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Tytuł :
NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer.
Autorzy :
Serej ZA; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Ebrahimi A; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Halic University, Istanbul, Turkey.
Kazemi T; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Najafi S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amini M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nastarin P; Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Baghbani E; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 30; Vol. 801, pp. 145844. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
MicroRNAs/*genetics
Nanog Homeobox Protein/*genetics
Antigens, CD/genetics ; Apoptosis/genetics ; Cadherins/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Female ; Gene Expression Regulation, Neoplastic ; HMGA2 Protein/genetics ; Humans ; Nanog Homeobox Protein/metabolism ; Neoplastic Stem Cells/pathology ; Octamer Transcription Factor-3/genetics ; RNA, Small Interfering ; RNA-Binding Proteins/genetics ; Spheroids, Cellular/pathology ; Transfection ; Vimentin/genetics
Czasopismo naukowe
Tytuł :
Identification and expression analysis of the β-defensin genes in the goat small intestine.
Autorzy :
Zhang L; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China; Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong 637009, Sichuan, China.
Xiao H; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China.
Huang J; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China.
Ouyang L; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China. Electronic address: .
Li S; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China.
Tang Y; Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China.
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Źródło :
Gene [Gene] 2021 Oct 30; Vol. 801, pp. 145846. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Goats/*genetics
Intestine, Small/*physiology
beta-Defensins/*genetics
Animals ; Antimicrobial Cationic Peptides/genetics ; Cattle ; Chromosomes ; DNA Copy Number Variations ; Evolution, Molecular ; Gene Expression ; Genome ; Multigene Family ; Phylogeny ; Pseudogenes ; Real-Time Polymerase Chain Reaction ; Sheep/genetics
Czasopismo naukowe
Tytuł :
Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach.
Autorzy :
Sharma K; Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Singh P; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Amjad Beg M; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Dohare R; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: .
Athar F; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Ali Syed M; Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 30; Vol. 801, pp. 145856. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Regulatory Networks*
Antihypertensive Agents/*pharmacology
Hypertension/*genetics
Protein Interaction Maps/*genetics
Drug Development/methods ; Gene Expression Profiling ; High-Throughput Screening Assays/methods ; Humans ; Hypertension/drug therapy ; Kininogens/chemistry ; Kininogens/genetics ; Limonins/chemistry ; Limonins/pharmacology ; MicroRNAs/genetics ; Models, Molecular ; Molecular Docking Simulation ; Telmisartan/chemistry ; Telmisartan/pharmacology ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Autorzy :
Smith AL; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Gjoka E; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Izhar M; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Novo KJ; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Mason BC; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
De Las Casas A; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Waddell DS; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 20; Vol. 800, pp. 145836. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Splice Sites*
Muscle, Skeletal/*enzymology
Muscular Atrophy/*genetics
Phosphotransferases/*genetics
Phosphotransferases/*metabolism
Animals ; Cell Differentiation/genetics ; Cells, Cultured ; Cytoplasm/enzymology ; Gene Expression Regulation, Enzymologic ; MAP Kinase Signaling System/genetics ; Mice ; Myoblasts/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Differential impact of Bt-transgenic rice plantings on bacterial community in three niches over consecutive years.
Autorzy :
Wu N; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Shi W; State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an 271018, China.
Liu W; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Gao Z; State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an 271018, China.
Han L; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Wang X; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Oct 15; Vol. 223, pp. 112569. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Bacillus thuringiensis*/genetics
Oryza*/genetics
Bacterial Proteins/genetics ; Endotoxins/genetics ; Hemolysin Proteins/genetics ; Plants, Genetically Modified ; Rhizosphere
Czasopismo naukowe
Tytuł :
Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney.
Autorzy :
Yin H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Zuo Z; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Yang Z; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Guo H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address: .
Fang J; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address: .
Cui H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Ouyang P; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Chen X; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Chen J; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Geng Y; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Chen Z; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Huang C; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Zhu Y; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Oct 15; Vol. 223, pp. 112583. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Autophagy ; Kidney/metabolism ; Mice ; Nickel ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
Autorzy :
Cai X; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Deng J; Department of Pathology, Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Zhou J; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Cai H; Department of Clinical Medicine, University of Aarhus, Palle Juul-Jensens Boulevard 82, 8200, Aarhus N, Denmark. .
Chen Z; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. .
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Oct 14; Vol. 21 (1), pp. 377. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Biomarkers, Tumor/genetics ; Cyclin-Dependent Kinases/genetics ; Humans ; Prognosis ; Transcriptional Activation ; Up-Regulation
Czasopismo naukowe
Tytuł :
Synergism of Bacillus thuringiensis Toxin Cry1Ac by a Fragment of Toxin-Binding Polycalin from Plutella xylostella .
Autorzy :
Zhu Q; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro -product Safety and Quality, Ministry of Agriculture, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Gao M; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro -product Safety and Quality, Ministry of Agriculture, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Lu L; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro -product Safety and Quality, Ministry of Agriculture, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Liu X; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro -product Safety and Quality, Ministry of Agriculture, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Oct 13; Vol. 69 (40), pp. 11816-11824. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Bacillus thuringiensis*/genetics
Moths*/genetics
Animals ; Bacillus thuringiensis Toxins ; Bacterial Proteins/genetics ; Endotoxins/genetics ; Hemolysin Proteins/genetics ; Insect Proteins/genetics ; Insecticide Resistance ; Larva/genetics
Czasopismo naukowe
Tytuł :
Zearalenone Induces Dopaminergic Neurodegeneration via DRP-1-Involved Mitochondrial Fragmentation and Apoptosis in a Caenorhabditis elegans Parkinson's Disease Model.
Autorzy :
Wei CC; Institute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan.
Yang NC; Institute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan.
Huang CW; Institute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Oct 13; Vol. 69 (40), pp. 12030-12038. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Parkinson Disease*/genetics
Parkinson Disease*/metabolism
Zearalenone*/metabolism
Zearalenone*/toxicity
Animals ; Apoptosis ; Caenorhabditis elegans/genetics ; Dopaminergic Neurons ; Mitochondria/genetics
Czasopismo naukowe
Tytuł :
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses.
Autorzy :
Ye C; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227; .; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Chiem K; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227.; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Park JG; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227.; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Silvas JA; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227.; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Morales Vasquez D; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227.; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Sourimant J; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Lin MJ; Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195.
Greninger AL; Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195.
Plemper RK; Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Torrelles JB; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227.; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
Kobie JJ; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294.
Walter MR; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
de la Torre JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
Martinez-Sobrido L; Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227; .; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Oct 12; Vol. 118 (41).
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/genetics
COVID-19*/metabolism
Gene Expression Regulation, Viral*
Genes, Reporter*
SARS-CoV-2*/genetics
SARS-CoV-2*/metabolism
Viral Proteins*/biosynthesis
Viral Proteins*/genetics
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Chlorocebus aethiops ; Coronavirus Nucleocapsid Proteins/biosynthesis ; Coronavirus Nucleocapsid Proteins/genetics ; Female ; Humans ; Mice ; Mice, Transgenic ; Teschovirus/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.
Autorzy :
Bjaanæs MM; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway. .; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway. .
Nilsen G; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Halvorsen AR; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.
Russnes HG; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Pathology, Oslo University Hospital, Oslo, Norway.
Solberg S; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Jørgensen L; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Brustugun OT; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Section of Oncology, Vestre Viken Hospital, Drammen, Norway.
Lingjærde OC; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Helland Å; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway.
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 09; Vol. 21 (1), pp. 1089. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Genes, p53*
Adenocarcinoma of Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Adenocarcinoma of Lung/pathology ; Alleles ; Carcinoma, Non-Small-Cell Lung/pathology ; Chromosomes, Human, Pair 7 ; Chromosomes, Human, Pair 9 ; Class I Phosphatidylinositol 3-Kinases/genetics ; DNA Copy Number Variations ; Ex-Smokers ; Female ; Gene Expression ; Genes, erbB-1/genetics ; Genes, ras/genetics ; Humans ; Lung Neoplasms/pathology ; Male ; Non-Smokers ; Polymorphism, Single Nucleotide ; Signal Transduction/genetics ; Smokers ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
The impact of codon choice on translation process in Saccharomyces cerevisiae: folding class, protein function and secondary structure.
Autorzy :
Santoni D; Institute for System Analysis and Computer Science 'Antonio Ruberti', National Research Council of Italy, Via dei Taurini 19, Rome 00185, Italy. Electronic address: .
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Źródło :
Journal of theoretical biology [J Theor Biol] 2021 Oct 07; Vol. 526, pp. 110806. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Proteins*/genetics
Saccharomyces cerevisiae*/genetics
Codon/genetics ; Protein Biosynthesis/genetics ; Protein Folding ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes.
Autorzy :
Mehravar M; Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Ghaemimanesh F; Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Poursani EM; Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło :
BMC genomics [BMC Genomics] 2021 Oct 05; Vol. 22 (1), pp. 718. Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Genome, Human*
Octamer Transcription Factor-3/*genetics
Transcription Factors/*genetics
Exons/genetics ; Genomics ; Humans ; Introns/genetics
Czasopismo naukowe
Tytuł :
Transcriptome and chromatin landscape changes associated with trastuzumab resistance in HER2+ breast cancer cells.
Autorzy :
Murad R; Department of Developmental & Cell Biology, University of California Irvine, Irvine, CA 92617, USA.
Avanes A; Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Ma X; Department of Developmental & Cell Biology, University of California Irvine, Irvine, CA 92617, USA.
Geng S; Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Mortazavi A; Department of Developmental & Cell Biology, University of California Irvine, Irvine, CA 92617, USA. Electronic address: .
Momand J; Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 05; Vol. 799, pp. 145808. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Chromatin/*drug effects
Drug Resistance, Neoplasm/*genetics
Trastuzumab/*pharmacology
Antineoplastic Agents, Immunological/pharmacology ; Autophagy/drug effects ; Autophagy/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Chromatin/genetics ; Dopamine and cAMP-Regulated Phosphoprotein 32/genetics ; Drug Resistance, Neoplasm/drug effects ; Female ; Forkhead Transcription Factors/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks ; Humans ; Receptor, ErbB-2/metabolism ; SOXB1 Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
High prevalence of multidrug-resistant Escherichia coli and first detection of IncHI2/IncX4-plasmid carrying mcr-1 E. coli in retail ready-to-eat foods in China.
Autorzy :
Zhang S; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Huang Y; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Yang G; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Lei T; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Chen M; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Ye Q; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Wang J; College of Food Science, South China Agricultural University, Guangzhou, Guangdong Province 510642, China.
Gu Q; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Wei X; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Zhang J; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Wu Q; Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China. Electronic address: .
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Źródło :
International journal of food microbiology [Int J Food Microbiol] 2021 Oct 02; Vol. 355, pp. 109349. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Multiple, Bacterial*/genetics
Escherichia coli*/genetics
Escherichia coli*/isolation & purification
Escherichia coli Infections*/epidemiology
Escherichia coli Infections*/microbiology
Escherichia coli Proteins*/genetics
Fast Foods*/microbiology
Food Microbiology*
Anti-Bacterial Agents/pharmacology ; Humans ; Microbial Sensitivity Tests ; Plasmids/genetics ; Prevalence ; beta-Lactamases/genetics
Czasopismo naukowe
Tytuł :
Klebsiella pneumoniae ST11 Producing GES-5 Carbapenemase Isolated from Tertiary-Care Hospital.
Autorzy :
Lee AJ
Suh HS
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Źródło :
Clinical laboratory [Clin Lab] 2021 Oct 01; Vol. 67 (10).
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents*/pharmacology
Drug Resistance, Bacterial*/genetics
Klebsiella pneumoniae*/drug effects
Klebsiella pneumoniae*/genetics
Bacterial Proteins/genetics ; Humans ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Phylogeny ; Tertiary Care Centers ; beta-Lactamases/genetics
Czasopismo naukowe
Tytuł :
A Special Case of Cirrhosis with a Novel ATP7B Mutation and Occult Chronic HBV Infection.
Autorzy :
Jiang Y; Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
Chen M; Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
Ruan Y; Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
Ma J; Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
Li N; Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
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Źródło :
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2021 Oct; Vol. 31 (10), pp. 1231-1233.
Typ publikacji :
Case Reports
MeSH Terms :
Hepatitis B, Chronic*
Hepatolenticular Degeneration*/diagnosis
Hepatolenticular Degeneration*/genetics
Copper-Transporting ATPases/*genetics
Copper ; Hepatitis B virus/genetics ; Humans ; Liver Cirrhosis/genetics ; Mutation
Raport
Tytuł :
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.
Autorzy :
Cejas P; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .; Translational Oncology Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBERONC, La Paz University Hospital, Madrid, Spain. .
Xie Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Font-Tello A; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Lim K; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Syamala S; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Qiu X; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Tewari AK; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shah N; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Nguyen HM; Department of Urology, University of Washington, Seattle, WA, USA.
Patel RA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Brown L; Department of Urology, University of Washington, Seattle, WA, USA.
Coleman I; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hackeng WM; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Brosens L; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Dreijerink KMA; Department of Endocrinology, Amsterdam UMC, Amsterdam, The Netherlands.
Ellis L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Alaiwi SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Baca S; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Beltran H; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Khani F; Weill Cornell Medical Center, Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, New York, NY, USA.
Pomerantz M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Dall'Agnese A; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA, 02142, USA.
Crowdis J; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bellmunt J; Beth Israel Deaconess Medical Center and PSMAR-IMIM Lab. Harvard Medical School, Boston, Massachusetts, USA.
Morrisey C; Department of Urology, University of Washington, Seattle, WA, USA.
Nelson PS; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
DeCaprio J; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Farago A; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Dyson N; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Drapkin B; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, Dallas, TX, USA.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Liu XS; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Freedman M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Haffner MC; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Pathology, University of Washington, Seattle, WA, USA.
Corey E; Department of Urology, University of Washington, Seattle, WA, USA.
Brown M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .
Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5775. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Neuroendocrine/*genetics
Prostatic Neoplasms/*genetics
Transcription Factors/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Male ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Autorzy :
Ma J; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Shi Q; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Sheng H; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Zhou Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Yan Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
He Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Wang L; Divison of Computational Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.
Wang Y; Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, BC, Canada.
Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .; Department of Cancer Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .
Ye D; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. .; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
Wang C; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China. .
Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5779. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Geminin/*metabolism
Nuclear Proteins/*genetics
Repressor Proteins/*genetics
Ubiquitin-Protein Ligase Complexes/*genetics
Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA Replication/genetics ; DNA Replication/physiology ; Geminin/genetics ; Humans ; Male ; Mice ; Mice, SCID ; Minichromosome Maintenance Proteins/genetics ; Minichromosome Maintenance Proteins/metabolism ; Mutation/genetics ; Ubiquitination/genetics ; Ubiquitination/physiology
Czasopismo naukowe
Tytuł :
Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma.
Autorzy :
Nepal P; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hozaka Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Tanaka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Wada M; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Asai S; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
Minemura C; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
Idichi T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Arigami T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kurahara H; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Seki N; Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan .
Ohtsuka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Oct; Vol. 41 (10), pp. 4821-4836.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Pancreatic Ductal/*pathology
Genes, Tumor Suppressor/*physiology
Pancreatic Neoplasms/*pathology
Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/mortality ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Core Binding Factor beta Subunit/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Membrane Proteins/genetics ; MicroRNAs/genetics ; MicroRNAs/physiology ; Neoplasm Proteins/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/mortality ; Ribonucleoside Diphosphate Reductase/genetics ; Ribonucleoside Diphosphate Reductase/metabolism ; Survival Analysis
Czasopismo naukowe

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