Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Autorzy:
Vissers MFJM; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands. Heuberger JAAC; Centre for Human Drug Research, Leiden, The Netherlands. Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands. Oude Nijhuis J; Department of Neurology and Alzheimer Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. De Deyn PP; Department of Neurology and Alzheimer Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences and Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Hadi S; PRA Health Sciences, Groningen, The Netherlands. Harris J; Denali Therapeutics Inc., South San Francisco, California, USA. Tsai RM; Denali Therapeutics Inc., South San Francisco, California, USA. Cruz-Herranz A; Denali Therapeutics Inc., South San Francisco, California, USA. Huang F; Denali Therapeutics Inc., South San Francisco, California, USA. Tong V; Denali Therapeutics Inc., South San Francisco, California, USA. Erickson R; Denali Therapeutics Inc., South San Francisco, California, USA. Zhu Y; Denali Therapeutics Inc., South San Francisco, California, USA. Scearce-Levie K; Denali Therapeutics Inc., South San Francisco, California, USA. Hsiao-Nakamoto J; Denali Therapeutics Inc., South San Francisco, California, USA. Tang X; Denali Therapeutics Inc., South San Francisco, California, USA. Chang M; Denali Therapeutics Inc., South San Francisco, California, USA. FoxBM; Denali Therapeutics Inc., South San Francisco, California, USA. Estrada AA; Denali Therapeutics Inc., South San Francisco, California, USA. Pomponio RJ; Sanofi Genzyme, Cambridge, Massachusetts, USA. Alonso-Alonso M; Sanofi Genzyme, Cambridge, Massachusetts, USA. Zilberstein M; Sanofi Genzyme, Cambridge, Massachusetts, USA. Atassi N; Sanofi Genzyme, Cambridge, Massachusetts, USA. Troyer MD; Denali Therapeutics Inc., South San Francisco, California, USA. Ho C; Denali Therapeutics Inc., South San Francisco, California, USA.
Early life stress induces dysregulation of the heme pathway in adult mice.
Autorzy:
Pettway YD; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Neder TH; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Ho DH; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. FoxBM; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Burch M; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Colson J; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Liu X; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Kellum CE; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Hyndman KA; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Pollock JS; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Intraventricular metastatic melanoma: A case report and review of the literature.
Autorzy:
Bernstock JD; Department of Neurosurgery Brigham and Women's Hospital Harvard Medical School Boston MA USA. Chagoya G; Department of Neurosurgery The University of Alabama at Birmingham Birmingham AL USA. Elsayed GA; Department of Neurosurgery The University of Alabama at Birmingham Birmingham AL USA. FoxBM; Medical Scientist Training Program The University of Alabama at Birmingham Birmingham AL USA. Mir N; Department of Internal Medicine The University of Alabama at Birmingham Birmingham AL USA. Gupta S; Department of Neurosurgery Brigham and Women's Hospital Harvard Medical School Boston MA USA. Chua M; Department of Neurosurgery Brigham and Women's Hospital Harvard Medical School Boston MA USA. Atchley TJ; Department of Neurosurgery The University of Alabama at Birmingham Birmingham AL USA. Lobbous M; Division of Neuro-Oncology Department of Neurology University of Alabama at Birmingham Birmingham AL USA. Sotoudeh H; Department of Neuroradiology University of Alabama at Birmingham Birmingham AL USA. Hackney J; Department of Pathology University of Alabama at Birmingham Birmingham AL USA. Friedman GK; Division of Pediatric Hematology and Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham AL USA. Harrigan MR; Department of Neurosurgery The University of Alabama at Birmingham Birmingham AL USA.
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Źródło:
Clinical case reports [Clin Case Rep] 2020 Jul 03; Vol. 8 (9), pp. 1757-1764. Date of Electronic Publication: 2020 Jul 03 (Print Publication: 2020).
SUMOylation in Glioblastoma: A Novel Therapeutic Target.
Autorzy:
FoxBM; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. .; Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA. . Janssen A; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. . Estevez-Ordonez D; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. . Gessler F; Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528 Frankfurt, Germany. . Vicario N; Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Via S. Sofia n. 97, Torre Biologica, 95123 Catania, Italy. . Chagoya G; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. . Elsayed G; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. . Sotoudeh H; Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419-619 19th Street South, Birmingham, AL 35223, USA. . Stetler W; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. . Friedman GK; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. .; Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419-619 19th Street South, Birmingham, AL 35223, USA. .; Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Lowder 512, 1600 7th Avenue South, Birmingham, AL 35223, USA. . Bernstock JD; Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. .; Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA. .
Sex-specific alterations in NOS regulation of vascular function in aorta and mesenteric arteries from spontaneously hypertensive rats compared to Wistar Kyoto rats.
Autorzy:
Loria AS; Department of Pharmacology and Nutritional Sciences, University of Kentucky, St. Lexington, Kentucky. Brinson KN; Department of Physiology, Georgia Regents University, Augusta, Georgia. FoxBM; Department of Physiology, Georgia Regents University, Augusta, Georgia. Sullivan JC; Department of Physiology, Georgia Regents University, Augusta, Georgia.
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Źródło:
Physiological reports [Physiol Rep] 2014 Aug 28; Vol. 2 (8). Date of Electronic Publication: 2014 Aug 28 (Print Publication: 2014).
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