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Wyświetlanie 1-5 z 5
Tytuł :
Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Feb; Vol. 136, pp. 110961. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Death/*drug effects
Hippocampus/*drug effects
Nerve Tissue Proteins/*metabolism
Neurons/*drug effects
Paraquat/*toxicity
Receptors, Estrogen/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Down-Regulation ; Female ; Herbicides/toxicity ; Hippocampus/metabolism ; Lipid Peroxidation/drug effects ; Pregnancy ; Protein Carbonylation/drug effects ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Oxidative stress and cell death induction by amitraz and its metabolite BTS-27271 mediated through cytochrome P450 and NRF2 pathway alteration in primary hippocampal cell.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
Ruiz M; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon Baselga MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Jul; Vol. 129, pp. 87-96. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amidines/*toxicity
Cell Death/*drug effects
Cytochrome P-450 Enzyme System/*metabolism
Hippocampus/*drug effects
Insecticides/*toxicity
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Toluidines/*toxicity
Animals ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cells, Cultured ; Cytochrome P-450 Enzyme System/genetics ; Female ; Gene Expression/drug effects ; Gene Knockdown Techniques ; Hippocampus/cytology ; NF-E2-Related Factor 2/genetics ; Neurons/drug effects ; Pregnancy ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz GG; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Diaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Pelayo A; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Sola E; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2017 Sep 01; Vol. 390, pp. 88-99. Date of Electronic Publication: 2017 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholine/*metabolism
Acetylcholinesterase/*metabolism
Glutamic Acid/*metabolism
Herbicides/*toxicity
Hippocampus/*drug effects
Neurons/*drug effects
Paraquat/*toxicity
Synaptic Transmission/*drug effects
Acetylcholinesterase/genetics ; Animals ; Behavior, Animal/drug effects ; Cell Death/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Choline O-Acetyltransferase/genetics ; Choline O-Acetyltransferase/metabolism ; Cognition/drug effects ; Dose-Response Relationship, Drug ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gestational Age ; Glutaminase/genetics ; Glutaminase/metabolism ; Hippocampus/enzymology ; Hippocampus/pathology ; Hippocampus/physiopathology ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Neurons/enzymology ; Neurons/pathology ; Primary Cell Culture ; RNA Interference ; Rats, Wistar ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Baselga MJA; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Capo MA; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2015 Jul 03; Vol. 333, pp. 107-117. Date of Electronic Publication: 2015 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
4-Aminopyridine/*pharmacology
Hippocampus/*drug effects
Kv Channel-Interacting Proteins/*drug effects
Neuroprotective Agents/*pharmacology
Potassium Channel Blockers/*pharmacology
Shal Potassium Channels/*antagonists & inhibitors
Synaptic Transmission/*drug effects
gamma-Aminobutyric Acid/*metabolism
4-Aminopyridine/toxicity ; Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Cytoprotection ; Dose-Response Relationship, Drug ; Hippocampus/embryology ; Hippocampus/metabolism ; Kv Channel-Interacting Proteins/genetics ; Kv Channel-Interacting Proteins/metabolism ; Neuroprotective Agents/toxicity ; Potassium Channel Blockers/toxicity ; Primary Cell Culture ; RNA Interference ; Rats, Wistar ; Semicarbazides/pharmacology ; Shal Potassium Channels/genetics ; Shal Potassium Channels/metabolism ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Baselga MJ; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Neurotoxicology and teratology [Neurotoxicol Teratol] 2015 Jul-Aug; Vol. 50, pp. 82-7. Date of Electronic Publication: 2015 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Glutamates/*analysis
Hippocampus/*drug effects
Pesticide Synergists/*toxicity
Synaptic Transmission/*drug effects
Toluidines/*toxicity
gamma-Aminobutyric Acid/*analysis
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Female ; Glutamate Decarboxylase/genetics ; Hippocampus/chemistry ; Rats, Wistar
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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