Temat: "G1 Phase Cell Cycle Checkpoints" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Evidence that PKCα inhibition in Dalton's Lymphoma cells augments cell cycle arrest and mitochondrial-dependent apoptosis.
Autorzy :: Singh RK; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Verma PK; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Kumar S; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Shukla A; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Kumar N; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Kumar S; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Acharya A; Tumor Immunology Lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Electronic address: .; Pokaż więcej
Źródło :: Leukemia research [Leuk Res] 2022 Feb; Vol. 113, pp. 106772. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Apoptosis/*drug effects
Carbazoles/*pharmacology
G1 Phase Cell Cycle Checkpoints/*drug effects
Lymphoma, Non-Hodgkin/*enzymology
Mitochondria/*metabolism
Protein Kinase C-alpha/*antagonists & inhibitors
Animals ; Carbazoles/chemistry ; Caspases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation/drug effects ; Lymphoma, Non-Hodgkin/metabolism ; Lymphoma, Non-Hodgkin/pathology ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred BALB C ; Mitochondria/physiology ; Molecular Structure ; Protein Kinase C-alpha/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects ; Tumor Suppressor Protein p53/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: SARS-CoV-2 N Protein Induces Acute Kidney Injury via Smad3-Dependent G1 Cell Cycle Arrest Mechanism.
Autorzy :: Wang W; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, 510632, China.; Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, 510080, China.; The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Chen J; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510080, China.
Hu D; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Pan P; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, 510632, China.
Liang L; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Wu W; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, 510080, China.
Tang Y; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510080, China.
Huang XR; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, 510080, China.
Yu X; Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, 510080, China.
Wu J; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, 510632, China.; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Lan HY; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.; The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, 999077, China.; Pokaż więcej
Źródło :: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Jan; Vol. 9 (3), pp. e2103248. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Acute Kidney Injury*/genetics
Acute Kidney Injury*/metabolism
Acute Kidney Injury*/virology
COVID-19*/genetics
COVID-19*/metabolism
Coronavirus Nucleocapsid Proteins*/genetics
Coronavirus Nucleocapsid Proteins*/metabolism
G1 Phase Cell Cycle Checkpoints*
SARS-CoV-2*/genetics
SARS-CoV-2*/metabolism
Smad3 Protein*/genetics
Smad3 Protein*/metabolism
Animals ; Cell Line ; Disease Models, Animal ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; Phosphoproteins/genetics ; Phosphoproteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line.
Autorzy :: Weiner F; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Schille JT; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Koczan D; Core Facility for Microarray Analysis, Institute for Immunology, University of Rostock, 18057, Rostock, Germany.
Wu XF; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Beller M; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Junghanss C; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Hewicker-Trautwein M; Department of Pathology, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.
Murua Escobar H; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.; Comprehensive Cancer Center - Mecklenburg Vorpommern (CCC-MV), Campus Rostock, University of Rostock, 18057, Rostock, Germany.
Nolte I; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany. .; Pokaż więcej
Źródło :: BMC cancer [BMC Cancer] 2021 Oct 08; Vol. 21 (1), pp. 1088. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :: Journal Article
MeSH Terms :: Antineoplastic Agents/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
G1 Phase Cell Cycle Checkpoints/*drug effects
Isoquinolines/*pharmacology
NF-kappa B/*metabolism
Prostatic Neoplasms, Castration-Resistant/*metabolism
Antineoplastic Agents/therapeutic use ; E2F1 Transcription Factor/antagonists & inhibitors ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression/drug effects ; Gene Expression Profiling/methods ; Humans ; Isoquinolines/therapeutic use ; Male ; Middle Aged ; PC-3 Cells ; Plasminogen Activator Inhibitor 1/metabolism ; Prostatic Neoplasms, Castration-Resistant/genetics ; S Phase Cell Cycle Checkpoints ; Time Factors ; Tissue Array Analysis
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 4 4.

Tytuł :: Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G 0 state arrest.
Autorzy :: Hnit SST; Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, The University of Sydney, Sydney, Australia; Department of Endocrisnology, Royal Prince Alfred Hospital, Sydney, Australia.
Ding R; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Bi L; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xie C; Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, The University of Sydney, Sydney, Australia; Department of Endocrisnology, Royal Prince Alfred Hospital, Sydney, Australia.
Yao M; Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, The University of Sydney, Sydney, Australia; Department of Endocrisnology, Royal Prince Alfred Hospital, Sydney, Australia.
De Souza P; School of Medicine, Western Sydney University, Australia.
Xu L; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li Z; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address: .
Dong Q; Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, The University of Sydney, Sydney, Australia; Department of Endocrisnology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: .; Pokaż więcej
Źródło :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Sep; Vol. 141, pp. 111795. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :: Journal Article
MeSH Terms :: Agrimonia*
Antineoplastic Agents, Phytogenic/*pharmacology
Butanones/*pharmacology
G1 Phase Cell Cycle Checkpoints/*drug effects
Phenols/*pharmacology
Plant Extracts/*pharmacology
Tumor Burden/*drug effects
A549 Cells ; Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Butanones/isolation & purification ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/physiology ; Dose-Response Relationship, Drug ; Ellagic Acid/pharmacology ; G1 Phase Cell Cycle Checkpoints/physiology ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phenols/isolation & purification ; Plant Extracts/isolation & purification ; Tumor Burden/physiology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Differential effects of phenolic extracts from red-fleshed apple peels and flesh induced G1 cell cycle arrest and apoptosis in human breast cancer MDA-MB-231 cells.
Autorzy :: Li CX; College of Life Sciences and Enology, Taishan University, Tai'an, Shandong, China.; State Key Laboratory of Crop Biology, College of Horticulture Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.
Lin ZX; College of Life Sciences and Enology, Taishan University, Tai'an, Shandong, China.
Zhao XH; College of Life Sciences and Enology, Taishan University, Tai'an, Shandong, China.
Zuo WF; State Key Laboratory of Crop Biology, College of Horticulture Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.
Wang N; State Key Laboratory of Crop Biology, College of Horticulture Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.
Zhang ZY; State Key Laboratory of Crop Biology, College of Horticulture Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.
Chen XS; State Key Laboratory of Crop Biology, College of Horticulture Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong, China.; Pokaż więcej
Źródło :: Journal of food science [J Food Sci] 2021 Sep; Vol. 86 (9), pp. 4209-4222. Date of Electronic Publication: 2021 Aug 15.
Typ publikacji :: Journal Article
MeSH Terms :: Fruit*/chemistry
G1 Phase Cell Cycle Checkpoints*/drug effects
Malus*/chemistry
Plant Extracts*/pharmacology
Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, Liquid ; Female ; Humans ; Phenols/chemistry ; Tandem Mass Spectrometry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Specific Interaction of DDX6 with an RNA Hairpin in the 3' UTR of the Dengue Virus Genome Mediates G 1 Phase Arrest.
Autorzy :: Choksupmanee O; The Laboratory of RNA Biology, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand.
Tangkijthavorn W; The Laboratory of RNA Biology, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand.; Siriraj Center of Research Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Hodge K; Systems Biology Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Trisakulwattana K; The Laboratory of RNA Biology, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand.
Phornsiricharoenphant W; National Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Khlong Luang, Pathum Thani, Thailand.
Narkthong V; Siriraj Center of Research Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tulakarnwong S; Siriraj Center of Research Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ngamphiw C; National Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Khlong Luang, Pathum Thani, Thailand.
Tongsima S; National Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Khlong Luang, Pathum Thani, Thailand.
Chimnaronk S; The Laboratory of RNA Biology, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand.; Siriraj Center of Research Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Pokaż więcej
Źródło :: Journal of virology [J Virol] 2021 Aug 10; Vol. 95 (17), pp. e0051021. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: 3' Untranslated Regions*
G1 Phase Cell Cycle Checkpoints*
Genome, Viral*
DEAD-box RNA Helicases/*metabolism
Dengue/*virology
Dengue Virus/*genetics
Proto-Oncogene Proteins/*metabolism
RNA, Viral/*genetics
DEAD-box RNA Helicases/genetics ; Humans ; Nucleic Acid Conformation ; Proto-Oncogene Proteins/genetics ; RNA, Viral/chemistry ; Virus Replication
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Kurarinone induced p53-independent G0/G1 cell cycle arrest by degradation of K-RAS via WDR76 in human colorectal cancer cells.
Autorzy :: Kwon M; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, South Korea.
Oh T; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 28160, South Korea.
Jang M; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea.
Kim GH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea.
Kim JH; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea.
Ryu HW; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea.
Oh SR; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea.
Jang JH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, South Korea.
Ahn JS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, South Korea. Electronic address: .
Ko SK; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, South Korea. Electronic address: .; Pokaż więcej
Źródło :: European journal of pharmacology [Eur J Pharmacol] 2022 May 15; Vol. 923, pp. 174938. Date of Electronic Publication: 2022 Apr 02.
Typ publikacji :: Journal Article
MeSH Terms :: Cell Cycle Proteins*/metabolism
Colorectal Neoplasms*/drug therapy
DNA-Binding Proteins*/metabolism
Flavonoids*/pharmacology
Apoptosis ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; G1 Phase Cell Cycle Checkpoints ; Humans ; Proto-Oncogene Proteins p21(ras) ; Tumor Suppressor Protein p53/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
Autorzy :: Thomas AF; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Kelly GL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Strasser A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia. .; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. .; Pokaż więcej
Źródło :: Cell death and differentiation [Cell Death Differ] 2022 May; Vol. 29 (5), pp. 961-971. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Neoplasms*/genetics
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/metabolism ; DNA Damage ; G1 Phase Cell Cycle Checkpoints ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Camptothecin enhances I-rituximab-induced G1-arrest and apoptosis in Burkitt lymphoma cells.
Autorzy :: Kumar C; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
Sharma R; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
Repaka KM; Radiopharmaceutical Quality Control Program, Board of Radiation and Isotope Technology, Navi Mumbai, Maharashtra, India.
Pareri AU; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
Dash A; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.; Pokaż więcej
Źródło :: Journal of cancer research and therapeutics [J Cancer Res Ther] 2021 Jul-Sep; Vol. 17 (4), pp. 943-950.
Typ publikacji :: Journal Article
MeSH Terms :: Apoptosis*
G1 Phase Cell Cycle Checkpoints*
Burkitt Lymphoma/*pathology
Camptothecin/*pharmacology
Rituximab/*pharmacology
Antineoplastic Agents, Phytogenic/pharmacology ; Burkitt Lymphoma/immunology ; Burkitt Lymphoma/therapy ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Radioimmunotherapy ; Tumor Cells, Cultured ; p38 Mitogen-Activated Protein Kinases/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 10 10.

Tytuł :: Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Autorzy :: Karelia DN; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Kim S; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
K Pandey M; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Plano D; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Amin S; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.; Penn State Cancer Institute, 500 University Drive, Hershey, PA 17033, USA.
Lu J; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.; Penn State Cancer Institute, 500 University Drive, Hershey, PA 17033, USA.
Sharma AK; Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.; Penn State Cancer Institute, 500 University Drive, Hershey, PA 17033, USA.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2021 May 07; Vol. 22 (9). Date of Electronic Publication: 2021 May 07.
Typ publikacji :: Journal Article
MeSH Terms :: Apoptosis*/drug effects
Apoptosis*/genetics
G1 Phase Cell Cycle Checkpoints*/drug effects
Adenocarcinoma/*pathology
Aspirin/*pharmacology
Carcinoma, Pancreatic Ductal/*pathology
Deoxycytidine/*analogs & derivatives
NF-kappa B/*metabolism
Pancreatic Neoplasms/*pathology
Acetylcysteine/pharmacology ; Adenocarcinoma/genetics ; Aspirin/chemistry ; Carcinoma, Pancreatic Ductal/genetics ; Caspases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Deoxycytidine/pharmacology ; Enzyme Activation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Inflammation Mediators/metabolism ; Pancreatic Neoplasms/genetics ; Signal Transduction/drug effects ; Transcriptome/drug effects ; Transcriptome/genetics
SCR Disease Name :: Pancreatic Carcinoma
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 11 11.

Tytuł :: A new hierarchical approach to multi-level model abstraction for simplifying ODE models of biological networks and a case study: The G1/S Checkpoint/DNA damage signalling pathways of mammalian cell cycle.
Autorzy :: Khazaaleh M; Complex Systems, Big Data and Informatics Initiative (CSBII), New Zealand.
Samarasinghe S; Complex Systems, Big Data and Informatics Initiative (CSBII), New Zealand; Centre for Advanced Computational Solutions, Lincoln University, Christchurch, New Zealand. Electronic address: .
Kulasiri D; Complex Systems, Big Data and Informatics Initiative (CSBII), New Zealand; Centre for Advanced Computational Solutions, Lincoln University, Christchurch, New Zealand.; Pokaż więcej
Źródło :: Bio Systems [Biosystems] 2021 May; Vol. 203, pp. 104374. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :: Journal Article
MeSH Terms :: DNA Damage*
G1 Phase Cell Cycle Checkpoints*
Animals ; Cell Cycle ; Mammals ; Models, Biological ; Models, Theoretical ; Signal Transduction ; Systems Biology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: β-Arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells.
Autorzy :: Donia T; Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Abouda M; Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Kelany M; Department of Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hessien M; Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt. .; Pokaż więcej
Źródło :: Medical oncology (Northwood, London, England) [Med Oncol] 2021 Mar 15; Vol. 38 (4), pp. 38. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :: Journal Article
MeSH Terms :: Apoptosis*/drug effects
Autophagy*/drug effects
G1 Phase Cell Cycle Checkpoints*/drug effects
Receptors, Vasopressin/*metabolism
beta-Arrestins/*antagonists & inhibitors
Adaptor Protein Complex 2/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Pyrimidines/pharmacology ; Receptors, Vasopressin/agonists ; Signal Transduction/drug effects ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; beta-Arrestins/genetics ; beta-Arrestins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Autorzy :: Salamina M; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Montefiore BC; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Liu M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA.
Wood DJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Heath R; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Ault JR; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Wang LZ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Korolchuk S; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Baslé A; Biosciences Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Pastok MW; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Reeks J; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Tatum NJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Sobott F; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Arold ST; Division of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; Centre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, 34090 Montpellier, France.
Pagano M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA.
Noble MEM; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Endicott JA; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: .; Pokaż więcej
Źródło :: Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166795. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: G1 Phase Cell Cycle Checkpoints*
Cyclin A/*chemistry
Cyclin-Dependent Kinase 2/*chemistry
Cyclin-Dependent Kinase Inhibitor p27/*chemistry
S-Phase Kinase-Associated Proteins/*chemistry
Binding Sites ; CDC2-CDC28 Kinases/chemistry ; CDC2-CDC28 Kinases/genetics ; CDC2-CDC28 Kinases/metabolism ; Cyclin A/genetics ; Cyclin A/metabolism ; Cyclin E/chemistry ; Cyclin E/genetics ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; S-Phase Kinase-Associated Proteins/genetics ; S-Phase Kinase-Associated Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Eimeria bovis infections induce G 1 cell cycle arrest and a senescence-like phenotype in endothelial host cells.
Autorzy :: Velásquez ZD; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
López-Osorio S; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.; Research Group CIVAB, School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellin, Colombia.
Waiger D; Center for Scientific Imaging, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot, Hebrew University of Jerusalem Israel, Rehovot, Israel.
Manosalva C; Faculty of Veterinary Sciences, Institute of Pharmacology, Universidad Austral de Chile, Valdivia, Chile.
Pervizaj-Oruqaj L; Cardio Pulmonary Institute (CPI), Giessen, Germany.; Universities Giessen & Marburg Lung Center (UGMLC), Giessen, Germany.; German Center for Lung Research (DZL), Giessen, Germany.
Herold S; Cardio Pulmonary Institute (CPI), Giessen, Germany.; Universities Giessen & Marburg Lung Center (UGMLC), Giessen, Germany.; German Center for Lung Research (DZL), Giessen, Germany.
Hermosilla C; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Taubert A; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.; Pokaż więcej
Źródło :: Parasitology [Parasitology] 2021 Mar; Vol. 148 (3), pp. 341-353. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :: Journal Article
MeSH Terms :: G1 Phase Cell Cycle Checkpoints*
Aging/*physiology
Cattle Diseases/*parasitology
Coccidiosis/*veterinary
Endothelial Cells/*physiology
Animals ; Cattle ; Coccidiosis/parasitology ; Eimeria/physiology ; Male ; Phenotype
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells.
Autorzy :: Mundhara N; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Majumder A; Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Panda D; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.; Pokaż więcej
Źródło :: The Biochemical journal [Biochem J] 2021 Jan 15; Vol. 478 (1), pp. 179-196.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: G1 Phase Cell Cycle Checkpoints*/genetics
G1 Phase Cell Cycle Checkpoints*/physiology
Cellular Senescence/*physiology
Cytoskeleton/*metabolism
Histone Deacetylase 6/*metabolism
Hyperthermia/*metabolism
Stress Fibers/*metabolism
Acetylation ; Actins/metabolism ; Apoptosis/physiology ; Cell Adhesion/physiology ; Cell Division/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Shape ; Cell Size ; HSP70 Heat-Shock Proteins/metabolism ; Histone Deacetylase 6/genetics ; Humans ; Hyperthermia/genetics ; Membrane Potential, Mitochondrial/physiology ; Microtubules/metabolism ; Reactive Oxygen Species/metabolism ; Up-Regulation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Lysosome-targeted ruthenium(II) complexes induce both apoptosis and autophagy in HeLa cells.
Autorzy :: Pan NL; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China; Department of Pharmacy, Dongguan Peaple's Hospital, Dongguan 523059, China.
Liao JX; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Huang MY; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Zhang YQ; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Chen JX; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address: .
Zhang ZW; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Yang ZX; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Long XE; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Wu XT; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Sun J; School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address: .; Pokaż więcej
Źródło :: Journal of inorganic biochemistry [J Inorg Biochem] 2022 Apr; Vol. 229, pp. 111729. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Coordination Complexes/*pharmacology
Lysosomes/*metabolism
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/radiation effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/radiation effects ; DNA Damage/drug effects ; Drug Screening Assays, Antitumor ; Fluorouracil/analogs & derivatives ; Fluorouracil/pharmacology ; Fluorouracil/toxicity ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Ligands ; Pyridines/chemical synthesis ; Pyridines/pharmacology ; Pyridines/toxicity ; Reactive Oxygen Species/metabolism ; Ruthenium/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma.
Autorzy :: Deng J; Department of Oncology, Hubei NO. 3 People's Hospital of Jianghan University, Wuhan, Hubei, China.
Liu L; Department of Oncology, Hubei NO. 3 People's Hospital of Jianghan University, Wuhan, Hubei, China.
Li L; Department of Oncology, Hubei NO. 3 People's Hospital of Jianghan University, Wuhan, Hubei, China.
Sun J; Department of Oncology, Hubei NO. 3 People's Hospital of Jianghan University, Wuhan, Hubei, China.
Yan F; Department of Oncology, Hubei NO. 3 People's Hospital of Jianghan University, Wuhan, Hubei, China.; Pokaż więcej
Źródło :: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Apr; Vol. 36 (4), pp. e22981. Date of Electronic Publication: 2022 Jan 04.
Typ publikacji :: Journal Article
MeSH Terms :: Bile Duct Neoplasms*
Cholangiocarcinoma*/drug therapy
Hesperidin*/pharmacology
Bile Ducts, Intrahepatic ; Cell Cycle ; Cell Line, Tumor ; G1 Phase Cell Cycle Checkpoints ; Humans ; Signal Transduction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Discovery of Pteridine-7(8 H )-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK).
Autorzy :: Dou D; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Diao Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Sha W; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Su R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Tong L; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Li W; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Leng L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xie L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Yu Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Song H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Shen Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Zhu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Zhao Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xie H; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chen Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Li H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Xu Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.; Pokaż więcej
Źródło :: Journal of medicinal chemistry [J Med Chem] 2022 Feb 10; Vol. 65 (3), pp. 2694-2709. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors
Antineoplastic Agents/*therapeutic use
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pteridines/*therapeutic use
Agammaglobulinaemia Tyrosine Kinase/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Pteridines/chemical synthesis ; Pteridines/metabolism ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt.
Autorzy :: Cao W; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Shen R; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Richard S; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Liu Y; Sir Run Run Shaw Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.
Jalalirad M; Mayo Clinic, Rochester, MN 55905, USA.
Cleary MP; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
D'Assoro AB; Mayo Clinic, Rochester, MN 55905, USA.
Gradilone SA; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Yang DQ; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.; Pokaż więcej
Źródło :: Oncology reports [Oncol Rep] 2022 Feb; Vol. 47 (2). Date of Electronic Publication: 2021 Dec 27.
Typ publikacji :: Journal Article
MeSH Terms :: Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors
Cell Proliferation/*drug effects
Hydroxamic Acids/*pharmacology
Mammary Neoplasms, Experimental/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
Pyrimidines/*pharmacology
Triple Negative Breast Neoplasms/*drug therapy
Tumor Suppressor Protein p53/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Disease Models, Animal ; Drug Therapy, Combination ; G1 Phase Cell Cycle Checkpoints/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: The G1 phase optical reporter serves as a sensor of CDK4/6 inhibition in vivo .
Autorzy :: Guo C; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.; Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
Guo Y; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.; Present address: Department of Thyroid and Breast Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Liu J; Cancer Center & Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Gao Y; Cancer Center & Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Wei M; Cancer Center & Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Zhao R; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Chen M; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Clinical Central Research Core and Key Laboratory for Endocrine-Related Cancer Precision Medicine of Xiamen, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China.
Zhang G; Cancer Center & Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Clinical Central Research Core and Key Laboratory for Endocrine-Related Cancer Precision Medicine of Xiamen, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China.; Pokaż więcej
Źródło :: International journal of biological sciences [Int J Biol Sci] 2021 Jan 31; Vol. 17 (3), pp. 728-741. Date of Electronic Publication: 2021 Jan 31 (Print Publication: 2021).
Typ publikacji :: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cyclin E*
Fluorescent Dyes*
G1 Phase Cell Cycle Checkpoints*
Luciferases*
Optical Imaging/*methods
Animals ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Feasibility Studies ; Fluorouracil ; Genes, Reporter ; HeLa Cells ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Piperazines ; Pyridines ; Recombinant Fusion Proteins
: Czasopismo naukowe

Szczegóły

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