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Wyszukujesz frazę ""Frejo MT"" wg kryterium: Autor


Tytuł :
Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Sanjuna J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28041 Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Nov 06. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Oct 15; Vol. 203, pp. 110975. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Basal Forebrain/*drug effects
Cholinergic Neurons/*drug effects
Environmental Pollutants/*toxicity
HSP70 Heat-Shock Proteins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Manganese/*toxicity
Proteasome Endopeptidase Complex/*metabolism
tau Proteins/*metabolism
Animals ; Basal Forebrain/metabolism ; Basal Forebrain/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinergic Neurons/metabolism ; Cholinergic Neurons/pathology ; Dose-Response Relationship, Drug ; Environmental Pollutants/metabolism ; Manganese/metabolism ; Mice ; Oxidative Stress/drug effects
Czasopismo naukowe
Tytuł :
Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28041, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Oct; Vol. 144, pp. 111611. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Muñoz-Calero P; Alborada Foundation, 28690, Brunete, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Jul; Vol. 251, pp. 126426. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorpyrifos/*toxicity
Insecticides/*toxicity
Receptors, Aryl Hydrocarbon/*metabolism
Sterol Esterase/*metabolism
Cell Proliferation/drug effects ; Chlorpyrifos/analogs & derivatives ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1 ; Estrogen Receptor alpha ; Estrogens/pharmacology ; Humans ; MCF-7 Cells ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Feb; Vol. 136, pp. 110961. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Death/*drug effects
Hippocampus/*drug effects
Nerve Tissue Proteins/*metabolism
Neurons/*drug effects
Paraquat/*toxicity
Receptors, Estrogen/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Down-Regulation ; Female ; Herbicides/toxicity ; Hippocampus/metabolism ; Lipid Peroxidation/drug effects ; Pregnancy ; Protein Carbonylation/drug effects ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Proteasome 20S and Rab5 Alteration after 24 h and 14 Days Chlorpyrifos Exposure Lead to β-Amyloid and Tau Protein Level Increases and SN56 Neuronal Cell Death.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia JM; Department of Legal Medicine, Psychiatry and Pathology, Medicine School , Complutense University of Madrid , 28040 Madrid , Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia J; Department of Pharmacology, Health Sciences School , Alfonso X University , 28691 Madrid , Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Oct 21; Vol. 32 (10), pp. 1920-1924. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cell Death/*drug effects
Chlorpyrifos/*pharmacology
Insecticides/*pharmacology
Neurons/*drug effects
Proteasome Endopeptidase Complex/*metabolism
rab5 GTP-Binding Proteins/*biosynthesis
tau Proteins/*metabolism
Animals ; Cell Line ; Mice ; Neurons/pathology
Czasopismo naukowe
Tytuł :
Oxidative stress and cell death induction by amitraz and its metabolite BTS-27271 mediated through cytochrome P450 and NRF2 pathway alteration in primary hippocampal cell.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
Ruiz M; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon Baselga MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Jul; Vol. 129, pp. 87-96. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amidines/*toxicity
Cell Death/*drug effects
Cytochrome P-450 Enzyme System/*metabolism
Hippocampus/*drug effects
Insecticides/*toxicity
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Toluidines/*toxicity
Animals ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cells, Cultured ; Cytochrome P-450 Enzyme System/genetics ; Female ; Gene Expression/drug effects ; Gene Knockdown Techniques ; Hippocampus/cytology ; NF-E2-Related Factor 2/genetics ; Neurons/drug effects ; Pregnancy ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment.
Autorzy :
Moyano P; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Mar; Vol. 125, pp. 583-594. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Basal Forebrain/*drug effects
Cholinergic Neurons/*drug effects
Hydrogen Peroxide/*metabolism
Manganese/*toxicity
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Lipid Peroxidation/drug effects ; Mice ; Oxidative Stress/drug effects ; Protein Carbonylation/drug effects
Czasopismo naukowe
Tytuł :
Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to Aβ and phosphorylated Tau protein generation and cell death.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadón MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Sola E; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pino JD; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Nov; Vol. 121, pp. 297-308. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cadmium/*toxicity
Cell Death/*drug effects
Cholinergic Neurons/*drug effects
Heat-Shock Proteins/*metabolism
tau Proteins/*metabolism
Animals ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinergic Neurons/metabolism ; Gene Expression Regulation/drug effects ; Gene Knockdown Techniques ; Humans ; Mice ; Phosphorus Compounds ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
SN56 neuronal cell death after 24 h and 14 days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2018 Jun 01; Vol. 402-403, pp. 17-27. Date of Electronic Publication: 2018 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*biosynthesis
Chlorpyrifos/*toxicity
Glutamic Acid/*metabolism
Glycogen Synthase Kinase 3 beta/*biosynthesis
Neurons/*metabolism
tau Proteins/*biosynthesis
Animals ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Insecticides/toxicity ; Mice ; Neurons/drug effects ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Time Factors
Czasopismo naukowe

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