- Tytuł:
- Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus.
- Autorzy:
- Źródło:
- Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2004 Aug; Vol. 34 (8), pp. 707-22.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Coumarins/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Microsomes, Liver/*enzymology
7-Alkoxycoumarin O-Dealkylase/metabolism ; Adolescent ; Adult ; Aged ; Animals ; Coumarins/chemistry ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP2B1/antagonists & inhibitors ; Cytochrome P-450 CYP2B1/metabolism ; Enzyme Induction/drug effects ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; In Vitro Techniques ; Isoenzymes/metabolism ; Male ; Microsomes, Liver/drug effects ; Middle Aged ; Molecular Probes ; Molecular Structure ; Phenobarbital/pharmacology ; Rats ; Rats, Wistar ; Selegiline/pharmacology ; Substrate Specificity ; beta-Naphthoflavone/pharmacology
Czasopismo naukowe