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Tytuł :
Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction.
Autorzy :
Shi H; Department of Chemistry, Duke University, Durham, NC, 27710, USA.
Rangadurai A; Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
Abou Assi H; Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA.
Roy R; Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Case DA; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, 08854, USA. .
Herschlag D; Department of Biochemistry, Stanford University, Stanford, CA, 94305, USA. .; Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA. .; ChEM-H Institute, Stanford University, Stanford, CA, 94305, USA. .
Yesselman JD; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA. .
Al-Hashimi HM; Department of Chemistry, Duke University, Durham, NC, 27710, USA. .; Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5531. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
RNA Folding*
Cheminformatics/*methods
HIV-1/*chemistry
RNA, Viral/*ultrastructure
HIV Long Terminal Repeat ; HIV-1/genetics ; HIV-1/ultrastructure ; Models, Chemical ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; RNA, Viral/chemistry ; RNA, Viral/genetics
Czasopismo naukowe
Tytuł :
Synthesis runs counter to directional folding of a nascent protein domain.
Autorzy :
Chen X; CMDB Graduate Program, Johns Hopkins University, Baltimore, MD, USA.
Rajasekaran N; CMDB Graduate Program, Johns Hopkins University, Baltimore, MD, USA.
Liu K; CMDB Graduate Program, Johns Hopkins University, Baltimore, MD, USA.; Molecular Biology Program, Sloan Kettering Institute, New York, NY, USA.
Kaiser CM; Department of Biology, Johns Hopkins University, Baltimore, MD, USA. .; Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 09; Vol. 11 (1), pp. 5096. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
Peptide Elongation Factor G/*biosynthesis
Peptide Elongation Factor G/*chemistry
Luminescence ; Peptide Elongation Factor G/genetics ; Protein Biosynthesis ; Protein Domains ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
RNAthor - fast, accurate normalization, visualization and statistical analysis of RNA probing data resolved by capillary electrophoresis.
Autorzy :
Gumna J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Zok T; Institute of Computing Science, Poznan University of Technology, Poznan, Poland.
Figurski K; Institute of Computing Science, Poznan University of Technology, Poznan, Poland.
Pachulska-Wieczorek K; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Szachniuk M; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.; Institute of Computing Science, Poznan University of Technology, Poznan, Poland.
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Źródło :
PloS one [PLoS One] 2020 Oct 01; Vol. 15 (10), pp. e0239287. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electrophoresis, Capillary*
RNA Folding*
Computational Biology/*methods
RNA/*chemistry
Statistics as Topic/*methods
Internet ; Time Factors
Czasopismo naukowe
Tytuł :
The Lon Protease Links Nucleotide Metabolism with Proteotoxic Stress.
Autorzy :
Zeinert RD; Department of Biochemistry and Molecular Biology, Molecular and Cellular Biology Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Baniasadi H; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Tu BP; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chien P; Department of Biochemistry and Molecular Biology, Molecular and Cellular Biology Program, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Sep 03; Vol. 79 (5), pp. 758-767.e6. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Folding*
Caulobacter crescentus/*metabolism
Nucleotides/*metabolism
Protease La/*metabolism
Bacterial Proteins/metabolism ; Caulobacter crescentus/enzymology ; DNA Transposable Elements ; Dideoxynucleosides/metabolism ; Gene Expression Regulation, Bacterial ; Nucleotide Deaminases/genetics ; Nucleotide Deaminases/metabolism ; Ribonucleotide Reductases/metabolism ; Stress, Physiological ; Transcription Factors/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Introducing Foldit Education Mode.
Autorzy :
Miller JA; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA.
Khatib F; Department of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, MA, USA.
Hammond H; Department of Chemistry & Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
Cooper S; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA.
Horowitz S; Department of Chemistry & Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 769-770.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Education, Distance*
Protein Folding*
Software*
Biochemistry/*education
Proteins/*chemistry
Humans ; Models, Molecular ; Peptides/chemistry ; Protein Conformation ; Video Games
Raport
Tytuł :
A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels.
Autorzy :
Díaz-Franulic I; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile, 2340000; .; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile, 8370146.
Raddatz N; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile, 2340000.
Castillo K; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile, 2340000.
González-Nilo FD; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile, 2340000.; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile, 8370146.
Latorre R; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile, 2340000; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 20298-20304. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Domains*
Protein Folding*
TRPM Cation Channels/*chemistry
Animals ; Cold Temperature ; Cryoelectron Microscopy ; Humans ; Ion Channel Gating ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Oocytes ; Protein Conformation ; TRPM Cation Channels/metabolism ; Thermodynamics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Cotranslational folding cooperativity of contiguous domains of α-spectrin.
Autorzy :
Kemp G; Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.
Nilsson OB; Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.; Department of Clinical Neuroscience, Therapeutic Immune Design Unit, Karolinska Institutet, SE-171 77 Solna, Sweden.
Tian P; Protein Engineering, Novozymes A/S, DK-2880 Bagsvaerd, Denmark.
Best RB; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
von Heijne G; Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden; .; Science for Life Laboratory, Stockholm University, SE-171 21 Solna, Sweden.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 23; Vol. 117 (25), pp. 14119-14126. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
Spectrin/*chemistry
Escherichia coli ; Molecular Dynamics Simulation ; Protein Biosynthesis ; Protein Domains ; Spectrin/genetics ; Spectrin/metabolism
Czasopismo naukowe
Tytuł :
Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway.
Autorzy :
Marshall KE; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK.
Vadukul DM; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK.
Staras K; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK. .
Serpell LC; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (23), pp. 5031-5043. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Folding*/drug effects
Amyloid beta-Peptides/*chemistry
Amyloid beta-Peptides/*metabolism
Endosomes/*metabolism
Lysosomes/*metabolism
Peptide Fragments/*chemistry
Peptide Fragments/*metabolism
Amyloid beta-Peptides/toxicity ; Animals ; Cells, Cultured ; Dynamins/metabolism ; Endocytosis/drug effects ; Endosomes/ultrastructure ; Hydrogen-Ion Concentration ; Lysosomes/drug effects ; Lysosomes/ultrastructure ; Neurons/drug effects ; Neurons/pathology ; Ovalbumin/metabolism ; Peptide Fragments/toxicity ; Rats
Czasopismo naukowe
Tytuł :
Expanding the space of protein geometries by computational design of de novo fold families.
Autorzy :
Pan X; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. .; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, CA, USA.
Thompson MC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
Zhang Y; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
Liu L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA.
Kelly MJS; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Kortemme T; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. .; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507), pp. 1132-1136.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Computer-Aided Design*
Protein Folding*
Protein Structure, Secondary*
Protein Engineering/*methods
Czasopismo naukowe
Tytuł :
Heterogeneous folding and stretched kinetics.
Autorzy :
Bilsel O; Microgradient Fluidics LLC, Worcester, MA 01605; .; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605.; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 18915-18917. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Protein Folding*
Kinetics ; Protein Conformation ; Radiography ; X-Rays
Czasopismo naukowe
Tytuł :
Mechanistic modeling of chromatin folding to understand function.
Autorzy :
Brackey CA; SUPA School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK.
Marenduzzo D; SUPA School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK. .
Gilbert N; MRC Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK. .
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Źródło :
Nature methods [Nat Methods] 2020 Aug; Vol. 17 (8), pp. 767-775. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Computer Simulation*
Models, Chemical*
Protein Folding*
Chromatin/*chemistry
Chromatin/*physiology
Animals
Czasopismo naukowe
Tytuł :
Crystal structure and ligand-induced folding of the SAM/SAH riboswitch.
Autorzy :
Huang L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China.; RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China.; Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Liao TW; Department of Biophysics.
Wang J; Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Ha T; Department of Biophysics.; Department of Biophysics and Biophysical Chemistry.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.; Howard Hughes Medical Institute, Baltimore, MD, USA.
Lilley DMJ; Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 27; Vol. 48 (13), pp. 7545-7556.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
RNA Folding*
Riboswitch*
S-Adenosylhomocysteine/*chemistry
S-Adenosylmethionine/*chemistry
Base Pairing ; Fluorescence Resonance Energy Transfer ; S-Adenosylhomocysteine/metabolism ; S-Adenosylmethionine/metabolism
Czasopismo naukowe
Tytuł :
Crystal structure of an atypical cobalamin riboswitch reveals RNA structural adaptability as basis for promiscuous ligand binding.
Autorzy :
Chan CW; Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.
Mondragón A; Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 27; Vol. 48 (13), pp. 7569-7583.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
RNA Folding*
Riboswitch*
Aptamers, Nucleotide/*chemistry
Cobamides/*chemistry
Vitamin B 12/*chemistry
Bacillus subtilis
Czasopismo naukowe
Tytuł :
Topological constraints of RNA pseudoknotted and loop-kissing motifs: applications to three-dimensional structure prediction.
Autorzy :
Xu X; Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, China.
Chen SJ; Department of Physics, Department of Biochemistry, and Informatics Institute, University of Missouri, Columbia, MO 65211, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 09; Vol. 48 (12), pp. 6503-6512.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Dynamics Simulation*
RNA Folding*
RNA/*chemistry
Nucleotide Motifs
Czasopismo naukowe
Tytuł :
Fast three-color single-molecule FRET using statistical inference.
Autorzy :
Yoo J; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.
Kim JY; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.
Louis JM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.
Gopich IV; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.
Chung HS; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3336. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Algorithms*
Models, Theoretical*
Protein Conformation*
Protein Folding*
Fluorescence Resonance Energy Transfer/*methods
Proteins/*chemistry
Color ; Fluorescence Resonance Energy Transfer/instrumentation ; Fluorescence Resonance Energy Transfer/statistics & numerical data ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/metabolism ; Kinetics ; Microscopy, Confocal ; Photobleaching ; Photons ; Protein Binding ; Proteins/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Structure of a nascent membrane protein as it folds on the BAM complex.
Autorzy :
Tomasek D; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Rawson S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Lee J; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY, USA.
Wzorek JS; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Harrison SC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .; Howard Hughes Medical Institute, Boston, MA, USA. .
Li Z; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .; Howard Hughes Medical Institute, Boston, MA, USA. .
Kahne D; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. .; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. .; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Jul; Vol. 583 (7816), pp. 473-478. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
Bacterial Outer Membrane Proteins/*metabolism
Escherichia coli Proteins/*metabolism
Membrane Proteins/*chemistry
Membrane Proteins/*metabolism
Multiprotein Complexes/*chemistry
Multiprotein Complexes/*metabolism
Bacterial Outer Membrane Proteins/chemistry ; Chloroplasts/chemistry ; Escherichia coli Proteins/chemistry ; Gram-Negative Bacteria/chemistry ; Hydrogen Bonding ; Mitochondria/chemistry ; Models, Molecular ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
BamA is required for autotransporter secretion.
Autorzy :
Ryoo D; Interdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, Atlanta, GA 30332, United States of America.
Rydmark MO; Department of Biosciences, University of Oslo, Oslo, Norway.
Pang YT; School of Physics, Georgia Institute of Technology, Atlanta, GA 30313, United States of America.
Lundquist KP; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States of America.
Linke D; Department of Biosciences, University of Oslo, Oslo, Norway.
Gumbart JC; School of Physics, Georgia Institute of Technology, Atlanta, GA 30313, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2020 Jul; Vol. 1864 (7), pp. 129581. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Molecular*
Protein Folding*
Bacterial Outer Membrane Proteins/*genetics
Escherichia coli Proteins/*genetics
Type V Secretion Systems/*genetics
Bacterial Outer Membrane Proteins/ultrastructure ; Biological Transport/genetics ; Escherichia coli/genetics ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/ultrastructure ; Humans ; Serine Endopeptidases/genetics ; Serine Endopeptidases/ultrastructure
Czasopismo naukowe
Tytuł :
Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Autorzy :
Egbe E; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
Levy CW; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
Tabernero L; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
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Źródło :
PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235133. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Computer Simulation*
Protein Folding*
Protein Tyrosine Phosphatases*/chemistry
Protein Tyrosine Phosphatases*/genetics
Phosphatidylinositols/*chemistry
Catalytic Domain ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Mutually stabilizing interactions between proto-peptides and RNA.
Autorzy :
Frenkel-Pinter M; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; NASA Center for the Origins of Life, Georgia Institute of Technology, Atlanta, GA, USA.
Haynes JW; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Mohyeldin AM; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
C M; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Sargon AB; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Petrov AS; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; NASA Center for the Origins of Life, Georgia Institute of Technology, Atlanta, GA, USA.
Krishnamurthy R; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Hud NV; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA.; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Williams LD; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA. .; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA. .; NASA Center for the Origins of Life, Georgia Institute of Technology, Atlanta, GA, USA. .
Leman LJ; NSF/NASA Center for Chemical Evolution, Atlanta, GA, USA. .; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 19; Vol. 11 (1), pp. 3137. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Evolution, Molecular*
Protein Folding*
RNA Stability*
Peptides/*metabolism
RNA/*metabolism
Amino Acid Sequence ; Aminobutyrates/chemistry ; Aminobutyrates/metabolism ; Cations/chemistry ; Cations/metabolism ; Circular Dichroism ; Hydrolysis ; Nuclear Magnetic Resonance, Biomolecular ; Origin of Life ; Ornithine/chemistry ; Ornithine/metabolism ; Peptides/chemistry ; Protein Stability ; RNA/chemistry ; beta-Alanine/analogs & derivatives ; beta-Alanine/chemistry ; beta-Alanine/metabolism
Czasopismo naukowe
Tytuł :
Disordered proteins follow diverse transition paths as they fold and bind to a partner.
Autorzy :
Kim JY; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chung HS; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Jun 12; Vol. 368 (6496), pp. 1253-1257.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Protein Folding*
Fluorescence Resonance Energy Transfer/*methods
Intrinsically Disordered Proteins/*chemistry
Single Molecule Imaging/*methods
Protein Binding ; Protein Conformation ; Static Electricity
Czasopismo naukowe

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