Temat: "Folic Acid" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3.
Autorzy:: Ren Q; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Zhang G; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Yan R; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Zhou D; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Huang L; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Zhang Q; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Li W; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Huang G; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Li Z; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Yan J; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.; Department of Social Medicine and Health Administration, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 25; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid Deficiency*/metabolism
Rats ; Animals ; Male ; Female ; Animals, Newborn ; bcl-2-Associated X Protein/genetics ; Caspase 3 ; Rats, Sprague-Dawley ; Folic Acid ; Apoptosis/physiology ; S-Adenosylmethionine/metabolism

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Skocz do pozycji: 2.

Tytuł:: Dual-Target Mycobacterium tuberculosis Inhibition: Insights into the Molecular Mechanism of Antifolate Drugs.
Autorzy:: Ramharack P; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Cape Town 7505, South Africa.; Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban 4001, South Africa.
Salifu EY; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Cape Town 7505, South Africa.
Agoni C; Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban 4001, South Africa.; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, D04 V1W8 Belfield, Ireland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 13; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:: Journal Article
MeSH Terms:: Mycobacterium tuberculosis*
Folic Acid Antagonists*/pharmacology
Aspartic Acid ; Catalysis ; Folic Acid

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Skocz do pozycji: 3.

Tytuł:: Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection.
Autorzy:: Bigot S; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.
Leprohon P; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.
Ouellette M; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Jun 29; Vol. 17 (6), pp. e0011458. Date of Electronic Publication: 2023 Jun 29 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Leishmania major*/genetics
Folic Acid Antagonists*/pharmacology
Folic Acid Antagonists*/metabolism
Parasites*/metabolism
Animals ; Methotrexate/pharmacology ; Methotrexate/metabolism ; Drug Resistance/genetics ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism ; Folic Acid/metabolism ; Thymidylate Synthase/genetics

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Skocz do pozycji: 4.

Tytuł:: Folate deficiency among women of reproductive age in Ethiopia: A systematic review and meta-analysis.
Autorzy:: Gebremichael B; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Roba HS; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.; School of Health and Medical Sciences, University of Southern Queensland, Queensland, Australia.
Getachew A; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Tesfaye D; Department of Psychiatry, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Asmerom H; School of Medical Laboratory Science, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 May 08; Vol. 18 (5), pp. e0285281. Date of Electronic Publication: 2023 May 08 (Print Publication: 2023).
Typ publikacji:: Meta-Analysis; Systematic Review; Journal Article
MeSH Terms:: Reproduction*
Folic Acid Deficiency*/epidemiology
Humans ; Female ; Ethiopia/epidemiology ; Cross-Sectional Studies ; Folic Acid ; Prevalence

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Skocz do pozycji: 5.

Tytuł:: Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate.
Autorzy:: Lange K; Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey, United States of America.
Frey KM; School of Pharmacy and Health Sciences, Fairleigh Dickinson University, Florham Park, New Jersey, United States of America.
Eck T; Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey, United States of America.
Janson CA; Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey, United States of America.
Gubler U; Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey, United States of America.
Goodey NM; Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Apr 27; Vol. 17 (4), pp. e0011303. Date of Electronic Publication: 2023 Apr 27 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid Antagonists*/pharmacology
Folic Acid Antagonists*/metabolism
Elephantiasis, Filarial*
Animals ; Wuchereria bancrofti ; Folic Acid ; Tetrahydrofolate Dehydrogenase/metabolism ; NADP ; Molecular Docking Simulation

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Skocz do pozycji: 6.

Tytuł:: Developing Folate-Conjugated miR-34a Therapeutic for Prostate Cancer: Challenges and Promises.
Autorzy:: Li WJ; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA.
Wang Y; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Liu X; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Wu S; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Wang M; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Turowski SG; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Spernyak JA; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Tracz A; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Abdelaal AM; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Sudarshan K; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Puzanov I; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Chatta G; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Kasinski AL; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Tang DG; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
MicroRNAs*/metabolism
MicroRNAs*/therapeutic use
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/genetics
Folic Acid*/pharmacology
Folic Acid*/therapeutic use
Humans ; Male ; Cell Line, Tumor ; Cell Proliferation/genetics ; Folate Receptor 1/genetics ; Folate Receptor 1/metabolism ; Folate Receptor 1/therapeutic use ; Gene Expression Regulation, Neoplastic ; Ligands

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Skocz do pozycji: 7.

Tytuł:: Preconception folic acid supplementation for the prevention of birth defects: a prospective, population-based cohort study in mainland China.
Autorzy:: Zhou Q; Department of Obsterics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
Dong G; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Wang Q; National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, Beijing, China.
Shen H; National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, Beijing, China.
Zhang Y; National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, Beijing, China.
Zhang S; National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, Beijing, China.
Chen J; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. .
Li X; Department of Obsterics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China. .; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China. .; Department of Obsterics, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, 518028, Guangdong, China. .; Pokaż więcej
Źródło:: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2024 Feb 06; Vol. 24 (1), pp. 114. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid*
Neural Tube Defects*/prevention & control
Pregnancy ; Female ; Humans ; Male ; Cohort Studies ; Prospective Studies ; Retrospective Studies ; Dietary Supplements ; China

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Skocz do pozycji: 8.

Tytuł:: Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?
Autorzy:: Wang X; Beijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory, Capital Institute of Pediatrics, Beijing 100020, China.
Yu J; Beijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory, Capital Institute of Pediatrics, Beijing 100020, China.
Wang J; Beijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory, Capital Institute of Pediatrics, Beijing 100020, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 22; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neural Tube Defects*/genetics
Folic Acid Deficiency*/metabolism
Humans ; Folic Acid/metabolism ; DNA Repair/genetics ; DNA ; Genomic Instability

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Skocz do pozycji: 9.

Tytuł:: Redox-Responsive Gold Nanoparticles Coated with Hyaluronic Acid and Folic Acid for Application in Targeting Anticancer Therapy.
Autorzy:: Munderere R; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.; New-Senior Oriented Smart Health Care Education Center (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea.
Gulfam M; Ashland Specialties Ireland Ltd., N91 F6PD Mullingar, Ireland.
Ali I; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Kim SH; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.; New-Senior Oriented Smart Health Care Education Center (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea.
Vu TT; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Park SH; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.; Major of Biomedical Engineering, Division of Smart Healthcare, College of Information Technology and Convergence, Pukyong National University, Busan 48513, Republic of Korea.
Lim KT; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.; Institute of Display Semiconductor Technology, Pukyong National University, Busan 48513, Republic of Korea.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 31; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 31.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid*
Metal Nanoparticles*
Humans ; Gold ; Hyaluronic Acid ; HEK293 Cells ; Methotrexate/pharmacology ; Glutathione

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Skocz do pozycji: 10.

Tytuł:: Mean corpuscular volume as a prognostic factor for 30-day mortality in major trauma patients: a retrospective cohort study.
Autorzy:: Choi H; Department of Surgery, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Lee JY; Deparment of Trauma Surgery, Trauma Center, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea. .; Department of Trauma Surgery, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea. .
Sul Y; Deparment of Trauma Surgery, Trauma Center, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.; Department of Trauma Surgery, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Kim SH; Deparment of Trauma Surgery, Trauma Center, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.
Ye JB; Deparment of Trauma Surgery, Trauma Center, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.
Lee JS; Deparment of Trauma Surgery, Trauma Center, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.
Yoon SY; Department of Cardiovascular and Thoracic Surgery, Trauma Center, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Seok J; Department of Cardiovascular and Thoracic Surgery, Trauma Center, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Choi JH; Department of Anesthesiology and Pain Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 17; Vol. 14 (1), pp. 3951. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:: Journal Article
MeSH Terms:: Anemia*
Anemia, Macrocytic*
Folic Acid Deficiency*
Hypotension*
Male ; Humans ; Female ; Aged ; Erythrocyte Indices ; Retrospective Studies ; Prognosis

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Skocz do pozycji: 11.

Tytuł:: Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice.
Autorzy:: Bennett C; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.; College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.
Green J; Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Ciancio M; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Goral J; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Pitstick L; Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Pytynia M; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Meyer A; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Kwatra N; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.; College of Dental Medicine, Midwestern University, Glendale, AZ, USA.
Jadavji NM; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.; College of Veterinary Medicine, Midwestern University, Glendale, AZ, USA.; Department of Neuroscience, Carleton University, Ottawa, Canada.; Pokaż więcej
Źródło:: Nutritional neuroscience [Nutr Neurosci] 2022 Oct; Vol. 25 (10), pp. 2057-2065. Date of Electronic Publication: 2021 May 27.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid Deficiency*
Acetylcholine/metabolism ; Carbon ; Caspase 3/metabolism ; Diet ; Female ; Folic Acid ; Hippocampus/metabolism ; Humans ; Male

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Skocz do pozycji: 12.

Tytuł:: Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities.
Autorzy:: Kovalev IS; Department of Organic & Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.
Zyryanov GV; Department of Organic & Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.; I. Ya. Postovskiy Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620219 Yekaterinburg, Russia.
Santra S; Department of Organic & Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.
Majee A; Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India.
Varaksin MV; Department of Organic & Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.; I. Ya. Postovskiy Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620219 Yekaterinburg, Russia.
Charushin VN; Department of Organic & Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.; I. Ya. Postovskiy Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620219 Yekaterinburg, Russia.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 22; Vol. 27 (19). Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Folic Acid Antagonists*/pharmacology
Folic Acid Antagonists*/therapeutic use
Antimetabolites ; Folic Acid ; Methotrexate ; Pemetrexed ; Quinazolines ; Thiophenes

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Skocz do pozycji: 13.

Tytuł:: Plasma folate levels in relation to cognitive impairment: a community-based cohort of older adults in China.
Autorzy:: Chen X; School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yang J; Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Zhang H; Human Phenome Institute, Fudan University, Shanghai, China.; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Huang Y; School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Cao Y; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yan S; School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zong G; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Zheng Y; State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
Wang X; Human Phenome Institute, Fudan University, Shanghai, China. .; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. .
Yuan C; School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. .; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. .; Pokaż więcej
Źródło:: European journal of nutrition [Eur J Nutr] 2022 Aug; Vol. 61 (5), pp. 2837-2845. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:: Journal Article
MeSH Terms:: Cognitive Dysfunction*/epidemiology
Folic Acid Deficiency*/epidemiology
Aged ; China/epidemiology ; Cohort Studies ; Female ; Folic Acid ; Humans ; Male ; Middle Aged ; Vitamin B 12

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Skocz do pozycji: 14.

Tytuł:: Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis.
Autorzy:: Zhou D; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Li Z; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Sun Y; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Yan J; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.; Department of Social Medicine and Health Administration, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Huang G; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Li W; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 22; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid Deficiency*/complications
Folic Acid Deficiency*/metabolism
Animals ; Cognition ; Dietary Supplements ; Female ; Folic Acid/metabolism ; Rats ; Telomere/metabolism ; Uracil

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Skocz do pozycji: 15.

Tytuł:: Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
Autorzy:: Krucinska J; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA.
Lombardo MN; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA.
Erlandsen H; Center for Open Research Resources & Equipment (COR2E), University of Connecticut, 91N. Eagleville Rd., Storrs, CT, 06269, USA.
Estrada A; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA.
Si D; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA.
Viswanathan K; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA.
Wright DL; Department of Pharmaceutical Sciences, University of Connecticut, 69N. Eagleville Rd., Storrs, CT, 06269, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2022 May 13; Vol. 5 (1), pp. 459. Date of Electronic Publication: 2022 May 13.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:: Folic Acid Antagonists*/chemistry
Folic Acid Antagonists*/metabolism
Folic Acid Antagonists*/pharmacology
Trimethoprim Resistance*/genetics
Escherichia coli/genetics ; Escherichia coli/metabolism ; Folic Acid/analogs & derivatives ; Plasmids/genetics ; Tetrahydrofolate Dehydrogenase/chemistry ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism

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Skocz do pozycji: 16.

Tytuł:: A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid.
Autorzy:: Ni Y; The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China.
Liu B; The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China.
Zhang W; The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China.
Shi S; The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China.
Deng J; The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China.; Pokaż więcej
Źródło:: Journal of infection in developing countries [J Infect Dev Ctries] 2024 Jan 31; Vol. 18 (1), pp. 168-171. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Folic Acid*
Hemorrhagic Fever with Renal Syndrome*
Male ; Humans ; Adult ; Ferritins ; Vitamin B 12 ; Kidney

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Skocz do pozycji: 17.

Tytuł:: Dietary supplements, guideline alignment and biochemical nutrient status in pregnancy: Findings from the Queensland Family Cohort pilot study.
Autorzy:: Gallo LA; School of Health, University of the Sunshine Coast, Petrie, QLD, Australia.; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.
Steane SE; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.; Mater Research Institute, The University of Queensland, South Brisbane, QLD, Australia.
Young SL; School of Health, University of the Sunshine Coast, Petrie, QLD, Australia.
de Jersey S; Department of Dietetics and Foodservices, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Brisbane, QLD, Australia.; Centre for Health Services Research, The University of Queensland, Herston, QLD, Australia.
Schoenaker DAJM; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS, Southampton, UK.
Borg DJ; Mater Research Institute, The University of Queensland, South Brisbane, QLD, Australia.
Lockett J; Mater Research Institute, The University of Queensland, South Brisbane, QLD, Australia.
Collins CE; School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Perkins AV; School of Health, University of the Sunshine Coast, Petrie, QLD, Australia.
Kumar S; Mater Research Institute, The University of Queensland, South Brisbane, QLD, Australia.
Clifton VL; Mater Research Institute, The University of Queensland, South Brisbane, QLD, Australia.
Wilkinson SA; School of Pharmacy, The University of Queensland, St Lucia, QLD, Australia.; Department of Obstetric Medicine, Mater Mothers Hospital, South Brisbane, QLD, Australia.; Pokaż więcej
Źródło:: Maternal & child nutrition [Matern Child Nutr] 2024 Jan; Vol. 20 (1), pp. e13589. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:: Journal Article; Observational Study
MeSH Terms:: Dietary Supplements*
Folic Acid*
Female ; Humans ; Pregnancy ; Australia ; Iron ; Longitudinal Studies ; Micronutrients ; Nutrients ; Pilot Projects ; Prospective Studies ; Queensland

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Skocz do pozycji: 18.

Tytuł:: Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial.
Autorzy:: Godfrey KM; MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton, NHS Foundation Trust, Southampton, United Kingdom.
Titcombe P; MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.
El-Heis S; MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton, NHS Foundation Trust, Southampton, United Kingdom.
Albert BB; Liggins Institute, University of Auckland, Auckland, New Zealand.
Tham EH; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
Barton SJ; MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.
Kenealy T; Liggins Institute, University of Auckland, Auckland, New Zealand.
Chong MF; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Nield H; MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.
Chong YS; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Chan SY; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Cutfield WS; Liggins Institute, University of Auckland, Auckland, New Zealand.; A Better Start, New Zealand National Science Challenge, Auckland, New Zealand.; Pokaż więcej
Corporate Authors:: NiPPeR Study Group
Źródło:: PLoS medicine [PLoS Med] 2023 Dec 05; Vol. 20 (12), pp. e1004260. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2023).
Typ publikacji:: Randomized Controlled Trial; Journal Article
MeSH Terms:: Folic Acid*
Vitamin B Complex*
Female ; Humans ; Pregnancy ; Cross-Sectional Studies ; Dietary Supplements ; Pregnancy Outcome ; Riboflavin ; Vitamin B 12 ; Vitamin B 6 ; Vitamin D ; Adolescent ; Young Adult ; Adult

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Skocz do pozycji: 19.

Tytuł:: Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors.
Autorzy:: Mahnashi M; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Alshahrani MM; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
Al Ali A; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.
Asiri A; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.
Abou-Salim MA; Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2203879.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
Folic Acid Antagonists*
Neoplasms*
Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Pyrimidines/chemistry ; Molecular Structure ; Cell Proliferation ; Drug Design

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Skocz do pozycji: 20.

Tytuł:: Design, synthesis and antitumor evaluation of novel pyrazolo[3,4- d ]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors.
Autorzy:: Salem IM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Mostafa SM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Salama I; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
El-Sabbagh OI; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hegazy WAH; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.; Pharmacy Program, Department of Pharmaceutical Sciences, Oman College of Health Sciences, Muscat, Oman.
Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 203-215.
Typ publikacji:: Journal Article
MeSH Terms:: Folic Acid Antagonists*
Antineoplastic Agents*/chemistry
Breast Neoplasms*/drug therapy
Humans ; Female ; Pyrimidines/chemistry ; bcl-2-Associated X Protein ; Methotrexate/pharmacology ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Amino Acids ; Structure-Activity Relationship ; Tetrahydrofolate Dehydrogenase/metabolism ; Caspases/metabolism

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