Temat: "G-Protein-Coupled Receptor Kinase 1" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Non-Invasive Diagnostics of Renal Cell Carcinoma Using Ultrasensitive Immunodetection of Cancer-Retina Antigens.
Autorzy:: Shlyapnikov YM; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. .
Malakhova EA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. .
Potoldykova NV; Institute for Urology and Reproductive Health, Sechenov First Moscow State Medical University, Moscow, 119991, Russia. .
Svetocheva YA; Institute for Urology and Reproductive Health, Sechenov First Moscow State Medical University, Moscow, 119991, Russia. .
Vinarov AZ; Institute for Urology and Reproductive Health, Sechenov First Moscow State Medical University, Moscow, 119991, Russia. .
Zinchenko DV; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Region, 117997, Russia. .
Zernii EY; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. .
Zamyatnin AA Jr; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. .; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, 119991, Russia.; Department of Biotechnology, Sirius University of Science and Technology, Sochi, 354340, Russia.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Shlyapnikova EA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. .; Pokaż więcej
Źródło:: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2022 Jul; Vol. 87 (7), pp. 658-666.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Renal Cell*/diagnosis
Carcinoma, Renal Cell*/pathology
Kidney Neoplasms*/diagnosis
Kidney Neoplasms*/pathology
Arrestins ; Biomarkers, Tumor ; G-Protein-Coupled Receptor Kinase 1 ; Humans ; Recoverin ; Retina ; Transducin

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Skocz do pozycji: 2.

Tytuł:: Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling.
Autorzy:: Baksheeva VE; Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Baldin AV; Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Department of General, Visceral, and Transplant Surgery, Ludwig Maximilians University Munich, 81377 Munich, Germany.; V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia.
Zalevsky AO; Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Nazipova AA; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Kazakov AS; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Vladimirov VI; Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Gorokhovets NV; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Devred F; Institut de Neurophysiopathologie, INP, CNRS, Faculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, 13005 Marseille, France.; Plateforme Interactome Timone, PINT, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Université, 13009 Marseille, France.
Philippov PP; Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Bazhin AV; Department of General, Visceral, and Transplant Surgery, Ludwig Maximilians University Munich, 81377 Munich, Germany.; Partner Site Munich, German Cancer Consortium (DKTK), 80336 Munich, Germany.
Golovin AV; Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.; Sirius University of Science and Technology, 354340 Sochi, Russia.
Zamyatnin AA Jr; Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Sirius University of Science and Technology, 354340 Sochi, Russia.; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK.
Zinchenko DV; Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Tsvetkov PO; Institut de Neurophysiopathologie, INP, CNRS, Faculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, 13005 Marseille, France.; Plateforme Interactome Timone, PINT, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Université, 13009 Marseille, France.
Permyakov SE; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Zernii EY; Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 22; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 22.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium Signaling/*genetics
G-Protein-Coupled Receptor Kinase 1/*genetics
Neoplasms/*genetics
Neuronal Calcium-Sensor Proteins/*genetics
Neurons/*metabolism
Neuropeptides/*genetics
Calcium/metabolism ; Calcium-Binding Proteins/genetics ; Cell Line, Tumor ; Dimerization ; Disulfides/chemistry ; EF Hand Motifs/genetics ; HEK293 Cells ; Humans ; Kinetics ; Neoplasms/pathology ; Neuronal Calcium-Sensor Proteins/antagonists & inhibitors ; Neurons/chemistry ; Neuropeptides/antagonists & inhibitors ; Oxidation-Reduction ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/genetics ; Zinc/metabolism

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Skocz do pozycji: 3.

Tytuł:: A novel missense mutation of the GRK1 gene in Oguchi disease.
Autorzy:: Teke MY; SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara 06230, Turkey.
Citirik M; SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara 06230, Turkey.
Kabacam S; Department of Medical Genetics, Hacettepe University, School of Medicine, Ankara 06230, Turkey.
Demircan S; SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara 06230, Turkey.
Alikasifoglu M; Department of Medical Genetics, Hacettepe University, School of Medicine, Ankara 06230, Turkey.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2016 Oct; Vol. 14 (4), pp. 3129-33. Date of Electronic Publication: 2016 Aug 09.
Typ publikacji:: Journal Article
MeSH Terms:: Mutation, Missense*
G-Protein-Coupled Receptor Kinase 1/*genetics
Night Blindness/*genetics
Adolescent ; Adult ; Amino Acid Sequence ; Animals ; Child ; Eye Diseases, Hereditary ; Female ; G-Protein-Coupled Receptor Kinase 1/chemistry ; Humans ; Male ; Middle Aged ; Night Blindness/epidemiology ; Pedigree ; Phylogeny ; Sequence Alignment ; Turkey/epidemiology ; Young Adult
SCR Disease Name:: Oguchi disease

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Skocz do pozycji: 4.

Tytuł:: Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach.
Autorzy:: Borsatto A; Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy. .; Department of Physics, University of Trento, 38123 Trento, Italy. .
Marino V; Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy. .; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56026 Pisa, Italy. .
Abrusci G; Department of Physics, University of Trento, 38123 Trento, Italy. .; Trento Institute for Fundamental Physics and Applications (INFN-TIFPA), Via Sommarive 14, Povo, 38123 Trento, Italy. .
Lattanzi G; Department of Physics, University of Trento, 38123 Trento, Italy. .; Trento Institute for Fundamental Physics and Applications (INFN-TIFPA), Via Sommarive 14, Povo, 38123 Trento, Italy. .
Dell'Orco D; Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Oct 10; Vol. 20 (20). Date of Electronic Publication: 2019 Oct 10.
Typ publikacji:: Journal Article
MeSH Terms:: G-Protein-Coupled Receptor Kinase 1/*chemistry
G-Protein-Coupled Receptor Kinase 1/*metabolism
Membrane Proteins/*chemistry
Membrane Proteins/*metabolism
Recoverin/*chemistry
Recoverin/*metabolism
Allosteric Site ; Calcium-Binding Proteins ; Computational Biology ; Eye Proteins/chemistry ; Hydrophobic and Hydrophilic Interactions ; Light Signal Transduction ; Models, Molecular ; Molecular Dynamics Simulation ; Myristic Acids ; Nerve Tissue Proteins/chemistry ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Sequence Analysis, Protein

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Skocz do pozycji: 5.

Tytuł:: Phosphorylation mapping of Laminin β1-chain: Kinases in association with active sites.
Autorzy:: Verrou KM; Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Galliou PA
Papaioannou M
Koliakos G; Pokaż więcej
Źródło:: Journal of biosciences [J Biosci] 2019 Jun; Vol. 44 (2).
Typ publikacji:: Journal Article
MeSH Terms:: Protein Processing, Post-Translational*
Computational Biology/*methods
Laminin/*chemistry
Peptide Mapping/*methods
Amino Acid Sequence ; Casein Kinase I/chemistry ; Casein Kinase I/metabolism ; Casein Kinase II/chemistry ; Casein Kinase II/metabolism ; Catalytic Domain ; Cyclic AMP-Dependent Protein Kinases/chemistry ; Cyclic AMP-Dependent Protein Kinases/metabolism ; G-Protein-Coupled Receptor Kinase 1/chemistry ; G-Protein-Coupled Receptor Kinase 1/metabolism ; Gene Expression ; Humans ; Laminin/genetics ; Laminin/metabolism ; Phosphorylation ; Protein Kinase C/chemistry ; Protein Kinase C/metabolism

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Skocz do pozycji: 6.

Tytuł:: Experimental Insight into the Structural and Functional Roles of the 'Black' and 'Gray' Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs.
Autorzy:: Permyakov SE; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Vologzhannikova AS; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Nemashkalova EL; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.
Kazakov AS; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.; Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, 142290 Pushchino, Russia.
Denesyuk AI; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland.
Denessiouk K; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland.; Pharmaceutical Sciences Laboratory, Pharmacy, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland.
Baksheeva VE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Zamyatnin AA Jr; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Zernii EY; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Uversky VN; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia. .; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. .
Permyakov EA; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia. .; Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, 142290 Pushchino, Russia. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2019 Jul 08; Vol. 24 (13). Date of Electronic Publication: 2019 Jul 08.
Typ publikacji:: Journal Article
MeSH Terms:: Recoverin/*chemistry
Recoverin/*metabolism
Alanine/chemistry ; Amino Acid Motifs ; Amino Acid Substitution ; Calcium/metabolism ; G-Protein-Coupled Receptor Kinase 1/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Models, Molecular ; Mutation ; Phosphorylation ; Protein Binding ; Recoverin/genetics ; Rhodopsin/metabolism

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Skocz do pozycji: 7.

Tytuł:: Characterization of phototransduction gene knockouts revealed important signaling networks in the light-induced retinal degeneration.
Autorzy:: Krishnan J; Department of Molecular Science and Technology, College of Natural Sciences, Ajou University, Suwon 443-749, South Korea.
Lee G
Han SU
Choi S; Pokaż więcej
Źródło:: Journal of biomedicine & biotechnology [J Biomed Biotechnol] 2008; Vol. 2008, pp. 327468.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Vision, Ocular*
Apoptosis Regulatory Proteins/*metabolism
Arrestin/*metabolism
G-Protein-Coupled Receptor Kinase 1/*metabolism
Retinal Degeneration/*metabolism
Retinal Rod Photoreceptor Cells/*metabolism
Transcription Factors/*metabolism
Animals ; Arrestin/genetics ; G-Protein-Coupled Receptor Kinase 1/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Retina/metabolism

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Skocz do pozycji: 8.

Tytuł:: A novel GRK1 mutation in an Italian patient with Oguchi disease.
Autorzy:: Mucciolo DP; a Department of Translational Surgery and Medicine, Eye Clinic , University of Florence , Florence , Italy.
Sodi A; a Department of Translational Surgery and Medicine, Eye Clinic , University of Florence , Florence , Italy.
Murro V; a Department of Translational Surgery and Medicine, Eye Clinic , University of Florence , Florence , Italy.
Passerini I; b Department of Genetic Diagnosis , Careggi Teaching Hospital , Florence , Italy.
Palchetti S; b Department of Genetic Diagnosis , Careggi Teaching Hospital , Florence , Italy.
Pelo E; b Department of Genetic Diagnosis , Careggi Teaching Hospital , Florence , Italy.
Virgili G; a Department of Translational Surgery and Medicine, Eye Clinic , University of Florence , Florence , Italy.
Rizzo S; a Department of Translational Surgery and Medicine, Eye Clinic , University of Florence , Florence , Italy.; Pokaż więcej
Źródło:: Ophthalmic genetics [Ophthalmic Genet] 2018 Jan-Feb; Vol. 39 (1), pp. 137-138. Date of Electronic Publication: 2017 May 16.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Mutation, Missense*
G-Protein-Coupled Receptor Kinase 1/*genetics
Night Blindness/*genetics
Adult ; Electroretinography ; Eye Diseases, Hereditary ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Italy ; Night Blindness/diagnosis ; Night Blindness/physiopathology ; Retina/physiopathology ; Tomography, Optical Coherence ; Visual Fields/physiology
SCR Disease Name:: Oguchi disease

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Skocz do pozycji: 9.

Tytuł:: Bifunctional Diaminoterephthalate Fluorescent Dye as Probe for Cross-Linking Proteins.
Autorzy:: Wallisch M; Institut für Chemie, Carl von Ossietzky-Universität Oldenburg, 26111, Oldenburg, Germany.
Sulmann S; Biochemistry Group, Department of Neuroscience, Carl von Ossietzky-Universität Oldenburg, 26111, Oldenburg, Germany.
Koch KW; Biochemistry Group, Department of Neuroscience, Carl von Ossietzky-Universität Oldenburg, 26111, Oldenburg, Germany.
Christoffers J; Institut für Chemie, Carl von Ossietzky-Universität Oldenburg, 26111, Oldenburg, Germany.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 May 11; Vol. 23 (27), pp. 6535-6543. Date of Electronic Publication: 2017 Apr 06.
Typ publikacji:: Journal Article
MeSH Terms:: Biotin/*chemistry
Fluorescent Dyes/*chemistry
Phthalic Acids/*chemistry
Animals ; Azides/chemistry ; Biotin/metabolism ; Cattle ; Click Chemistry ; Cross-Linking Reagents/chemistry ; Dimerization ; G-Protein-Coupled Receptor Kinase 1/chemistry ; Humans ; Maleimides/chemistry ; Protein Binding ; Recoverin/chemistry ; Streptavidin/chemistry ; Streptavidin/metabolism ; Sulfhydryl Compounds/chemistry

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Skocz do pozycji: 10.

Tytuł:: Sex differences in genomics in lupus: girls with systemic lupus have high interferon gene expression while boys have high levels of tumour necrosis factor-related gene expression.
Autorzy:: Hui-Yuen JS; a Division of Pediatric Rheumatology, Cohen Children's Medical Center , North Shore-Long Island Jewish Hospital , New York , USA.
Christiano AM; b Departments of Dermatology, Molecular Genetics and Molecular Biology , Columbia University Medical Center , New York , USA.
Askanase A; c Division of Rheumatology, New York-Presbyterian Hospital , Columbia University Medical Center , New York , USA.; Pokaż więcej
Źródło:: Scandinavian journal of rheumatology [Scand J Rheumatol] 2016 Oct; Vol. 45 (5), pp. 394-6. Date of Electronic Publication: 2016 Feb 17.
Typ publikacji:: Journal Article
MeSH Terms:: Sex Factors*
Transcriptome*
Interferons/*genetics
Lupus Erythematosus, Systemic/*genetics
Adaptor Proteins, Signal Transducing ; Adolescent ; Antigens/genetics ; Carrier Proteins/genetics ; Case-Control Studies ; Child ; Cytoskeletal Proteins/genetics ; Female ; G-Protein-Coupled Receptor Kinase 1/genetics ; Gene Expression ; Genomics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Linear Models ; Male ; Membrane Proteins/genetics ; Microarray Analysis ; Mitochondrial Proteins/genetics ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; RNA-Binding Proteins ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/genetics ; Sialic Acid Binding Ig-like Lectin 1/genetics ; Thyroxine-Binding Globulin/genetics ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics

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Skocz do pozycji: 11.

Tytuł:: Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution.
Autorzy:: Fernández-Sampedro MA; Grup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Edifici Gaia, Rambla de Sant Nebridi 22, 08222 Terrassa, Catalonia, Spain.
Invergo BM; IBE - Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), CEXS-UPF-PRBB, Barcelona, Catalonia, Spain.
Ramon E; Grup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Edifici Gaia, Rambla de Sant Nebridi 22, 08222 Terrassa, Catalonia, Spain.
Bertranpetit J; IBE - Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), CEXS-UPF-PRBB, Barcelona, Catalonia, Spain.
Garriga P; Grup de Biotecnologia Molecular i Industrial, Centre de Biotecnologia Molecular, Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Edifici Gaia, Rambla de Sant Nebridi 22, 08222 Terrassa, Catalonia, Spain.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Feb 11; Vol. 6, pp. 21570. Date of Electronic Publication: 2016 Feb 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amino Acid Substitution*
Biological Evolution*
Phylogeny*
Mammals/*genetics
Rhodopsin/*chemistry
Adaptation, Physiological ; Alanine/chemistry ; Alanine/metabolism ; Amino Acid Sequence ; Animals ; Arginine/chemistry ; Arginine/metabolism ; COS Cells ; Chlorocebus aethiops ; G-Protein-Coupled Receptor Kinase 1/genetics ; G-Protein-Coupled Receptor Kinase 1/metabolism ; Gene Expression ; Glutamine/chemistry ; Glutamine/metabolism ; Glycosylation ; Humans ; Mammals/classification ; Mammals/metabolism ; Methionine/chemistry ; Methionine/metabolism ; Models, Molecular ; Mutation ; Phenylalanine/chemistry ; Phenylalanine/metabolism ; Phosphorylation ; Protein Folding ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Rhodopsin/genetics ; Rhodopsin/metabolism ; Selection, Genetic ; Serine/chemistry ; Serine/metabolism

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Skocz do pozycji: 12.

Tytuł:: Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor.
Autorzy:: Homan KT; Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Wu E; Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Cannavo A; Center for Translation Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Koch WJ; Center for Translation Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Tesmer JJ; Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2014 Oct 22; Vol. 19 (10), pp. 16937-49. Date of Electronic Publication: 2014 Oct 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Discovery*
Aminopyridines/*pharmacology
Anti-Allergic Agents/*pharmacology
G-Protein-Coupled Receptor Kinase 5/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Small Molecule Libraries/*pharmacology
Aminopyridines/chemistry ; Animals ; Animals, Newborn ; Anti-Allergic Agents/chemistry ; Cattle ; Cells, Cultured ; Crystallography, X-Ray ; G-Protein-Coupled Receptor Kinase 1/chemistry ; G-Protein-Coupled Receptor Kinase 1/metabolism ; G-Protein-Coupled Receptor Kinase 5/metabolism ; High-Throughput Screening Assays ; Humans ; Kinetics ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Rats ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship