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Tytuł:
A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer.
Autorzy:
Ortega Duran M; Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
Shaheed SU; Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9BQ, UK.
Sutton CW; Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
Shnyder SD; Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
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Źródło:
Cells [Cells] 2024 Feb 14; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Humans ; Proteomics ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Mucoproteins ; Oncogene Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Binding Pattern and Structural Interactome of the Anticancer Drug 5-Fluorouracil: A Critical Review.
Autorzy:
Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, Taichung City 403, Taiwan.
Huang CY; Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 402, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fluorouracil*/metabolism
Antineoplastic Agents*
Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer.
Autorzy:
Alyabsi MS; Population Health Research Section, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Alqarni AH; Population Health Research Section, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Princess Noura Bint Abdul Rahman University, Health, and Rehabilitation Sciences College, Riyadh, Saudi Arabia.
Almutairi AF; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Alselaim NA; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Algarni MA; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Oncology, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
Alshammari KM; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Oncology, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
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Źródło:
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [Saudi J Gastroenterol] 2024 Mar 01; Vol. 30 (2), pp. 114-122. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/epidemiology
Colonic Neoplasms*/pathology
Male ; Female ; Humans ; Oxaliplatin/therapeutic use ; Saudi Arabia/epidemiology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bovine Serum Albumin as a Platform for Designing Biologically Active Nanocarriers-Experimental and Computational Studies.
Autorzy:
Adamczyk O; Department of Physics, Cracow University of Technology, 30-084 Krakow, Poland.
Szota M; Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, 31-355 Krakow, Poland.
Rakowski K; Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, 31-355 Krakow, Poland.
Prochownik M; Department of Physics, Cracow University of Technology, 30-084 Krakow, Poland.
Doveiko D; Department of Physics, University of Strathclyde, Glasgow G4 0NG, UK.
Chen Y; Department of Physics, University of Strathclyde, Glasgow G4 0NG, UK.
Jachimska B; Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, 31-355 Krakow, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 19; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Serum Albumin, Bovine*
Fluorouracil*
Molecular Docking Simulation ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Corneal Endothelial Toxicity Secondary to Topical 5-fluorouracil.
Autorzy:
Alsaleh A; Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Alfarhan A; Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
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Źródło:
Middle East African journal of ophthalmology [Middle East Afr J Ophthalmol] 2024 Jan 22; Vol. 30 (1), pp. 55-58. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2023).
Typ publikacji:
Case Reports
MeSH Terms:
Endothelium, Corneal*
Fluorouracil*/adverse effects
Humans ; Cornea ; Anterior Chamber ; Conjunctiva
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Specifics of Pharmacokinetics and Biodistribution of 5-Fluorouracil Polymeric Complex.
Autorzy:
Zhukova OV; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Dubovskaya NA; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Zykova DA; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Arkhipova EV; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Vorobeva OA; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Zaborskaya OG; Department of Pharmaceutical Chemistry and Pharmacognosy, Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russia.
Zaitsev SD; Department of High-Molecular Compounds and Colloid Chemistry, National Research Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
Grigoreva AO; Department of High-Molecular Compounds and Colloid Chemistry, National Research Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
Chicharov AA; Department of High-Molecular Compounds and Colloid Chemistry, National Research Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
Ryabov SA; Department of High-Molecular Compounds and Colloid Chemistry, National Research Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 15; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/chemistry
Drug Carriers*/chemistry
Rats ; Animals ; Tissue Distribution ; Polymers/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer.
Autorzy:
Liao AH; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.; Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan.
Lee YA; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Lin DL; Spirit Scientific Co., Ltd, Taiwan Branch (Cayman), New Taipei City, Taiwan.
Chuang HC; Department of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan.
Wang JK; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Chang CE; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Li HT; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Wu TY; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Shih CP; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wang CH; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Chu YH; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
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Źródło:
Drug delivery [Drug Deliv] 2023 Dec; Vol. 30 (1), pp. 1-13.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Head and Neck Neoplasms*/drug therapy
Mice ; Animals ; Microbubbles ; Tissue Distribution ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preclinical Synergistic Combination Therapy of Lurbinectedin with Irinotecan and 5-Fluorouracil in Pancreatic Cancer.
Autorzy:
Tummala T; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Sevilla Uruchurtu AS; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Cruz A; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Huntington KE; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.
George A; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Liguori NR; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.
Zhang L; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.
Zhou L; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Joint Program in Cancer Biology, Lifespan Health System and Brown University, Providence, RI 02903, USA.
Abbas AE; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Joint Program in Cancer Biology, Lifespan Health System and Brown University, Providence, RI 02903, USA.; Department of Surgery, Brown University, Providence, RI 02912, USA.
Azzoli CG; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.; Joint Program in Cancer Biology, Lifespan Health System and Brown University, Providence, RI 02903, USA.; Hematology/Oncology Division, Department of Medicine, Lifespan Health System and Brown University, Providence, RI 02903, USA.
El-Deiry WS; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Legorreta Cancer Center at Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Joint Program in Cancer Biology, Lifespan Health System and Brown University, Providence, RI 02903, USA.; Hematology/Oncology Division, Department of Medicine, Lifespan Health System and Brown University, Providence, RI 02903, USA.
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Źródło:
Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Oct 31; Vol. 30 (11), pp. 9611-9626. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/pathology
Humans ; Irinotecan/pharmacology ; Irinotecan/therapeutic use ; Carbolines/pharmacology ; Carbolines/therapeutic use ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Characterization of Methoxy-Exfoliated Montmorillonite Nanosheets as Potential Carriers of 5-Fluorouracil Drug with Enhanced Loading, Release, and Cytotoxicity Properties.
Autorzy:
Alqahtani MD; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Bin Jumah MN; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Al-Hashimi A; Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Allam AA; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.
Abukhadra MR; Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt.; Materials Technologies and Their Applications Laboratory, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.
Bellucci S; INFN-Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Aug 05; Vol. 28 (15). Date of Electronic Publication: 2023 Aug 05.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/chemistry
Bentonite*/chemistry
Drug Carriers/chemistry ; Drug Liberation ; Ions
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Scutellaria baicalensis enhances 5-fluorouracil-based chemotherapy via inhibition of proliferative signaling pathways.
Autorzy:
Liu H; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Liu H; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.; Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhou Z; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chung J; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Obstetrics and Gynecology, Abington-Jefferson Health, Abington, PA, USA.
Zhang G; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Chang J; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.; Department of Radiotherapy, Second Affiliated Hospital, Shandong First Medical University, Tai'an City, China.
Parise RA; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Chu E; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.; Albert Einstein Cancer Center, Cancer Therapeutics Program, Albert Einstein College of Medicine, Bronx, NY, USA.
Schmitz JC; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. .; Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Jun 19; Vol. 21 (1), pp. 147. Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Humans ; Animals ; Mice ; Scutellaria baicalensis ; Signal Transduction ; Cell Proliferation ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
XPF-ERCC1 Blocker Improves the Therapeutic Efficacy of 5-FU- and Oxaliplatin-Based Chemoradiotherapy in Colorectal Cancer.
Autorzy:
Huang MY; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Radiation Oncology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Huang YJ; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Cheng TL; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Jhang WY; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ke CC; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Chen YT; Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Kuo SH; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Lin IL; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Huang YH; Post-Graduate Year Training, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chuang CH; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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Źródło:
Cells [Cells] 2023 May 25; Vol. 12 (11). Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/etiology
Animals ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; DNA-Binding Proteins/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Organoplatinum Compounds/pharmacology ; Organoplatinum Compounds/therapeutic use ; Chemoradiotherapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Association of Oxaliplatin-Containing Adjuvant Chemotherapy Duration with Overall and Cancer-Specific Mortality in Individuals with Stage III Colon Cancer: A Population-Based Retrospective Cohort Study.
Autorzy:
Sue-Chue-Lam C; Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada.
Brezden-Masley C; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada.; Division of Medical Oncology, Sinai Health System, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Sutradhar R; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada.; ICES, Toronto, ON M4N 3M5, Canada.
Yu AYX; Department of Medicine (Neurology), University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Baxter NN; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada.; ICES, Toronto, ON M4N 3M5, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.; Melbourne School of Global and Population Health, 207 Bouverie St. Level 5, University of Melbourne, Melbourne, VIC 3010, Australia.
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Źródło:
Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Jul 06; Vol. 30 (7), pp. 6508-6532. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorouracil*/therapeutic use
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/pathology
Humans ; Adolescent ; Adult ; Oxaliplatin/therapeutic use ; Capecitabine ; Retrospective Studies ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols ; Leucovorin/therapeutic use ; Neoplasm Staging ; Organoplatinum Compounds/therapeutic use ; Chemotherapy, Adjuvant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen.
Autorzy:
Zhan Y; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; School of Medicine, Nankai University, Tianjin, China.
Ni K; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; School of Medicine, Nankai University, Tianjin, China.
Liu Z; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; School of Medicine, Nankai University, Tianjin, China.
Xin R; School of Medicine, Nankai University, Tianjin, China.
Han Q; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Ping H; School of Medicine, Nankai University, Tianjin, China.
Liu Y; School of Medicine, Nankai University, Tianjin, China.
Zhao X; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wang W; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yan S; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Sun J; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Zhang Q; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Wang G; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang Z; The Third Central, Clinical College of Tianjin Medical University, Tianjin, China.
Zhang X; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China.; Tianjin Institute of Coloproctology, Tianjin, China.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Hu X; Department of Agriculture Insect, Institute of Plant Protection, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Li G; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. .; Tianjin Institute of Coloproctology, Tianjin, China. .; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China. .
Zhang C; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. .; Tianjin Institute of Coloproctology, Tianjin, China. .; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 02; Vol. 13 (1), pp. 8969. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorouracil*/therapeutic use
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/genetics
Colonic Neoplasms*/surgery
Humans ; Oxaliplatin/therapeutic use ; DNA Mismatch Repair ; Neoplasm Staging ; Chemotherapy, Adjuvant ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
Autorzy:
Li N; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Wang Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.; The Cancer Institute, Qingdao University, Qingdao 266071, China.
Wang A; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Zhang J; Department of Medicine, Hematology/Oncology, Goethe University, 60590 Frankfurt, Germany.
Jia C; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Yu C; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Song Z; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Wang S; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Liu L; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Yi J; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Bao Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Huang Y; NMPA Key Laboratory for Quality of Cell and Gene Therapy Medicinal Products, Northeast Normal University, Changchun 130024, China.
Sun L; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 03; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/metabolism
Hematopoietic Stem Cells*/metabolism
Animals ; Humans ; Mice ; Cell Differentiation ; Molecular Docking Simulation ; Phosphoric Monoester Hydrolases/metabolism ; Stem Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population.
Autorzy:
Kanai M; Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawaguchi T; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kotaka M; Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan.
Manaka D; Department of Surgery, Gastrointestinal Center, Kyoto Katsura Hospital, Kyoto, Japan.
Hasegawa J; Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.
Takagane A; Department of Surgery, Hakodate Goryoukaku Hospital, Hakodate, Japan.
Munemoto Y; Department of Surgery, Fukui Ken Saiseikai Hospital, Fukui, Japan.
Kato T; Department of Surgery, Kansai Rosai Hospital, Amagasaki, Japan.
Eto T; Department of Gastroenterology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Touyama T; Department of Surgery, Nakagami Hospital, Okinawa, Japan.
Matsui T; Department of Gastroenterological Surgery, Aichi Cancer Center Aichi Hospital, Okazaki, Japan.
Shinozaki K; Division of Clinical Oncology, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Matsumoto S; Department of Real World Data Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mizushima T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Mori M; Tokai University School of Medicine, Isehara, Japan.
Sakamoto J; Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo, Japan.; Tokai Central Hospital, Kakamigahara, Japan.
Ohtsu A; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
Yoshino T; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
Saji S; Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo, Japan.
Matsuda F; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło:
Cancer medicine [Cancer Med] 2023 Apr; Vol. 12 (7), pp. 7808-7814. Date of Electronic Publication: 2022 Dec 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dihydrouracil Dehydrogenase (NADP)*/genetics
Fluorouracil*/adverse effects
Humans ; Genome-Wide Association Study ; Genotype ; Antimetabolites, Antineoplastic/adverse effects ; Capecitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro.
Autorzy:
Almanzar VMD; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Shah K; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
LaComb JF; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Mojumdar A; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Patel HR; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Cheung J; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Tang M; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Ju J; Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Bialkowska AB; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Pancreatic Stellate Cells*/drug effects
Pancreatic Stellate Cells*/pathology
Pancreatitis, Chronic*/pathology
Animals ; Mice ; Cell Proliferation/genetics ; Fibrosis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; YAP-Signaling Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.
Autorzy:
Favela-Mendoza AF; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Godínez-López AD; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Chávez-Arreguin M; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Aguilar-Velázquez JA; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Martínez-Cortes G; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Rangel-Villalobos H; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
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Źródło:
Annals of human biology [Ann Hum Biol] 2023 Feb; Vol. 50 (1), pp. 94-99.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*
Polymorphism, Genetic*
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Humans ; Alleles ; Genotype ; Polymorphism, Restriction Fragment Length ; Mexico
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New Transcriptomic Biomarkers of 5-Fluorouracil Resistance.
Autorzy:
Fekete JT; Research Center for Natural Sciences, Cancer Biomarker Research Group, Institute of Enzymology, Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.; National Laboratory for Drug Research and Development, Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Győrffy B; Department of Pediatrics, Semmelweis University, H-1094 Budapest, Hungary.; Department of Bioinformatics, Semmelweis University, H-1094 Budapest, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 12; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Drug Resistance, Neoplasm*/genetics
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Humans ; Biomarkers/metabolism ; Transcriptome ; Membrane Proteins/genetics ; Membrane Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigating the resistance mechanism of 5-fluorouracil in colorectal cancer based on surface markers of cancer stemness and cytokine level: A pre-clinical study.
Autorzy:
Patel SG; Department of Pharmaceutical Chemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology, Changa, India.
Patel A; Department of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology, Changa, India.
Patel N; Department of Cancer Biology, Immunohaematology Lab, Gujarat Cancer and Research Institute, Cancer Civil Hospital, Ahmedabad, India.
Raiya B; Department of Cancer Biology, Immunohaematology Lab, Gujarat Cancer and Research Institute, Cancer Civil Hospital, Ahmedabad, India.
Vora H; Department of Cancer Biology, Immunohaematology Lab, Gujarat Cancer and Research Institute, Cancer Civil Hospital, Ahmedabad, India.
Jain N; Department of Biological Sciences, P D Patel Institute of Applied Sciences, Charotar University of Science & Technology, Changa, Anand, Gujarat, India.
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Źródło:
Journal of cancer research and therapeutics [J Cancer Res Ther] 2023 Jan 01; Vol. 19 (Suppl 2), pp. S560-S568. Date of Electronic Publication: 2023 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*/pharmacology
Fluorouracil*/therapeutic use
Colorectal Neoplasms*/pathology
Humans ; Rats ; Animals ; Cell Line, Tumor ; Cytokines ; HCT116 Cells ; Rats, Sprague-Dawley ; Drug Resistance, Neoplasm
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biomarker analysis for patients with pancreatic cancer treated with nanoliposomal irinotecan plus 5-fluorouracil/leucovorin.
Autorzy:
Kawakami T; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan. .
Todaka A; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Oshima K; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Fushiki K; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Hamauchi S; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Tsushima T; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Yokota T; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Onozawa Y; Division of Clinical Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Yasui H; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Yamazaki K; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
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Źródło:
BMC cancer [BMC Cancer] 2023 Jan 20; Vol. 23 (1), pp. 68. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols*
Fluorouracil*/therapeutic use
Irinotecan*/therapeutic use
Leucovorin*/therapeutic use
Pancreatic Neoplasms*/diagnosis
Pancreatic Neoplasms*/drug therapy
Biomarkers, Tumor*
Humans ; CA-19-9 Antigen ; Camptothecin ; Liposomes ; Retrospective Studies ; Treatment Outcome ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 20819

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