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Wyświetlanie 1-6 z 6
Tytuł :
Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Muñoz-Calero P; Alborada Foundation, 28690, Brunete, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Jul; Vol. 251, pp. 126426. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorpyrifos/*toxicity
Insecticides/*toxicity
Receptors, Aryl Hydrocarbon/*metabolism
Sterol Esterase/*metabolism
Cell Proliferation/drug effects ; Chlorpyrifos/analogs & derivatives ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1 ; Estrogen Receptor alpha ; Estrogens/pharmacology ; Humans ; MCF-7 Cells ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Proteasome 20S and Rab5 Alteration after 24 h and 14 Days Chlorpyrifos Exposure Lead to β-Amyloid and Tau Protein Level Increases and SN56 Neuronal Cell Death.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia JM; Department of Legal Medicine, Psychiatry and Pathology, Medicine School , Complutense University of Madrid , 28040 Madrid , Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia J; Department of Pharmacology, Health Sciences School , Alfonso X University , 28691 Madrid , Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Oct 21; Vol. 32 (10), pp. 1920-1924. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cell Death/*drug effects
Chlorpyrifos/*pharmacology
Insecticides/*pharmacology
Neurons/*drug effects
Proteasome Endopeptidase Complex/*metabolism
rab5 GTP-Binding Proteins/*biosynthesis
tau Proteins/*metabolism
Animals ; Cell Line ; Mice ; Neurons/pathology
Czasopismo naukowe
Tytuł :
SN56 neuronal cell death after 24 h and 14 days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2018 Jun 01; Vol. 402-403, pp. 17-27. Date of Electronic Publication: 2018 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*biosynthesis
Chlorpyrifos/*toxicity
Glutamic Acid/*metabolism
Glycogen Synthase Kinase 3 beta/*biosynthesis
Neurons/*metabolism
tau Proteins/*biosynthesis
Animals ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Insecticides/toxicity ; Mice ; Neurons/drug effects ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Time Factors
Czasopismo naukowe
Tytuł :
Toxicogenomic profile of apoptotic and necrotic SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Gómez G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Neurotoxicology and teratology [Neurotoxicol Teratol] 2017 Jan - Feb; Vol. 59, pp. 68-73. Date of Electronic Publication: 2016 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Necrosis*
Toxicogenetics*
Basal Forebrain/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Gene Expression/*drug effects
Acetylcholinesterase/metabolism ; Animals ; Cell Survival/drug effects ; Cells, Cultured ; Insecticides/toxicity ; Mice ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and α7-nAChRs alterations mediated partially by AChE variants disruption.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Gómez G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2016 Apr 15; Vol. 353-354, pp. 48-57. Date of Electronic Publication: 2016 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
Basal Forebrain/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Insecticides/*toxicity
Oxidative Stress/*drug effects
Acetylcholine/metabolism ; Animals ; Basal Forebrain/pathology ; Cell Death/drug effects ; Cell Line ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Gene Knockdown Techniques ; Hydrogen Peroxide/metabolism ; Malondialdehyde/metabolism ; Mice ; Receptor, Nerve Growth Factor/genetics ; Up-Regulation/drug effects ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration.
Autorzy :
del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2015 Oct 02; Vol. 336, pp. 1-9. Date of Electronic Publication: 2015 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*drug effects
Basal Forebrain/*drug effects
Cell Death/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Insecticides/*toxicity
Acetylcholine/analysis ; Animals ; Basal Forebrain/chemistry ; Basal Forebrain/cytology ; Cell Line, Tumor ; Cell Survival/drug effects ; Choline O-Acetyltransferase/drug effects ; Cholinergic Neurons/chemistry ; Mice ; Real-Time Polymerase Chain Reaction ; Synaptic Transmission/drug effects
Czasopismo naukowe
    Wyświetlanie 1-6 z 6

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