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Tytuł:
Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway.
Autorzy:
Tajima O; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Fujita Y; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.; Department of Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan.
Ohmi Y; Department of Clinical Engineering, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Furukawa K; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Furukawa K; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.
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Źródło:
PloS one [PLoS One] 2023 Feb 24; Vol. 18 (2), pp. e0281414. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G(M3) Ganglioside*
Insulin Resistance*
Mice ; Animals ; Insulin/metabolism ; Diet, High-Fat ; Signal Transduction ; Gangliosides/metabolism ; Insulin, Regular, Human ; G(M2) Ganglioside
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Homeostatic and pathogenic roles of the GM3 ganglioside.
Autorzy:
Inokuchi JI; Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Core for Medicine and Science Collaborative Research and Education (MS-CORE), Project Research Center for Fundamental Sciences, Osaka University, Japan.
Kanoh H; Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Inamori KI; Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Nagafuku M; Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Nitta T; Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Fukase K; Core for Medicine and Science Collaborative Research and Education (MS-CORE), Project Research Center for Fundamental Sciences, Osaka University, Japan.; Department of Chemistry, Graduate School of Science, Osaka University, Japan.
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Źródło:
The FEBS journal [FEBS J] 2022 Sep; Vol. 289 (17), pp. 5152-5165. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
G(M3) Ganglioside*/chemistry
G(M3) Ganglioside*/metabolism
Insulin Resistance*
Adipose Tissue/metabolism ; Homeostasis ; Humans ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhanced Anti-Atherosclerotic Efficacy of pH-Responsively Releasable Ganglioside GM3 Delivered by Reconstituted High-Density Lipoprotein.
Autorzy:
Rong T; College of Life Sciences, Nanchang University, 999 Xuefu Ave, Honggutan District, Nanchang 330031, China.; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Wei B; College of Life Sciences, Nanchang University, 999 Xuefu Ave, Honggutan District, Nanchang 330031, China.
Ao M; School of Basic Medical Sciences, Jiangxi University of Chinese Medicine, Nanchang 330025, China.
Zhao H; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Li Y; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Zhang Y; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Qin Y; College of Life Sciences, Nanchang University, 999 Xuefu Ave, Honggutan District, Nanchang 330031, China.; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Zhou J; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Zhou F; College of Life Sciences, Nanchang University, 999 Xuefu Ave, Honggutan District, Nanchang 330031, China.; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Chen Y; College of Life Sciences, Nanchang University, 999 Xuefu Ave, Honggutan District, Nanchang 330031, China.; Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Lipoproteins, HDL*
Atherosclerosis/*drug therapy
G(M3) Ganglioside/*pharmacology
Macrophages/*drug effects
Nanoparticles/*chemistry
Plaque, Atherosclerotic/*drug therapy
Animals ; Atherosclerosis/immunology ; Atherosclerosis/metabolism ; Atherosclerosis/prevention & control ; Drug Delivery Systems ; G(M3) Ganglioside/therapeutic use ; Humans ; Hydrogen-Ion Concentration ; Lipid Metabolism ; Macrophages/metabolism ; Male ; Mice ; Mice, Knockout, ApoE ; RAW 264.7 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-coverage targeted lipidomics revealed dramatic lipid compositional changes in asthenozoospermic spermatozoa and inverse correlation of ganglioside GM3 with sperm motility.
Autorzy:
Chen S; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Wang M; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Li L; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Wang J; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Ma X; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Zhang H; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Cai Y; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Kang B; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China.
Huang J; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China. .
Li B; Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an, China. .
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Źródło:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Jul 07; Vol. 19 (1), pp. 105. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Asthenozoospermia/*metabolism
G(M3) Ganglioside/*metabolism
Lipid Metabolism/*physiology
Lipidomics/*methods
Sperm Motility/*physiology
Spermatozoa/*metabolism
Adult ; Asthenozoospermia/diagnosis ; G(M3) Ganglioside/analysis ; Humans ; Lipids/analysis ; Male ; Spermatozoa/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of Gangliosides on Spermatozoa, Oocytes, and Preimplantation Embryos.
Autorzy:
Kim BH; CHA Fertility Center, 5455 Wilshire Blvd. Los Angeles, CA 90036, USA.
Ju WS; Department of Biological Science, College of Natural Sciences, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, Korea.
Kim JS; Primate Resources Center (PRC), Korea Research Institute of Bioscience and Biotechnology, Neongme-gil, Ibam-myeon, Jeongup-si, Jeonvuk 56216, Korea.
Kim SU; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, 30, Yeonggudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do 28116, Korea.
Park SJ; Department of Biological Science, College of Natural Sciences, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, Korea.
Ward SM; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Lyu JH; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Choo YK; Department of Biological Science, College of Natural Sciences, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, Korea.; Institute for Glycoscience, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeollabuk-do 54538, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 22; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Blastocyst/*drug effects
Embryonic Development/*drug effects
G(M3) Ganglioside/*pharmacology
Oocytes/*drug effects
Spermatozoa/*drug effects
Animals ; Apoptosis/drug effects ; Blastocyst/metabolism ; Carbohydrate Sequence ; Female ; G(M3) Ganglioside/chemistry ; G(M3) Ganglioside/metabolism ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aberrant expression of N-glycolyl GM3 ganglioside is associated with the aggressive biological behavior of human sarcomas.
Autorzy:
Pilco-Janeta D; Department of Clinical Oncology, 'Teodoro Maldonado Carbo' Hospital, 26 de Julio Avenue, 090203, Guayaquil, Ecuador. .; Sarcoma Translational Research Laboratory, Vall d'Hebron Institute of Oncology (VHIO), 08035, Barcelona, Spain. .; Department of Clinical Oncology, 'Hermanos Ameijeiras' Clinical and Surgical Hospital, San Lázaro Street N° 701 and Belascoaín, 10400, Havana, Cuba. .
De la Cruz Puebla M; Atlantic Fellows for Equity in Brain Health, University of California, San Francisco (UCSF), Nelson Rising Lane, Suite 190, San Francisco, CA, 94143, USA.
Soriano J; Department of Clinical Oncology, 'Hermanos Ameijeiras' Clinical and Surgical Hospital, San Lázaro Street N° 701 and Belascoaín, 10400, Havana, Cuba.
Osorio M; Clinical Trials Unit, National Institute of Oncology and Radiobiology, 29 and F Street Vedado, 10400, Havana, Cuba.
Caballero I; Department of Clinical Oncology, 'Hermanos Ameijeiras' Clinical and Surgical Hospital, San Lázaro Street N° 701 and Belascoaín, 10400, Havana, Cuba.
Pérez AC; Department of Cell Biology and Tissues Banking, National Institute of Oncology and Radiobiology, 29 and F Street Vedado, 10400, Havana, Cuba.
Savon L; Department of Anatomic Pathology, 'Hermanos Ameijeiras' Clinical and Surgical Hospital, San Lázaro Street N° 701 and Belascoaín, 10400, Havana, Cuba.
Cremades N; Department of Anatomic Pathology, 'Teodoro Maldonado Carbo' Hospital, 26 de Julio Avenue, 090203, Guayaquil, Ecuador.
Blanco R; Laboratory of Recognition and Biological Activity Assays, 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba.
Carr A; Research and Development Direction, 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba.
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Źródło:
BMC cancer [BMC Cancer] 2019 Jun 10; Vol. 19 (1), pp. 556. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
G(M3) Ganglioside/*analogs & derivatives
Sarcoma/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Female ; G(M3) Ganglioside/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Sarcoma/mortality ; Survival Analysis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease.
Autorzy:
Dodge JC; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA. .
Tamsett TJ; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Treleaven CM; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Taksir TV; Translational In Vivo Models, Sanofi, 5 Mountain Road, Framingham, MA, 01701, USA.
Piepenhagen P; Translational In Vivo Models, Sanofi, 5 Mountain Road, Framingham, MA, 01701, USA.
Sardi SP; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Cheng SH; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Shihabuddin LS; Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Feb 01; Vol. 14 (1), pp. 19. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Amyloid beta-Peptides ; Animals ; Disease Models, Animal ; G(M3) Ganglioside ; Glucosyltransferases ; Memory, Long-Term ; Mice ; Mice, Transgenic ; Plaque, Amyloid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Altered Expression of Ganglioside Metabolizing Enzymes Results in GM3 Ganglioside Accumulation in Cerebellar Cells of a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis.
Autorzy:
Somogyi A; Center for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. .
Petcherski A; Center for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. .
Beckert B; Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. .
Huebecker M; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. .
Priestman DA; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. .
Banning A; Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. .
Cotman SL; Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital Research Institute, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. .
Platt FM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. .
Ruonala MO; Center for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. .
Tikkanen R; Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Feb 22; Vol. 19 (2). Date of Electronic Publication: 2018 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebellum/*enzymology
Cerebellum/*pathology
G(M3) Ganglioside/*metabolism
Neuronal Ceroid-Lipofuscinoses/*enzymology
Neuronal Ceroid-Lipofuscinoses/*pathology
Animals ; Cholera Toxin/metabolism ; Disease Models, Animal ; G(M3) Ganglioside/chemistry ; Lysosomes/metabolism ; Membrane Glycoproteins/metabolism ; Mice ; Molecular Chaperones/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Glycation Interferes with the Expression of Sialyltransferases in Meningiomas.
Autorzy:
Selke P; Medical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Bork K; Medical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Zhang T; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Wuhrer M; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Strauss C; Department of Neurosurgery, University Hospital Halle, 06120 Halle (Saale), Germany.
Horstkorte R; Medical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Scheer M; Medical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.; Department of Neurosurgery, University Hospital Halle, 06120 Halle (Saale), Germany.
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Źródło:
Cells [Cells] 2021 Nov 25; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Meningioma/*enzymology
Sialyltransferases/*metabolism
Cell Line, Tumor ; G(M3) Ganglioside/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glycosylation/drug effects ; Humans ; Meningioma/genetics ; N-Acetylneuraminic Acid/biosynthesis ; Pyruvaldehyde/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sialyltransferases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GM3 Ganglioside Linked to Neurofibrillary Pathology in a Transgenic Rat Model for Tauopathy.
Autorzy:
Olešová D; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 84510 Bratislava, Slovakia.; Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, 04181 Kosice, Slovakia.
Majerová P; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 84510 Bratislava, Slovakia.
Hájek R; Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow SK9 4AX, UK.
Piešťanský J; Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, 83232 Bratislava, Slovakia.
Brumarová R; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, I. P. Pavlova 6, 77900 Olomouc, Czech Republic.
Michalicová A; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 84510 Bratislava, Slovakia.
Jurkanin B; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 84510 Bratislava, Slovakia.
Friedecký D; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, I. P. Pavlova 6, 77900 Olomouc, Czech Republic.
Kováč A; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 84510 Bratislava, Slovakia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 22; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
G(M3) Ganglioside/*genetics
Neurofibrils/*genetics
Tauopathies/*genetics
tau Proteins/*genetics
Acidic Glycosphingolipids/genetics ; Acidic Glycosphingolipids/isolation & purification ; Aging/genetics ; Aging/pathology ; Animals ; Animals, Genetically Modified ; Brain/metabolism ; Brain/pathology ; Chromatography, Liquid ; Disease Models, Animal ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects ; Neurofibrils/pathology ; Rats ; Sulfoglycosphingolipids/isolation & purification ; Sulfoglycosphingolipids/metabolism ; Tauopathies/metabolism ; Tauopathies/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glycosphingolipid GM3 is localized in both exoplasmic and cytoplasmic leaflets of Plasmodium falciparum malaria parasite plasma membrane.
Autorzy:
Koudatsu S; Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan.
Masatani T; Transboundary Animal Diseases Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan.; Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Konishi R; Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan.
Asada M; Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, 080-8555, Japan.
Hakimi H; Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, 080-8555, Japan.
Kurokawa Y; Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan.
Tomioku K; Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan.
Kaneko O; Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
Fujita A; Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 21; Vol. 11 (1), pp. 14890. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G(M3) Ganglioside/*metabolism
Plasmodium falciparum/*metabolism
Plasmodium falciparum/*pathogenicity
Cytoplasm/metabolism ; Erythrocyte Membrane/metabolism ; Glycosylphosphatidylinositols/metabolism ; Humans ; Lipid Metabolism ; Membrane Microdomains/metabolism ; Protein Transport ; Virulence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse.
Autorzy:
Paget TL; Mechanisms in Cell Biology and Disease Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Parkinson-Lawrence EJ; Mechanisms in Cell Biology and Disease Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Trim PJ; Proteomics, Metabolomics and MS-Imaging Core Facility, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Autilio C; Department of Biochemistry, Faculty of Biology and Research Institute Hospital 12 de Octubre (Imas12), Complutense University, 28003 Madrid, Spain.
Panchal MH; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Koster G; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Echaide M; Department of Biochemistry, Faculty of Biology and Research Institute Hospital 12 de Octubre (Imas12), Complutense University, 28003 Madrid, Spain.
Snel MF; Proteomics, Metabolomics and MS-Imaging Core Facility, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Postle AD; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Morrison JL; Early Origins Adult Health Research Group, Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Pérez-Gil J; Department of Biochemistry, Faculty of Biology and Research Institute Hospital 12 de Octubre (Imas12), Complutense University, 28003 Madrid, Spain.
Orgeig S; Mechanisms in Cell Biology and Disease Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
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Źródło:
Cells [Cells] 2021 Apr 08; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heparitin Sulfate/*metabolism
Mucopolysaccharidosis III/*metabolism
Pulmonary Alveoli/*metabolism
Pulmonary Surfactants/*metabolism
Animals ; Biophysical Phenomena ; Bronchoalveolar Lavage Fluid ; Cholesterol/metabolism ; Chromatography, Liquid ; G(M3) Ganglioside/metabolism ; Gene Expression Regulation ; Lysophospholipids/metabolism ; Mice, Inbred C57BL ; Monoglycerides/metabolism ; Phospholipids/metabolism ; Reference Standards ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Anti-NeuGcGM3 reactivity: a possible role of natural antibodies and B-1 cells in tumor immunosurveillance.
Autorzy:
Rodriguez-Zhurbenko N; Natural Antibodies Group, Tumor Immunology Division, Center of Molecular Immunology, Havana, Cuba.
Rabade-Chediak M; Chimeric Proteins Group, Immunobiology Division, Center of Molecular Immunology, Havana, Cuba.
Martinez D; Natural Antibodies Group, Tumor Immunology Division, Center of Molecular Immunology, Havana, Cuba.
Griñan T; Natural Antibodies Group, Tumor Immunology Division, Center of Molecular Immunology, Havana, Cuba.
Hernandez AM; Natural Antibodies Group, Tumor Immunology Division, Center of Molecular Immunology, Havana, Cuba.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2015 Dec; Vol. 1362, pp. 224-38. Date of Electronic Publication: 2015 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Autoantibodies/*immunology
B-Lymphocyte Subsets/*immunology
G(M3) Ganglioside/*analogs & derivatives
Hybridomas/*immunology
Immunologic Surveillance/*immunology
Animals ; Autoantibodies/blood ; B-Lymphocyte Subsets/metabolism ; Cell Line, Tumor ; Dogs ; Female ; G(M3) Ganglioside/blood ; G(M3) Ganglioside/immunology ; Horses ; Humans ; Hybridomas/metabolism ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Immunoreactivity of the 14F7 Mab raised against N-Glycolyl GM3 Ganglioside in retinoblastoma tumours.
Autorzy:
Torbidoni AV; Department of Hemato-Oncology, Pediatric Hospital 'Prof. Dr. Juan P. Garrahan', Buenos Aires, Argentina.
Scursoni A; Department of Pathology, Pediatric Hospital 'Prof. Dr. Juan P. Garrahan', Buenos Aires, Argentina.
Camarero S; Department of Pathology, Pediatric Hospital 'Prof. Dr. Juan P. Garrahan', Buenos Aires, Argentina.
Segatori V; Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina.
Gabri M; Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina.
Alonso D; Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina.
Chantada G; Department of Hemato-Oncology, Pediatric Hospital 'Prof. Dr. Juan P. Garrahan', Buenos Aires, Argentina.
de Dávila MT; Department of Pathology, Pediatric Hospital 'Prof. Dr. Juan P. Garrahan', Buenos Aires, Argentina.
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Źródło:
Acta ophthalmologica [Acta Ophthalmol] 2015 Jun; Vol. 93 (4), pp. e294-300. Date of Electronic Publication: 2014 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantigens/*analysis
G(M3) Ganglioside/*analogs & derivatives
Retinal Neoplasms/*chemistry
Retinoblastoma/*chemistry
Antibodies, Monoclonal/immunology ; Cell Line, Tumor ; G(M3) Ganglioside/analysis ; G(M3) Ganglioside/immunology ; Humans ; Immunoenzyme Techniques
Czasopismo naukowe
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Tytuł:
Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways.
Autorzy:
Huang X; Department of Clinical Biochemistry, College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Li Y; Department of Clinical Laboratory, The Second Affiliated Hospital, Dalian, Liaoning 116023, P.R. China.
He X; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Chen Y; Department of Clinical Biochemistry, College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Wei W; Department of Clinical Biochemistry, College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Yang X; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Ma K; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2020 Nov; Vol. 22 (5), pp. 3994-4002. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement/*drug effects
Cell Movement/*genetics
Colonic Neoplasms/*metabolism
G(M2) Ganglioside/*pharmacology
G(M3) Ganglioside/*pharmacology
Kangai-1 Protein/*metabolism
Signal Transduction/*drug effects
Signal Transduction/*genetics
Tyrosine/*metabolism
Cell Line, Tumor ; Colonic Neoplasms/pathology ; Down-Regulation/drug effects ; Down-Regulation/genetics ; ErbB Receptors/metabolism ; Humans ; Kangai-1 Protein/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Phosphorylation/genetics ; Transfection
Czasopismo naukowe
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Tytuł:
Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3.
Autorzy:
Sugawara Y; Laboratory of Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Iwamori M; Department of Biochemistry, Faculty of Science and Technology, Kinki University, Higashi-Osaka, Osaka, Japan.
Matsumura T; Laboratory of Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Yutani M; Laboratory of Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Amatsu S; Laboratory of Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Fujinaga Y; Laboratory of Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
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Źródło:
The FEBS journal [FEBS J] 2015 Sep; Vol. 282 (17), pp. 3334-47. Date of Electronic Publication: 2015 Jul 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Proteins/*metabolism
Clostridium botulinum/*chemistry
G(M3) Ganglioside/*metabolism
Hemagglutinins/*metabolism
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/pharmacology ; Cadherins/genetics ; Cadherins/metabolism ; Carbohydrate Sequence ; Cell Adhesion/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Clostridium botulinum/metabolism ; Dogs ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; G(M3) Ganglioside/chemistry ; Gene Expression ; Hemagglutinins/genetics ; Hemagglutinins/pharmacology ; Madin Darby Canine Kidney Cells ; Mice ; Microarray Analysis ; Molecular Sequence Data ; Protein Binding ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Sialic Acids/chemistry ; Sialic Acids/metabolism ; Sialyltransferases/deficiency ; Sialyltransferases/genetics
Czasopismo naukowe
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Tytuł:
Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling.
Autorzy:
Li Y; Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
Huang X; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Wang C; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
Li Y; Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
Luan M; Department of Microbiology Laboratory, Dalian Center for Disease and Prevention, Dalian, Liaoning 116021, P.R. China.
Ma K; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2015 Apr; Vol. 11 (4), pp. 2959-66. Date of Electronic Publication: 2014 Dec 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement/*drug effects
ErbB Receptors/*metabolism
G(M3) Ganglioside/*pharmacology
Proto-Oncogene Proteins c-met/*metabolism
Signal Transduction/*drug effects
Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Epidermal Growth Factor/pharmacology ; G(M3) Ganglioside/biosynthesis ; Hepatocyte Growth Factor/pharmacology ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; Sialyltransferases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice.
Autorzy:
Nowling TK; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Rodgers J; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Thiyagarajan T; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Wolf B; Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Bruner E; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Sundararaj K; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Molano I; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Gilkeson G; Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Mar 18; Vol. 15 (3), pp. e0230499. Date of Electronic Publication: 2020 Mar 18 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Glycosphingolipids/*metabolism
Lupus Nephritis/*drug therapy
Lupus Nephritis/*metabolism
Animals ; Ceramides/metabolism ; Female ; G(M3) Ganglioside/metabolism ; Kidney/drug effects ; Kidney/metabolism ; Lactosylceramides/metabolism ; Mice ; Mice, Inbred MRL lpr ; Neuraminidase/metabolism ; Oseltamivir/analogs & derivatives ; Oseltamivir/therapeutic use ; Phosphorous Acids/therapeutic use ; Pilot Projects ; Proteinuria/drug therapy ; Proteinuria/metabolism
Czasopismo naukowe
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Tytuł:
Ganglioside GM3 Up-Regulate Chondrogenic Differentiation by Transform Growth Factor Receptors.
Autorzy:
Ryu JS; Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon 35365, Korea.; Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Korea.
Seo SY; Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea.
Jeong EJ; Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea.; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Kim JY; Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon 35365, Korea.; Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Korea.
Koh YG; Center for Stem Cell & Arthritis Research, Department of Orthopaedic Surgery, Yonsei Sarang Hospital, Seoul 06698, Korea.
Kim YI; Department of Stem Cell Research, TJC Life Research and Development Center, TJC Life, Seoul 08512, Korea.
Choo YK; Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 13; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation*
Chondrocytes/*metabolism
G(M3) Ganglioside/*pharmacology
Mesenchymal Stem Cells/*metabolism
Receptors, Transforming Growth Factor beta/*metabolism
Cells, Cultured ; Chondrocytes/cytology ; Chondrogenesis ; Glycosaminoglycans/metabolism ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Signal Transduction ; Smad Proteins/metabolism ; Synovial Membrane/cytology ; Transforming Growth Factor beta/metabolism ; Up-Regulation
Czasopismo naukowe
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Tytuł:
GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells.
Autorzy:
Bedia C; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain. .; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain. .
Badia M; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain.
Muixí L; Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, E-08908, Spain.
Levade T; INSERM UMR 1037, Centre de Recherches en Cancérologie de Toulouse (CRCT), 31037, Toulouse, France.
Tauler R; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain.
Sierra A; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain.; Centre d'Estudis Sanitaris i Socials-CESS, University of Vic - Central University of Catalonia (UVic-UCC), Vic, E-08500, Spain.
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14241. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms/*secondary
Carcinoma/*secondary
G(M2) Activator Protein/*biosynthesis
G(M2) Ganglioside/*analysis
G(M3) Ganglioside/*analysis
Membrane Glycoproteins/*physiology
Neoplasm Proteins/*physiology
Animals ; Brain Neoplasms/metabolism ; Carcinoma/metabolism ; Cell Line, Tumor ; Culture Media, Conditioned/chemistry ; Down-Regulation ; Female ; G(M2) Activator Protein/genetics ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Humans ; Lipidomics ; Lysosomes/metabolism ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/genetics ; Mice ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Triple Negative Breast Neoplasms/pathology ; beta-Hexosaminidase alpha Chain/biosynthesis ; beta-Hexosaminidase alpha Chain/genetics
Czasopismo naukowe
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