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Tytuł:
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.
Autorzy:
Diogo D; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America.
Bastarache L; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America.
Liao KP; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Graham RR; ITGR Human Genetics Group, Genentech Inc, San Francisco, California, United States of America.
Fulton RS; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Greenberg JD; New York University Hospital for Joint Diseases, New York, New York, United States of America.
Eyre S; Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Bowes J; Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Cui J; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Lee A; The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Pappas DA; Columbia University, College of Physicians and Surgeons, New York, New York, United States of America.
Kremer JM; The Albany Medical College and The Center for Rheumatology, Albany, New York, United States of America.
Barton A; Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Coenen MJ; Radboud university medical center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
Franke B; Radboud University Medical Center, Donders Centre for Neurosciences, Department of Psychiatry and Human Genetics, Nijmegen, The Netherlands.
Kiemeney LA; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Mariette X; Université Paris-Sud, Orsay, France; APHP-Hôpital Bicêtre, INSERM U1012, Le Kremlin Bicêtre, Paris, France.
Richard-Miceli C; Université Paris-Sud, Orsay, France; APHP-Hôpital Bicêtre, INSERM U1012, Le Kremlin Bicêtre, Paris, France.
Canhão H; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Santa Maria Hospital-CHLN, Lisbon, Portugal.
Fonseca JE; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Santa Maria Hospital-CHLN, Lisbon, Portugal.
de Vries N; Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology, Academic Medical Center /University of Amsterdam, Amsterdam, The Netherlands.
Tak PP; Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology, Academic Medical Center /University of Amsterdam, Amsterdam, The Netherlands.
Crusius JB; Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Nurmohamed MT; Amsterdam Rheumatology and Immunology Center, Department of Rheumatology, Reade, Amsterdam, The Netherlands.
Kurreeman F; Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands.
Mikuls TR; Division of Rheumatology and Immunology, Omaha VA and University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Okada Y; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.
Stahl EA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.
Larson DE; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Deluca TL; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
O'Laughlin M; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Fronick CC; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Fulton LL; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Kosoy R; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America.
Ransom M; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America.
Bhangale TR; ITGR Human Genetics Group, Genentech Inc, San Francisco, California, United States of America.
Ortmann W; ITGR Human Genetics Group, Genentech Inc, San Francisco, California, United States of America.
Cagan A; Information Systems, Partners Healthcare, Charlestown, Massachusetts, United States of America.
Gainer V; Information Systems, Partners Healthcare, Charlestown, Massachusetts, United States of America.
Karlson EW; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Kohane I; Information Systems, Partners Healthcare, Charlestown, Massachusetts, United States of America.
Murphy SN; Information Systems, Partners Healthcare, Charlestown, Massachusetts, United States of America.
Martin J; Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada, 18100, Spain.
Zhernakova A; Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands; Genetics Department, University Medical Center and Groningen University, Groningen, The Netherlands.
Klareskog L; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.
Padyukov L; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.
Worthington J; Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Mardis ER; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Seldin MF; Division of Rheumatology and Immunology, Omaha VA and University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Gregersen PK; The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Behrens T; ITGR Human Genetics Group, Genentech Inc, San Francisco, California, United States of America.
Raychaudhuri S; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America; Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Denny JC; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
Plenge RM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Apr 07; Vol. 10 (4), pp. e0122271. Date of Electronic Publication: 2015 Apr 07 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Pleiotropy*
Polymorphism, Single Nucleotide*
Arthritis, Rheumatoid/*enzymology
Arthritis, Rheumatoid/*genetics
Autoimmunity/*genetics
TYK2 Kinase/*genetics
Cell Adhesion Molecules/genetics ; Electronic Health Records ; Exons/genetics ; Genetic Loci/genetics ; Genetic Predisposition to Disease/genetics ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes.
Autorzy:
Staudová B; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Strouhal M; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Zobaníková M; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Cejková D; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Fulton LL; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Chen L; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Giacani L; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Centurion-Lara A; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Bruisten SM; Public Health Service GGD Amsterdam, Amsterdam, The Netherlands.
Sodergren E; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Weinstock GM; The Genome Institute, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Smajs D; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Nov 06; Vol. 8 (11), pp. e3261. Date of Electronic Publication: 2014 Nov 06 (Print Publication: 2014).
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Bacterial/*genetics
Syphilis/*microbiology
Treponema pallidum/*genetics
Yaws/*microbiology
Base Sequence ; Bosnia and Herzegovina ; Cluster Analysis ; Gene Transfer, Horizontal ; Humans ; Molecular Sequence Data ; Sequence Alignment ; Sequence Analysis, DNA ; Species Specificity ; Synteny ; Treponema pallidum/classification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.
Autorzy:
Hughes AE; Center for Genome Sciences and Systems Biology, Washington University, St. Louis, Missouri, United States of America.
Magrini V; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America.
Demeter R; The Genome Institute, Washington University, St. Louis, Missouri, United States of America.
Miller CA; The Genome Institute, Washington University, St. Louis, Missouri, United States of America.
Fulton R; The Genome Institute, Washington University, St. Louis, Missouri, United States of America.
Fulton LL; The Genome Institute, Washington University, St. Louis, Missouri, United States of America.
Eades WC; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America.
Elliott K; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America.
Heath S; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America.
Westervelt P; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Ding L; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America.
Conrad DF; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America.
White BS; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America.
Shao J; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Link DC; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
DiPersio JF; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Mardis ER; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America.
Wilson RK; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Ley TJ; The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Walter MJ; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America.
Graubert TA; Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2014 Jul 10; Vol. 10 (7), pp. e1004462. Date of Electronic Publication: 2014 Jul 10 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Clone Cells*
Single-Cell Analysis*
Clonal Evolution/*genetics
Leukemia, Myeloid, Acute/*genetics
Adult ; Aged ; Cell Line, Tumor ; Female ; Gene Frequency ; High-Throughput Nucleotide Sequencing ; Humans ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
Autorzy:
Wu G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Diaz AK; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163.
Paugh BS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Rankin SL; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Ju B; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Li Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Zhu X; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Qu C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Zhang J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Easton J; Department of Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN 38105.
Edmonson M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Lu C; The Genome Institute, Washington University, 633108.
Nagahawatte P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Hedlund E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Lin T; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Onar-Thomas A; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Huether R; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Kriwacki R; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Parker M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Gupta P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Becksfort J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Wei L; Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14263.
Mulder HL; Department of Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN 38105.
Boggs K; Department of Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN 38105.
Vadodaria B; Department of Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN 38105.
Yergeau D; Department of Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN 38105.
Russell JC; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Ochoa K; The Genome Institute, Washington University, 633108.
Fulton RS; The Genome Institute, Washington University, 633108.
Fulton LL; The Genome Institute, Washington University, 633108.
Jones C; Division of Molecular Pathology, Institute for Cancer Research, London, UK SM2 5NG.; Division of Cancer Therapeutics, Institute for Cancer Research, London, UK SM2 5NG.
Boop FA; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105.
Broniscer A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Wetmore C; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Gajjar A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Ding L; The Genome Institute, Washington University, 633108.
Mardis ER; The Genome Institute, Washington University, 633108.
Wilson RK; The Genome Institute, Washington University, 633108.
Taylor MR; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Ellison DW; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Baker SJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163.
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Źródło:
Nature genetics [Nat Genet] 2014 May; Vol. 46 (5), pp. 444-450. Date of Electronic Publication: 2014 Apr 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Activin Receptors, Type I/*genetics
Brain Stem Neoplasms/*genetics
Glioma/*genetics
Signal Transduction/*genetics
Animals ; Child ; Cohort Studies ; Computational Biology ; Gene Expression Profiling ; Gene Fusion/genetics ; Humans ; Immunoblotting ; Immunohistochemistry ; Microarray Analysis ; Receptor, trkA/genetics ; Receptor, trkB/genetics ; Receptor, trkC/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis, DNA ; Statistics, Nonparametric ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.
Autorzy:
Parker M; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [3].
Mohankumar KM; 1] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [2].
Punchihewa C; 1] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [2].
Weinlich R; 1] Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [2].
Dalton JD; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Li Y; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Lee R; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Tatevossian RG; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Phoenix TN; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Thiruvenkatam R; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
White E; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Tang B; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Orisme W; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Gupta K; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Rusch M; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Chen X; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Li Y; 1] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [2] Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Nagahawhatte P; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Hedlund E; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Finkelstein D; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Wu G; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Shurtleff S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Easton J; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Boggs K; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Yergeau D; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Vadodaria B; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Mulder HL; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Becksfort J
Gupta P; Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Huether R; Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Ma J; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Song G; St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Gajjar A; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Merchant T; Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Boop F; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Smith AA; MD Anderson Cancer Center Orlando, Pediatric Hematology/Oncology, 92 West Miller MP 318, Orlando, Florida 32806, USA.
Ding L; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [3] Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Lu C; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Ochoa K; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [3] Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Zhao D; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Fulton RS; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Fulton LL; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [3] Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Mardis ER; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [3] Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [4] Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Wilson RK; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [3] Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA [4] Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA.
Downing JR; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Zhang J; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Ellison DW; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Gilbertson RJ; 1] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Pokaż więcej
Źródło:
Nature [Nature] 2014 Feb 27; Vol. 506 (7489), pp. 451-5. Date of Electronic Publication: 2014 Feb 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Transformation, Neoplastic*/genetics
Signal Transduction*
Ependymoma/*genetics
Ependymoma/*metabolism
NF-kappa B/*metabolism
Proteins/*metabolism
Transcription Factor RelA/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Base Sequence ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line ; Cell Nucleus/metabolism ; Chromosomes, Human, Pair 11/genetics ; Ependymoma/pathology ; Female ; Humans ; Mice ; Models, Genetic ; Molecular Sequence Data ; NF-kappa B/genetics ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Proteins/genetics ; Transcription Factor RelA/genetics ; Transcription Factors ; Translocation, Genetic/genetics ; YAP-Signaling Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.
Autorzy:
Service SK; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America.
Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Ramensky V; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America.
Yajnik P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Koboldt DC; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Larson DE; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Zhang Q; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Lin L; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Welch R; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Ding L; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
McLellan MD; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
O'Laughlin M; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Fronick C; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Fulton LL; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Magrini V; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Swift A; Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom ; Faculty of Medicine, St Mary's Campus, Imperial College London, London, United Kingdom.
Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom ; Institute of Health Sciences, University of Oulu, Oulu, Finland ; Biocenter Oulu, University of Oulu, Oulu, Finland ; Unit of Primary Care, Oulu University Hospital, Oulu, Finland ; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Kaakinen M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom ; Institute of Health Sciences, University of Oulu, Oulu, Finland ; Biocenter Oulu, University of Oulu, Oulu, Finland.
McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, United Kingdom ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom ; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Headington, Oxford, United Kingdom.
Peltonen L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland ; The Program for Human and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Pouta A; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland ; Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.
Bonnycastle LL; Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Collins FS; Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Narisu N; Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Tuomilehto J; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Ripatti S; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland ; Hjelt Institute, University of Helsinki, Helsinki, Finland ; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Fulton RS; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Sabatti C; Department of Health and Research Policy, Stanford University, Stanford, California, United States of America.
Wilson RK; The Genome Institute at Washington University, St. Louis, Missouri, United States of America.
Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Freimer NB; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2014 Jan 30; Vol. 10 (1), pp. e1004147. Date of Electronic Publication: 2014 Jan 30 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Quantitative Trait Loci*
Cholesterol/*genetics
Cholesterol, HDL/*genetics
Cholesterol/metabolism ; Cholesterol, HDL/metabolism ; Finland ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Linkage Disequilibrium ; Phenotype ; Population Groups ; White People
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
Autorzy:
Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wu G
Miller CP
Tatevossian RG
Dalton JD
Tang B
Orisme W
Punchihewa C
Parker M
Qaddoumi I
Boop FA
Lu C
Kandoth C
Ding L
Lee R
Huether R
Chen X
Hedlund E
Nagahawatte P
Rusch M
Boggs K
Cheng J
Becksfort J
Ma J
Song G
Li Y
Wei L
Wang J
Shurtleff S
Easton J
Zhao D
Fulton RS
Fulton LL
Dooling DJ
Vadodaria B
Mulder HL
Tang C
Ochoa K
Mullighan CG
Gajjar A
Kriwacki R
Sheer D
Gilbertson RJ
Mardis ER
Wilson RK
Downing JR
Baker SJ
Ellison DW
Pokaż więcej
Corporate Authors:
St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
Źródło:
Nature genetics [Nat Genet] 2013 Jun; Vol. 45 (6), pp. 602-12. Date of Electronic Publication: 2013 Apr 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms/*genetics
Glioma/*genetics
Adolescent ; Animals ; Base Sequence ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Gene Duplication ; Gene Rearrangement ; Genes, myb ; Genome-Wide Association Study ; Glioma/pathology ; Humans ; Infant ; Male ; Mice ; Mice, Nude ; Molecular Sequence Data ; Mutation ; Neoplasm Grading ; Neoplasm Transplantation ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Sequence Analysis, DNA ; Signal Transduction ; Trans-Activators/genetics ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole genome sequence of the Treponema Fribourg-Blanc: unspecified simian isolate is highly similar to the yaws subspecies.
Autorzy:
Zobaníková M; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Strouhal M
Mikalová L
Cejková D
Ambrožová L
Pospíšilová P
Fulton LL
Chen L
Sodergren E
Weinstock GM
Smajs D
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2013 Apr 18; Vol. 7 (4), pp. e2172. Date of Electronic Publication: 2013 Apr 18 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Bacterial/*genetics
Treponema/*genetics
Yaws/*microbiology
Animals ; Humans ; Papio/microbiology ; Treponema/classification ; Treponema/pathogenicity ; Treponemal Infections/microbiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
Autorzy:
Smith JJ; Department of Biology, University of Kentucky, Lexington, Kentucky, USA. />Kuraku S
Holt C
Sauka-Spengler T
Jiang N
Campbell MS
Yandell MD
Manousaki T
Meyer A
Bloom OE
Morgan JR
Buxbaum JD
Sachidanandam R
Sims C
Garruss AS
Cook M
Krumlauf R
Wiedemann LM
Sower SA
Decatur WA
Hall JA
Amemiya CT
Saha NR
Buckley KM
Rast JP
Das S
Hirano M
McCurley N
Guo P
Rohner N
Tabin CJ
Piccinelli P
Elgar G
Ruffier M
Aken BL
Searle SM
Muffato M
Pignatelli M
Herrero J
Jones M
Brown CT
Chung-Davidson YW
Nanlohy KG
Libants SV
Yeh CY
McCauley DW
Langeland JA
Pancer Z
Fritzsch B
de Jong PJ
Zhu B
Fulton LL
Theising B
Flicek P
Bronner ME
Warren WC
Clifton SW
Wilson RK
Li W
Pokaż więcej
Źródło:
Nature genetics [Nat Genet] 2013 Apr; Vol. 45 (4), pp. 415-21, 421e1-2. Date of Electronic Publication: 2013 Feb 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Chromosome Mapping*
Evolution, Molecular*
Genome*
Petromyzon/*genetics
Vertebrates/*genetics
Animals ; Phylogeny ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The genomic landscape of hypodiploid acute lymphoblastic leukemia.
Autorzy:
Holmfeldt L; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wei L
Diaz-Flores E
Walsh M
Zhang J
Ding L
Payne-Turner D
Churchman M
Andersson A
Chen SC
McCastlain K
Becksfort J
Ma J
Wu G
Patel SN
Heatley SL
Phillips LA
Song G
Easton J
Parker M
Chen X
Rusch M
Boggs K
Vadodaria B
Hedlund E
Drenberg C
Baker S
Pei D
Cheng C
Huether R
Lu C
Fulton RS
Fulton LL
Tabib Y
Dooling DJ
Ochoa K
Minden M
Lewis ID
To LB
Marlton P
Roberts AW
Raca G
Stock W
Neale G
Drexler HG
Dickins RA
Ellison DW
Shurtleff SA
Pui CH
Ribeiro RC
Devidas M
Carroll AJ
Heerema NA
Wood B
Borowitz MJ
Gastier-Foster JM
Raimondi SC
Mardis ER
Wilson RK
Downing JR
Hunger SP
Loh ML
Mullighan CG
Pokaż więcej
Źródło:
Nature genetics [Nat Genet] 2013 Mar; Vol. 45 (3), pp. 242-52. Date of Electronic Publication: 2013 Jan 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aneuploidy*
Chromosome Aberrations*
Mutation*
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Animals ; Base Sequence ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Haploidy ; Humans ; Ikaros Transcription Factor/genetics ; Ikaros Transcription Factor/metabolism ; Mice ; Molecular Sequence Data ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Signal Transduction ; Transplantation, Heterologous ; Treatment Outcome ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel mutations target distinct subgroups of medulloblastoma.
Autorzy:
Robinson G; St Jude Children's Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.
Parker M
Kranenburg TA
Lu C
Chen X
Ding L
Phoenix TN
Hedlund E
Wei L
Zhu X
Chalhoub N
Baker SJ
Huether R
Kriwacki R
Curley N
Thiruvenkatam R
Wang J
Wu G
Rusch M
Hong X
Becksfort J
Gupta P
Ma J
Easton J
Vadodaria B
Onar-Thomas A
Lin T
Li S
Pounds S
Paugh S
Zhao D
Kawauchi D
Roussel MF
Finkelstein D
Ellison DW
Lau CC
Bouffet E
Hassall T
Gururangan S
Cohn R
Fulton RS
Fulton LL
Dooling DJ
Ochoa K
Gajjar A
Mardis ER
Wilson RK
Downing JR
Zhang J
Gilbertson RJ
Pokaż więcej
Źródło:
Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 43-8.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*classification
Cerebellar Neoplasms/*genetics
Medulloblastoma/*classification
Medulloblastoma/*genetics
Mutation/*genetics
Animals ; Antigens, CD ; CREB-Binding Protein/genetics ; Cadherins/genetics ; Cdh1 Proteins ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cell Lineage ; Cerebellar Neoplasms/pathology ; Child ; Class I Phosphatidylinositol 3-Kinases ; DEAD-box RNA Helicases/genetics ; DNA Copy Number Variations ; DNA Helicases/genetics ; DNA Mutational Analysis ; Disease Models, Animal ; Genome, Human/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/pathology ; Methylation ; Mice ; Nuclear Proteins/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Autorzy:
Ellis MJ; Department of Internal Medicine, Division of Oncology, Washington University, St Louis, Missouri 63110, USA.
Ding L
Shen D
Luo J
Suman VJ
Wallis JW
Van Tine BA
Hoog J
Goiffon RJ
Goldstein TC
Ng S
Lin L
Crowder R
Snider J
Ballman K
Weber J
Chen K
Koboldt DC
Kandoth C
Schierding WS
McMichael JF
Miller CA
Lu C
Harris CC
McLellan MD
Wendl MC
DeSchryver K
Allred DC
Esserman L
Unzeitig G
Margenthaler J
Babiera GV
Marcom PK
Guenther JM
Leitch M
Hunt K
Olson J
Tao Y
Maher CA
Fulton LL
Fulton RS
Harrison M
Oberkfell B
Du F
Demeter R
Vickery TL
Elhammali A
Piwnica-Worms H
McDonald S
Watson M
Dooling DJ
Ota D
Chang LW
Bose R
Ley TJ
Piwnica-Worms D
Stuart JM
Wilson RK
Mardis ER
Pokaż więcej
Źródło:
Nature [Nature] 2012 Jun 10; Vol. 486 (7403), pp. 353-60. Date of Electronic Publication: 2012 Jun 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aromatase/*metabolism
Aromatase Inhibitors/*therapeutic use
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Genome, Human/*genetics
Anastrozole ; Androstadienes/pharmacology ; Androstadienes/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; DNA Repair ; Exome/genetics ; Exons/genetics ; Female ; Genetic Variation/genetics ; Humans ; Letrozole ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase Kinase 1/genetics ; Mutation/genetics ; Nitriles/pharmacology ; Nitriles/therapeutic use ; Receptors, Estrogen/metabolism ; Treatment Outcome ; Triazoles/pharmacology ; Triazoles/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Autorzy:
Zhang J; Department of Computational Biology and Bioinformatics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Ding L
Holmfeldt L
Wu G
Heatley SL
Payne-Turner D
Easton J
Chen X
Wang J
Rusch M
Lu C
Chen SC
Wei L
Collins-Underwood JR
Ma J
Roberts KG
Pounds SB
Ulyanov A
Becksfort J
Gupta P
Huether R
Kriwacki RW
Parker M
McGoldrick DJ
Zhao D
Alford D
Espy S
Bobba KC
Song G
Pei D
Cheng C
Roberts S
Barbato MI
Campana D
Coustan-Smith E
Shurtleff SA
Raimondi SC
Kleppe M
Cools J
Shimano KA
Hermiston ML
Doulatov S
Eppert K
Laurenti E
Notta F
Dick JE
Basso G
Hunger SP
Loh ML
Devidas M
Wood B
Winter S
Dunsmore KP
Fulton RS
Fulton LL
Hong X
Harris CC
Dooling DJ
Ochoa K
Johnson KJ
Obenauer JC
Evans WE
Pui CH
Naeve CW
Ley TJ
Mardis ER
Wilson RK
Downing JR
Mullighan CG
Pokaż więcej
Źródło:
Nature [Nature] 2012 Jan 11; Vol. 481 (7380), pp. 157-63. Date of Electronic Publication: 2012 Jan 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease/*genetics
Mutation/*genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Age of Onset ; Child ; DNA Copy Number Variations/genetics ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Hematopoiesis/genetics ; Histones/metabolism ; Humans ; Janus Kinases/genetics ; Janus Kinases/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Molecular Sequence Data ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Receptors, Interleukin-7/genetics ; Reelin Protein ; Sequence Analysis, DNA ; Signal Transduction/genetics ; Stem Cells/metabolism ; Stem Cells/pathology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Translocation, Genetic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A novel retinoblastoma therapy from genomic and epigenetic analyses.
Autorzy:
Zhang J; Department of Computational Biology and Bioinformatics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Benavente CA
McEvoy J
Flores-Otero J
Ding L
Chen X
Ulyanov A
Wu G
Wilson M
Wang J
Brennan R
Rusch M
Manning AL
Ma J
Easton J
Shurtleff S
Mullighan C
Pounds S
Mukatira S
Gupta P
Neale G
Zhao D
Lu C
Fulton RS
Fulton LL
Hong X
Dooling DJ
Ochoa K
Naeve C
Dyson NJ
Mardis ER
Bahrami A
Ellison D
Wilson RK
Downing JR
Dyer MA
Pokaż więcej
Źródło:
Nature [Nature] 2012 Jan 11; Vol. 481 (7381), pp. 329-34. Date of Electronic Publication: 2012 Jan 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genomics*
Molecular Targeted Therapy*
Epigenesis, Genetic/*genetics
Protein Kinase Inhibitors/*pharmacology
Retinoblastoma/*drug therapy
Retinoblastoma/*genetics
Aneuploidy ; Animals ; Cell Death/drug effects ; Cell Line ; Cell Survival/drug effects ; Chromosomal Instability/genetics ; Gene Expression Regulation, Neoplastic ; Genes, Retinoblastoma/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mutation/genetics ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Mas ; Retinoblastoma/pathology ; Retinoblastoma Protein/deficiency ; Retinoblastoma Protein/genetics ; Sequence Analysis, DNA ; Syk Kinase ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence.
Autorzy:
Cejková D; Department of Biology, Masaryk University, Brno, Czech Republic.
Zobaníková M
Chen L
Pospíšilová P
Strouhal M
Qin X
Mikalová L
Norris SJ
Muzny DM
Gibbs RA
Fulton LL
Sodergren E
Weinstock GM
Smajs D
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2012 Jan; Vol. 6 (1), pp. e1471. Date of Electronic Publication: 2012 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Genome, Bacterial*
DNA, Bacterial/*chemistry
DNA, Bacterial/*genetics
Syphilis/*microbiology
Treponema pallidum/*genetics
Yaws/*microbiology
Gene Order ; Genetic Variation ; Humans ; Molecular Sequence Data ; Sequence Analysis, DNA ; Synteny ; Treponema pallidum/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 24

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