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Title:
Antimicrobial Potency of Fmoc-Phe-Phe Dipeptide Hydrogels with Encapsulated Porphyrin Chromophores Is a Promising Alternative in Antimicrobial Resistance.
Authors:
Apostolidou CP; Department of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.
Kokotidou C; Department of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.
Platania V; Department of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.
Nikolaou V; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Landrou G; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Nikoloudakis E; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Charalambidis G; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.; Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., 11635 Athens, Greece.
Chatzinikolaidou M; Department of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.
Coutsolelos AG; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Mitraki A; Department of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.; Institute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.
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Source:
Biomolecules [Biomolecules] 2024 Feb 16; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 16.
Publication Type:
Journal Article
MeSH Terms:
Porphyrins*/pharmacology
Porphyrins*/chemistry
Anti-Infective Agents*/pharmacology
Anti-Infective Agents*/chemistry
Fluorenes*
Animals ; Mice ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Escherichia coli ; Staphylococcus aureus ; Hydrogels/pharmacology ; NIH 3T3 Cells ; Drug Resistance, Bacterial ; Dipeptides/pharmacology
Academic Journal
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Title:
Compounds Derived from 9,9-Dialkylfluorenes: Syntheses, Crystal Structures and Initial Binding Studies (Part II).
Authors:
Seidel P; Institut für Organische Chemie, Technische Universität Bergakademie Freiberg, Leipziger Straße 29, 09599, Freiberg, Germany.
Seichter W; Institut für Organische Chemie, Technische Universität Bergakademie Freiberg, Leipziger Straße 29, 09599, Freiberg, Germany.
Mazik M; Institut für Organische Chemie, Technische Universität Bergakademie Freiberg, Leipziger Straße 29, 09599, Freiberg, Germany.
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Source:
ChemistryOpen [ChemistryOpen] 2023 Jul; Vol. 12 (7), pp. e202300019.
Publication Type:
Journal Article
MeSH Terms:
Fluorenes*/chemistry
Carbohydrates*
Molecular Structure ; Ions/chemistry
Academic Journal
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Title:
Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks.
Authors:
Sarabia-Vallejo Á; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Molina A; Unidad de Química Analítica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Martínez-Orts M; Unidad de Química Analítica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
D'Onofrio A; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Staderini M; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Bolognesi ML; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Martín MA; Unidad de Química Analítica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Olives AI; Unidad de Química Analítica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Menéndez JC; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 07; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 07.
Publication Type:
Journal Article
MeSH Terms:
Insulin*
Amyloid*/chemistry
Amyloidogenic Proteins ; Fluorometry ; Fluorenes/chemistry
Academic Journal
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Title:
Effectiveness of artemether-lumefantrine for treating uncomplicated malaria in low- and high-transmission areas of Ghana.
Authors:
Mawuli MA; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana. .; Department of Pathology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana. .
Amoah LE; Department of Immunology, Noguchi Memorial Institute for Medical Research College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Cui L; Department of Internal Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, 33612, USA.
Quashie NB; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.; Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, University of Ghana, Korle-Bu, Accra, Ghana.
Afrane YA; Department of Medical Microbiology, University of Ghana Medical School College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
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Source:
Malaria journal [Malar J] 2024 Feb 05; Vol. 23 (1), pp. 40. Date of Electronic Publication: 2024 Feb 05.
Publication Type:
Journal Article
MeSH Terms:
Antimalarials*/therapeutic use
Artemisinins*/therapeutic use
Malaria, Falciparum*/drug therapy
Humans ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Ghana ; Drug Combinations ; Artemether/therapeutic use ; Recurrence ; Parasitemia/drug therapy ; Ethanolamines/therapeutic use ; Fluorenes/therapeutic use ; Plasmodium falciparum/genetics
Academic Journal
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Title:
Effect of Differential Backbone Di-substitution of Gamma Amino Acid Residues on the Conformation and Assembly of their Fmoc Derivatives in Solid and Solution States.
Authors:
Debnath S; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Ghosh S; Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Kumar D; Plant Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India.
Vasudev PG; Plant Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India.
Satpati P; Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Chatterjee S; Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
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Source:
Chemistry, an Asian journal [Chem Asian J] 2022 Jul 15; Vol. 17 (14), pp. e202200356. Date of Electronic Publication: 2022 Jun 10.
Publication Type:
Journal Article
MeSH Terms:
Amino Acids*/chemistry
Fluorenes*/chemistry
Hydrogen Bonding ; Molecular Conformation ; Solvents
Academic Journal
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Title:
Innovative Thin-Layer Chromatography/Fluorescence Detection Approach for Sensitive and Specific Determination of Ledipasvir in Rats' Feces and Pharmaceutical Dosage Form.
Authors:
Abdel-Lateef MA; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Omar MA; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medinah, 42353, Saudi Arabia.; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Ali R; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Almahri A; General courses unit, Faculty of Sciences and Arts, King Khalid University, Dhahran Aljanoub, 61421, Saudi Arabia.
Derayea SM; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
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Source:
Journal of chromatographic science [J Chromatogr Sci] 2021 Jun 21; Vol. 59 (7), pp. 634-641.
Publication Type:
Journal Article
MeSH Terms:
Benzimidazoles/*analysis
Chromatography, Thin Layer/*methods
Feces/*chemistry
Fluorenes/*analysis
Animals ; Benzimidazoles/chemistry ; Benzimidazoles/radiation effects ; Fluorenes/chemistry ; Fluorenes/radiation effects ; Limit of Detection ; Linear Models ; Male ; Rats ; Reproducibility of Results ; Spectrometry, Fluorescence ; Tablets ; Time Factors ; Ultraviolet Rays
Academic Journal
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Title:
Human Mass Balance and Metabolite Profiling of [ C]-Pamiparib, a Poly (ADP-Ribose) Polymerase Inhibitor, in Patients With Advanced Cancer.
Authors:
Mu S; BeiGene USA, Inc., San Mateo, California, USA.
Palmer D; Liverpool CR UK/NIHR Experimental Cancer Medicine Centre, University of Liverpool and Clatterbridge Cancer Centre, Liverpool, UK.
Fitzgerald R; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals, Liverpool, UK.
Andreu-Vieyra C; BeiGene USA, Inc., San Mateo, California, USA.
Zhang H; BeiGene USA, Inc., San Mateo, California, USA.
Tang Z; BeiGene USA, Inc., San Mateo, California, USA.
Su D; BeiGene (Beijing) Co., Ltd., Beijing, China.
Sahasranaman S; BeiGene USA, Inc., San Mateo, California, USA.
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Source:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Sep; Vol. 10 (9), pp. 1108-1120. Date of Electronic Publication: 2021 Apr 19.
Publication Type:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorenes/*pharmacokinetics
Neoplasms/*drug therapy
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacokinetics
Cytochrome P-450 CYP2C8/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Female ; Fluorenes/administration & dosage ; Half-Life ; Humans ; Male ; Middle Aged ; Phenotype ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage
Academic Journal
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Title:
Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first-line platinum-based chemotherapy: Phase 2 study results.
Authors:
Ciardiello F; Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy.
Bang YJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Cervantes A; Department of Medical Oncology, Biomedical Research Institute INCLIVA, CiberOnc, University of Valencia, Valencia, Spain.
Dvorkin M; Algorithmic Biology Laboratory, St. Petersburg Academic University, Russian Academy of Sciences, St. Petersburg, Russia.
Lopez CD; Department of Medicine, Knight Cancer Institute/Oregon Health and Science University, Portland, Oregon, USA.
Metges JP; Institute of Oncology and Haematology, CHU Morvan, Arpego Network, Brest, France.
Sánchez Ruiz A; Hospital Puerta de Hierro Majadohonda, Madrid, Spain.
Calvo M; Department of Medical Oncology, ONCOBELL Program (IDIBELL), Institut Català d'Oncologia-L'Hospitalet, Barcelona, Spain.
Strickland AH; Department of Medical Oncology, Monash Health, Monash University, Melbourne, Victoria, Australia.
Kannourakis G; Ballarat Oncology & Haematology Services, Wendouree, Victoria, Australia.; The Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia.
Muro K; Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
Kawakami H; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
Wei J; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China.
Borg C; University Hospital of Besançon, Medical Oncology Department, CIC-BT1431, Besançon, France.; UMR1098, Molecular and Cellular Immune Therapies of Cancers, INSERM, Besançon, France.
Zhu Z; Clinical Development, BeiGene Ltd, Cambridge, Massachusetts, USA.
Gupta N; Clinical Development, BeiGene Ltd, Cambridge, Massachusetts, USA.
Pelham RJ; Clinical Development, BeiGene Ltd, Cambridge, Massachusetts, USA.
Shen L; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China.
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Source:
Cancer medicine [Cancer Med] 2023 Jun; Vol. 12 (12), pp. 13145-13154. Date of Electronic Publication: 2023 Jun 01.
Publication Type:
Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/etiology
Humans ; Platinum ; Fluorenes ; Progression-Free Survival ; Double-Blind Method ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Academic Journal
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Title:
Fluorene Thiophene α-Cyanostilbene Hexacatenar-Generating LCs with Hexagonal Columnar Phases and Gels with Helical Morphologies as Well as a Light-Emitting LC Display.
Authors:
Zhao H; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.; School of Science, Yunnan Agricultural University, Kunming 650201, China.
Cheng X; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 May 26; Vol. 24 (11). Date of Electronic Publication: 2023 May 26.
Publication Type:
Journal Article
MeSH Terms:
Liquid Crystals*
Fluorenes ; Gels ; Thiophenes
Academic Journal
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Title:
Efficacy and safety of pyronaridine-artesunate versus artemether-lumefantrine in the treatment of acute uncomplicated malaria in children in South-West Nigeria: an open-labelled randomized controlled trial.
Authors:
Falade CO; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria. .; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. .
Orimadegun AE; Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olusola FI; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Michael OS; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Anjorin OE; Department of Accident and Emergency, Obafemi Awolowo University Teaching, Hospital, Ile-Ife, Nigeria.
Funwei RI; Department of Pharmacology, Babcock University, Ilisan, Remo, Ogun State, Nigeria.
Adedapo AD; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olusanya AL; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Orimadegun BE; Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Mokuolu OA; Department of Paediatrics, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
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Source:
Malaria journal [Malar J] 2023 May 13; Vol. 22 (1), pp. 154. Date of Electronic Publication: 2023 May 13.
Publication Type:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Antimalarials*/adverse effects
Artemisinins*/adverse effects
Malaria, Falciparum*/drug therapy
Humans ; Child ; Male ; Infant ; Female ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Nigeria ; Retrospective Studies ; Artemether/therapeutic use ; Drug Combinations ; Ethanolamines/therapeutic use ; Treatment Outcome ; Fluorenes/adverse effects
SCR Disease Name:
Acute malaria
Academic Journal
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Title:
Ledipasvir/Sofosbuvir in Adolescents With Chronic Hepatitis C Genotype 4 With and Without Hematological Disorders: Virological Efficacy and Impact on Liver Stiffness.
Authors:
Makhlouf NA; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abdelmalek MO; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ibrahim ME; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abu-Faddan NH; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Kheila AE; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud AA; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
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Source:
Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2021 Feb 13; Vol. 10 (1), pp. 7-13.
Publication Type:
Journal Article
MeSH Terms:
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Fluorenes/*therapeutic use
Hematologic Diseases/*complications
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Liver/*pathology
Sofosbuvir/*therapeutic use
Adolescent ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Benzimidazoles/administration & dosage ; Benzimidazoles/adverse effects ; Drug Therapy, Combination ; Elasticity Imaging Techniques ; Female ; Fluorenes/administration & dosage ; Fluorenes/adverse effects ; Hepacivirus/drug effects ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Liver/drug effects ; Male ; Sofosbuvir/administration & dosage ; Sofosbuvir/adverse effects ; Treatment Outcome
Academic Journal
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Title:
New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles.
Authors:
Vlad IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Nuță DC; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Ancuceanu RV; Department of Pharmaceutical Botany, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Caproiou MT; Costin D. Nenițescu' The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Dumitrascu F; Costin D. Nenițescu' The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Marinas IC; Department of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.
Chifiriuc MC; Department of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.; Academy of Romanian Scientists, 3 Ilfov Street, 050045 Bucharest, Romania.
Măruţescu LG; Department of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.
Zarafu I; Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania.
Papacocea IR; Department of Physiology I, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 8 Eroilor Sanitari, 050474 Bucharest, Romania.
Vasile BȘ; Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.
Nicoară AI; Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.
Ilie CI; Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.
Ficai A; Academy of Romanian Scientists, 3 Ilfov Street, 050045 Bucharest, Romania.; Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.
Limban C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Carol Davila' University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2021 May 18; Vol. 26 (10). Date of Electronic Publication: 2021 May 18.
Publication Type:
Journal Article
MeSH Terms:
Anti-Infective Agents/*pharmacology
Biofilms/*drug effects
Fluorenes/*pharmacology
Magnetic Iron Oxide Nanoparticles/*chemistry
Bacteria/drug effects ; Bacterial Adhesion/drug effects ; Carbon-13 Magnetic Resonance Spectroscopy ; Fluorenes/chemistry ; Fungi/drug effects ; Magnetic Iron Oxide Nanoparticles/ultrastructure ; Magnetometry ; Microbial Sensitivity Tests ; Plankton/drug effects ; Proton Magnetic Resonance Spectroscopy ; Spectroscopy, Fourier Transform Infrared
Academic Journal
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Title:
Pamiparib dose escalation in Chinese patients with non-mucinous high-grade ovarian cancer or advanced triple-negative breast cancer.
Authors:
Xu B; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yin Y; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Dong M; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Song Y; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li W; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huang X; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang T; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
He J; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mu X; BeiGene (Shanghai) Co., Ltd., Shanghai, China.
Li L; BeiGene (Beijing) Co., Ltd., Beijing, China.
Mu S; BeiGene USA, Inc., San Mateo, CA, USA.
Zhang W; BeiGene (Beijing) Co., Ltd., Beijing, China.
Li M; BeiGene (Beijing) Co., Ltd., Beijing, China.
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Source:
Cancer medicine [Cancer Med] 2021 Jan; Vol. 10 (1), pp. 109-118. Date of Electronic Publication: 2020 Oct 31.
Publication Type:
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorenes/*administration & dosage
Ovarian Neoplasms/*drug therapy
Poly(ADP-ribose) Polymerase Inhibitors/*administration & dosage
Triple Negative Breast Neoplasms/*drug therapy
Adult ; Aged ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; China ; Drug Dosage Calculations ; Female ; Fluorenes/adverse effects ; Fluorenes/pharmacokinetics ; Humans ; Middle Aged ; Mutation ; Neoplasm Grading ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacokinetics ; Progression-Free Survival ; Time Factors ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
Academic Journal
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Title:
Treatment of chronic hepatitis C with sofosbuvir in a hemodialysis patient: a case report.
Authors:
Tchoupe MD; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Chaker H; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Boudabbous M; Hepato-Gastroenterology Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Toumi S; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Kissou FP; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Gargouri S; Microbiology Laboratory, Habib Bourguiba University Hospital, Sfax, Tunisia.
Kammoun K; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Jarraya F; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Tahri N; Hepato-Gastroenterology Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Yaich S; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
Hmida MB; Nephrology Department, Faculty of Medicine, Hedi Chaker University Hospital and UR 12ES14, Sfax, Tunisia.
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Source:
The Pan African medical journal [Pan Afr Med J] 2021 Feb 08; Vol. 38, pp. 137. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
Publication Type:
Case Reports
MeSH Terms:
Renal Dialysis*
Antiviral Agents/*administration & dosage
Benzimidazoles/*administration & dosage
Fluorenes/*administration & dosage
Hepatitis C, Chronic/*drug therapy
Sofosbuvir/*administration & dosage
Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Fluorenes/adverse effects ; Follow-Up Studies ; Genotype ; Glomerular Filtration Rate ; Hepacivirus/genetics ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/virology ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Sofosbuvir/adverse effects ; Sustained Virologic Response
Report
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Title:
New Fluorene Derivatives from Dendrobium gibsonii and Their α -Glucosidase Inhibitory Activity.
Authors:
Thant MT; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Chatsumpun N; Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Mekboonsonglarp W; Scientific and Technological Research Equipment Centre, Chulalongkorn University, Bangkok 10330, Thailand.
Sritularak B; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.; Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Likhitwitayawuid K; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 25; Vol. 25 (21). Date of Electronic Publication: 2020 Oct 25.
Publication Type:
Journal Article
MeSH Terms:
Dendrobium/*chemistry
Fluorenes/*isolation & purification
Glycoside Hydrolase Inhibitors/*isolation & purification
Plant Extracts/*isolation & purification
alpha-Glucosidases/*metabolism
Fluorenes/metabolism ; Glucans/chemistry ; Glycoside Hydrolase Inhibitors/metabolism ; Molecular Structure ; Phenanthrenes/isolation & purification ; Phenanthrenes/metabolism ; Plant Extracts/metabolism ; Solvents/chemistry
Academic Journal
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Title:
Comparing direct acting antivirals for hepatitis C using observational data - Why and how?
Authors:
Young J; Division of Infectious Diseases and Chronic Viral Illness Service, Department of Medicine, Glen Site, McGill University Health Centre, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, University of Basel, Basel, Switzerland.
Wong S; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Janjua NZ; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Klein MB; Division of Infectious Diseases and Chronic Viral Illness Service, Department of Medicine, Glen Site, McGill University Health Centre, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.; CIHR Canadian HIV Trials Network, Vancouver, BC, Canada.
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Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Oct; Vol. 8 (5), pp. e00650.
Publication Type:
Clinical Trial; Comparative Study; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents/*administration & dosage
Benzimidazoles/*administration & dosage
Carbamates/*administration & dosage
Fluorenes/*administration & dosage
Hepacivirus/*genetics
Hepatitis C/*drug therapy
Heterocyclic Compounds, 4 or More Rings/*administration & dosage
Sofosbuvir/*administration & dosage
Antiviral Agents/pharmacology ; Bayes Theorem ; Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Comparative Effectiveness Research ; Drug Combinations ; Female ; Fluorenes/pharmacology ; Genotype ; Hepacivirus/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Male ; Middle Aged ; Propensity Score ; Sofosbuvir/pharmacology ; Treatment Failure
Academic Journal
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Title:
Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein.
Authors:
Agapova YK; National Research Center 'Kurchatov Institute', Akad. Kurchatova pl., 1, Moscow, 123182, Russian Federation. .
Altukhov DA; National Research Center 'Kurchatov Institute', Akad. Kurchatova pl., 1, Moscow, 123182, Russian Federation.
Timofeev VI; Federal Scientific Research Center 'Crystallography and Photonics', Russian Academy of Sciences, Leninskii Pr., 59, Moscow, 119333, Russian Federation.
Stroylov VS; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr., 47, Moscow, 119991, Russian Federation.
Mityanov VS; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr., 47, Moscow, 119991, Russian Federation.; D. Mendeleyev, University of Chemical Technology of Russia, Miusskaya sq., 9, Moscow, 125047, Russian Federation.
Korzhenevskiy DA; National Research Center 'Kurchatov Institute', Akad. Kurchatova pl., 1, Moscow, 123182, Russian Federation.
Vlaskina AV; National Research Center 'Kurchatov Institute', Akad. Kurchatova pl., 1, Moscow, 123182, Russian Federation.
Smirnova EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russian Federation.
Bocharov EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russian Federation. .; Moscow Institute of Physics and Technology (State University), Institutskiy Per., 9, Dolgoprudny, Moscow Region, 141701, Russian Federation. .
Rakitina TV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russian Federation. .
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Source:
Scientific reports [Sci Rep] 2020 Sep 15; Vol. 10 (1), pp. 15128. Date of Electronic Publication: 2020 Sep 15.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Docking Simulation*
Protein Conformation, alpha-Helical*
Bacterial Proteins/*antagonists & inhibitors
DNA, Bacterial/*metabolism
DNA-Binding Proteins/*antagonists & inhibitors
Fluorenes/*pharmacology
Histones/*chemistry
Spiroplasma/*growth & development
Amino Acid Sequence ; Bacterial Proteins/metabolism ; Binding Sites ; DNA-Binding Proteins/metabolism ; Fluorenes/chemistry ; High-Throughput Screening Assays ; Molecular Dynamics Simulation ; Spiroplasma/drug effects ; Spiroplasma/metabolism
SCR Organism:
Spiroplasma melliferum
Academic Journal
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Title:
Efficacy and Safety of Ledispavir/Sofosbuvir with or without Ribavirin in patients with Decompensated Liver Cirrhosis and Hepatitis C Infection: a Cohort Study.
Authors:
Gheorghe LS; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania. . .
Preda C; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania. . preda_.
Iliescu L; Carol Davila University of Medicine and Pharmacy, Internal Medicine Depart, Clinic Fundeni Institute, Bucharest, Romania. laura_.
Istratescu D; Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest; 4) Carol Davila University of Medicine and Pharmacy, Internal Medicine Depart, Emergency Universitary Hospital, Bucharest, Romania. .
Chifulescu AE; Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest; 4) Carol Davila University of Medicine and Pharmacy, Internal Medicine Depart, Emergency Universitary Hospital, Bucharest, Romania. .
Pop CS; UMF 'Carol Davila' Internal Medicine Department, Emergency Universitary Hospital, Bucharest, Romania. .
Trifan A; Gr. T. Popa University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Gastroenterol and Hepatol Institute, Iasi, Romania. .
Stanciu C; Gr. T. Popa University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Gastroenterol and Hepatol Institute, Iasi, Romania. .
Diculescu M; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania. .
Voiosu T; Carol Davila University of Medicine and Pharmacy, Internal Medicine Depart, Colentina Hospital, Bucharest, Romania. .
Baicus C; Carol Davila University of Medicine and Pharmacy, Internal Medicine Depart, Colentina Hospital, Bucharest, Romania. .
Tugui L; Gastroenterology and Hepatology Department, Clinic Fundeni Institute, Bucharest, Romania. .
Iacob S; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania. .
Tieranu C; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Elias Emergency Hospital, Bucharest, Romania. .
Meianu C; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania.
Manuc M; Carol Davila University of Medicine and Pharmacy, Gastroenterol and Hepatol Depart, Clinic Fundeni Institute, Bucharest, Romania. m_.
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Source:
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2020 Sep 09; Vol. 29 (3), pp. 385-390. Date of Electronic Publication: 2020 Sep 09.
Publication Type:
Journal Article; Multicenter Study
MeSH Terms:
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Fluorenes/*therapeutic use
Hepatitis C/*drug therapy
Liver Cirrhosis/*drug therapy
Ribavirin/*therapeutic use
Sofosbuvir/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Female ; Fluorenes/adverse effects ; Genotype ; Hepacivirus/genetics ; Hepatitis C/diagnosis ; Hepatitis C/virology ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Retrospective Studies ; Ribavirin/adverse effects ; Romania ; Sofosbuvir/adverse effects ; Sustained Virologic Response ; Time Factors ; Treatment Outcome ; Viral Load
Academic Journal
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Title:
Efficient Method for the Concentration Determination of Fmoc Groups Incorporated in the Core-Shell Materials by Fmoc-Glycine.
Authors:
Szczepańska E; Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Grobelna B; Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Ryl J; Corrosion and Materials Engineering, Department of Electrochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Kulpa A; Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Ossowski T; Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Niedziałkowski P; Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 01; Vol. 25 (17). Date of Electronic Publication: 2020 Sep 01.
Publication Type:
Journal Article
MeSH Terms:
Fluorenes/*chemistry
Glycine/*analogs & derivatives
Fluorenes/chemical synthesis ; Glycine/chemical synthesis ; Glycine/chemistry ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Photoelectron Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Thermogravimetry
Academic Journal
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Title:
Synthesis and Spectrophotometric Analysis of 1-Azafluorenone Derivatives.
Authors:
Angello NH; Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA.
Wiley RE; Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA.
Abelt CJ; Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA.
Scheerer JR; Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2020 Jul 24; Vol. 25 (15). Date of Electronic Publication: 2020 Jul 24.
Publication Type:
Journal Article
MeSH Terms:
Fluorenes/*chemical synthesis
Cycloaddition Reaction ; Fluorenes/chemistry ; Molecular Structure ; Oxidation-Reduction ; Spectrophotometry ; Stereoisomerism
Academic Journal
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Showing 1-20 from 1969 results

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