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Tytuł :
Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Sanjuna J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28041 Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Nov 06. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Oct 15; Vol. 203, pp. 110975. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Basal Forebrain/*drug effects
Cholinergic Neurons/*drug effects
Environmental Pollutants/*toxicity
HSP70 Heat-Shock Proteins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Manganese/*toxicity
Proteasome Endopeptidase Complex/*metabolism
tau Proteins/*metabolism
Animals ; Basal Forebrain/metabolism ; Basal Forebrain/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinergic Neurons/metabolism ; Cholinergic Neurons/pathology ; Dose-Response Relationship, Drug ; Environmental Pollutants/metabolism ; Manganese/metabolism ; Mice ; Oxidative Stress/drug effects
Czasopismo naukowe
Tytuł :
Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28041, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Oct; Vol. 144, pp. 111611. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Muñoz-Calero P; Alborada Foundation, 28690, Brunete, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Jul; Vol. 251, pp. 126426. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorpyrifos/*toxicity
Insecticides/*toxicity
Receptors, Aryl Hydrocarbon/*metabolism
Sterol Esterase/*metabolism
Cell Proliferation/drug effects ; Chlorpyrifos/analogs & derivatives ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1 ; Estrogen Receptor alpha ; Estrogens/pharmacology ; Humans ; MCF-7 Cells ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Feb; Vol. 136, pp. 110961. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Death/*drug effects
Hippocampus/*drug effects
Nerve Tissue Proteins/*metabolism
Neurons/*drug effects
Paraquat/*toxicity
Receptors, Estrogen/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Down-Regulation ; Female ; Herbicides/toxicity ; Hippocampus/metabolism ; Lipid Peroxidation/drug effects ; Pregnancy ; Protein Carbonylation/drug effects ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Proteasome 20S and Rab5 Alteration after 24 h and 14 Days Chlorpyrifos Exposure Lead to β-Amyloid and Tau Protein Level Increases and SN56 Neuronal Cell Death.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia JM; Department of Legal Medicine, Psychiatry and Pathology, Medicine School , Complutense University of Madrid , 28040 Madrid , Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
Garcia J; Department of Pharmacology, Health Sciences School , Alfonso X University , 28691 Madrid , Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School , Complutense University of Madrid , 28040 Madrid , Spain.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Oct 21; Vol. 32 (10), pp. 1920-1924. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cell Death/*drug effects
Chlorpyrifos/*pharmacology
Insecticides/*pharmacology
Neurons/*drug effects
Proteasome Endopeptidase Complex/*metabolism
rab5 GTP-Binding Proteins/*biosynthesis
tau Proteins/*metabolism
Animals ; Cell Line ; Mice ; Neurons/pathology
Czasopismo naukowe
Tytuł :
Oxidative stress and cell death induction by amitraz and its metabolite BTS-27271 mediated through cytochrome P450 and NRF2 pathway alteration in primary hippocampal cell.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
Ruiz M; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon Baselga MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Jul; Vol. 129, pp. 87-96. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amidines/*toxicity
Cell Death/*drug effects
Cytochrome P-450 Enzyme System/*metabolism
Hippocampus/*drug effects
Insecticides/*toxicity
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Toluidines/*toxicity
Animals ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cells, Cultured ; Cytochrome P-450 Enzyme System/genetics ; Female ; Gene Expression/drug effects ; Gene Knockdown Techniques ; Hippocampus/cytology ; NF-E2-Related Factor 2/genetics ; Neurons/drug effects ; Pregnancy ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment.
Autorzy :
Moyano P; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Mar; Vol. 125, pp. 583-594. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Basal Forebrain/*drug effects
Cholinergic Neurons/*drug effects
Hydrogen Peroxide/*metabolism
Manganese/*toxicity
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Lipid Peroxidation/drug effects ; Mice ; Oxidative Stress/drug effects ; Protein Carbonylation/drug effects
Czasopismo naukowe
Tytuł :
Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to Aβ and phosphorylated Tau protein generation and cell death.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadón MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Sola E; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pino JD; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Nov; Vol. 121, pp. 297-308. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cadmium/*toxicity
Cell Death/*drug effects
Cholinergic Neurons/*drug effects
Heat-Shock Proteins/*metabolism
tau Proteins/*metabolism
Animals ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinergic Neurons/metabolism ; Gene Expression Regulation/drug effects ; Gene Knockdown Techniques ; Humans ; Mice ; Phosphorus Compounds ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
SN56 neuronal cell death after 24 h and 14 days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
García J; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2018 Jun 01; Vol. 402-403, pp. 17-27. Date of Electronic Publication: 2018 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*biosynthesis
Chlorpyrifos/*toxicity
Glutamic Acid/*metabolism
Glycogen Synthase Kinase 3 beta/*biosynthesis
Neurons/*metabolism
tau Proteins/*biosynthesis
Animals ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Insecticides/toxicity ; Mice ; Neurons/drug effects ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Time Factors
Czasopismo naukowe
Tytuł :
Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
de Frias M; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Sola E; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Pelayo A; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2018 Feb 01; Vol. 394, pp. 54-62. Date of Electronic Publication: 2017 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholinesterase/*metabolism
Cadmium Chloride/*toxicity
Cholinergic Neurons/*drug effects
Reactive Oxygen Species/*metabolism
Receptor, Muscarinic M1/*metabolism
Receptor, Muscarinic M2/*metabolism
Animals ; Cell Line ; Cell Survival/drug effects ; Cholinergic Neurons/metabolism ; Cholinergic Neurons/pathology ; Lipid Peroxidation/drug effects ; Memory/drug effects ; Mice ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Oxidative Stress/drug effects ; Prosencephalon/drug effects ; Prosencephalon/metabolism ; Prosencephalon/pathology
Czasopismo naukowe
Tytuł :
Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz GG; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Diaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Pelayo A; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Sola E; Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2017 Sep 01; Vol. 390, pp. 88-99. Date of Electronic Publication: 2017 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholine/*metabolism
Acetylcholinesterase/*metabolism
Glutamic Acid/*metabolism
Herbicides/*toxicity
Hippocampus/*drug effects
Neurons/*drug effects
Paraquat/*toxicity
Synaptic Transmission/*drug effects
Acetylcholinesterase/genetics ; Animals ; Behavior, Animal/drug effects ; Cell Death/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Choline O-Acetyltransferase/genetics ; Choline O-Acetyltransferase/metabolism ; Cognition/drug effects ; Dose-Response Relationship, Drug ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gestational Age ; Glutaminase/genetics ; Glutaminase/metabolism ; Hippocampus/enzymology ; Hippocampus/pathology ; Hippocampus/physiopathology ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Neurons/enzymology ; Neurons/pathology ; Primary Cell Culture ; RNA Interference ; Rats, Wistar ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Ruiz M; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadón MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Labajo-González E; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Chemosphere [Chemosphere] 2017 Aug; Vol. 181, pp. 518-529. Date of Electronic Publication: 2017 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Central Nervous System/*chemistry
Dopamine/*metabolism
Estradiol/*metabolism
Insecticides/*toxicity
Norepinephrine/*metabolism
Serotonin/*metabolism
Toluidines/*pharmacology
Animals ; Brain/drug effects ; Brain/enzymology ; Corpus Striatum/metabolism ; Dopamine/biosynthesis ; Estradiol/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Hippocampus/drug effects ; Hippocampus/enzymology ; Insecticides/pharmacology ; Male ; Neostriatum/drug effects ; Neostriatum/enzymology ; Neurotransmitter Agents/metabolism ; Norepinephrine/biosynthesis ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/enzymology ; Rats ; Serotonin/biosynthesis ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Toxicogenomic profile of apoptotic and necrotic SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure.
Autorzy :
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Gómez G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Neurotoxicology and teratology [Neurotoxicol Teratol] 2017 Jan - Feb; Vol. 59, pp. 68-73. Date of Electronic Publication: 2016 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Necrosis*
Toxicogenetics*
Basal Forebrain/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Gene Expression/*drug effects
Acetylcholinesterase/metabolism ; Animals ; Cell Survival/drug effects ; Cells, Cultured ; Insecticides/toxicity ; Mice ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Zeballos G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz GG; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Lobo M; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2016 Jun 15; Vol. 361-362, pp. 1-11. Date of Electronic Publication: 2016 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*chemistry
Basal Forebrain/*cytology
Cadmium/*toxicity
Cell Death/*drug effects
Neurons/*drug effects
Parasympathetic Nervous System/*cytology
Receptor, Muscarinic M1/*drug effects
Acetylcholinesterase/genetics ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Choline O-Acetyltransferase/genetics ; Choline O-Acetyltransferase/metabolism ; Female ; Gene Silencing ; Genetic Variation ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Muscarinic Antagonists/pharmacology ; Pregnancy ; Rats ; Rats, Wistar ; Receptor, Muscarinic M1/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels.
Autorzy :
Del Pino J; Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain. .
Zeballos G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Anadón MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
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Źródło :
Archives of toxicology [Arch Toxicol] 2016 May; Vol. 90 (5), pp. 1081-92. Date of Electronic Publication: 2015 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Cadmium Chloride/*toxicity
Cholinergic Neurons/*drug effects
Glycogen Synthase Kinase 3 beta/*metabolism
Muscarinic Antagonists/*toxicity
Prosencephalon/*drug effects
Receptor, Muscarinic M1/*drug effects
tau Proteins/*metabolism
Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Cell Death/drug effects ; Cell Line, Tumor ; Cholinergic Neurons/enzymology ; Cholinergic Neurons/pathology ; Dose-Response Relationship, Drug ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Mice ; Phosphorylation ; Prosencephalon/enzymology ; Prosencephalon/pathology ; RNA Interference ; Receptor, Muscarinic M1/genetics ; Receptor, Muscarinic M1/metabolism ; Signal Transduction/drug effects ; Transfection ; Up-Regulation
Czasopismo naukowe
Tytuł :
SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and α7-nAChRs alterations mediated partially by AChE variants disruption.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Gómez G; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2016 Apr 15; Vol. 353-354, pp. 48-57. Date of Electronic Publication: 2016 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
Basal Forebrain/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Insecticides/*toxicity
Oxidative Stress/*drug effects
Acetylcholine/metabolism ; Animals ; Basal Forebrain/pathology ; Cell Death/drug effects ; Cell Line ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Gene Knockdown Techniques ; Hydrogen Peroxide/metabolism ; Malondialdehyde/metabolism ; Mice ; Receptor, Nerve Growth Factor/genetics ; Up-Regulation/drug effects ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration.
Autorzy :
del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Moyano P; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Anadon MJ; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691 Madrid, Spain.
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2015 Oct 02; Vol. 336, pp. 1-9. Date of Electronic Publication: 2015 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*drug effects
Basal Forebrain/*drug effects
Cell Death/*drug effects
Chlorpyrifos/*toxicity
Cholinergic Neurons/*drug effects
Insecticides/*toxicity
Acetylcholine/analysis ; Animals ; Basal Forebrain/chemistry ; Basal Forebrain/cytology ; Cell Line, Tumor ; Cell Survival/drug effects ; Choline O-Acetyltransferase/drug effects ; Cholinergic Neurons/chemistry ; Mice ; Real-Time Polymerase Chain Reaction ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Baselga MJA; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Capo MA; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
García JM; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Toxicology [Toxicology] 2015 Jul 03; Vol. 333, pp. 107-117. Date of Electronic Publication: 2015 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
4-Aminopyridine/*pharmacology
Hippocampus/*drug effects
Kv Channel-Interacting Proteins/*drug effects
Neuroprotective Agents/*pharmacology
Potassium Channel Blockers/*pharmacology
Shal Potassium Channels/*antagonists & inhibitors
Synaptic Transmission/*drug effects
gamma-Aminobutyric Acid/*metabolism
4-Aminopyridine/toxicity ; Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Cytoprotection ; Dose-Response Relationship, Drug ; Hippocampus/embryology ; Hippocampus/metabolism ; Kv Channel-Interacting Proteins/genetics ; Kv Channel-Interacting Proteins/metabolism ; Neuroprotective Agents/toxicity ; Potassium Channel Blockers/toxicity ; Primary Cell Culture ; RNA Interference ; Rats, Wistar ; Semicarbazides/pharmacology ; Shal Potassium Channels/genetics ; Shal Potassium Channels/metabolism ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells.
Autorzy :
Del Pino J; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: .
Frejo MT; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Baselga MJ; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Toxicology and Legal Medicine, Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
Díaz MJ; Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
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Źródło :
Neurotoxicology and teratology [Neurotoxicol Teratol] 2015 Jul-Aug; Vol. 50, pp. 82-7. Date of Electronic Publication: 2015 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Glutamates/*analysis
Hippocampus/*drug effects
Pesticide Synergists/*toxicity
Synaptic Transmission/*drug effects
Toluidines/*toxicity
gamma-Aminobutyric Acid/*analysis
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Female ; Glutamate Decarboxylase/genetics ; Hippocampus/chemistry ; Rats, Wistar
Czasopismo naukowe

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