :
Journal of chromatographic science [J Chromatogr Sci] 2020 Jan 17; Vol. 57 (10), pp. 910-919.
Typ publikacji :
Journal Article
MeSH Terms :
Benzimidazoles/*analysis
Chromatography, High Pressure Liquid/*methods
Fluorenes/*analysis
Imidazoles/*analysis
Sofosbuvir/*analysis
Benzimidazoles/chemistry ; Fluorenes/chemistry ; Imidazoles/chemistry ; Limit of Detection ; Linear Models ; Reproducibility of Results ; Sofosbuvir/chemistry ; Tablets
Czasopismo naukowe
Tytuł :
Phthalocyanine-Cored Fluorophores with Fluorene-Containing Peripheral Two-Photon Antennae as Photosensitizers for Singlet Oxygen Generation.
Autorzy :
Abid S; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.; Faculté des Sciences de Bizerte, Université de Carthage, 7021 Jarzouna, Tunisie.
Hassine SB; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.; Campus Universitaire Farhat Hached, Université de Tunis El Manar, B.P. n° 94-ROMMANA, Tunis 1068, Tunisie.
Richy N; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.
Camerel F; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.
Jamoussi B; Department of Environmental Sciences, Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University, Jeddah 2798-22253, Saudi Arabia.
Blanchard-Desce M; Institut des Sciences Moléculaires (CNRS UMR 5255), Univ. Bordeaux, 33405 Talence, France.
Mongin O; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.
Paul F; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.
Paul-Roth CO; Univ Rennes, INSA Rennes, CNRS, UMR 6226 (Institut des Sciences Chimiques de Rennes), F-35000 Rennes, France.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 07; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorenes/*chemistry
Indoles/*chemistry
Photosensitizing Agents/*chemistry
Singlet Oxygen/*chemistry
Energy Transfer ; Fluorenes/chemical synthesis ; Indoles/chemical synthesis ; Light ; Luminescence ; Models, Molecular ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Photons ; Porphyrins/chemistry ; Singlet Oxygen/isolation & purification ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.
Autorzy :
Kawaguchi I; Market Access AbbVie GK, Tokyo, Japan. .
Chayama K; Hiroshima University Hospital, Hiroshima, Japan.
Gonzalez YS; Global HCV Health Economics and Outcomes Research AbbVie Inc, Mettawa, IL, USA.
Virabhak S; Medicus Economics LLC, Milton, MA, USA.
Mitchell D; Medicus Economics LLC, Milton, MA, USA.
Yuen C; Area Market Access and Policy AbbVie Pte. Ltd, Singapore, Singapore.
Kumada H; Toranomon Hospital, Tokyo, Japan.
Pokaż więcej
Źródło :
Advances in therapy [Adv Ther] 2020 Jan; Vol. 37 (1), pp. 457-476. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*economics
Benzimidazoles/*economics
Fluorenes/*economics
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*economics
Quinoxalines/*economics
Sulfonamides/*economics
Uridine Monophosphate/*analogs & derivatives
Adult ; Antiviral Agents/therapeutic use ; Benzimidazoles/therapeutic use ; Cost-Benefit Analysis ; Drug Therapy, Combination ; Female ; Fluorenes/therapeutic use ; Humans ; Japan ; Quinoxalines/therapeutic use ; Ribavirin/economics ; Sofosbuvir/economics ; Sulfonamides/therapeutic use ; Uridine Monophosphate/economics ; Uridine Monophosphate/therapeutic use
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of 9-fluorenone derivatives for SPECT imaging of α7-nicotinic acetylcholine receptor.
Autorzy :
Gao H; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. Electronic address: .
Wang S; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Qi Y; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
He G; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Qiang B; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Wang S; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Zhang H; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Dec 01; Vol. 29 (23), pp. 126724. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorenes/*chemical synthesis
Molecular Docking Simulation/*methods
Tomography, Emission-Computed, Single-Photon/*methods
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Animals ; Fluorenes/chemistry ; Mice
Czasopismo naukowe
Tytuł :
Fluorescence Imaging of Mitochondria with Three Different Sets of Signals Based on Fluorene Cation Fluorescent Probe.
Autorzy :
Wang W; Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, University of Jinan, Shandong, 250022, People's Republic of China.
Liu Y; Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, University of Jinan, Shandong, 250022, People's Republic of China.
Niu J; Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, University of Jinan, Shandong, 250022, People's Republic of China.
Lin W; Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, University of Jinan, Shandong, 250022, People's Republic of China. .
Pokaż więcej
Źródło :
Journal of fluorescence [J Fluoresc] 2019 Nov; Vol. 29 (6), pp. 1457-1465. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Optical Imaging*
Fluorenes/*chemistry
Fluorescent Dyes/*chemistry
Mitochondria/*chemistry
Animals ; Cations/chemical synthesis ; Cations/chemistry ; Cations/pharmacology ; Cell Survival/drug effects ; Fluorenes/chemical synthesis ; Fluorenes/pharmacology ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/pharmacology ; HeLa Cells ; Humans ; Microscopy, Confocal ; Molecular Structure ; Tumor Cells, Cultured ; Zebrafish
Czasopismo naukowe
Tytuł :
Design, synthesis of 4,5-diazafluorene derivatives and their anticancer activity via targeting telomeric DNA G-quadruplex.
Autorzy :
Zhou K; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Liu J; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Xiong X; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Cheng M; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Hu X; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Narva S; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Zhao X; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Wu Y; Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China. Electronic address: .
Zhang W; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Lab of Chemical Biology and Molecular Drug Design, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Sep 15; Vol. 178, pp. 484-499. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Fluorenes/*pharmacology
G-Quadruplexes/*drug effects
Telomere/*drug effects
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fluorenes/chemical synthesis ; Fluorenes/chemistry ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Wound Healing/drug effects
Czasopismo naukowe
Tytuł :
SARS-CoV-2 in patients on antiviral HBV and HCV therapy in Spain.
Autorzy :
Lens S; Liver Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain, CIBERehd. Electronic address: .
Miquel M; Hepatology Unit, Digestive Disease Department, Parc Taulí Hospital Universitari, Institutd'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain, CIBERehd.
Mateos-Muñoz B; Hepatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain, CIBERehd.
García-Samaniego J; Liver Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, CIBERehd.
Forns X; Liver Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain, CIBERehd.
Pokaż więcej
Źródło :
Journal of hepatology [J Hepatol] 2020 Nov; Vol. 73 (5), pp. 1262-1263. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Antiviral Agents*/therapeutic use
Coronavirus Infections*
Hepatitis C*/drug therapy
Hepatitis C*/epidemiology
Pandemics*
Pneumonia, Viral*
SARS Virus*
Benzimidazoles ; Betacoronavirus ; Carbamates ; Drug Repositioning ; Fluorenes ; Hepatitis B virus ; Heterocyclic Compounds, 4 or More Rings ; Humans ; Peptide Hydrolases ; Spain/epidemiology
SCR Disease Name :
COVID-19
Raport
Tytuł :
Acute fluorene-9-bisphenol exposure damages early development and induces cardiotoxicity in zebrafish (Danio rerio).
Autorzy :
Mi P; State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.
Tang YQ; State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.
Feng XZ; State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China. Electronic address: .
Pokaż więcej
Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Oct 01; Vol. 202, pp. 110922. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Benzhydryl Compounds/*toxicity
Phenols/*toxicity
Water Pollutants, Chemical/*toxicity
Animals ; Cardiotoxicity/metabolism ; Embryo, Nonmammalian/drug effects ; Embryonic Development/drug effects ; Fluorenes/toxicity ; Mice ; Oocytes/growth & development ; Plastics ; Toxicity Tests, Acute ; Water Pollutants, Chemical/metabolism ; Zebrafish
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies