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Tytuł :
The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A protocol for systematic review and meta-analysis.
Autorzy :
Gao Q; Affiliated Hospital of Shaoxing University of Edocrine and Metabolism Department, Zhejiang, China.
Zhang W
Li T
Yang G
Zhu W
Chen N
Jin H
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 19; Vol. 100 (7), pp. e24873.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Enzyme Activators/*pharmacology
Glucokinase/*drug effects
Hypoglycemic Agents/*therapeutic use
Blood Glucose/analysis ; Blood Glucose/drug effects ; Case-Control Studies ; Data Management ; Enzyme Activators/therapeutic use ; Fasting/blood ; Glucokinase/metabolism ; Humans ; Placebos/administration & dosage ; Randomized Controlled Trials as Topic ; Safety ; Treatment Outcome
Czasopismo naukowe
Tytuł :
ADP-dependent glucokinase as a novel onco-target for haematological malignancies.
Autorzy :
Tandon A; Division of Child Neurology and Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany. .; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. .
Birkenhagen J; Division of Child Neurology and Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Nagalla D; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Kölker S; Division of Child Neurology and Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Sauer SW; Division of Child Neurology and Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 12; Vol. 10 (1), pp. 13584. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*genetics
Glucokinase/*genetics
Hematologic Neoplasms/*genetics
Zebrafish/*genetics
Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Coculture Techniques ; Gene Knockout Techniques ; Glucokinase/metabolism ; Glycolysis/genetics ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/pathology ; Humans ; Jurkat Cells ; Macrophages/metabolism ; Macrophages/pathology ; T-Lymphocytes/metabolism ; THP-1 Cells ; Transplantation, Heterologous ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
MiR-330-3p contributes to INS-1 cell dysfunction by targeting glucokinase in gestational diabetes mellitus.
Autorzy :
Xiao Y; Department of Pediatrics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, People's Republic of China.; Department of Pediatrics, Zhejiang University Hospital, Hangzhou, People's Republic of China.
Ding J; Department of Pediatrics, Shaoxing Hospital of Zhejiang University, Shaoxing, People's Republic of China.
Shi Y; Department of Pediatrics, Zhenyuan County People's Hospital, Guizhou, Qiandongnan Autonomous Prefecture, People's Republic of China.
Lin L; Department of Pediatrics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, People's Republic of China.
Huang W; Department of Pediatrics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, People's Republic of China.
Shen D; Department of Pediatrics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, People's Republic of China.
Wang W; Department of Pediatrics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, People's Republic of China.
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Źródło :
The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2020 Jun; Vol. 46 (6), pp. 864-875. Date of Electronic Publication: 2020 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Glucose/*metabolism
Diabetes, Gestational/*genetics
Glucokinase/*blood
MicroRNAs/*blood
Apoptosis ; Diabetes, Gestational/blood ; Female ; Gene Expression Regulation ; Glucokinase/genetics ; Humans ; Insulin Secretion/genetics ; Pregnancy ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Prunus Hexokinase 3 genes alter primary C-metabolism and promote drought and salt stress tolerance in Arabidopsis transgenic plants.
Autorzy :
Pérez-Díaz, Jorge
Batista-Silva, Willian
Almada, Rubén
Medeiros, David B.
Arrivault, Stéphanie
Correa, Francisco
Bastías, Adriana
Rojas, Pamela
Beltrán, María Francisca
Pozo, María Francisca
Araújo, Wagner L.
Sagredo, Boris
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Źródło :
Scientific Reports. 3/29/2021, Vol. 11 Issue 1, p1-15. 15p.
Czasopismo naukowe
Tytuł :
Metabolic control analysis of hepatic glycogen synthesis in vivo.
Autorzy :
Nozaki Y; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1628655 Tokyo, Japan.
Petersen MC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Zhang D; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Vatner DF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Perry RJ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Abulizi A; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Haedersdal S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Center for Clinical Metabolic Research, Gentofte and Herlev Hospital, 2900 Hellerup, Denmark.; Type 2 Biology, Steno Diabetes Center Copenhagen, 2820 Gentofte, Denmark.
Zhang XM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Butrico GM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Samuel VT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Medicine, Veterans Affairs Medical Center, West Haven, CT 06516.
Mason GF; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520.
Cline GW; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Petersen KF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Rothman DL; Center for Clinical Metabolic Research, Gentofte and Herlev Hospital, 2900 Hellerup, Denmark.; Department of Biomedical Engineering, Yale School of Medicine, New Haven, CT 06520.
Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520; .; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 07; Vol. 117 (14), pp. 8166-8176. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Liver/*pathology
Glucokinase/*metabolism
Glucose/*metabolism
Liver/*metabolism
Liver Glycogen/*biosynthesis
Animals ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Liver/etiology ; Gene Knockdown Techniques ; Glucokinase/genetics ; Glucose/administration & dosage ; Glucose-6-Phosphate/analysis ; Glucose-6-Phosphate/metabolism ; Humans ; Hyperglycemia/etiology ; Hyperglycemia/pathology ; Hyperinsulinism/etiology ; Hyperinsulinism/pathology ; Insulin/metabolism ; Insulin Resistance ; Liver/pathology ; Male ; Metabolomics ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
Autorzy :
Suwitheechon OU
Schermerhorn T
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Źródło :
American journal of veterinary research [Am J Vet Res] 2021 Feb; Vol. 82 (2), pp. 110-117.
Typ publikacji :
Journal Article
MeSH Terms :
Dog Diseases*
Insulinoma*/veterinary
Pancreatic Neoplasms*/veterinary
Rodent Diseases*
Animals ; Dogs ; Glucokinase/genetics ; Glucose ; Hexokinase/genetics ; Insulin ; Mice
Czasopismo naukowe
Tytuł :
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast.
Autorzy :
Stoddard PR; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.; Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Lynch EM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Farrell DP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Dosey AM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
DiMaio F; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Williams TA; School of Biological Sciences, University of Bristol, Bristol BS8 1TQ, UK.
Kollman JM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Murray AW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. .; Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Garner EC; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. .; Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Feb 28; Vol. 367 (6481), pp. 1039-1042.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*chemistry
Adenosine Triphosphatases/*chemistry
Glucokinase/*chemistry
Hexokinase/*chemistry
Saccharomyces cerevisiae/*enzymology
Saccharomyces cerevisiae Proteins/*chemistry
Adenosine Triphosphatases/genetics ; Glucokinase/genetics ; Hexokinase/genetics ; Polymerization ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Autorzy :
Hinklin RJ; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States. Electronic address: .
Baer BR; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Boyd SA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Chicarelli MD; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Condroski KR; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
DeWolf WE Jr; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Fischer J; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Frank M; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Hingorani GP; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Lee PA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Neitzel NA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Pratt SA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Singh A; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Sullivan FX; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Turner T; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Voegtli WC; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Wallace EM; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Williams L; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
Aicher TD; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Jan 01; Vol. 28 (1), pp. 115232. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Activators/*chemistry
Glucokinase/*chemistry
Hypoglycemic Agents/*chemistry
Animals ; Binding Sites ; Blood Glucose/analysis ; Crystallography, X-Ray ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Drug Design ; Drug Evaluation, Preclinical ; Enzyme Activators/metabolism ; Enzyme Activators/therapeutic use ; Glucokinase/metabolism ; Glucose Tolerance Test ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Kinetics ; Mice ; Mice, Inbred C57BL ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Thiadiazoles/chemistry ; Thiadiazoles/metabolism
Czasopismo naukowe
Tytuł :
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics.
Autorzy :
Grewal AS; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Lather V; Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.
Charaya N; Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Haryana, India.
Sharma N; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Singh S; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Kairys V; Department of Bioinformatics, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2020; Vol. 26 (21), pp. 2510-2552.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Glucokinase*
Chemistry, Pharmaceutical ; Enzyme Activators/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Insulin
Czasopismo naukowe
Tytuł :
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms.
Autorzy :
Langer S; Institute of Medical Biochemistry and Molecular Biology, University Medicine, University of Rostock, 18057 Rostock, Germany.
Hofmeister-Brix A; Institute of Medical Biochemistry and Molecular Biology, University Medicine, University of Rostock, 18057 Rostock, Germany; Institute of Clinical Biochemistry, Hannover Medical School, 30623 Hannover, Germany.
Waterstradt R; Institute of Medical Biochemistry and Molecular Biology, University Medicine, University of Rostock, 18057 Rostock, Germany.
Baltrusch S; Institute of Medical Biochemistry and Molecular Biology, University Medicine, University of Rostock, 18057 Rostock, Germany; Department Life, Light & Matter, University of Rostock, Germany. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Oct; Vol. 168, pp. 149-161. Date of Electronic Publication: 2019 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucokinase/*metabolism
Insulin-Secreting Cells/*enzymology
Mannoheptulose/*metabolism
Mutant Proteins/*metabolism
Phosphofructokinase-2/*metabolism
Thiazoles/*metabolism
Allosteric Site ; Animals ; Catalytic Domain ; Cell Line, Tumor ; Glucokinase/chemistry ; Glucokinase/genetics ; Humans ; Insulin-Secreting Cells/drug effects ; Mannoheptulose/chemistry ; Mice ; Phosphofructokinase-2/chemistry ; Protein Binding ; Protein Conformation, alpha-Helical ; Thiazoles/chemistry ; Transfection
Czasopismo naukowe
Tytuł :
Crystal Structure of Kluyveromyces lactis Glucokinase ( Kl Glk1).
Autorzy :
Zak KM; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. .; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .
Kalińska M; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .
Wątor E; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .
Kuśka K; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Krakow, Poland. .
Krutyhołowa R; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Krakow, Poland. .
Dubin G; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Krakow, Poland. .
Popowicz GM; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. .; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany. .
Grudnik P; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7a, 30-387 Krakow, Poland. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Sep 28; Vol. 20 (19). Date of Electronic Publication: 2019 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Molecular*
Protein Conformation*
Glucokinase/*chemistry
Kluyveromyces/*enzymology
Glucokinase/genetics ; Glucokinase/metabolism ; Glucose/metabolism ; Kinetics ; Kluyveromyces/genetics ; Kluyveromyces/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
A novel reverse two-hybrid method for the identification of missense mutations that disrupt protein-protein binding.
Autorzy :
Vincent O; Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, 28029, Madrid, Spain. .
Gutierrez-Nogués A; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Trejo-Herrero A; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Navas MA; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 03; Vol. 10 (1), pp. 21043. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Function Mutation*
Protein Interaction Maps*
Two-Hybrid System Techniques*
Reverse Genetics/*methods
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Binding Sites ; Glucokinase/genetics ; Glucokinase/metabolism ; Humans ; Mutation, Missense ; Protein Binding ; Saccharomyces cerevisiae
Czasopismo naukowe
Tytuł :
P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats.
Autorzy :
Li L; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Yang J; Undergraduate Student of Clinic Medicine Department, Medical School of Nanchang University, Nanchang, 330006, PR China.
Liu B; Undergraduate Student of Clinic Medicine Department, Medical School of Nanchang University, Nanchang, 330006, PR China.
Zou Y; Undergraduate Student of Clinic Medicine Department, Medical School of Nanchang University, Nanchang, 330006, PR China.
Sun M; Undergraduate Student of Clinic Medicine Department, Medical School of Nanchang University, Nanchang, 330006, PR China.
Li Z; Undergraduate Student of Clinic Medicine Department, Medical School of Nanchang University, Nanchang, 330006, PR China.
Yang R; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Xu X; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Zou L; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Li G; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Liu S; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Li G; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China.
Liang S; Neuropharmacology Laboratory of Physiology Department, Basic Medical School of Nanchang University, Nanchang, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110803. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*physiopathology
Diabetes Mellitus, Type 2/*physiopathology
Glucokinase/*metabolism
Receptors, Purinergic P2Y12/*genetics
Animals ; Diabetes Mellitus, Experimental/enzymology ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/genetics ; Hepatocytes/pathology ; Hyperglycemia/genetics ; Hyperglycemia/physiopathology ; Inflammation/genetics ; Inflammation/pathology ; Liver/enzymology ; Male ; RNA, Small Interfering/administration & dosage ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [Ca ] Response.
Autorzy :
Dwulet JM; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Ludin NWF; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Piscopio RA; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Schleicher WE; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Moua O; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Westacott MJ; Department of Bioengineering, University of Colorado, Aurora, Colorado.
Benninger RKP; Department of Bioengineering, University of Colorado, Aurora, Colorado; Barbara Davis Center for Childhood Diabetes, Anschutz Medical Campus, University of Colorado, Aurora, Colorado. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2019 Dec 03; Vol. 117 (11), pp. 2188-2203. Date of Electronic Publication: 2019 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gap Junctions*
Calcium/*metabolism
Glucokinase/*metabolism
Islets of Langerhans/*cytology
Islets of Langerhans/*metabolism
Animals ; Glucokinase/genetics ; Islets of Langerhans/enzymology ; Mice ; Mutation
Czasopismo naukowe
Tytuł :
Discovery of antichagasic inhibitors by high-throughput screening with Trypanosoma cruzi glucokinase.
Autorzy :
Mercaldi GF; Brazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory, Campinas, SP 13083-970, Brazil.
D'Antonio EL; Department of Natural Sciences, University of South Carolina Beaufort, 1 University Boulevard, Bluffton, SC 29909, USA. Electronic address: .
Aguessi A; Department of Microbiology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA.
Rodriguez A; Department of Microbiology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA.
Cordeiro AT; Brazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory, Campinas, SP 13083-970, Brazil.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Aug 01; Vol. 29 (15), pp. 1948-1953. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chagas Disease/*drug therapy
Enzyme Inhibitors/*therapeutic use
Glucokinase/*therapeutic use
High-Throughput Screening Assays/*methods
Enzyme Inhibitors/pharmacology ; Glucokinase/pharmacology ; Trypanosoma cruzi
Czasopismo naukowe

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