Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""GLUCAGON-like peptide 1"" wg kryterium: Temat


Tytuł :
Display of quintuple glucagon-like peptide 1 (28-36) nonapeptide on Bacillus subtilis spore for oral administration in the treatment of type 2 diabetes.
Autorzy :
Kang M; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Feng F; School of Biological and Food Engineering, Suzhou University, Suzhou, Anhui, PR China.
Ge Q; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.; School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Zhu F; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Chen L; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Lv P; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Ma S; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Yao Q; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Chen K; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Pokaż więcej
Źródło :
Journal of applied microbiology [J Appl Microbiol] 2021 Feb; Vol. 130 (2), pp. 314-324. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Bacillus subtilis/*metabolism
Diabetes Mellitus, Type 2/*drug therapy
Glucagon-Like Peptide 1/*administration & dosage
Glucagon-Like Peptide 1/*metabolism
Incretins/*administration & dosage
Administration, Oral ; Animals ; Bacillus subtilis/genetics ; Blood Glucose/drug effects ; Cell Surface Display Techniques ; Diabetes Mellitus, Experimental ; Glucagon-Like Peptide 1/genetics ; Insulin/blood ; Male ; Mice ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Spores, Bacterial/genetics ; Spores, Bacterial/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity.
Autorzy :
Maselli DB; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Camilleri M; Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. .
Pokaż więcej
Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1307, pp. 171-192.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Gastric Emptying*
Glucagon-Like Peptide 1*/agonists
Glucagon-Like Peptide 1*/analogs & derivatives
Obesity*/drug therapy
Blood Glucose ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents
Czasopismo naukowe
Tytuł :
Expression of a novel dual-functional polypeptide and its pharmacological action research.
Autorzy :
Li X; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China; School of Mental Health, Jining Medical University, Jining, Shandong 272067, China.
Yang X; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Umar M; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Zhang Z; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Luo W; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Fan Y; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Ma D; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China.
Li M; State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, 300071 Tianjin, China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118890. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon-Like Peptide 1/*pharmacology
Hypoglycemia/*drug therapy
Subtilisins/*pharmacology
Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Glucagon-Like Peptide 1/metabolism ; Hypoglycemia/metabolism ; Insulin/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Peptides/metabolism ; Peptides/pharmacology ; Subtilisins/metabolism ; Thrombosis/drug therapy ; Thrombosis/metabolism
Czasopismo naukowe
Tytuł :
Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.
Autorzy :
Ribeiro-Parenti L; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jarry AC; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Cavin JB; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Willemetz A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Le Beyec J; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Sorbonne Université, AP-HP, Hôpital Pitié-Salpêtrière-Charles Foix, Biochimie Endocrinienne et Oncologique, Paris, France.
Sannier A; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Benadda S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Cell and Tissue Imaging Platform, Inserm, U1149, CNRS, ERL8252, 75018, Paris, France.
Pelletier AL; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.
Hourseau M; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Léger T; Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS, 75205, Paris, France.; Université Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, 35000, Rennes, France.
Morlet B; Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS, 75205, Paris, France.
Couvelard A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Department of Pathology Bichat Hospital, AP-HP, 75018, Paris, France.
Anini Y; Department of Obstetrics and Gynecology, Dalhousie University, IWK Health Centre, Halifax, New Brunswick, Canada.
Msika S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Marmuse JP; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France.
Ledoux S; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France.; Service des Explorations Fonctionnelles Hôpital Louis Mourier, AP-HP, Centre Intégré Nord Francilien de prise en charge de l'Obésité (CINFO), 92701, Colombes, France.
Le Gall M; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France. .
Bado A; Université de Paris, Inserm U1149, Centre de Recherche sur l'inflammation, Paris, France. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 110. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bariatric Surgery*
Gastric Mucosa/*metabolism
Gastric Mucosa/*pathology
Glucagon-Like Peptide 1/*metabolism
1-Methyl-3-isobutylxanthine/pharmacology ; Adult ; Amino Acid Sequence ; Animals ; Diet, High-Fat ; Female ; Glucagon-Like Peptide 1/chemistry ; Glucose/metabolism ; Humans ; Male ; Middle Aged ; Obesity/pathology ; Phenotype ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes.
Autorzy :
Grespan E; Institute of Neuroscience, National Research Council, Padua 35127, Italy.
Giorgino T; Biophysics Institute, National Research Council, Milan 20133, Italy; Department of Biosciences, University of Milan, Milan 20133, Italy.
Natali A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy.
Ferrannini E; Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy.
Mari A; Institute of Neuroscience, National Research Council, Padua 35127, Italy. Electronic address: .
Pokaż więcej
Źródło :
Metabolism: clinical and experimental [Metabolism] 2021 Jan; Vol. 114, pp. 154415. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Gastric Inhibitory Polypeptide/*administration & dosage
Glucagon-Like Peptide 1/*administration & dosage
Incretins/*administration & dosage
Insulin Secretion/*drug effects
Insulin-Secreting Cells/*drug effects
Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Gastric Inhibitory Polypeptide/therapeutic use ; Glucagon-Like Peptide 1/therapeutic use ; Glucose Tolerance Test ; Humans ; Incretins/therapeutic use ; Insulin-Secreting Cells/metabolism ; Models, Theoretical
Czasopismo naukowe
Tytuł :
Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and Diabetes.
Autorzy :
Chen X; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Fu J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Zhou F; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Yang Q; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Wang J; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Feng H; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jiang W; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jin L; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Tang X; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.
Jiang N; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, PR China.
Yin J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Han J; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China.; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12595-12613. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide 1/*agonists
Hypoglycemic Agents/*chemistry
Receptor, Cholecystokinin B/*agonists
Xenopus Proteins/*agonists
Xenopus laevis/*metabolism
Animals ; Body Weight/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Disease Models, Animal ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/metabolism ; Glucose Tolerance Test ; Half-Life ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mutagenesis, Site-Directed ; Obesity/metabolism ; Obesity/pathology ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use ; Receptor, Cholecystokinin B/metabolism ; Structure-Activity Relationship ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism
Czasopismo naukowe
Tytuł :
Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis.
Autorzy :
Martchenko SE; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Martchenko A; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Cox BJ; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Naismith K; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Waller A; Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada.
Gurges P; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Sweeney ME; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Philpott DJ; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Brubaker PL; Department of Physiology, University of Toronto, Toronto, Ontario, Canada .; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Pokaż więcej
Źródło :
Diabetes [Diabetes] 2020 Dec; Vol. 69 (12), pp. 2589-2602. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Rhythm*
Gastrointestinal Microbiome*
Homeostasis*
Glucagon-Like Peptide 1/*metabolism
Animals ; Dietary Carbohydrates/administration & dosage ; Dietary Fats/administration & dosage ; Female ; Gene Expression Regulation/drug effects ; Glucagon-Like Peptide 1/genetics ; Glucose/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Sucrose
Czasopismo naukowe
Tytuł :
Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway.
Autorzy :
Yang S; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.; Department of Endocrinology, Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, China.
Lin C; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Zhuo X; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Wang J; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Rao S; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
Xu W; Laboratory of Diabetology, Department of Endocrinology and Metabolism, Guangdong Provincial Key Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cheng Y; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Yang L; Department of Endocrinology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Pokaż więcej
Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Dec 01; Vol. 319 (6), pp. E1019-E1030. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Diabetic Nephropathies/*prevention & control
Glucagon-Like Peptide 1/*therapeutic use
AMP-Activated Protein Kinases/metabolism ; Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Exenatide/pharmacology ; Exenatide/therapeutic use ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; HEK293 Cells ; Humans ; Rats ; Rats, Zucker ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Serotonin receptor HTR4 as a counter actor of lipid-induced increases of serum glucagon-like peptide-1 levels.
Autorzy :
Breit A; Walther Straub Institute of Pharmacology and Toxicology, Medical Faculty, LMU Munich, Goethestrasse 33, 80336, Munich, Germany. .
Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Medical Faculty, LMU Munich, Goethestrasse 33, 80336, Munich, Germany.
Pokaż więcej
Źródło :
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2020 Oct; Vol. 472 (10), pp. 1433-1434. Date of Electronic Publication: 2020 Aug 22.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Glucagon-Like Peptide 1*
Serotonin*
Animals ; Enteroendocrine Cells ; Intestines ; Lipids ; Mice
Opinia redakcyjna
Tytuł :
Hope in Hopeless Times: Gearing Up to Fight the Obesity Pandemic.
Autorzy :
Belsham DD; Departments of Physiology, University of Toronto, Toronto, Ontario, Canada.; Departments of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.; Departments of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hanchard J; APHAIA Pharma AG, Zug, Switzerland.
Bolz SS; Departments of Physiology, University of Toronto, Toronto, Ontario, Canada.; Departments of Medicine, University of Toronto, Toronto, Ontario, Canada.; APHAIA Pharma AG, Zug, Switzerland.; Toronto Centre for Microvascular Medicine at The Ted Rogers Centre for Heart Research Translational Biology and Engineering Program, University of Toronto, Toronto, Ontario, Canada.
Pokaż więcej
Źródło :
Endocrinology [Endocrinology] 2020 Oct 01; Vol. 161 (10).
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Glucagon-Like Peptide 1*
Pandemics*/prevention & control
Humans ; Hyperphagia ; Obesity/epidemiology
Czasopismo naukowe
Tytuł :
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors.
Autorzy :
Darbalaei S; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yuliantie E; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Dai A; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Chang R; School of Pharmacy, Fudan University, Shanghai 201203, China.
Zhao P; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
Yang D; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang MW; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmacy, Fudan University, Shanghai 201203, China; School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: .
Sexton PM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia. Electronic address: .
Wootten D; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia. Electronic address: .
Pokaż więcej
Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114150. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide 1/*agonists
Oxyntomodulin/*pharmacology
Peptides/*pharmacology
Receptors, Glucagon/*agonists
Amino Acid Sequence ; Dose-Response Relationship, Drug ; Drug Agonism ; Glucagon-Like Peptide 1/metabolism ; HEK293 Cells ; Humans ; Oxyntomodulin/genetics ; Oxyntomodulin/metabolism ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management.
Autorzy :
Chun JH; Ji Hyun Chun practices endocrinology at OptumCare Medical Group in Orange County, Calif.; is a medical science liaison at Corcept Therapeutics in Menlo Park, Calif.; and is immediate past president of the American Society of Endocrine Physician Assistants. Amy Butts practices endocrinology at Wheeling (W. Va.) Hospital. Mr. Chun has no conflicts to disclose beyond his employment at Corcept Therapeutics. Ms. Butts has served on speakers' bureaus and advisory boards for Novo Nordisk Inc., on speakers' bureaus for Janssen Pharmaceuticals and Xeris Pharmaceuticals, and on advisory boards for Merck. This manuscript was funded by Novo Nordisk Inc. The authors have disclosed no other potential conflicts of interest, financial or otherwise.
Butts A
Pokaż więcej
Źródło :
JAAPA : official journal of the American Academy of Physician Assistants [JAAPA] 2020 Aug; Vol. 33 (S8 Suppl 1), pp. 3-18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Glucagon-Like Peptide 1/*therapeutic use
Glucagon-Like Peptide-1 Receptor/*agonists
Glucagon-Like Peptides/*analogs & derivatives
Hypoglycemic Agents/*therapeutic use
Immunoglobulin Fc Fragments/*therapeutic use
Liraglutide/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Administration, Oral ; Delayed-Action Preparations ; Diabetes Mellitus, Type 2/metabolism ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide 1/physiology ; Glucagon-Like Peptides/administration & dosage ; Glucagon-Like Peptides/pharmacology ; Glucagon-Like Peptides/therapeutic use ; Glucose/metabolism ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Immunoglobulin Fc Fragments/administration & dosage ; Immunoglobulin Fc Fragments/pharmacology ; Liraglutide/administration & dosage ; Liraglutide/pharmacology ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/pharmacology ; Safety ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from Dendrobium officinale.
Autorzy :
Kuang MT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Li JY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Yang XB; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Yang L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; Bio-Innovation Center of DR PLANT, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China.
Xu JY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China; Bio-Innovation Center of DR PLANT, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China.
Yan S; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; Bio-Innovation Center of DR PLANT, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China.
Lv YF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Ren FC; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Hu JM; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China; Bio-Innovation Center of DR PLANT, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China. Electronic address: .
Zhou J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China. Electronic address: .
Pokaż więcej
Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Aug 01; Vol. 241, pp. 116326. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon-Like Peptide 1*/blood
Glucagon-Like Peptide 1*/metabolism
Hypoglycemic Agents*/chemistry
Hypoglycemic Agents*/pharmacology
Plant Extracts*/chemistry
Plant Extracts*/pharmacology
Polysaccharides*/chemistry
Polysaccharides*/pharmacology
Dendrobium/*chemistry
Diabetes Mellitus, Experimental/*drug therapy
Animals ; Cell Line ; Insulin Secretion ; Male ; Mice ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Synthetic protease-activated class B GPCRs.
Autorzy :
Willard FS; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. Electronic address: .
Meredith TD; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Showalter AD; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Ma W; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Ho JD; Structural Biology, Lilly Biotechnology Center, San Diego, CA, USA.
Sauder JM; Structural Biology, Lilly Biotechnology Center, San Diego, CA, USA.
Sloop KW; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Sep 10; Vol. 530 (1), pp. 246-251. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Exenatide/*metabolism
Glucagon-Like Peptide 1/*metabolism
Glucagon-Like Peptide-1 Receptor/*metabolism
Peptide Hydrolases/*metabolism
Protein Engineering/*methods
Animals ; Cell Line ; Exenatide/genetics ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide-1 Receptor/genetics ; HEK293 Cells ; Humans ; Insulin Secretion ; Proteolysis ; Rats ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Transfection
Czasopismo naukowe
Tytuł :
(E X -4) 2 -Fc, an effective long-acting GLP-1 receptor agonist, reduces obesity-related inflammation by inhibiting leptin expression.
Autorzy :
Zhou B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Dong C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Zhao B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Su X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Luo Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Xie L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Tian Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Zhang R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Yang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Aug 27; Vol. 529 (3), pp. 562-568. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue/*drug effects
Glucagon-Like Peptide 1/*pharmacology
Glucagon-Like Peptide-1 Receptor/*agonists
Inflammation/*prevention & control
Leptin/*antagonists & inhibitors
Obesity/*metabolism
Adipose Tissue/cytology ; Adipose Tissue/metabolism ; Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat/adverse effects ; Glucagon-Like Peptide 1/chemistry ; Inflammation/metabolism ; Leptin/metabolism ; Macrophage Activation/drug effects ; Macrophages/classification ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Obese ; NF-kappa B/metabolism ; Obesity/etiology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
A Role for GLP-1 in Treating Hyperphagia and Obesity.
Autorzy :
Grill HJ; Institute of Diabetes, Obesity and Metabolism, Graduate Groups for Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA.
Pokaż więcej
Źródło :
Endocrinology [Endocrinology] 2020 Aug 01; Vol. 161 (8).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Glucagon-Like Peptide 1/*therapeutic use
Hyperphagia/*drug therapy
Obesity/*drug therapy
Animals ; Bariatric Surgery ; Behavior Therapy ; Eating/physiology ; Glucagon-Like Peptide 1/physiology ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hyperphagia/complications ; Hyperphagia/metabolism ; Hyperphagia/therapy ; Obesity/etiology ; Obesity/metabolism ; Obesity/therapy ; Receptors, Glucagon/metabolism ; Weight Loss/physiology
Czasopismo naukowe
Tytuł :
Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction.
Autorzy :
Xiong X; Department of general surgery, the Third Affiliated Hospital of Nanchang University, Nanchang, 330008, China.
Lu W; Department of General surgery, the Sixth Medical Center, PLA General Hospital, Beijing, 100853, China.
Qin X; Department of general surgery, the Third Affiliated Hospital of Nanchang University, Nanchang, 330008, China.
Luo Q; Department of general surgery, the Third Affiliated Hospital of Nanchang University, Nanchang, 330008, China.
Zhou W; Department of vascular surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, 330008, China. Electronic address: .
Pokaż więcej
Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Jul; Vol. 127, pp. 110218. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Adiponectin/*biosynthesis
Cyclic AMP Response Element-Binding Protein/*metabolism
Diabetes Mellitus, Experimental/*physiopathology
Glucagon-Like Peptide 1/*metabolism
Myocytes, Smooth Muscle/*metabolism
Vasoconstriction/*physiology
Adenylate Kinase/metabolism ; Adiponectin/genetics ; Animals ; Blood Pressure/physiology ; Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors ; Diabetes Mellitus, Experimental/pathology ; Down-Regulation ; Glucagon-Like Peptide 1/pharmacology ; Humans ; Male ; Mice ; Mice, Knockout ; Mitochondria/drug effects ; Muscle, Smooth, Vascular/pathology ; Organophosphorus Compounds/pharmacology ; Phosphorylation ; Piperidines/pharmacology ; Rats ; Reactive Oxygen Species/metabolism ; Sirtuin 1/biosynthesis ; Vasoconstriction/drug effects
Czasopismo naukowe
Tytuł :
Engineering Xaa-Pro dipeptidyl aminopeptidase for specific cleavage of glucagon and glucagon-like peptide 1 from fusion proteins.
Autorzy :
Vernet E; Novo Nordisk A/S, 2760, Måløv, Denmark. Electronic address: .
Pedersen MØ; Novo Nordisk A/S, 2760, Måløv, Denmark.
Thøgersen H; Novo Nordisk A/S, 2760, Måløv, Denmark.
Shaw AC; Novo Nordisk A/S, 2760, Måløv, Denmark.
Pokaż więcej
Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Jun; Vol. 170, pp. 105590. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*genetics
Dipeptidases/*genetics
Glucagon/*genetics
Glucagon-Like Peptide 1/*genetics
Lactococcus lactis/*enzymology
Amino Acid Substitution ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Cloning, Molecular ; Dipeptidases/chemistry ; Dipeptidases/metabolism ; Enzyme Assays ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glucagon/chemistry ; Glucagon/metabolism ; Glucagon-Like Peptide 1/chemistry ; Glucagon-Like Peptide 1/metabolism ; Humans ; Kinetics ; Lactococcus lactis/genetics ; Mutagenesis, Site-Directed ; Protein Engineering/methods ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in prehypertensive rats.
Autorzy :
Jensen EP; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Møller S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hviid AV; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Veedfald S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Holst JJ; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pedersen J; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ørskov C; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sorensen CM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pokaż więcej
Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Jun 01; Vol. 318 (6), pp. F1409-F1417. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arterioles/*drug effects
Blood Pressure/*drug effects
Glucagon-Like Peptide 1/*pharmacology
Glucagon-Like Peptide-1 Receptor/*agonists
Kidney/*blood supply
Prehypertension/*metabolism
Renal Artery/*drug effects
Vasodilation/*drug effects
Vasodilator Agents/*pharmacology
Animals ; Arterioles/metabolism ; Arterioles/physiopathology ; Disease Models, Animal ; Female ; Glucagon-Like Peptide 1/analogs & derivatives ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Prehypertension/genetics ; Prehypertension/physiopathology ; Rats, Inbred SHR ; Renal Artery/metabolism ; Renal Artery/physiopathology
Czasopismo naukowe
Tytuł :
Stroke in the patient with diabetes (Part 2) - Prevention and the effects of glucose lowering therapies.
Autorzy :
Bell DSH; Southside Endocrinology, Diabetes and Thyroid Associates, Birmingham, AL, United States.
Goncalves E; Southside Endocrinology, Diabetes and Thyroid Associates, Birmingham, AL, United States. Electronic address: .
Pokaż więcej
Źródło :
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2020 Jun; Vol. 164, pp. 108199. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*complications
Glucagon-Like Peptide 1/*therapeutic use
Hypoglycemic Agents/*agonists
Diabetes Mellitus, Type 2/drug therapy ; Female ; Glucagon-Like Peptide 1/pharmacology ; Humans ; Hypoglycemic Agents/adverse effects ; Male
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies