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Tytuł :
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line.
Autorzy :
Manoel-Caetano FS; Department of Biology, UNESP, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Rossi AFT; Department of Biology, UNESP, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Ribeiro ML; Clinical Pharmacology and Gastroenterology Unit, São Francisco University, Bragança Paulista, São Paulo, Brazil.
Prates J; Department of Biology, UNESP, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Oliani SM; Department of Biology, UNESP, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Silva AE; Department of Biology, UNESP, São Paulo State University, São José do Rio Preto, São Paulo, Brazil. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2020 Dec; Vol. 96, pp. 102976. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
DNA Repair*
G2 Phase Cell Cycle Checkpoints*
Helicobacter pylori*
DNA-(Apurinic or Apyrimidinic Site) Lyase/*genetics
Hydrogen Peroxide/*toxicity
Stomach Neoplasms/*physiopathology
Ataxia Telangiectasia Mutated Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation ; DNA Breaks, Double-Stranded ; DNA Damage ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Histones ; Humans ; Hydrogen Peroxide/pharmacology ; MicroRNAs/genetics ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/therapy
Czasopismo naukowe
Tytuł :
FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery.
Autorzy :
Lafranchi L; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Müllers E; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Rutishauser D; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Science for Life Laboratory, SE-171 65 Stockholm, Sweden.
Lindqvist A; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
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Źródło :
Cells [Cells] 2020 Sep 19; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CDC2 Protein Kinase/*genetics
Cell Cycle Proteins/*genetics
Fibroblasts/*metabolism
G2 Phase Cell Cycle Checkpoints/*genetics
M Phase Cell Cycle Checkpoints/*genetics
Mitosis/*drug effects
Protein-Serine-Threonine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Aurora Kinase A/genetics ; Aurora Kinase A/metabolism ; CDC2 Protein Kinase/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cyclin B1/genetics ; Cyclin B1/metabolism ; DNA Damage ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Flow Cytometry ; Fluorescence Resonance Energy Transfer ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Signal Transduction ; Tumor Suppressor p53-Binding Protein 1/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Zinostatin/pharmacology
Czasopismo naukowe
Tytuł :
Besnoitia besnoiti-driven endothelial host cell cycle alteration.
Autorzy :
Velásquez ZD; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University, Schubertstr. 81, 35392, Giessen, Germany. .
Lopez-Osorio S; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University, Schubertstr. 81, 35392, Giessen, Germany.; Research Group CIVAB, School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellín, Colombia.
Pervizaj-Oruqaj L; Cardio Pulmonary Institute (CPI), Giessen, Germany.; Universities Giessen & Marburg Lung Center (UGMLC), Giessen, Germany.; German Center for Lung Research (DZL), Giessen, Germany.
Herold S; Cardio Pulmonary Institute (CPI), Giessen, Germany.; Universities Giessen & Marburg Lung Center (UGMLC), Giessen, Germany.; German Center for Lung Research (DZL), Giessen, Germany.
Hermosilla C; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University, Schubertstr. 81, 35392, Giessen, Germany.
Taubert A; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University, Schubertstr. 81, 35392, Giessen, Germany.
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Źródło :
Parasitology research [Parasitol Res] 2020 Aug; Vol. 119 (8), pp. 2563-2577. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
G2 Phase Cell Cycle Checkpoints*
M Phase Cell Cycle Checkpoints*
Cattle Diseases/*physiopathology
Coccidiosis/*veterinary
Sarcocystidae/*physiology
Animals ; Apoptosis ; Cattle ; Cattle Diseases/parasitology ; Coccidiosis/parasitology ; Coccidiosis/physiopathology ; Endothelial Cells/cytology ; Endothelial Cells/parasitology
Czasopismo naukowe
Tytuł :
Biology of Glioblastoma Multiforme-Exploration of Mitotic Catastrophe as a Potential Treatment Modality.
Autorzy :
Vitovcova B; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Skarkova V; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Rudolf K; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Rudolf E; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 27; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain Neoplasms*/metabolism
Brain Neoplasms*/mortality
Brain Neoplasms*/pathology
Brain Neoplasms*/therapy
G2 Phase Cell Cycle Checkpoints*
Glioblastoma*/metabolism
Glioblastoma*/mortality
Glioblastoma*/therapy
M Phase Cell Cycle Checkpoints*
Mitosis*
Humans
Czasopismo naukowe
Tytuł :
Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest.
Autorzy :
Nagata K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Shindo K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan. Electronic address: .
Matsui Y; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Shirakawa K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 18; Vol. 527 (1), pp. 257-263. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G2 Phase Cell Cycle Checkpoints*
Blood Proteins/*metabolism
Protein Phosphatase 2/*metabolism
vif Gene Products, Human Immunodeficiency Virus/*metabolism
HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Autorzy :
Liu X; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Zhang Y; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Wu S; Chongqing Productivity Promotion Center of Chinese Traditional Medicine, Modernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Xu M; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Shen Y; Chongqing Productivity Promotion Center of Chinese Traditional Medicine, Modernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yu M; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Fan J; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Wei S; Chongqing Productivity Promotion Center of Chinese Traditional Medicine, Modernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Xu C; Chongqing Productivity Promotion Center of Chinese Traditional Medicine, Modernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Huang L; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Zhao H; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China.
Li X; Chongqing Productivity Promotion Center of Chinese Traditional Medicine, Modernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. Electronic address: .
Ye X; Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 May; Vol. 175, pp. 113933. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/metabolism
Aurora Kinase A/*antagonists & inhibitors
Berberine Alkaloids/*administration & dosage
G2 Phase Cell Cycle Checkpoints/*drug effects
M Phase Cell Cycle Checkpoints/*drug effects
Mitochondria/*drug effects
Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Aurora Kinase A/metabolism ; Dose-Response Relationship, Drug ; Drug Delivery Systems/methods ; G2 Phase Cell Cycle Checkpoints/physiology ; HCT116 Cells ; HT29 Cells ; Humans ; M Phase Cell Cycle Checkpoints/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondria/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
In vitro effects of Trastuzumab Emtansine (T-DM1) and concurrent irradiation on HER2-positive breast cancer cells.
Autorzy :
Mignot F; Institut Curie, département de radiothérapie, 26, rue d'Ulm, 75005 Paris, France. Electronic address: .
Kirova Y; Institut Curie, département de radiothérapie, 26, rue d'Ulm, 75005 Paris, France.
Verrelle P; Institut Curie, département de radiothérapie, 26, rue d'Ulm, 75005 Paris, France.
Teulade-Fichou MP; Institut Curie, Bât. 110-112, rue H. Becquerel, centre universitaire, 91405 Orsay, France; Université Paris-Saclay, centre universitaire, 91405 Orsay, France; INSERM U1196/CNRS UMR9187, France.
Megnin-Chanet F; Institut Curie, Bât. 110-112, rue H. Becquerel, centre universitaire, 91405 Orsay, France; Université Paris-Saclay, centre universitaire, 91405 Orsay, France; INSERM U1196/CNRS UMR9187, France.
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Źródło :
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2021 Apr; Vol. 25 (2), pp. 126-134. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Ado-Trastuzumab Emtansine/*therapeutic use
Antineoplastic Agents, Immunological/*therapeutic use
Breast Neoplasms/*metabolism
Breast Neoplasms/*therapy
Chemoradiotherapy/*methods
Receptor, ErbB-2/*metabolism
Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Culture Techniques ; Female ; Flow Cytometry/methods ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/radiation effects ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; M Phase Cell Cycle Checkpoints/radiation effects ; Radiation Tolerance/drug effects ; Time Factors
Czasopismo naukowe
Tytuł :
The Mechanism of the Synergistic Anticancer Effect of CDDP and EPA in the TE1 Cell Line.
Autorzy :
Ogo A; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan; .
Miyake S; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan.
Kubota H; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
Higashida M; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
Matsumoto H; Mitsugi General Hospital, Hiroshima, Japan.
Teramoto F; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan.
Hirai T; Mitsugi General Hospital, Hiroshima, Japan.
Ueno T; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Apr; Vol. 41 (4), pp. 1771-1778.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Cisplatin/*pharmacology
Eicosapentaenoic Acid/*pharmacology
Esophageal Neoplasms/*drug therapy
Apoptosis/drug effects ; Cell Line, Tumor ; Drug Synergism ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Interleukin-6/metabolism ; NF-kappa B/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Signal Transduction
Czasopismo naukowe
Tytuł :
The quinazoline derivative, 04NB-03, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells in a reactive oxygen species-dependent manner.
Autorzy :
Wang R; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Zhu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Chen J; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Song X; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Jin F; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China. Electronic address: .
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Apr 01; Vol. 338, pp. 109371. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Cell Cycle Checkpoints/*drug effects
Liver Neoplasms/*pathology
Quinazolines/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Inhibitory Concentration 50 ; M Phase Cell Cycle Checkpoints/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Quinazolines/chemistry
Czasopismo naukowe
Tytuł :
Bioreductive Activation of Antitumour Drugs, Doxorubicin and Pirarubicin, Does Not Affect Their Ability to Induce Apoptosis of Sensitive and Multidrug Resistant Leukaemia HL60 Cells.
Autorzy :
Kostrzewa-Nowak D; Department of Biochemistry, Faculty of Biology, University of Szczecin, Szczecin, Poland.
Tarasiuk J
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Źródło :
Anticancer research [Anticancer Res] 2021 Mar; Vol. 41 (3), pp. 1429-1438.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Doxorubicin/*analogs & derivatives
Doxorubicin/*pharmacology
Drug Resistance, Multiple/*drug effects
Drug Resistance, Neoplasm/*drug effects
Leukemia/*pathology
Antineoplastic Agents/pharmacology ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA Fragmentation/drug effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; HL-60 Cells ; Humans ; Leukemia/metabolism ; NADPH-Ferrihemoprotein Reductase/metabolism
Czasopismo naukowe
Tytuł :
Involvement of mTOR/Survivin signaling pathway in TUA(2β, 3β, 23-trihydroxy-urs-12-ene-28-olic acid)-induced apoptosis in human gastric cancer cell line BGC823 cells.
Autorzy :
Cheng Q; College of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, PR China. Electronic address: .
Li Y; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha 410006, Hunan Province, PR China. Electronic address: .
Guo X; College of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, PR China.
Li H; College of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113437. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Stomach Neoplasms/*drug therapy
Survivin/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Triterpenes/*pharmacology
Animals ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Signal Transduction ; Stomach Neoplasms/enzymology ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Survivin/genetics ; TOR Serine-Threonine Kinases/genetics ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
Induction of Apoptosis and Regulation of MicroRNA Expression by (2 E ,6 E )-2,6- bis -(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) Treatment on MCF-7 Breast Cancer Cells.
Autorzy :
Yeap SK; China-ASEAN College of Marine Sciences, Xiamen University Malaysia Campus, Jalan Sunsuria, Bandar Sunsuria, Sepang 43900, Selangor, Malaysia.
Mohd Ali N; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.; Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sungai Long Campus, Jalan Sungai Long, Bandar Sungai Long, Cheras, Kajang 43000, Selangor, Malaysia.
Akhtar MN; Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Kuantan Pahang, Malaysia.
Razak NA; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Chong ZX; School of Biomedical Sciences, The University of Nottingham Malaysia Campus, Jalan Broga, Semenyih 43500, Selangor, Malaysia.
Ho WY; School of Biomedical Sciences, The University of Nottingham Malaysia Campus, Jalan Broga, Semenyih 43500, Selangor, Malaysia.
Boo L; Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sungai Long Campus, Jalan Sungai Long, Bandar Sungai Long, Cheras, Kajang 43000, Selangor, Malaysia.
Zareen S; Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak 26300, Kuantan Pahang, Malaysia.
Kurniawan TA; Key Laboratory of the Coastal and Wetland Ecosystems (Xiamen University), Ministry of Education, College of the Environment and Ecology, Xiamen University, Fujian 361102, China.
Avtar R; Faculty of Environmental Earth Sciences, Hokkaido University, Sapporo 060-0810, Japan.
Ng SYL; China-ASEAN College of Marine Sciences, Xiamen University Malaysia Campus, Jalan Sunsuria, Bandar Sunsuria, Sepang 43900, Selangor, Malaysia.
Ong AHK; Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sungai Long Campus, Jalan Sungai Long, Bandar Sungai Long, Cheras, Kajang 43000, Selangor, Malaysia.
Alitheen NB; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.; UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 26; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Cell Proliferation/*drug effects
MicroRNAs/*genetics
Antineoplastic Agents/pharmacology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Curcumin/analogs & derivatives ; Curcumin/pharmacology ; Cyclohexanones/pharmacology ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing Drug-resistant Cancer Cells.
Autorzy :
Jiang C; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Lee SH; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Park JH; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Lee JS; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Park JW; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Kim JR; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Lee SH; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Kim HS; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea .
Yoon S; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea .
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 687-697.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Antipsychotic Agents/*pharmacology
Aripiprazole/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Furans/*pharmacology
Ketones/*pharmacology
Mouth Neoplasms/*drug therapy
Squamous Cell Carcinoma of Head and Neck/*drug therapy
Vincristine/*pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology
Czasopismo naukowe
Tytuł :
CKS2 modulates cell-cycle progression of tongue squamous cell carcinoma cells partly via modulating the cellular distribution of DUTPase.
Autorzy :
Gao F; Operation Room, Jinan Stomatological Hospital, Jinan, China.
Li C; Department of Outpatient Nursing, Jinan Stomatological Hospital, Jinan, China.
Zhao X; Department of Pediatric Dentistry, Jinan Stomatological Hospital, Jinan, China.
Xie J; Department of Prosthodontics, Jinan Stomatological Hospital, Jinan, China.
Fang G; Clinical laboratory, Jinan Stomatological Hospital, Jinan, China.
Li Y; Department of Outpatient Nursing, Jinan Stomatological Hospital, Jinan, China.
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Źródło :
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2021 Feb; Vol. 50 (2), pp. 175-182. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
CDC2-CDC28 Kinases*/genetics
CDC2-CDC28 Kinases*/metabolism
Carcinoma, Squamous Cell*/genetics
Tongue Neoplasms*/genetics
Apoptosis ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Division ; Cell Line, Tumor ; Cell Proliferation ; G2 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; Humans ; Pyrophosphatases ; Tongue
Czasopismo naukowe
Tytuł :
Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway.
Autorzy :
Zhang L; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Yang C; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Huang Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
Huang H; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Yuan X; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Zhang P; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Ye C; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Wei M; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
Wang Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
Luo X; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
Luo J; School of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111155. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Bone Neoplasms/*drug therapy
Cell Proliferation/*drug effects
Chalcones/*pharmacology
JNK Mitogen-Activated Protein Kinases/*metabolism
Osteosarcoma/*drug therapy
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Apoptosis/drug effects ; Bone Neoplasms/enzymology ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Enzyme Activation ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Osteosarcoma/enzymology ; Osteosarcoma/pathology ; Phosphorylation ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer.
Autorzy :
Oshi M; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Takahashi H; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Tokumaru Y; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Surgical Oncology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Yan L; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Rashid OM; Department of Surgery, Holy Cross Hospital, Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, FL 33308, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Matsuyama R; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Takabe K; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14263, USA.; Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo 160-8402, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 22; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
G2 Phase Cell Cycle Checkpoints*/genetics
Signal Transduction*
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Receptors, Estrogen/*metabolism
Breast Neoplasms/etiology ; Breast Neoplasms/mortality ; Cell Proliferation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer.
Autorzy :
Liu HY; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Liu YY; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yang F; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhang L; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhang FL; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Hu X; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Breast Cancer, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Shao ZM; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Breast Cancer, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Li DQ; Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Shanghai Key Laboratory of Breast Cancer, Shanghai Medical College, Fudan University, Shanghai 200032, China.; International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai 200032, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 17; Vol. 48 (7), pp. 3638-3656.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
G2 Phase Cell Cycle Checkpoints*
Breast Neoplasms/*enzymology
N-Terminal Acetyltransferases/*metabolism
Transcription Factors/*metabolism
Acetylation ; Antineoplastic Agents ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; CDC2 Protein Kinase/genetics ; CDC2 Protein Kinase/metabolism ; Cell Line, Tumor ; Cyclin B1/genetics ; Cyclin B1/metabolism ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; Lysine/metabolism ; Radiation, Ionizing ; Sirtuin 2/metabolism ; Transcription Factors/chemistry
Czasopismo naukowe
Tytuł :
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Autorzy :
Arroyo M; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Sánchez A; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Cañuelo A; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Heredia-Molina RF; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Martínez-Molina E; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Clarke DJ; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Marchal JA; Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
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Źródło :
Genes [Genes (Basel)] 2020 Apr 08; Vol. 11 (4). Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Cytoskeletal Proteins/*genetics
DNA Topoisomerases, Type II/*genetics
G2 Phase Cell Cycle Checkpoints/*drug effects
Mitosis/*genetics
Catalytic Domain/genetics ; DNA, Catenated/genetics ; Enzyme Inhibitors/pharmacology ; G2 Phase Cell Cycle Checkpoints/genetics ; HeLa Cells ; Humans ; Topoisomerase II Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.
Autorzy :
Müller I; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany.
Strozyk E; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany.
Schindler S; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany.
Beissert S; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany.
Oo HZ; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
Sauter T; Systems Biology, Life Science Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg.
Lucarelli P; Systems Biology, Life Science Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg.
Raeth S; Institute of Cell Biology and Immunology and Stuttgart Research Centre Systems Biology, University of Stuttgart, Stuttgart 70569, Germany.
Hausser A; Institute of Cell Biology and Immunology and Stuttgart Research Centre Systems Biology, University of Stuttgart, Stuttgart 70569, Germany.
Al Nakouzi N; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
Fazli L; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
Gleave ME; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
Liu H; Institute of Pharmacology, University of Bern, Bern 3010, Switzerland.
Simon HU; Institute of Pharmacology, University of Bern, Bern 3010, Switzerland.
Walczak H; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London WC1E 6DD, UK.
Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bartek J; Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 171 77, Sweden.
Daugaard M; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
Kulms D; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Mar 05; Vol. 77 (5), pp. 970-984.e7. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
G2 Phase Cell Cycle Checkpoints*/drug effects
Caspase 8/*metabolism
Cell Nucleus/*enzymology
Neoplasms/*enzymology
Tumor Suppressor Protein p53/*metabolism
Ubiquitin Thiolesterase/*metabolism
Antineoplastic Agents/pharmacology ; Apoptosis ; Caspase 8/genetics ; Cell Nucleus/drug effects ; Cell Nucleus/genetics ; Cell Nucleus/pathology ; Drug Resistance, Neoplasm ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HeLa Cells ; Humans ; MCF-7 Cells ; Male ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; PC-3 Cells ; Protein Stability ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics ; Ubiquitin Thiolesterase/genetics
Czasopismo naukowe
Tytuł :
Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.
Autorzy :
Ding Q; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang W; Department of Orthopaedics, The People's Hospital of China Three Gorges University, The First People's Hospital of YiChang, Yichang, China.
Cheng C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mo F; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Chen L; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Peng G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cai X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang J; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Mar; Vol. 235 (3), pp. 2911-2924. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cell Death/*drug effects
Diosgenin/*analogs & derivatives
G2 Phase Cell Cycle Checkpoints/*drug effects
Osteosarcoma/*drug therapy
Apoptosis/physiology ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Cell Cycle Checkpoints/physiology ; Cell Death/physiology ; Cell Line, Tumor ; Diosgenin/pharmacology ; G2 Phase Cell Cycle Checkpoints/physiology ; Humans ; Osteosarcoma/metabolism ; Pyroptosis/physiology ; Receptors, Estrogen/drug effects ; Receptors, Estrogen/metabolism
Czasopismo naukowe

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