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    Wyświetlanie 1-16 z 16
    Tytuł:
    Aptamer Display on Diverse DNA Polyhedron Supports.
    Autorzy:
    Shiu SC; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Fraser LA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. lewis-fraser@hku.hk.
    Ding Y; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Tanner JA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 Jul 11; Vol. 23 (7). Date of Electronic Publication: 2018 Jul 11.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Aptamers, Nucleotide/*chemistry
    DNA/*chemistry
    L-Lactate Dehydrogenase/blood ; L-Lactate Dehydrogenase/metabolism ; Nanostructures/chemistry ; Plasmodium falciparum/enzymology ; Recombinant Proteins/blood ; Recombinant Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1.
    Autorzy:
    Tucker WO; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. .
    Kinghorn AB; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. .
    Fraser LA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. lewis-fraser@hku.hk.
    Cheung YW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. .
    Tanner JA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2018 Mar 07; Vol. 19 (3). Date of Electronic Publication: 2018 Mar 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Protein Interaction Domains and Motifs*
    Aptamers, Nucleotide/*metabolism
    Ubiquitin-Protein Ligases/*metabolism
    Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/genetics ; Base Sequence ; Binding Sites ; Calcification, Physiologic/genetics ; Cell Line ; Core Binding Factor Alpha 1 Subunit/metabolism ; Humans ; Models, Molecular ; Nucleic Acid Conformation ; Osteoblasts/metabolism ; Protein Binding ; Protein Conformation ; Protein Transport ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitination
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Aptamer Bioinformatics.
    Autorzy:
    Kinghorn AB; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
    Fraser LA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
    Lang S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
    Shiu SCC; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
    Tanner JA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2017 Nov 24; Vol. 18 (12). Date of Electronic Publication: 2017 Nov 24.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Aptamers, Nucleotide/*chemistry
    Computational Biology/*methods
    SELEX Aptamer Technique/*methods
    Aptamers, Nucleotide/pharmacology ; Ligands ; Molecular Docking Simulation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection.
    Autorzy:
    Fraser LA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. lewis-fraser@hku.hk.
    Kinghorn AB; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Tang MS; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Cheung YW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Lim B; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Liang S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Dirkzwager RM; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
    Tanner JA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2015 Dec 01; Vol. 20 (12), pp. 21298-312. Date of Electronic Publication: 2015 Dec 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Microspheres*
    Aptamers, Nucleotide/*chemistry
    High-Throughput Screening Assays/*methods
    Oligonucleotides/*chemistry
    SELEX Aptamer Technique/*methods
    Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Patterns of use for brand-name versus generic oral bisphosphonate drugs in Ontario over a 13-year period: a descriptive study.
    Autorzy:
    Fraser LA; Department of Medicine, University of Western Ontario, London, Ont.
    Albaum JM; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont.
    Tadrous M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont.
    Burden AM; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont.
    Shariff SZ; Institute for Clinical and Evaluative Sciences (ICES), London, Ont.
    Cadarette SM; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont. ; Institute for Clinical and Evaluative Sciences (ICES), London, Ont.
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    Źródło:
    CMAJ open [CMAJ Open] 2015 Jan 13; Vol. 3 (1), pp. E91-6. Date of Electronic Publication: 2015 Jan 13 (Print Publication: 2015).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Type 1 diabetes and osteoporosis: from molecular pathways to bone phenotype.
    Autorzy:
    Khan TS; Department of Medicine, Western University, London, ON, Canada.
    Fraser LA; Department of Medicine, Western University, London, ON, Canada ; Division of Endocrinology and Metabolism, St. Joseph's Health Care, 268 Grosvenor Street, London, ON, Canada N6A 4V2.
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    Źródło:
    Journal of osteoporosis [J Osteoporos] 2015; Vol. 2015, pp. 174186. Date of Electronic Publication: 2015 Mar 22.
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Build better bones with exercise: protocol for a feasibility study of a multicenter randomized controlled trial of 12 months of home exercise in women with a vertebral fracture.
    Autorzy:
    Giangregorio LM; L.M. Giangregorio, PhD, Department of Kinesiology, University of Waterloo, 200 University Ave W, Waterloo, Ontario, Canada N2L 3G1; Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada; and Schlegel-UW Research Institute for Aging, Kitchener, Ontario, Canada. .
    Thabane L; L. Thabane, PhD, Clinical Epidemiology and Biostatistics, System Linked Research Unit on Health and Social Service Utilization (SLRU), Population Health Research Institute (PHRI), Hamilton Health Sciences, and Departments of Pediatrics and Anesthesia, McMaster University, Hamilton, Ontario, Canada; and Biostatistics Unit and Centre for Evaluation of Medicines, St Joseph's Healthcare, Hamilton, Ontario, Canada.
    Adachi JD; J.D. Adachi, MD, FRCPC, Department of Medicine, McMaster University.
    Ashe MC; M.C. Ashe, BScPT, PhD, Department of Family Practice, University of British Columbia, and Centre for Hip Health and Mobility, Vancouver, British Columbia, Canada.
    Bleakney RR; R.R. Bleakney, MB, BAO, BCh, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
    Braun EA; E.A. Braun, MD, MSc, FRCPC, FACP, Department of Medicine, McMaster University.
    Cheung AM; A.M. Cheung, MD, PhD, Departments of Medicine and Medical Imaging, University of Toronto.
    Fraser LA; L-A. Fraser, MD, MSc, Department of Medicine, University of Western Ontario.
    Gibbs JC; J.C. Gibbs, PhD, Department of Kinesiology, University of Waterloo.
    Hill KD; K.D. Hill, PhD, School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
    Hodsman AB; A.B. Hodsman, MD, Department of Medicine, University of Western Ontario.
    Kendler DL; D.L. Kendler, MD, FRC(PC), Department of Medicine, University of British Columbia.
    Mittmann N; N. Mittmann, PhD, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
    Prasad S; S. Prasad, MD, FRCP(C), Department of Medicine, McMaster University.
    Scherer SC; S.C. Scherer, MBBS, Broadmeadows Health Service, Northern Health, Melbourne, Australia.
    Wark JD; J.D. Wark, MB, BS, PhD, Department of Medicine and Bone & Mineral Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
    Papaioannou A; A. Papaioannou, MD, MSc, Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University.
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    Źródło:
    Physical therapy [Phys Ther] 2014 Sep; Vol. 94 (9), pp. 1337-52. Date of Electronic Publication: 2014 May 01.
    Typ publikacji:
    Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Exercise Therapy/*methods
    Spinal Fractures/*rehabilitation
    Accidental Falls/prevention & control ; Aged ; Australia ; Canada ; Counseling ; Feasibility Studies ; Female ; Humans ; Pain Measurement ; Patient Compliance ; Pilot Projects ; Quality of Life ; Self Efficacy ; Single-Blind Method ; Surveys and Questionnaires ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Fractures are increased and bisphosphonate use decreased in individuals with insulin-dependent diabetes: a 10 year cohort study.
    Autorzy:
    Fraser LA; Department of Medicine, University of Western Ontario, London, Ontario, Canada. Lisaann.Fraser@sjhc.london.on.ca.
    Papaioannou A
    Adachi JD
    Ma J
    Thabane L
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    Corporate Authors:
    CaMos Research Group
    Źródło:
    BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2014 Jun 11; Vol. 15, pp. 201. Date of Electronic Publication: 2014 Jun 11.
    Typ publikacji:
    Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bone Density Conservation Agents/*therapeutic use
    Diabetes Mellitus, Type 1/*epidemiology
    Diphosphonates/*therapeutic use
    Fractures, Spontaneous/*epidemiology
    Osteoporosis/*epidemiology
    Aged ; Bone Density ; Canada/epidemiology ; Comorbidity ; Female ; Fractures, Spontaneous/etiology ; Fractures, Spontaneous/prevention & control ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Osteoporosis/complications ; Osteoporosis/drug therapy ; Proportional Hazards Models ; Prospective Studies ; Risk ; Surveys and Questionnaires
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Elevated content of cortisol in hair of patients with severe chronic pain: a novel biomarker for stress.
    Autorzy:
    Van Uum SH; Division of Endocrinology and Metabolism, University of Western Ontario, Ontario, Canada. />Sauvé B
    Fraser LA
    Morley-Forster P
    Paul TL
    Koren G
    Pokaż więcej
    Źródło:
    Stress (Amsterdam, Netherlands) [Stress] 2008 Nov; Vol. 11 (6), pp. 483-8.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Biomarkers/*analysis
    Hair/*chemistry
    Hydrocortisone/*analysis
    Pain/*diagnosis
    Stress, Psychological/*metabolism
    Adult ; Analgesics, Opioid/therapeutic use ; Chronic Disease ; Female ; Humans ; Male ; Middle Aged ; Pain/drug therapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-16 z 16

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