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Wyszukujesz frazę ""Folate Receptors, GPI-Anchored"" wg kryterium: Temat


Tytuł :
Preparation and Evaluation of Novel Folate Isonitrile Tc Complexes as Potential Tumor Imaging Agents to Target Folate Receptors.
Autorzy :
Feng J; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Perking University, Beijing 100091, China.
Zhang X; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Perking University, Beijing 100091, China.
Ruan Q; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Perking University, Beijing 100091, China.
Jiang Y; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Perking University, Beijing 100091, China.
Zhang J; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Perking University, Beijing 100091, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 28; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Diagnostic Imaging/*methods
Folate Receptors, GPI-Anchored/*metabolism
Folic Acid/*chemistry
Kidney/*diagnostic imaging
Nitriles/*chemistry
Radiopharmaceuticals/*chemical synthesis
Tomography, Emission-Computed, Single-Photon/*methods
Animals ; Binding, Competitive ; Drug Stability ; Folate Receptors, GPI-Anchored/genetics ; Folic Acid/pharmacokinetics ; Gene Expression ; Humans ; Hydrophobic and Hydrophilic Interactions ; KB Cells ; Kidney/metabolism ; Mice ; Protein Binding ; Radiopharmaceuticals/pharmacokinetics ; Technetium/chemistry ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach.
Autorzy :
Rana A; Amity Institute of Biotechnology, Amity University, Sector125, Noida, Uttar Pradesh, India. Electronic address: .
Bhatnagar S; Amity Institute of Biotechnology, Amity University, Sector125, Noida, Uttar Pradesh, India. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104946. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Folate Receptors, GPI-Anchored/*antagonists & inhibitors
Neoplasms/*drug therapy
Small Molecule Libraries/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Folate Receptors, GPI-Anchored/metabolism ; Humans ; Molecular Structure ; Neoplasms/metabolism ; Neoplasms/pathology ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells.
Autorzy :
Huang Y; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Meng L; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Nie Q; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Zhou Y; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Chen L; School of Pharmacy, Second Military Medical University, Shanghai, China.
Yang S; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Fung YME; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Li X; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Huang C; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Cao Y; School of Pharmacy, Second Military Medical University, Shanghai, China. .
Li Y; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China. .; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China. .
Li X; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China. .; Laboratory for Synthetic Chemistry and Chemical Biology of , Hong Kong SAR, China. .
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Źródło :
Nature chemistry [Nat Chem] 2021 Jan; Vol. 13 (1), pp. 77-88. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbonic Anhydrases/*chemistry
DNA/*chemistry
ErbB Receptors/*chemistry
Folate Receptors, GPI-Anchored/*chemistry
Small Molecule Libraries/*chemistry
Antibodies, Immobilized/chemistry ; Antibodies, Immobilized/immunology ; Carbonic Anhydrases/metabolism ; ErbB Receptors/immunology ; ErbB Receptors/metabolism ; Fluorescein-5-isothiocyanate/chemistry ; Folate Receptors, GPI-Anchored/metabolism ; HeLa Cells ; Humans ; Ligands ; Microscopy, Fluorescence ; Small Molecule Libraries/metabolism
Czasopismo naukowe
Tytuł :
Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry.
Autorzy :
Patil RA; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Srinivasarao M; Department of Chemistry, Purdue University, West Lafayette, IN, 47906, USA.
Amiji MM; Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, 02115, USA.
Low PS; Department of Chemistry, Purdue University, West Lafayette, IN, 47906, USA.
Niedre M; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA. .
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Źródło :
Molecular imaging and biology [Mol Imaging Biol] 2020 Oct; Vol. 22 (5), pp. 1280-1289.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Staining and Labeling*
Flow Cytometry/*methods
Folate Receptors, GPI-Anchored/*metabolism
Molecular Probes/*chemistry
Neoplastic Cells, Circulating/*pathology
Animals ; Cell Line, Tumor ; Fluorescence ; Folate Receptors, GPI-Anchored/blood ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Redox-Sensitive and Folate-Receptor-Mediated Targeting of Cervical Cancer Cells for Photodynamic Therapy Using Nanophotosensitizers Composed of Chlorin e6-Conjugated β-Cyclodextrin via Diselenide Linkage.
Autorzy :
Kim H; Department of Medicine, Graduate School, Dongguk University, Gyeongju 38067, Korea.
Kim MW; Department of Anesthesiology and Pain Medicine, College of Medicine, Dongguk University, Gyeongju 38067, Korea.
Jeong YI; Research Institute of Convergence of Biomedical Sciences, Pusan National University Yangsan Hospital, Gyeongnam 50612, Korea.; The Institute of Dental Science, Chosun University, Gwangju 61452, Korea.
Yang HS; Department of Obstetrics and Gynecology, Dongguk University College of Medicine, Gyeongju 38067, Korea.
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Źródło :
Cells [Cells] 2021 Aug 25; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Folate Receptors, GPI-Anchored/*metabolism
Nanoparticles/*administration & dosage
Oxidation-Reduction/*drug effects
Photosensitizing Agents/*pharmacology
Porphyrins/*pharmacology
Uterine Cervical Neoplasms/*drug therapy
beta-Cyclodextrins/*pharmacology
Animals ; Cell Line ; Cell Line, Tumor ; Female ; Folic Acid/metabolism ; HeLa Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Particle Size ; Photochemotherapy/methods ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers.
Autorzy :
Karges J; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Tharaud M; Université de Paris, Institut de Physique du Globe de Paris, CNRS, F-75005 Paris, France.
Gasser G; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4612-4622. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coordination Complexes/*chemistry
Photosensitizing Agents/*chemistry
Polymers/*chemistry
Ruthenium/*chemistry
Cell Culture Techniques ; Cell Line ; Cell Survival/drug effects ; Coordination Complexes/pharmacology ; Coordination Complexes/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Folate Receptors, GPI-Anchored/chemistry ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/metabolism ; Humans ; Light ; Nanoparticles/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Singlet Oxygen/metabolism ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism
Czasopismo naukowe
Tytuł :
Homogeneous label-free protein binding assay using small-molecule-labeled DNA nanomachine with DNAzyme-Based chemiluminescence detection.
Autorzy :
Zhen Z; Bao'an District Center for Disease Control and Prevention, Shenzhen, 518101, PR China.
Liu JW; State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China.
Wen Q; Department of Food Science and Technology, Central South University of Forestry and Technology, Changsha, 410004, PR China.
Wu Z; Key Laboratory of Phytochemical R&D of Hunan Province, and Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha, 410081, PR China. Electronic address: .
Jiang JH; State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. Electronic address: .
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Źródło :
Talanta [Talanta] 2020 Jan 01; Vol. 206, pp. 120175. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
DNA, Catalytic/*chemistry
Folate Receptors, GPI-Anchored/*metabolism
Folic Acid/*metabolism
Nanostructures/*chemistry
Biosensing Techniques/methods ; Deoxyribonuclease I/chemistry ; Folate Receptors, GPI-Anchored/blood ; Hemin/chemistry ; Humans ; Limit of Detection ; Luminescent Measurements/methods ; Luminol/chemistry ; Proof of Concept Study
Czasopismo naukowe
Tytuł :
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Autorzy :
Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
Tong N; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.
O'Connor C; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
Zhou X; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
Bao X; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
Garcia GE; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.
Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
Kim S; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
Dann CE 3rd; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States. Electronic address: .
Matherly LH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States. Electronic address: .
Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 May 01; Vol. 37, pp. 116093. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Phosphoribosylaminoimidazolecarboxamide Formyltransferase/*antagonists & inhibitors
Phosphoribosylglycinamide Formyltransferase/*antagonists & inhibitors
Pyrimidines/*pharmacology
Thiophenes/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; CHO Cells ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cricetulus ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Folate Receptors, GPI-Anchored/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/metabolism ; Phosphoribosylglycinamide Formyltransferase/metabolism ; Protein Binding ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/metabolism
Czasopismo naukowe
Tytuł :
Preparation of FA-targeted magnetic nanocomposites co-loading TFPI-2 plasmid and cis-platinum and its targeted therapy effects on nasopharyngeal carcinoma.
Autorzy :
Liu F; Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Chen B; Department of Joint Surgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, 341000, China.
Chen W; Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Chen S; Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Ma D; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering,Jinan University, Guangzhou, 510632, China.
Xie M; Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
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Źródło :
International journal of medical sciences [Int J Med Sci] 2021 Apr 09; Vol. 18 (11), pp. 2355-2365. Date of Electronic Publication: 2021 Apr 09 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Cisplatin/*administration & dosage
Drug Carriers/*chemistry
Glycoproteins/*genetics
Nasopharyngeal Carcinoma/*therapy
Nasopharyngeal Neoplasms/*therapy
Animals ; Cell Line, Tumor ; Drug Carriers/pharmacology ; Drug Compounding/methods ; Female ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/chemistry ; Folic Acid/pharmacology ; Humans ; Magnetite Nanoparticles/chemistry ; Mice ; Molecular Targeted Therapy/methods ; Nanocomposites/chemistry ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/pathology ; Plasmids/administration & dosage ; Plasmids/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Final analysis of a phase I/IIa trial of the folate-binding protein-derived E39 peptide vaccine to prevent recurrence in ovarian and endometrial cancer patients.
Autorzy :
Brown TA; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Byrd K; National Capital Consortium Fellowship in Gynecologic Oncology, Walter Reed National Military Medical Center Bethesda, Bethesda, Maryland.
Vreeland TJ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Clifton GT; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Jackson DO; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Hale DF; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Herbert GS; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Myers JW; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Greene JM; Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.
Berry JS; Department of Surgery, Womack Army Medical Center, Fayetteville, North Carolina.
Martin J; Cancer Vaccine Development Program, San Antonio, Texas.
Elkas JC; Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Annandale, Virginia.; Mid-Atlantic Gynecologic Oncology and Pelvic Surgical Associates, Annandale, Virginia.
Conrads TP; National Capital Consortium Fellowship in Gynecologic Oncology, Walter Reed National Military Medical Center Bethesda, Bethesda, Maryland.; Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Annandale, Virginia.; Inova Health System, Inova Schar Cancer Institute, Annandale, Virginia.
Darcy KM; National Capital Consortium Fellowship in Gynecologic Oncology, Walter Reed National Military Medical Center Bethesda, Bethesda, Maryland.
Hamilton CA; National Capital Consortium Fellowship in Gynecologic Oncology, Walter Reed National Military Medical Center Bethesda, Bethesda, Maryland.
Maxwel GL; National Capital Consortium Fellowship in Gynecologic Oncology, Walter Reed National Military Medical Center Bethesda, Bethesda, Maryland.; Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Annandale, Virginia.; Inova Health System, Inova Schar Cancer Institute, Annandale, Virginia.
Peoples GE; Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Annandale, Virginia.
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Źródło :
Cancer medicine [Cancer Med] 2019 Aug; Vol. 8 (10), pp. 4678-4687. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cancer Vaccines/*administration & dosage
Endometrial Neoplasms/*prevention & control
Folate Receptors, GPI-Anchored/*chemistry
Neoplasm Recurrence, Local/*prevention & control
Ovarian Neoplasms/*prevention & control
Vaccines, Subunit/*administration & dosage
Aged ; Cancer Vaccines/immunology ; Dose-Response Relationship, Drug ; Endometrial Neoplasms/immunology ; Female ; Folate Receptors, GPI-Anchored/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; HLA-A2 Antigen/metabolism ; Humans ; Immunization, Secondary ; Middle Aged ; Neoplasm Recurrence, Local/immunology ; Ovarian Neoplasms/immunology ; Prospective Studies ; Survival Analysis ; Treatment Outcome ; Vaccines, Subunit/immunology
Czasopismo naukowe
Tytuł :
Development of Tc-labeled trivalent isonitrile radiotracer for folate receptor imaging.
Autorzy :
Lodhi NA; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH), P. O, Nilore, Islamabad, Pakistan.
Park JY; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hong MK; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim YJ; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lee YS; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Cheon GJ; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jeong JM; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 May 15; Vol. 27 (10), pp. 1925-1931. Date of Electronic Publication: 2019 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Folate Receptors, GPI-Anchored/*metabolism
Nitriles/*chemistry
Radiopharmaceuticals/*chemistry
Animals ; Drug Stability ; Folate Receptors, GPI-Anchored/chemistry ; Humans ; KB Cells ; Mice ; Mice, Nude ; Neoplasms/diagnostic imaging ; Nitriles/blood ; Nitriles/metabolism ; Organotechnetium Compounds/chemistry ; Radiopharmaceuticals/blood ; Radiopharmaceuticals/metabolism ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Enhancement of Binding Affinity of Folate to Its Receptor by Peptide Conjugation.
Autorzy :
Dharmatti R; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .; Department of Computer Science, School of Computing, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan. .
Miyatake H; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
Nandakumar A; Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
Ueda M; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .; Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
Kobayashi K; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
Kiga D; Department of Computer Science, School of Computing, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan. .; Department of Electrical Engineering and Bioscience, Waseda University, 2-2 Wakamatsu Cho, Shinjyuku-ku, Tokyo,162-8480, Japan. .
Yamamura M; Department of Computer Science, School of Computing, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan. .
Ito Y; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .; Department of Computer Science, School of Computing, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan. .; Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 30; Vol. 20 (9). Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Folate Receptors, GPI-Anchored/*metabolism
Folic Acid/*analogs & derivatives
Alkynes/chemistry ; Azides/chemistry ; Click Chemistry/methods ; Cyclooctanes/chemistry ; Folate Receptors, GPI-Anchored/chemistry ; Folic Acid/metabolism ; Molecular Docking Simulation ; Peptides/chemistry ; Phenylalanine/analogs & derivatives ; Phenylalanine/chemistry ; Propanols/chemistry ; Protein Binding
Czasopismo naukowe
Tytuł :
Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor.
Autorzy :
Wang Y; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Chen L; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 2967-2970. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Hypoxia*
Fluorescent Dyes/*metabolism
Neoplasms/*diagnostic imaging
Nitroreductases/*metabolism
Cell Line, Tumor ; Fluorescent Dyes/chemistry ; Folate Receptors, GPI-Anchored/metabolism ; Humans ; Neoplasms/metabolism ; Optical Imaging/methods
Czasopismo naukowe
Tytuł :
A Carrier-Free Folate Receptor-Targeted Ursolic Acid/Methotrexate Nanodelivery System for Synergetic Anticancer Therapy.
Autorzy :
Lan JS; Experiment Center of Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Qin YH; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Liu L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Zeng RF; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Yang Y; Science and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Wang K; Science and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Ding Y; Experiment Center of Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Zhang T; Experiment Center of Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Ho RJY; Department of Pharmaceutics, University of Washington, Seattle, WA, 98195, USA.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Mar 03; Vol. 16, pp. 1775-1787. Date of Electronic Publication: 2021 Mar 03 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*pharmacology
Drug Carriers/*chemistry
Folate Receptors, GPI-Anchored/*metabolism
Methotrexate/*pharmacology
Nanoparticles/*chemistry
Triterpenes/*pharmacology
Animals ; Antineoplastic Agents/administration & dosage ; Cell Death/drug effects ; Cell Survival/drug effects ; Drug Liberation ; Drug Synergism ; Endocytosis/drug effects ; Female ; Folic Acid/chemistry ; Humans ; MCF-7 Cells ; Methotrexate/administration & dosage ; Methotrexate/chemistry ; Mice, Nude ; Nanoparticles/ultrastructure ; Rats, Wistar ; Triterpenes/administration & dosage ; Triterpenes/chemistry
Czasopismo naukowe
Tytuł :
Development of technetium-99m labeled ultrafine gold nanobioconjugates for targeted imaging of folate receptor positive cancers.
Autorzy :
Kumar D; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Sakhare N; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Das S; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Kale P; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Mathur A; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India. Electronic address: .
Mirapurkar S; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Muralidharan S; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Mumbai, India.
Chaudhari P; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Navi Mumbai, India.
Mohanty B; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Navi Mumbai, India.
Ballal A; Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India.
Patro P; Powder Metallurgy Division, Bhabha Atomic Research Centre, Mumbai, India.
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Źródło :
Nuclear medicine and biology [Nucl Med Biol] 2021 Feb; Vol. 93, pp. 1-10. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Folate Receptors, GPI-Anchored/*metabolism
Gold/*chemistry
Molecular Imaging/*methods
Nanostructures/*chemistry
Technetium/*chemistry
Animals ; Cell Line, Tumor ; Female ; Humans ; Isotope Labeling ; Mice ; Technetium/pharmacokinetics ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Detection of membrane receptors on per tumor cell by nonimmobilized cell capillary electrophoresis and a mathematic model.
Autorzy :
Wu R; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Liang C; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Zou J; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Li C; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Yan Y; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Hu X; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Ling X; The State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Jan 15; Vol. 222, pp. 121425. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*
Receptors, Cell Surface*
Electrophoresis, Capillary ; Folate Receptors, GPI-Anchored ; Folic Acid ; Humans ; Models, Theoretical
Czasopismo naukowe
Tytuł :
Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine.
Autorzy :
Halik PK; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Koźmiński P; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Gniazdowska E; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2021 Jan 04; Vol. 18 (1), pp. 33-43. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Methotrexate/*chemistry
Methotrexate/*therapeutic use
Radiopharmaceuticals/*chemistry
Radiopharmaceuticals/*therapeutic use
Antirheumatic Agents/chemistry ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/metabolism ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/metabolism ; Humans ; Nuclear Medicine/methods
Czasopismo naukowe
Tytuł :
Janus-Type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting.
Autorzy :
Villegas MR; Dpto. Química en Ciencias Farmacéuticas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria, Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n. CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain.
Lopez V; Dpto. Química en Ciencias Farmacéuticas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria, Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n. CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain.
Rodríguez-García V; Departamento de Ciencia de los Materiales, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid C/Profesor Aranguren s/n, Madrid, Spain.
Baeza A; Dpto. Materiales y Producción Aeroespacial, ETSI Aeronáutica y del Espacio, Universidad Politécnica de Madrid, Madrid, Spain. .
Vallet-Regí M; Dpto. Química en Ciencias Farmacéuticas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria, Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n. CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2275, pp. 341-361.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Folic Acid/*pharmacology
Mitochondria/*chemistry
Prostatic Neoplasms/*metabolism
Silicon Dioxide/*chemistry
Animals ; Cell Line, Tumor ; Drug Delivery Systems ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/chemistry ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Nanoparticles ; Organophosphorus Compounds/chemistry ; Porosity
Czasopismo naukowe
Tytuł :
Multivalent nanoparticles for personalized theranostics based on tumor receptor distribution behavior.
Autorzy :
Zhang Y; Key Laboratory of Functional Polymer Materials of the Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. .
Cheng M
Cao J
Zhang Y
Yuan Z
Wu Q
Wang W
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Źródło :
Nanoscale [Nanoscale] 2019 Mar 14; Vol. 11 (11), pp. 5005-5013.
Typ publikacji :
Journal Article
MeSH Terms :
Contrast Media/*chemistry
Drug Carriers/*chemistry
Folate Receptors, GPI-Anchored/*metabolism
Magnetite Nanoparticles/*chemistry
Theranostic Nanomedicine/*methods
Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Delivery Systems ; Endocytosis ; Folate Receptors, GPI-Anchored/genetics ; Gene Expression ; Humans ; Magnetic Resonance Imaging ; Mice ; Neoplasms/drug therapy ; Polyethyleneimine/chemistry ; Quinazolines/administration & dosage ; Quinazolines/chemistry ; Quinazolines/pharmacokinetics ; Thiophenes/administration & dosage ; Thiophenes/chemistry ; Thiophenes/pharmacokinetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Interacted mechanism of functional groups in ligand targeted with folate receptor via docking, molecular dynamic and MM/PBSA.
Autorzy :
Jiang Y; School of Science, TianJin ChengJian University, Tianjin, China.
Wang C; School of Science, TianJin ChengJian University, Tianjin, China. Electronic address: .
Zhang M; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
Fei X; School of Science, TianJin ChengJian University, Tianjin, China. Electronic address: .
Gu Y; School of Science, TianJin ChengJian University, Tianjin, China.
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2019 Mar; Vol. 87, pp. 121-128. Date of Electronic Publication: 2018 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Folate Receptors, GPI-Anchored/*chemistry
Folate Receptors, GPI-Anchored/antagonists & inhibitors ; Folic Acid/chemistry ; Ligands ; Molecular Structure ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe

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