Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Foam Cells"" wg kryterium: Temat


Tytuł :
PPARα/γ signaling pathways are involved in Chlamydia pneumoniae-induced foam cell formation via upregulation of SR-A1 and ACAT1 and downregulation of ABCA1/G1.
Autorzy :
Wu X; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Geriatrics, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, 316021, China.
Cheng B; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Guo X; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wu Q; Department of Geriatrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sun S; Department of Geriatrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
He P; Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: .
Pokaż więcej
Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Dec; Vol. 161 (Pt B), pp. 105284. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Chlamydophila pneumoniae*/metabolism
Foam Cells*/metabolism
ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Acyltransferases ; CD36 Antigens/genetics ; CD36 Antigens/metabolism ; Down-Regulation ; PPAR alpha/genetics ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway.
Autorzy :
Zhuang JL; Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai 519015, China.
Liu YY; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
Li ZZ; Panyu Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
Zhuang QZ; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
Tang WZ; Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai 519015, China.
Xiong Y; Panyu Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China. Electronic address: .
Huang XZ; Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China. Electronic address: .
Pokaż więcej
Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Nov 15; Vol. 431, pp. 115733. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*prevention & control
Biflavonoids/*pharmacology
CD36 Antigens/*metabolism
Foam Cells/*drug effects
Hypolipidemic Agents/*pharmacology
Lipid Metabolism/*drug effects
Lipoproteins, LDL/*toxicity
Muscle, Smooth, Vascular/*drug effects
Myocytes, Smooth Muscle/*drug effects
PPAR gamma/*metabolism
ATP Binding Cassette Transporter 1/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; CD36 Antigens/genetics ; Foam Cells/metabolism ; Foam Cells/pathology ; Humans ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; PPAR gamma/genetics ; Plaque, Atherosclerotic ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Periodontal Pathogens Promote Foam Cell Formation by Blocking Lipid Efflux.
Autorzy :
Rho JH; Department of Oral Pathology and BK21 FOUR Project, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.; Department of Periodontology, School of Dentistry, Pusan National University, Pusan National University Dental Hospital, Yangsan, Republic of Korea.
Kim HJ; Department of Oral Pathology and BK21 FOUR Project, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.; Department of Periodontology, School of Dentistry, Pusan National University, Pusan National University Dental Hospital, Yangsan, Republic of Korea.
Joo JY; Department of Periodontology, School of Dentistry, Pusan National University, Pusan National University Dental Hospital, Yangsan, Republic of Korea.; Periodontal Disease Signaling Network Research Center, Dental & Life Science Institute, Pusan National University, Yangsan, Republic of Korea.
Lee JY; Department of Periodontology, School of Dentistry, Pusan National University, Pusan National University Dental Hospital, Yangsan, Republic of Korea.; Periodontal Disease Signaling Network Research Center, Dental & Life Science Institute, Pusan National University, Yangsan, Republic of Korea.
Lee JH; Department of Oral Pathology and BK21 FOUR Project, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.; Periodontal Disease Signaling Network Research Center, Dental & Life Science Institute, Pusan National University, Yangsan, Republic of Korea.
Park HR; Department of Oral Pathology and BK21 FOUR Project, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.; Periodontal Disease Signaling Network Research Center, Dental & Life Science Institute, Pusan National University, Yangsan, Republic of Korea.
Pokaż więcej
Źródło :
Journal of dental research [J Dent Res] 2021 Nov; Vol. 100 (12), pp. 1367-1377. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Foam Cells*
Plaque, Atherosclerotic*
Humans ; Lipids ; Lipoproteins, LDL ; Macrophages
Czasopismo naukowe
Tytuł :
Two birds, one stone: NFATc3 controls dual actions of miR-204 in foam cell formation.
Autorzy :
van Solingen C; Leon H. Charney Division of Cardiology, NYU Cardiovascular Research Center, Department of Medicine, New York University School of Medicine, NY, USA.
Moore KJ; Leon H. Charney Division of Cardiology, NYU Cardiovascular Research Center, Department of Medicine, New York University School of Medicine, NY, USA.
Pokaż więcej
Źródło :
European heart journal [Eur Heart J] 2021 Dec 14; Vol. 42 (47), pp. 4862-4864.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Foam Cells*
MicroRNAs*/genetics
NFATC Transcription Factors
Raport
Tytuł :
High Content Image Analysis as a Tool to Morphologically Distinguish Macrophage Activation and Determine Its Importance for Foamy Alveolar Macrophage Responses.
Autorzy :
Hoffman E; Centre for Topical Drug Delivery and Toxicology School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Napieralska P; Department of Biochemistry and Molecular Diagnostics, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
Mahendran R; Centre for Topical Drug Delivery and Toxicology School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Murnane D; Centre for Topical Drug Delivery and Toxicology School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Hutter V; Centre for Topical Drug Delivery and Toxicology School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Pokaż więcej
Źródło :
Frontiers in immunology [Front Immunol] 2021 Sep 01; Vol. 12, pp. 611280. Date of Electronic Publication: 2021 Sep 01 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Imaging*/methods
Foam Cells/*metabolism
Foam Cells/*pathology
Macrophage Activation/*immunology
Macrophages/*cytology
Macrophages/*metabolism
Macrophages, Alveolar/*metabolism
Macrophages, Alveolar/*pathology
Biomarkers ; Cells, Cultured ; Cytokines/metabolism ; Foam Cells/immunology ; Immunophenotyping ; Lipid Metabolism ; Macrophages/immunology ; Macrophages, Alveolar/immunology ; Nitric Oxide/metabolism ; Phagocytosis/immunology
Czasopismo naukowe
Tytuł :
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Autorzy :
Ding Y; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Gong W; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Zhang S; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Shen J; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Liu X; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Wang Y; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Chen Y; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Meng G; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Oct; Vol. 192, pp. 114665. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol/*metabolism
Foam Cells/*metabolism
Lipoproteins, LDL/*metabolism
Macrophages/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Oxidative Stress/*physiology
Sirtuin 3/*deficiency
Animals ; Foam Cells/pathology ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sirtuin 3/genetics
Czasopismo naukowe
Tytuł :
Atypical antipsychotic drugs deregulate the cholesterol metabolism of macrophage-foam cells by activating NOX-ROS-PPARγ-CD36 signaling pathway.
Autorzy :
Chen CH; Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Leu SJ; Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan.
Hsu CP; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Pan CC; Cardiovascular Division, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Shyue SK; Cardiovascular Division, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: .
Lee TS; Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Metabolism: clinical and experimental [Metabolism] 2021 Oct; Vol. 123, pp. 154847. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antipsychotic Agents/*pharmacology
CD36 Antigens/*metabolism
Cholesterol/*metabolism
Foam Cells/*drug effects
NADPH Oxidases/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Atherosclerosis/pathology ; Foam Cells/metabolism ; Mice ; Mice, Knockout ; Olanzapine/pharmacology ; PPAR gamma/metabolism
Czasopismo naukowe
Tytuł :
Novel insights: Dynamic foam cells derived from the macrophage in atherosclerosis.
Autorzy :
Li J; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Meng Q; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Fu Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yu X; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Ji T; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Chao Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Chen Q; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Li Y; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Bian H; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Pokaż więcej
Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Sep; Vol. 236 (9), pp. 6154-6167. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Atherosclerosis/*pathology
Foam Cells/*pathology
Animals ; Cell Communication ; Cholesterol/metabolism ; Esterification ; Foam Cells/metabolism ; Humans ; Metabolome
Czasopismo naukowe
Tytuł :
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner.
Autorzy :
Chen X; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.; Xiamen Hospital, Beijing University of Chinese Medicine, Xiamen, 361000, China.
Zou D; Emergency Department, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Chen X; Cardiovascular Department, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, China.
Wu H; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Xu D; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. .; Cardiovascular Department, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. .; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, China. .; The Eighth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510006, China. .
Pokaż więcej
Źródło :
Journal of physiology and biochemistry [J Physiol Biochem] 2021 Aug; Vol. 77 (3), pp. 405-417. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cholesterol/*metabolism
Foam Cells/*drug effects
Hesperidin/*pharmacology
AMP-Activated Protein Kinase Kinases ; Atherosclerosis/metabolism ; Foam Cells/pathology ; Humans ; Liver X Receptors/metabolism ; Protein Kinases/metabolism ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Unusual White-Yellowish Dots in the Colon Reveal a Rare Metabolic Disease.
Autorzy :
Jeuring SFG; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: .
Verhaegh BPM; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Verbeek J; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Laboratory of Hepatology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Pokaż więcej
Źródło :
Gastroenterology [Gastroenterology] 2021 Aug; Vol. 161 (2), pp. e39-e40. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Case Reports
MeSH Terms :
Incidental Findings*
Colon/*chemistry
Foam Cells/*chemistry
Intestinal Mucosa/*chemistry
Lipids/*analysis
Tangier Disease/*diagnosis
Adult ; Biopsy ; Colon/ultrastructure ; Colonoscopy ; Foam Cells/ultrastructure ; Humans ; Immunohistochemistry ; Intestinal Mucosa/ultrastructure ; Male ; Microscopy, Electron ; Predictive Value of Tests ; Prognosis ; Splenomegaly/diagnosis ; Tangier Disease/metabolism ; Tangier Disease/pathology
Raport
Tytuł :
Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK-FoxO1-TFEB signalling axis.
Autorzy :
Tao J; Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, China.
Yang P; Department of Anatomy, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, China.
Xie L; Department of Cardiology, the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Pu Y; Department of Cardiology, the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Guo J; Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, China.
Jiao J; Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, China.
Sun L; Department of Cardiology, the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Lu D; Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, China.
Pokaż więcej
Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Jun; Vol. 25 (12), pp. 5769-5781. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Atherosclerosis/*prevention & control
Benzyl Alcohols/*pharmacology
Foam Cells/*drug effects
Gene Expression Regulation/*drug effects
Glucosides/*pharmacology
Lysosomes/*drug effects
Macrophages/*drug effects
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Foam Cells/metabolism ; Foam Cells/pathology ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O1/metabolism ; Lysosomes/metabolism ; Lysosomes/pathology ; Macrophages/metabolism ; Macrophages/pathology ; Mice
Czasopismo naukowe
Tytuł :
Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits.
Autorzy :
Li Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Tang J; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Gao H; Department of Pathology, Qinghai Provincial People's Hospital, Qinghai, 810007, China.
Xu Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Han Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Shang H; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Lu Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Qin C; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China. Electronic address: .
Pokaż więcej
Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Jun 07; Vol. 31 (6), pp. 1929-1938. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Plaque, Atherosclerotic*
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Aorta/*drug effects
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Foam Cells/*drug effects
Polysaccharides/*pharmacology
Triterpenes/*pharmacology
Animals ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/isolation & purification ; Aorta/metabolism ; Aorta/pathology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Apoptosis/drug effects ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Female ; Foam Cells/metabolism ; Foam Cells/pathology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Inflammation Mediators/metabolism ; Male ; Oxidative Stress/drug effects ; Polysaccharides/isolation & purification ; Rabbits ; Reactive Oxygen Species/metabolism ; Reishi/chemistry ; THP-1 Cells ; Triterpenes/isolation & purification
Czasopismo naukowe
Tytuł :
Clarifying the Distinct Roles of Smooth Muscle Cell-Derived Versus Macrophage Foam Cells and the Implications in Atherosclerosis.
Autorzy :
Miller CL; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville (C.L.M.).
Zhang H; Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York (H.Z.).
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jun; Vol. 41 (6), pp. 2035-2037. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Atherosclerosis*
Foam Cells*
Humans ; Macrophages ; Myocytes, Smooth Muscle
Raport
Tytuł :
A new activator of esterase D decreases blood cholesterol level through ESD/JAB1/ABCA1 pathway.
Autorzy :
Chen X; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.; Hubei Key Laboratory of Edible Wild Plants Conservation & Utilization, National Demonstration Center for Experimental Biology Education, School of Life Science, Hubei Normal University, Huangshi, P.R. China.
Su L; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.; State Key Laboratory of Biobased Material and Green Papermaking, School of bioengineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, P.R. China.
Yang Y; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.
Qv J; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, P.R. China.
Wei T; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, P.R. China.
Cui X; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.
Shao J; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.
Liu S; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.
Xu Z; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.
Zhao B; Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, P.R. China.
Miao J; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, P.R. China.; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, P.R. China.
Pokaż więcej
Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Jun; Vol. 236 (6), pp. 4750-4763. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter 1/*metabolism
Anticholesteremic Agents/*pharmacology
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
COP9 Signalosome Complex/*metabolism
Cholesterol/*blood
Enzyme Inhibitors/*pharmacology
Foam Cells/*drug effects
Peptide Hydrolases/*metabolism
Thiolester Hydrolases/*antagonists & inhibitors
Acetylation ; Animals ; Aortic Diseases/blood ; Aortic Diseases/enzymology ; Aortic Diseases/pathology ; Atherosclerosis/blood ; Atherosclerosis/enzymology ; Atherosclerosis/pathology ; Biomarkers/blood ; Diet, High-Fat ; Disease Models, Animal ; Down-Regulation ; Foam Cells/enzymology ; Foam Cells/pathology ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Non-alcoholic Fatty Liver Disease/enzymology ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/prevention & control ; Plaque, Atherosclerotic ; Protein Processing, Post-Translational ; RAW 264.7 Cells ; Thiolester Hydrolases/metabolism
Czasopismo naukowe
Tytuł :
Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation.
Autorzy :
Dubland JA; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Allahverdian S; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Besler KJ; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Ortega C; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Wang Y; Pathology and Laboratory Medicine (Y.W.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Pryma CS; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Boukais K; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Chan T; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Seidman MA; Laboratory Medicine and Pathobiology, University of Toronto, Canada (M.A.S.).
Francis GA; Departments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jun; Vol. 41 (6), pp. e354-e368. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*enzymology
Cholesterol/*metabolism
Foam Cells/*enzymology
Muscle, Smooth, Vascular/*enzymology
Myocytes, Smooth Muscle/*enzymology
Sterol Esterase/*metabolism
Animals ; Aorta/enzymology ; Aorta/pathology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Disease Models, Animal ; Foam Cells/pathology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18.
Autorzy :
Su G; Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, Heilongjiang, 150001, PR China. Electronic address: .
Yang W; Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, Heilongjiang, 150001, PR China. Electronic address: .
Wang S; Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, Heilongjiang, 150001, PR China. Electronic address: .
Geng C; Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, Heilongjiang, 150001, PR China. Electronic address: .
Guan X; Department of Laboratory Diagnostics, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, Heilongjiang, 150001, PR China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jul 05; Vol. 561, pp. 33-39. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*pathology
Foam Cells/*pathology
Interleukin-18/*metabolism
Interleukin-1beta/*metabolism
Iron Overload/*pathology
Sirtuin 1/*metabolism
Animals ; Atherosclerosis/metabolism ; Autophagy/physiology ; Cells, Cultured ; Disease Models, Animal ; Ferroptosis/physiology ; Foam Cells/metabolism ; Humans ; Interleukin-18/genetics ; Interleukin-1beta/genetics ; Iron Overload/metabolism ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice ; Mice, Knockout, ApoE ; Signal Transduction ; Sirtuin 1/genetics
Czasopismo naukowe
Tytuł :
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE mice.
Autorzy :
Wu H; Department of Endocrinology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University & The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
Feng K; Key Laboratory of Bioactive Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China.
Zhang C; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang H; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang J; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hua Y; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Dong Z; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhu Y; Department of Endocrinology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University & The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China. Electronic address: .
Yang S; Department of Endocrinology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University & The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China. Electronic address: .
Ma C; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 11; Vol. 557, pp. 334-341. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*genetics
Atherosclerosis/*drug therapy
Autophagy/*drug effects
Foam Cells/*drug effects
Kruppel-Like Transcription Factors/*metabolism
Metformin/*pharmacology
Plaque, Atherosclerotic/*drug therapy
Animals ; Aorta/drug effects ; Aorta/metabolism ; Aorta/pathology ; Apoptosis/drug effects ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Diet, High-Fat ; Foam Cells/metabolism ; Kruppel-Like Transcription Factors/genetics ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Metformin/therapeutic use ; Mice ; Mice, Inbred C57BL ; Plaque, Atherosclerotic/genetics ; Plaque, Atherosclerotic/metabolism ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
A New Small Molecule Increases Cholesterol Efflux.
Autorzy :
Groenen AG; Department of Pediatrics, University of Groningen, University Medical Center Groningen, The Netherlands.
Westerterp M; Department of Pediatrics, University of Groningen, University Medical Center Groningen, The Netherlands.
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jun; Vol. 41 (6), pp. 1851-1853. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Cholesterol*
Foam Cells*
ATP Binding Cassette Transporter 1
Czasopismo naukowe
Tytuł :
Oxidized low-density lipoprotein induced hepatoma-derived growth factor upregulation mediates foam cell formation of cultured rat aortic vascular smooth muscle cells.
Autorzy :
Cheng CI; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang-Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: .
Tai MH; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Chang HR; Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan.
Chou MH; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for General Education, Cheng-Shiu University, Kaohsiung, Taiwan.
Chen GT; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang-Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chen PH; Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan.
Kao YH; Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
European journal of cell biology [Eur J Cell Biol] 2021 Jun-Aug; Vol. 100 (5-6), pp. 151169. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Foam Cells*/metabolism
Muscle, Smooth, Vascular*
Animals ; Cells, Cultured ; Intercellular Signaling Peptides and Proteins ; Lipoproteins, LDL/metabolism ; Phosphatidylinositol 3-Kinases ; Rats ; Up-Regulation
Czasopismo naukowe
Tytuł :
MRTFA overexpression promotes conversion of human coronary artery smooth muscle cells into lipid-laden foam cells.
Autorzy :
Alajbegovic A; Department of Experimental Medical Science, Lund University, Sweden. Electronic address: .
Holmberg J; Department of Experimental Medical Science, Lund University, Sweden.
Daoud F; Department of Experimental Medical Science, Lund University, Sweden.
Rippe C; Department of Experimental Medical Science, Lund University, Sweden.
Kalliokoski G; Department of Experimental Medical Science, Lund University, Sweden.
Ekman M; Department of Experimental Medical Science, Lund University, Sweden.
Daudi S; Department of Clinical Science, Lund University, Lund, Sweden.
Ragnarsson S; Department of Clinical Science, Lund University, Lund, Sweden.
Swärd K; Department of Experimental Medical Science, Lund University, Sweden.
Albinsson S; Department of Experimental Medical Science, Lund University, Sweden.
Pokaż więcej
Źródło :
Vascular pharmacology [Vascul Pharmacol] 2021 Jun; Vol. 138, pp. 106837. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transdifferentiation*
Lipid Metabolism*
Foam Cells/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Trans-Activators/*metabolism
Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Foam Cells/pathology ; HEK293 Cells ; Humans ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Neointima ; Pinocytosis ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Trans-Activators/genetics ; Up-Regulation ; Vascular Remodeling
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies