- Tytuł:
-
Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall
Cell Lung Cancer. - Autorzy:
- Źródło:
- Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3307-3320. Date of Electronic Publication: 2023 Dec 17.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Carcinoma, Non-Small-
Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/pathology
Humans ; Animals ; Mice ;Cell Cycle Proteins ; Proteolysis Targeting Chimera ; Protein Serine-Threonine Kinases ; Polo-Like Kinase 1 ; Apoptosis ; Degrons ;Cell Line, Tumor ;G2 Phase Cell Cycle Checkpoints ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe