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Tytuł :
A novel molecular mechanism responsible for phosphorylation-independent desensitization of G protein-coupled receptors exemplified by the dopamine D 3 receptor.
Autorzy :
Zheng M; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea.
Zhang X; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea.
Sun N; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea.
Min X; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea.
Acharya S; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea.
Kim KM; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju, 61186, Republic of Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jul 30; Vol. 528 (3), pp. 432-439. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Dopamine D3/*metabolism
Receptors, G-Protein-Coupled/*metabolism
G-Protein-Coupled Receptor Kinase 2/antagonists & inhibitors ; G-Protein-Coupled Receptor Kinase 2/genetics ; G-Protein-Coupled Receptor Kinase 2/metabolism ; G-Protein-Coupled Receptor Kinase 3/metabolism ; Gene Knockdown Techniques ; HEK293 Cells ; Heterotrimeric GTP-Binding Proteins/metabolism ; Humans ; Mutation ; Phosphorylation ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Receptors, Dopamine D2/agonists ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/genetics ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction ; Ubiquitination ; beta-Arrestins/metabolism
Czasopismo naukowe
Tytuł :
Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition.
Autorzy :
Maning J; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
McCrink KA; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Pollard CM; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Desimine VL; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Ghandour J; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Perez A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Cora N; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Ferraino KE; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Parker BM; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Brill AR; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Aukszi B; Department of Chemistry and Physics, Halmos College of Natural Sciences and Oceanography, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Lymperopoulos A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 20; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Aldosterone/*metabolism
G-Protein-Coupled Receptor Kinase 2/*metabolism
G-Protein-Coupled Receptor Kinase 5/*metabolism
Myocytes, Cardiac/*metabolism
Receptors, Mineralocorticoid/*metabolism
Animals ; Apoptosis ; Cell Line ; G-Protein-Coupled Receptor Kinase 2/genetics ; G-Protein-Coupled Receptor Kinase 5/genetics ; Models, Biological ; Oxidative Stress ; Phosphorylation ; Protein Binding ; Rats ; Receptors, Adrenergic, beta-2/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
Autorzy :
Komolov KE; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sulon SM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bhardwaj A; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
van Keulen SC; Department of Computer Science, Department of Molecular and Cellular Physiology, Department of Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.
Duc NM; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea; Division of Precision Medicine, Research Institute, National Cancer Center, Goyang, South Korea.
Laurinavichyute DK; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lou HJ; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Turk BE; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Chung KY; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Dror RO; Department of Computer Science, Department of Molecular and Cellular Physiology, Department of Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA; Biophysics Program, Stanford University, Stanford, CA 94305, USA.
Benovic JL; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 323-339.e11. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Calmodulin/*chemistry
G-Protein-Coupled Receptor Kinase 5/*chemistry
Amino Acid Sequence ; Animals ; Baculoviridae/genetics ; Baculoviridae/metabolism ; Binding Sites ; Calmodulin/genetics ; Calmodulin/metabolism ; Cloning, Molecular ; Crystallography, X-Ray ; G-Protein-Coupled Receptor Kinase 5/genetics ; G-Protein-Coupled Receptor Kinase 5/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Phosphorylation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sf9 Cells ; Spodoptera ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects.
Autorzy :
Chaudhari SN; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Harris DA; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aliakbarian H; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Luo JN; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Henke MT; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Subramaniam R; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Vernon AH; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tavakkoli A; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sheu EG; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .
Devlin AS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Jan; Vol. 17 (1), pp. 20-29. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Obesity Agents/*pharmacology
Bariatric Surgery/*methods
Cholic Acid/*pharmacology
Obesity/*surgery
Receptors, G-Protein-Coupled/*genetics
Animals ; Anti-Obesity Agents/metabolism ; Bile/chemistry ; Bile/metabolism ; Caco-2 Cells ; Cholic Acid/biosynthesis ; Colon/metabolism ; Gene Expression Regulation ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/metabolism ; Glucose Tolerance Test ; HEK293 Cells ; Humans ; Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Sulfates
Czasopismo naukowe
Tytuł :
Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling.
Autorzy :
Gopallawa I; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Freund JR; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Lee RJ; Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Ravdin, 5th Floor, Suite A , 3400 Spruce Street, Philadelphia, PA, 19104, USA. .; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (1), pp. 271-286. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Phagocytosis*/drug effects
Signal Transduction*/drug effects
Calcium/*metabolism
Cyclic GMP/*metabolism
Nitric Oxide/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Cell Communication ; Cells, Cultured ; Coculture Techniques ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Pertussis Toxin/pharmacology ; Physostigmine/analogs & derivatives ; Physostigmine/pharmacology ; Quinolones/pharmacology ; Receptors, G-Protein-Coupled/agonists
Czasopismo naukowe
Tytuł :
Carboxy-Terminal Phosphoregulation of the Long Splice Isoform of Free-Fatty Acid Receptor-4 Mediates β -Arrestin Recruitment and Signaling to ERK1/2.
Autorzy :
Senatorov IS; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, Atlanta, Georgia.
Cheshmehkani A; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, Atlanta, Georgia.
Burns RN; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, Atlanta, Georgia.
Singh K; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, Atlanta, Georgia.
Moniri NH; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, Atlanta, Georgia .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 May; Vol. 97 (5), pp. 304-313. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*/drug effects
MAP Kinase Signaling System*/drug effects
Extracellular Signal-Regulated MAP Kinases/*metabolism
Receptors, G-Protein-Coupled/*chemistry
Receptors, G-Protein-Coupled/*metabolism
beta-Arrestin 2/*metabolism
Amino Acid Sequence ; Docosahexaenoic Acids/pharmacology ; G-Protein-Coupled Receptor Kinases/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; HEK293 Cells ; Humans ; Phosphorylation/drug effects ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Kinase C/metabolism ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation.
Autorzy :
Yang L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Lei XT; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
Huang Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Wang T; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. Electronic address: .
Sun HB; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China. Electronic address: .
Wang HY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119029. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Secretion*/drug effects
Inflammation/*pathology
Receptors, G-Protein-Coupled/*agonists
Adipose Tissue/pathology ; Animals ; Chronic Disease ; Glucagon-Like Peptide 1/metabolism ; Glucose/pharmacology ; Inflammation/blood ; Insulin Resistance ; Lipopolysaccharides/pharmacology ; Liver/pathology ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
Umami-enhancing effect of typical kokumi-active γ-glutamyl peptides evaluated via sensory analysis and molecular modeling approaches.
Autorzy :
Yang J; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Huang Y; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Cui C; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Dong H; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zeng X; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
Bai W; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Feb 15; Vol. 338, pp. 128018. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Taste*/drug effects
Dipeptides/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Sodium Glutamate/*metabolism
Adult ; Amino Acids/chemistry ; Amino Acids/metabolism ; Dipeptides/chemistry ; Female ; Flavoring Agents/chemistry ; Flavoring Agents/pharmacology ; Humans ; Hydrogen Bonding ; Male ; Middle Aged ; Models, Molecular ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/chemistry ; Sodium Glutamate/chemistry ; Sodium Glutamate/pharmacology
Czasopismo naukowe
Tytuł :
EJE AWARD 2020: Signalling by G protein-coupled receptors: why space and time matter.
Autorzy :
Calebiro D; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK.
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Źródło :
European journal of endocrinology [Eur J Endocrinol] 2021 Feb; Vol. 184 (2), pp. R41-R49.
Typ publikacji :
Historical Article; Journal Article; Review
MeSH Terms :
Receptors, G-Protein-Coupled/*physiology
Animals ; Awards and Prizes ; Endocrinology/organization & administration ; Endocrinology/standards ; Endocrinology/trends ; GTP-Binding Proteins/metabolism ; GTP-Binding Proteins/physiology ; History, 21st Century ; Humans ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology ; Time Factors ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.
Autorzy :
Rasul F; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Zheng F; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Dong F; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
He J; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Liu L; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Liu W; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Cheema JY; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China.
Wei W; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China. .
Fu C; Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 521. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Binding Proteins/*metabolism
Endoplasmic Reticulum/*metabolism
Mitochondria/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Binding Sites/genetics ; Calcium-Binding Proteins/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mutation ; Protein Binding ; Receptors, G-Protein-Coupled/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
Autorzy :
Erfinanda L; Institute of Physiology, Charité - Universitätsmedizin, Berlin, Germany.
Ravindran K; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
Kohse F; Institute of Physiology, Charité - Universitätsmedizin, Berlin, Germany.; Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.
Gallo K; Institute of Physiology, Charité - Universitätsmedizin, Berlin, Germany.
Preissner R; Institute of Physiology, Charité - Universitätsmedizin, Berlin, Germany.
Walther T; Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany .; Dept of Pharmacology and Therapeutics, School of Medicine, University College Cork, Cork, Ireland.; Shared senior authorship.
Kuebler WM; Institute of Physiology, Charité - Universitätsmedizin, Berlin, Germany.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.; Dept of Physiology and Dept of Surgery, University of Toronto, Toronto, ON, Canada.; Shared senior authorship.
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Źródło :
The European respiratory journal [Eur Respir J] 2021 Jan 21; Vol. 57 (1). Date of Electronic Publication: 2021 Jan 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Lung Injury/*genetics
Angiotensin I/*metabolism
COVID-19/*epidemiology
Capillary Permeability/*genetics
Endothelium, Vascular/*metabolism
Estrogens/*metabolism
Lung/*metabolism
Peptide Fragments/*metabolism
Proto-Oncogene Proteins/*genetics
Receptors, G-Protein-Coupled/*genetics
Respiratory Distress Syndrome/*epidemiology
Acute Lung Injury/metabolism ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angiotensin I/pharmacology ; Angiotensin-Converting Enzyme 2 ; Animals ; Capillary Permeability/drug effects ; Child ; Electric Impedance ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Estradiol/pharmacology ; Female ; Humans ; In Vitro Techniques ; Lung/drug effects ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Ovariectomy ; Peptide Fragments/pharmacology ; Platelet Activating Factor/pharmacology ; Proto-Oncogene Proteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; SARS-CoV-2 ; Sex Distribution ; Sex Factors ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł :
Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells.
Autorzy :
Liang F; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China. Electronic address: .
Zhang H; Department of Urology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Cheng D; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Gao H; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Wang J; Department of Urology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Yue J; Department of Urology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Zhang N; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Wang J; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Wang Z; Department of Urology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
Zhao B; Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou Central Hospital, Zhengzhou, China.
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118737. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*radiotherapy
Receptors, G-Protein-Coupled/*metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism ; Humans ; Male ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Radiation Tolerance ; Receptors, Androgen/genetics ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/genetics ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
GPER1 is required to protect fetal health from maternal inflammation.
Autorzy :
Harding AT; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Goff MA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Froggatt HM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Heaton NS; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA. .; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 15; Vol. 371 (6526), pp. 271-276.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Fetal Diseases/*immunology
Inflammation/*immunology
Maternal-Fetal Exchange/*immunology
Pregnancy Complications, Infectious/*immunology
Receptors, Estrogen/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Animals ; Benzodioxoles/pharmacology ; CRISPR-Cas Systems ; Female ; Fetal Diseases/virology ; Fetus/immunology ; Fetus/virology ; Humans ; Influenza A virus/immunology ; Influenza, Human/immunology ; Interferon Type I/immunology ; Mice ; Mice, Inbred C57BL ; Placenta/immunology ; Placenta/virology ; Pregnancy ; Quinolines/pharmacology ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, G-Protein-Coupled/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice.
Autorzy :
Lu Z; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.
Li Y; Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina.
Syn WK; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.; Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, Euskal Herriko Unibertsitatea/Universidad del País Vasco, Leioa, Spain.
Li AJ; Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Ritter WS; Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Wank SA; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Lopes-Virella MF; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.; Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina.
Huang Y; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.; Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Jan 01; Vol. 320 (1), pp. E30-E42. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CD36 Antigens/*biosynthesis
Fatty Liver/*metabolism
Liver/*metabolism
Receptors, G-Protein-Coupled/*deficiency
Animals ; Body Weight ; CD36 Antigens/genetics ; Diet, High-Fat ; Dyslipidemias/genetics ; Fatty Liver/pathology ; Hepatitis/metabolism ; Hepatitis/pathology ; Insulin Resistance/genetics ; Liver/pathology ; Liver Function Tests ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Receptors, G-Protein-Coupled/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1.
Autorzy :
Gohar EY; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama (E.Y.G, D.M.P); and Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (E.Y.G) .
Pollock DM; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama (E.Y.G, D.M.P); and Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (E.Y.G).
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Jan; Vol. 376 (1), pp. 98-105. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Natriuresis*
Receptor, Endothelin A/*metabolism
Receptor, Endothelin B/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Animals ; Atrasentan/pharmacology ; Endothelin Receptor Antagonists/pharmacology ; Female ; Kidney Medulla/drug effects ; Kidney Medulla/metabolism ; Pyrrolidines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/agonists
Czasopismo naukowe
Tytuł :
Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.
Autorzy :
Van Doren L; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).
Nguyen N; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).
Garzia C; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).
Fletcher EK; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).
Stevenson R; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).
Jaramillo D
Kuliopulos A; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).; Departments of Medicine (L.C., A.K.), Tufts University School of Medicine, Boston, MA.; Biochemistry (L.C., A.K.), Tufts University School of Medicine, Boston, MA.
Covic L; Division of Hematology/Oncology, Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Boston, MA (L.V.D., N.N., C.G., E.K.F., R.S., L.C., A.K.).; Departments of Medicine (L.C., A.K.), Tufts University School of Medicine, Boston, MA.; Biochemistry (L.C., A.K.), Tufts University School of Medicine, Boston, MA.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jan; Vol. 41 (1), pp. e33-e45. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hemostasis*
Platelet Aggregation*/drug effects
Blood Platelets/*metabolism
Carotid Artery Thrombosis/*blood
Receptors, G-Protein-Coupled/*blood
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/blood ; Animals ; CHO Cells ; Carotid Artery Thrombosis/prevention & control ; Cricetulus ; Disease Models, Animal ; Female ; Fibrinolytic Agents/pharmacology ; GTP-Binding Protein alpha Subunits, Gi-Go/blood ; Humans ; Male ; Platelet Aggregation Inhibitors/pharmacology ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, Thrombin/blood ; Signal Transduction ; Thrombin/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms of adhesion G protein-coupled receptor activation.
Autorzy :
Vizurraga A; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Adhikari R; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Yeung J; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Yu M; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Tall GG; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 09; Vol. 295 (41), pp. 14065-14083. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cell Membrane*/chemistry
Cell Membrane*/genetics
Cell Membrane*/metabolism
Models, Biological*
Receptors, G-Protein-Coupled*/chemistry
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*
Animals ; Cell Adhesion ; Humans ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity.
Autorzy :
Sánchez-Rodríguez I; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Djebari S; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Temprano-Carazo S; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Vega-Avelaira D; Departamento de Ciencias Biomédicas Básicas, European University of Madrid, Madrid, Spain.
Jiménez-Herrera R; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Iborra-Lázaro G; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Yajeya J; Instituto de Neurociencias de Castilla y León, University of Salamanca, Salamanca, Spain.
Jiménez-Díaz L; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Navarro-López JD; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 May; Vol. 153 (3), pp. 362-376. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloidosis/*metabolism
Excitatory Postsynaptic Potentials/*physiology
G Protein-Coupled Inwardly-Rectifying Potassium Channels/*metabolism
Hippocampus/*metabolism
Long-Term Synaptic Depression/*physiology
Memory Disorders/*metabolism
Amyloid beta-Peptides/toxicity ; Amyloidosis/chemically induced ; Animals ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/drug effects ; Long-Term Synaptic Depression/drug effects ; Male ; Memory Disorders/chemically induced ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Peptide Fragments/toxicity ; Potassium Channels, Inwardly Rectifying/metabolism ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling.
Autorzy :
Jang W; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Adams CE; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Liu H; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Zhang C; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Levy FO; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, 0188 Oslo, Norway.
Andressen KW; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, 0188 Oslo, Norway.
Lambert NA; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 01; Vol. 117 (48), pp. 30755-30762. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/drug effects
GTP-Binding Proteins/*metabolism
Multiprotein Complexes/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Dose-Response Relationship, Drug ; GTP-Binding Proteins/chemistry ; Kinetics ; Ligands ; Models, Biological ; Multiprotein Complexes/chemistry ; Protein Binding ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/chemistry ; Receptors, Serotonin/chemistry ; Receptors, Serotonin/metabolism ; Serotonin Antagonists ; Serotonin Receptor Agonists
Czasopismo naukowe
Tytuł :
Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.
Autorzy :
Chen LH; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhang Q; CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Xie X; CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Nan FJ; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; Yantai Institute of Materia Medica, Shandong 264000, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15399-15409. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, G-Protein-Coupled/*metabolism
Acetates/chemistry ; Acetates/pharmacology ; Acetates/therapeutic use ; Allosteric Regulation/drug effects ; Animals ; Binding Sites ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/metabolism ; Idiopathic Pulmonary Fibrosis/pathology ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Isoquinolines/chemistry ; Isoquinolines/pharmacology ; Isoquinolines/therapeutic use ; Ligands ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/antagonists & inhibitors
Czasopismo naukowe

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