Temat: "G1 Phase Cell Cycle Checkpoints" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Antitumor Effect of Regorafenib on MicroRNA Expression in Hepatocellular Carcinoma Cell Lines.
Autorzy:: Takuma K; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Fujihara S; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Fujita K; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Iwama H; Life Science Research Center, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Nakahara M; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Oura K; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Tadokoro T; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Mimura S; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Tani J; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Shi T; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Morishita A; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Kobara H; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Himoto T; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.
Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho 761-0793, Kita-gun, Kagawa, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 31; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
Liver Neoplasms/*drug therapy
MicroRNAs/*biosynthesis
Phenylurea Compounds/*pharmacology
Pyridines/*pharmacology
RNA, Neoplasm/*biosynthesis
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; MicroRNAs/genetics ; RNA, Neoplasm/genetics ; Resting Phase, Cell Cycle/drug effects ; Resting Phase, Cell Cycle/genetics

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Skocz do pozycji: 2.

Tytuł:: Broussoflavonol B from Broussonetia kazinoki Siebold Exerts Anti-Pancreatic Cancer Activity through Downregulating FoxM1.
Autorzy:: Jeong JH; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Ryu JH; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 May 16; Vol. 25 (10). Date of Electronic Publication: 2020 May 16.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Antineoplastic Agents, Phytogenic/*pharmacology
Broussonetia/*chemistry
Flavonols/*pharmacology
Forkhead Box Protein M1/*genetics
G1 Phase Cell Cycle Checkpoints/*drug effects
Antineoplastic Agents, Phytogenic/isolation & purification ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cyclin B1/genetics ; Cyclin B1/metabolism ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Diffusion Chambers, Culture ; Flavonols/isolation & purification ; Forkhead Box Protein M1/antagonists & inhibitors ; Forkhead Box Protein M1/metabolism ; G1 Phase Cell Cycle Checkpoints/genetics ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Pancreas/metabolism ; Pancreas/pathology ; Plant Bark/chemistry ; Plant Extracts/chemistry ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction ; Survivin/genetics ; Survivin/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism

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Skocz do pozycji: 3.

Tytuł:: NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0/G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807/811.
Autorzy:: Zhang L; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
Hu DL; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
Tang B; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
Cheng Y; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
Jiao C; Center for Medical Genetics, Central South University, Changsha, Hunan 410012, China.
Cheng L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, Guangdong, China.
Tan ZR; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
Zhou HH; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2019 May 05; Vol. 2019, pp. 2829798. Date of Electronic Publication: 2019 May 05 (Print Publication: 2019).
Typ publikacji:: Journal Article
MeSH Terms:: G1 Phase Cell Cycle Checkpoints*
Gene Expression Regulation, Neoplastic*
Basic-Leucine Zipper Transcription Factors/*genetics
Colorectal Neoplasms/*metabolism
Basic-Leucine Zipper Transcription Factors/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Down-Regulation ; HCT116 Cells ; Humans ; Salivary Proline-Rich Proteins/genetics ; Salivary Proline-Rich Proteins/metabolism

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Skocz do pozycji: 4.

Tytuł:: Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model.
Autorzy:: Surien O; Programme of Biomedical Science, Center for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
Ghazali AR; Programme of Biomedical Science, Center for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
Masre SF; Programme of Biomedical Science, Center for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Jul 21; Vol. 11 (1), pp. 14862. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anticarcinogenic Agents*
Carcinoma, Squamous Cell/*genetics
Carcinoma, Squamous Cell/*pathology
Cell Cycle Checkpoints/*drug effects
Cell Cycle Checkpoints/*genetics
G1 Phase Cell Cycle Checkpoints/*drug effects
G1 Phase Cell Cycle Checkpoints/*genetics
Gene Expression Regulation, Neoplastic/*drug effects
Gene Expression Regulation, Neoplastic/*genetics
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
Stilbenes/*pharmacology
Tumor Suppressor Protein p53/*genetics
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis/genetics ; Cell Proliferation/genetics ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Cyclins/genetics ; Cyclins/metabolism ; Disease Models, Animal ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Female ; Mice, Inbred BALB C ; Up-Regulation/drug effects ; Up-Regulation/genetics ; Mice

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Skocz do pozycji: 5.

Tytuł:: LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p.
Autorzy:: Zhang J; Department of Gastrointestinal Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China. jishui_.
Lv W; Department of Gastrointestinal Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China.
Liu Y; Department of Gastrointestinal Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China.
Fu W; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Chen B; Department of Gastrointestinal Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China.
Ma Q; Department of Gastrointestinal Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China.
Gao X; Department of Radiotherapy, Cangzhou Central Hospital, Cangzhou, 061001, Hebei, China.; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2021 Jun 02; Vol. 21 (1), pp. 657. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
DNA-Binding Proteins/*genetics
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Stomach Neoplasms/*genetics
Transcription Factors/*genetics
Apoptosis/genetics ; Biopsy ; Cell Line, Tumor ; G1 Phase Cell Cycle Checkpoints/genetics ; Gastric Mucosa/pathology ; Gene Knockdown Techniques ; Humans ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology ; Transcriptional Activation ; Up-Regulation

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Skocz do pozycji: 6.

Tytuł:: Trichodermin Induces G0/G1 Cell Cycle Arrest by Inhibiting c-Myc in Ovarian Cancer Cells and Tumor Xenograft-Bearing Mice.
Autorzy:: Gao Y; Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China.
Miles SL; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Dasgupta P; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Rankin GO; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Cutler S; College of Pharmacy, University of South Carolina, CLS Columbia, Columbia, SC 29208, USA.
Chen YC; College of Health, Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 09; Vol. 22 (9). Date of Electronic Publication: 2021 May 09.
Typ publikacji:: Journal Article
MeSH Terms:: Genes, myc*
G1 Phase Cell Cycle Checkpoints/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Trichodermin/*pharmacology
Animals ; Biomarkers, Tumor ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclin-Dependent Kinases/metabolism ; Disease Models, Animal ; Female ; Humans ; Mice ; Ovarian Neoplasms ; Trichodermin/chemistry ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 7.

Tytuł:: The c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through G 1 .
Autorzy:: Zhang J; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Wu Z; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Savin A; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Yang M; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Hsu YR; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Jantuan E; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Bacani JTC; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
Ingham RJ; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Oct 30; Vol. 8 (1), pp. 16019. Date of Electronic Publication: 2018 Oct 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: G1 Phase Cell Cycle Checkpoints*/genetics
Gene Expression Regulation, Neoplastic*
Hodgkin Disease/*genetics
Hodgkin Disease/*metabolism
Proto-Oncogene Proteins c-jun/*metabolism
Transcription Factors/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Gene Knockdown Techniques ; Hodgkin Disease/pathology ; Humans ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-jun/genetics ; RNA, Small Interfering/genetics ; Transcription Factors/genetics

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Skocz do pozycji: 8.

Tytuł:: Transcriptomic insight into salinomycin mechanisms in breast cancer cell lines: synergistic effects with dasatinib and induction of estrogen receptor β.
Autorzy:: Bellat V; Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Verchère A; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
Ashe SA; Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Law B; Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA. .; Lead contact, New York, USA. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2020 Jul 16; Vol. 20 (1), pp. 661. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*drug therapy
Dasatinib/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Pyrans/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Dasatinib/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Drug Screening Assays, Antitumor ; Drug Synergism ; E2F2 Transcription Factor/genetics ; E2F2 Transcription Factor/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; MCF-7 Cells ; Pyrans/therapeutic use ; Reactive Oxygen Species/metabolism ; Transcriptome/drug effects

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Skocz do pozycji: 9.

Tytuł:: Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1.
Autorzy:: Ling Z; Department of Otolaryngology Head and neck surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing City, China.
Long X; Department of Geriatrics, Yongchuan Hospital of Chongqing Medical University, Chongqing City, China.
Li J; Department of Otolaryngology Head and neck surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing City, China.
Feng M; Department of Otolaryngology Head and neck surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing City, China.; Pokaż więcej
Źródło:: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2020 Jul; Vol. 25 (7), pp. 466-474. Date of Electronic Publication: 2020 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Movement/*genetics
Cell Proliferation/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Homeodomain Proteins/*metabolism
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Neoplasms/*metabolism
Transcription Factors/*metabolism
Cell Line, Tumor ; Cell Survival/genetics ; Chromatin Immunoprecipitation ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Knockdown Techniques ; Homeodomain Proteins/genetics ; Humans ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Neoplasms/genetics ; Promoter Regions, Genetic ; Protein Binding ; RNA, Small Interfering ; Transcription Factors/genetics ; Up-Regulation ; Y-Box-Binding Protein 1/genetics ; Y-Box-Binding Protein 1/metabolism

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Skocz do pozycji: 10.

Tytuł:: Highly Expressed FOXF1 Inhibit Non-Small-Cell Lung Cancer Growth via Inducing Tumor Suppressor and G1-Phase Cell-Cycle Arrest.
Autorzy:: Wu CY; Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei 11031, Taiwan.; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chan CH; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Dubey NK; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Wei HJ; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Lu JH; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chang CC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Cheng HC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Dentistry, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Ou KL; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.; 3D Global Biotech Inc., New Taipei City 22175, Taiwan.
Deng WP; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Basic Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 May 02; Vol. 21 (9). Date of Electronic Publication: 2020 May 02.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Carcinoma, Non-Small-Cell Lung/*genetics
Forkhead Transcription Factors/*genetics
G1 Phase Cell Cycle Checkpoints/*genetics
Lung Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Animals ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/therapy ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Forkhead Transcription Factors/metabolism ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/therapy ; Mice, Inbred NOD ; Mice, SCID ; Tumor Burden/genetics ; Tumor Suppressor Proteins/metabolism ; Xenograft Model Antitumor Assays/methods

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Skocz do pozycji: 11.

Tytuł:: miR‑296‑3p promotes the proliferation of glioblastoma cells by targeting ICAT.
Autorzy:: Zhou J; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Du G; Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Fu H; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 May; Vol. 21 (5), pp. 2151-2161. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing/*metabolism
Brain Neoplasms/*metabolism
Cell Proliferation/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Glioblastoma/*metabolism
MicroRNAs/*metabolism
Wnt Signaling Pathway/*genetics
3' Untranslated Regions ; Adaptor Proteins, Signal Transducing/genetics ; Apoptosis/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Down-Regulation ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Silencing ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; MicroRNAs/genetics ; Neoplasm Grading ; Up-Regulation

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Skocz do pozycji: 12.

Tytuł:: Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms.
Autorzy:: Attanzio A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.
D'Agostino S; Department of Chemistry 'G. Ciamician', University of Bologna, via F. Selmi 2, 40126 Bologna, Italy.
Busà R; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.
Frazzitta A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.
Rubino S; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.
Girasolo MA; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.
Sabatino P; Department of Chemistry 'G. Ciamician', University of Bologna, via F. Selmi 2, 40126 Bologna, Italy.
Tesoriere L; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2020 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Apoptosis/*drug effects
Cytotoxins/*pharmacology
Organotin Compounds/*pharmacology
Pyrimidines/*pharmacology
Triazoles/*pharmacology
Apoptosis/genetics ; Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cytotoxins/chemical synthesis ; Drug Design ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/genetics ; HCT116 Cells ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Membrane Potential, Mitochondrial/drug effects ; Mitochondrial Membranes/drug effects ; Organotin Compounds/chemical synthesis ; Pyrimidines/chemical synthesis ; Reactive Oxygen Species/agonists ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism

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Skocz do pozycji: 13.

Tytuł:: Sinomenine hydrochloride exerts antitumor outcome in ovarian cancer cells by inhibition of long non-coding RNA HOST2 expression.
Autorzy:: Xu Y; Department of Gynecology, Jining No.1 People's Hospital, Jining, China.
Jiang T; Department of Gynecology, Jining No.1 People's Hospital, Jining, China.
Wang C; Department of Gynecology, Jining No.1 People's Hospital, Jining, China.
Wang F; Department of Gynecology, Jining No.1 People's Hospital, Jining, China.; Pokaż więcej
Źródło:: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 4131-4138.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Morphinans/*pharmacology
Ovarian Neoplasms/*pathology
RNA, Long Noncoding/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; Humans ; Prognosis ; Resting Phase, Cell Cycle/drug effects ; Resting Phase, Cell Cycle/genetics

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Skocz do pozycji: 14.

Tytuł:: ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
Autorzy:: Chen ZH; School of Basic Medicine, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, China. .; Heilongjiang Province Key Laboratory of Cancer Prevention and Treatment, Mudanjiang Medical University, No. 3, Tongxiang Street, Mudanjiang 157011, China. .
Jing YJ; Sciences Research Center, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, China.
Yu JB; Heilongjiang Province Key Laboratory of Cancer Prevention and Treatment, Mudanjiang Medical University, No. 3, Tongxiang Street, Mudanjiang 157011, China.
Jin ZS; Heilongjiang Province Key Laboratory of Cancer Prevention and Treatment, Mudanjiang Medical University, No. 3, Tongxiang Street, Mudanjiang 157011, China.
Li Z; Heilongjiang Province Key Laboratory of Cancer Prevention and Treatment, Mudanjiang Medical University, No. 3, Tongxiang Street, Mudanjiang 157011, China.
He TT; Sciences Research Center, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, China.
Su XZ; Sciences Research Center, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Jul 29; Vol. 20 (15). Date of Electronic Publication: 2019 Jul 29.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
RNA Stability*
Cyclin A2/*genetics
G1 Phase Cell Cycle Checkpoints/*genetics
RNA-Binding Proteins/*genetics
Uterine Cervical Neoplasms/*genetics
3' Untranslated Regions ; Cdc20 Proteins/genetics ; Cdc20 Proteins/metabolism ; Cell Line, Tumor ; Cyclin A2/metabolism ; Female ; Humans ; Immunohistochemistry ; Models, Biological ; Protein Binding ; RNA, Messenger/genetics ; RNA-Binding Proteins/metabolism ; Uterine Cervical Neoplasms/metabolism

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Skocz do pozycji: 15.

Tytuł:: Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities.
Autorzy:: Wang Z; Department of Basic Medicine, Qujing Medical College, Qujing, Yunnan 655000, P.R. China.
Li F; Department of Basic Medicine, Qujing Medical College, Qujing, Yunnan 655000, P.R. China.
Quan Y; School of Nursing, Qujing Medical College, Qujing, Yunnan 655000, P.R. China.
Shen J; Department of Traditional Chinese Medicine, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2019 Jun; Vol. 19 (6), pp. 5417-5423. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji:: Journal Article
MeSH Terms:: Cyclooxygenase 2/*metabolism
Flavonoids/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
NF-kappa B/*metabolism
PPAR gamma/*metabolism
Apoptosis/drug effects ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cyclooxygenase 2/genetics ; Drugs, Chinese Herbal/pharmacology ; Flavonoids/chemistry ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; NF-kappa B/genetics ; PPAR gamma/genetics

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Skocz do pozycji: 16.

Tytuł:: BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus.
Autorzy:: Ding F; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Wang M; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Du Y; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Du S; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Zhu Z; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Yan Z; Department of Clinical Pharmacology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Dec 02; Vol. 6, pp. 38331. Date of Electronic Publication: 2016 Dec 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
G1 Phase Cell Cycle Checkpoints/*drug effects
Pyrazoles/*pharmacology
beta Catenin/*genetics
A549 Cells ; Animals ; Cell Proliferation/drug effects ; Female ; G1 Phase Cell Cycle Checkpoints/genetics ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Signal Transduction ; Tumor Burden/drug effects ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Xenograft Model Antitumor Assays ; beta Catenin/antagonists & inhibitors ; beta Catenin/metabolism

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Skocz do pozycji: 17.

Tytuł:: A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells.
Autorzy:: Tsujimura N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Yamada NO; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .; Department of Anatomy, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Kuranaga Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Kumazaki M; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Shinohara H; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Taniguchi K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2016 Nov 05; Vol. 17 (11). Date of Electronic Publication: 2016 Nov 05.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Epithelial Cells/*metabolism
G1 Phase Cell Cycle Checkpoints/*genetics
Intercellular Signaling Peptides and Proteins/*genetics
Pinocytosis/*genetics
Adaptor Proteins, Signal Transducing ; Adenine/analogs & derivatives ; Adenine/pharmacology ; Amiloride/analogs & derivatives ; Amiloride/pharmacology ; Autophagy/drug effects ; Autophagy/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chemokines ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; G1 Phase Cell Cycle Checkpoints/drug effects ; Gene Silencing/drug effects ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Lysosomal Membrane Proteins/genetics ; Lysosomal Membrane Proteins/metabolism ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Pinocytosis/drug effects ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism

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Skocz do pozycji: 18.

Tytuł:: Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway.
Autorzy:: Wang R; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Zhang Q; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Peng X; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhou C; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhong Y; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Chen X; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Qiu Y; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Jin M; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Gong M; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Kong D; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 May 31; Vol. 6, pp. 27071. Date of Electronic Publication: 2016 May 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
G1 Phase Cell Cycle Checkpoints/*drug effects
Triterpenes/*pharmacology
A549 Cells ; Animals ; Antineoplastic Agents/isolation & purification ; Autophagy/drug effects ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Proliferation/drug effects ; Cyclin D1/antagonists & inhibitors ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/agonists ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; G1 Phase Cell Cycle Checkpoints/genetics ; Humans ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Porifera/chemistry ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Reactive Oxygen Species ; Signal Transduction ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Triterpenes/isolation & purification

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Skocz do pozycji: 19.

Tytuł:: Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib.
Autorzy:: Hehlgans S; Department of Radiotherapy and Oncology, Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Booms P; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Frankfurt Orofacial Regenerative Medicine (FORM), Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Güllülü Ö; Department of Radiotherapy and Oncology, Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Sader R; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Frankfurt Orofacial Regenerative Medicine (FORM), Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Rödel C; Department of Radiotherapy and Oncology, Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Balermpas P; Department of Radiotherapy and Oncology, Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Rödel F; Department of Radiotherapy and Oncology, Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .
Ghanaati S; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Frankfurt Orofacial Regenerative Medicine (FORM), Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2018 Aug 23; Vol. 19 (9). Date of Electronic Publication: 2018 Aug 23.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Anilides/*pharmacology
Antineoplastic Agents/*pharmacology
Gamma Rays/*therapeutic use
Hedgehog Proteins/*antagonists & inhibitors
Pyridines/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/metabolism ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Cell Line, Tumor ; Combined Modality Therapy/methods ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/radiation effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/radiation effects ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Organ Specificity ; Signal Transduction ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Survivin/genetics ; Survivin/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism

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Skocz do pozycji: 20.

Tytuł:: miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor.
Autorzy:: Liu Z; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.; Graduate School of Peking Union Medical College, NO. 9, Dongdansantiao, Dongcheng District, Beijing, 100730, China.
He F; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
OuYang S; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
Li Y; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
Ma F; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
Chang H; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
Cao D; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China.
Wu J; Department of Biochemistry & Immunology, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing, 100020, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2019 Apr 29; Vol. 19 (1), pp. 405. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Cell Proliferation/*genetics
MicroRNAs/*genetics
Signal Transduction/*genetics
Wilms Tumor/*genetics
Cell Line, Tumor ; Cell Movement/genetics ; Child ; Disease Progression ; Down-Regulation ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Profiling ; Gene Regulatory Networks/genetics ; Humans ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, IGF Type 1 ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptors, Somatomedin/genetics ; Receptors, Somatomedin/metabolism ; Smad2 Protein/genetics ; Smad2 Protein/metabolism ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Wilms Tumor/metabolism ; Wilms Tumor/pathology

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