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Tytuł:
Different Impacts of DNA-PK and mTOR Kinase Inhibitors in Combination with Ionizing Radiation on HNSCC and Normal Tissue Cells.
Autorzy:
Klieber N; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Hildebrand LS; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Faulhaber E; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Symank J; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Häck N; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Härtl A; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Fietkau R; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
Distel LV; Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2024 Feb 06; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/radiotherapy
Papillomavirus Infections*
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/radiotherapy
Humans ; Apoptosis ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Radiation, Ionizing ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; DNA-Activated Protein Kinase/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression.
Autorzy:
Fedr R; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
Kahounová Z; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00, Brno, Czech Republic.
Remšík J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Reiterová M; CLIP - Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Kalina T; CLIP - Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Souček K; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00, Brno, Czech Republic. .; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. .; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 25; Vol. 13 (1), pp. 4889. Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
G2 Phase*
Flow Cytometry/methods ; Cell Division ; Cell Cycle/physiology ; Cell Size
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe .
Autorzy:
Deng R; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li YL; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu JL; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 03; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Schizosaccharomyces*/genetics
Cell Cycle/genetics ; Cell Division ; Cell Proliferation ; G2 Phase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma.
Autorzy:
Coulter DW; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Chhonker YS; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kumar D; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kesherwani V; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Aldhafiri WN; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
McIntyre EM; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Alexander G; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ray S; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Joshi SS; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Li R; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Murry DJ; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Chaturvedi NK; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Department of Pediatrics, Hematology and Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 11; Vol. 43 (1), pp. 18. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Cerebellar Neoplasms*/drug therapy
Cerebellar Neoplasms*/genetics
Sirolimus/*analogs & derivatives
Humans ; Animals ; Mice ; G2 Phase Cell Cycle Checkpoints ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cytotoxicity and Radiosensitizing Potentials of Pilosulin-3, a Recombinant Ant Venom, in Breast Cancer Cells.
Autorzy:
Alzeer RM; Department of Zoology, College of Science, King Saud University, Riyadh 11541, Saudi Arabia.
Al-Hadyan KS; Biomedical Physics Department, Radiation Biology Section, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
Al-Harbi NM; Biomedical Physics Department, Radiation Biology Section, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
Bin Judia SS; Biomedical Physics Department, Radiation Biology Section, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
Almeer RS; Department of Zoology, College of Science, King Saud University, Riyadh 11541, Saudi Arabia.
Alsbeih GA; Biomedical Physics Department, Radiation Biology Section, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
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Źródło:
Toxins [Toxins (Basel)] 2023 Dec 15; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Ant Venoms*
Breast Neoplasms*/drug therapy
Breast Neoplasms*/radiotherapy
Humans ; Female ; Apoptosis ; Australia ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Peptides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells.
Autorzy:
Neamatallah T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Malebari AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Alamoudi AJ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Nazreen S; Department of Chemistry, Faculty of Science, Albaha University, Albaha, Saudi Arabia.
Alam MM; Department of Chemistry, Faculty of Science, Albaha University, Albaha, Saudi Arabia.
Bin-Melaih HH; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Abuzinadah OA; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Badr-Eldin SM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Alhassani G; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Makki L; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Nasrullah MZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło:
Drug delivery [Drug Deliv] 2023 Dec; Vol. 30 (1), pp. 2174209.
Typ publikacji:
Journal Article
MeSH Terms:
Diterpenes*/pharmacology
Liver Neoplasms*/drug therapy
Humans ; Hep G2 Cells ; Cell Proliferation ; Apoptosis ; G2 Phase Cell Cycle Checkpoints
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Biological Evaluation of Benzo [4,5]- and Naphtho[2',1':4,5]imidazo[1,2-c]pyrimidinone Derivatives.
Autorzy:
Kamzeeva P; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Dagaev N; Department of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Lizunova S; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Khodarovich Y; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.; Research and Educational Resource Center for Cellular Technologies, The Peoples' Friendship University of Russia, 117198 Moscow, Russia.
Sogomonyan A; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Kolchanova A; Department of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Pokrovsky V; N.N. Blokhin Cancer Research Center, 115478 Moscow, Russia.; Research Institute of Molecular and Cellular Medicine, RUDN University, 117198 Moscow, Russia.
Alferova V; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Chistov A; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Eshtukov-Shcheglov A; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Eshtukova-Shcheglova E; Lomonosov Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, Russia.
Belyaev E; Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Skvortsov D; Department of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Varizhuk A; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.; G4_Interact, USERN, University of Pavia, 27100 Pavia, Italy.
Aralov A; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.; G4_Interact, USERN, University of Pavia, 27100 Pavia, Italy.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 20; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Lung Neoplasms*/drug therapy
Animals ; Mice ; Apoptosis ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Cell Proliferation ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Keratinocytes Exposed to Blue or Red Light: Proteomic Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and Aldo-Keto Reductase Family 1 Member C3 Triggered Expression.
Autorzy:
Lazzarini R; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Tartaglione MF; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Ciarapica V; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Piva F; Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Giulietti M; Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Fulgenzi G; Department of Clinical and Molecular Sciences Experimental Pathology, Polytechnic University of Marche, 60126 Ancona, Italy.
Martelli M; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Ledda C; Section of Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy.
Vitale E; Faculty of Medicine and Surgery, Kore University, 94100 Enna, Italy.
Malavolta M; Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
Santarelli L; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Bracci M; Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 10; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/radiation effects
Proteomics*
Humans ; Aldo-Keto Reductase Family 1 Member C3 ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Keratinocytes/metabolism ; Light ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Thioredoxin Reductase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The cGAS/STING/IFN-1 Response in Squamous Head and Neck Cancer Cells after Genotoxic Challenges and Abrogation of the ATR-Chk1 and Fanconi Anemia Axis.
Autorzy:
Zahnreich S; Department of Radiation Oncology and Radiation Therapy, University Medical Centre of the Johannes Gutenberg, University Mainz, 55131 Mainz, Germany.
El Guerzyfy S; Department of Radiation Oncology and Radiation Therapy, University Medical Centre of the Johannes Gutenberg, University Mainz, 55131 Mainz, Germany.
Kaufmann J; Department of Radiation Oncology and Radiation Therapy, University Medical Centre of the Johannes Gutenberg, University Mainz, 55131 Mainz, Germany.
Schmidberger H; Department of Radiation Oncology and Radiation Therapy, University Medical Centre of the Johannes Gutenberg, University Mainz, 55131 Mainz, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 04; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:
Journal Article
MeSH Terms:
Fanconi Anemia*
Head and Neck Neoplasms*/genetics
Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Cisplatin/pharmacology ; Cisplatin/metabolism ; Apoptosis ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; DNA Damage ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS-Mediated Signaling in Colorectal Cancer Cell Lines.
Autorzy:
Chen JS; Department of Obstetrics and Gynecology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan.
Chiu SC; Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan.; Department of Laboratory Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan.; General Education Center, Tzu Chi University of Science and Technology, Hualien 973302, Taiwan.
Huang SY; Department of Ophthalmology, Hsinchu Mackay Memorial Hospital, Hsinchu 300044, Taiwan.
Chang SF; Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan.
Liao KF; Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 18; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:
Journal Article
MeSH Terms:
Sesquiterpenes*/pharmacology
Colorectal Neoplasms*/drug therapy
Humans ; Apoptosis ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Cell Cycle Checkpoints ; Autophagy ; Cell Proliferation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A co-formulation of interferons alpha2b and gamma distinctively targets cell cycle in the glioblastoma-derived cell line U-87MG.
Autorzy:
Miranda J; Bioinformatics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba. .
Vázquez-Blomquist D; Pharmacogenomics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba. .
Bringas R; Bioinformatics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
Fernandez-de-Cossio J; Bioinformatics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
Palenzuela D; Pharmacogenomics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
Novoa LI; Pharmacogenomics Group, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
Bello-Rivero I; Clinical Assays Division, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
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Źródło:
BMC cancer [BMC Cancer] 2023 Aug 29; Vol. 23 (1), pp. 806. Date of Electronic Publication: 2023 Aug 29.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Skin Neoplasms*
Humans ; Apoptosis ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Interferon-alpha/pharmacology ; Anaphase ; Interferon-gamma/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Endothelial Cell Response to Combined Photon or Proton Irradiation with Doxorubicin.
Autorzy:
Bernardo T; Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Kuntze A; Gerhard Domagk Institute of Pathology, University Hospital Muenster, 48149 Muenster, Germany.
Klein D; Institute of Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Heinzelmann F; West German Proton Therapy Centre Essen (WPE), 45147 Essen, Germany.; West German Cancer Centre (WTZ), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Faculty of Physics, Technical University (TU) Dortmund University, 44227 Dortmund, Germany.
Timmermann B; Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; West German Proton Therapy Centre Essen (WPE), 45147 Essen, Germany.; West German Cancer Centre (WTZ), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), 45147 Essen, Germany.
von Neubeck C; Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 16; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 16.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*
Protons*
Humans ; Photons ; Doxorubicin/pharmacology ; G2 Phase Cell Cycle Checkpoints
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miR-17-5p drives G2/M-phase accumulation by directly targeting CCNG2 and is related to recurrence of head and neck squamous cell carcinoma.
Autorzy:
Huang Q; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Shen YJ; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Hsueh CY; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Guo Y; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Zhang YF; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Li JY; Department of Pediatric, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.
Zhou L; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. .
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Źródło:
BMC cancer [BMC Cancer] 2021 Oct 02; Vol. 21 (1), pp. 1074. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji:
Journal Article
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
M Phase Cell Cycle Checkpoints*
Cyclin G2/*metabolism
Head and Neck Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Recurrence, Local/*genetics
Squamous Cell Carcinoma of Head and Neck/*metabolism
3' Untranslated Regions/genetics ; Apoptosis/genetics ; Area Under Curve ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cyclin G2/genetics ; Down-Regulation ; Female ; Gene Silencing ; Head and Neck Neoplasms/genetics ; Humans ; Luciferases/metabolism ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Recurrence, Local/metabolism ; RNA, Messenger/metabolism ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transfection ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Induction of G2/M Cell Cycle Arrest via p38/p21 -Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells.
Autorzy:
Pai JT; Division of Hematology and Oncology, Tao-Yuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Hsu MW; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Leu YL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.; Tissue Bank, Chang Gung Memorial Hospital, Linkou, Taoyuan City 33342, Taiwan.
Chang KT; Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Weng MS; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 25; Vol. 26 (17). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cell Cycle Checkpoints/*drug effects
Flavonoids/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
A549 Cells ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin B1 ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Lung Neoplasms/genetics ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Signal Transduction/genetics ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma.
Autorzy:
Amin N; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Wang H; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Song Q; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bhaskar M; Translational Neuroscience Center, National Institutes of Health, Bethesda, MD 20892, USA.
Yadav SP; Vaxess Technologies, Woburn, MA 02139, USA.
Gilbert MR; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pant H; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Tabouret E; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Institute of NeuroPhysiopathology (INP), National Centre for Scientific Research (CNRS), Aix-Marseille University, 13005 Marseille, France.
Zhuang Z; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 21; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclin-Dependent Kinase 5*/metabolism
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Mice ; Humans ; Animals ; Irinotecan/pharmacology ; Irinotecan/therapeutic use ; Apoptosis ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P53 status, and G2/M cell cycle arrest, are determining factors in cell-death induction mediated by ELF-EMF in glioblastoma.
Autorzy:
Mehdizadeh R; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Madjid Ansari A; Department of Integrative Oncology, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Forouzesh F; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Shahriari F; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Shariatpanahi SP; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Salaritabar A; Department of Integrative Oncology, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Javidi MA; Department of Integrative Oncology, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. .; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 05; Vol. 13 (1), pp. 10845. Date of Electronic Publication: 2023 Jul 05.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/pathology
Humans ; Tumor Suppressor Protein p53/genetics ; Electromagnetic Fields/adverse effects ; M Cells ; G2 Phase Cell Cycle Checkpoints/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Autorzy:
Li D; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
Liu Y; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.; College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Zhan Q; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
Zeng Y; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.; College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Peng Z; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
He Q; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.; College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Tan Q; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
Cao W; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
Wang S; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
Wang J; Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
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Źródło:
Cells [Cells] 2023 Jul 04; Vol. 12 (13). Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transforming Growth Factor beta1*/metabolism
Renal Insufficiency, Chronic*
Rats ; Humans ; Animals ; Epithelial-Mesenchymal Transition ; Proto-Oncogene Proteins c-akt/metabolism ; Apoptosis ; Molecular Docking Simulation ; Tumor Suppressor Protein p53 ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Fibrosis ; TOR Serine-Threonine Kinases/metabolism ; Autophagy ; Aldehyde Dehydrogenase, Mitochondrial/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kaempferol and Fisetin-Related Signaling Pathways Induce Apoptosis in Head and Neck Cancer Cells.
Autorzy:
Kubina R; Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 30 Ostrogórska Str., 41-200 Sosnowiec, Poland.; Silesia LabMed, Centre for Research and Implementation, Medical University of Silesia in Katowice, 18 Medyków Str., 40-752 Katowice, Poland.
Krzykawski K; Silesia LabMed, Centre for Research and Implementation, Medical University of Silesia in Katowice, 18 Medyków Str., 40-752 Katowice, Poland.
Dziedzic A; Department of Conservative Dentistry with Endodontics, Medical University of Silesia, 40-055 Katowice, Poland.
Kabała-Dzik A; Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 30 Ostrogórska Str., 41-200 Sosnowiec, Poland.
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Źródło:
Cells [Cells] 2023 Jun 06; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Head and Neck Neoplasms*/drug therapy
Humans ; Flavonoids/pharmacology ; Kaempferols/pharmacology ; Cytochromes c/metabolism ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Flavonols/pharmacology ; Signal Transduction ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pan-cancer analysis reveals the prognostic and immunotherapeutic value of cytoskeleton-associated protein 2-like.
Autorzy:
Yi B; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Fu Q; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Zheng Z; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Zhang M; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Institute of Endocrinology, Chu Hsien-I Memorial Hospital of Tianjin Medical University, Tianjin, China.
Liu D; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Liang Z; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Xu S; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Zhang Z; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 24; Vol. 13 (1), pp. 8368. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cytoskeletal Proteins*/genetics
Neoplasms*/genetics
Neoplasms*/therapy
Humans ; Cell Cycle Proteins ; Cell Line, Tumor ; Cytoskeleton ; G2 Phase Cell Cycle Checkpoints ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle.
Autorzy:
Węgierek-Ciuk A; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Arabski M; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Ciepluch K; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Brzóska K; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Lisowska H; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Czerwińska M; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Stępkowski T; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.; Remedy International Research Agenda Unit, Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland.
Lis K; Holy Cross Cancer Center, Artwinskiego 3, 25-734 Kielce, Poland.
Lankoff A; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji:
Journal Article
MeSH Terms:
Berberine Alkaloids/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*genetics
G2 Phase Cell Cycle Checkpoints/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Up-Regulation/*drug effects
A549 Cells ; Actin Cytoskeleton/drug effects ; Actin Cytoskeleton/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; G2 Phase Cell Cycle Checkpoints/radiation effects ; Humans ; Microscopy, Confocal ; Radiation, Ionizing ; Radiation-Sensitizing Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1600

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