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Tytuł:
"Pesto" Mutation: Phenotypic and Genotypic Characteristics of Eight GCK/MODY Ligurian Patients.
Autorzy:
Salina A; LABSIEM (Laboratory for the Study of Inborn Errors of Metabolism), Pediatric Clinic, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Bassi M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.; Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Aloi C; LABSIEM (Laboratory for the Study of Inborn Errors of Metabolism), Pediatric Clinic, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Strati MF; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.; Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Bocciardi R; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
d'Annunzio G; Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Maghnie M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.; Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Minuto N; Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Glucokinase*/genetics
Humans ; Glycated Hemoglobin/analysis ; Mutation
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New-Generation Glucokinase Activators: Potential Game-Changers in Type 2 Diabetes Treatment.
Autorzy:
Haddad D; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Dsouza VS; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Al-Mulla F; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Al Madhoun A; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.; Animal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 01; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Drug-Related Side Effects and Adverse Reactions*
Humans ; Glucokinase ; Pancreas ; Glycemic Control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader.
Autorzy:
Cho J; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.
Miyagawa A; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Aichi, Japan.
Yamaguchi K; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Aichi, Japan.
Abe W; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Aichi, Japan.
Tsugawa Y; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.
Yamamura H; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Aichi, Japan.
Imai T; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 13; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Glucokinase*/genetics
Glucokinase*/metabolism
Animals ; Glucose/metabolism ; Glucose-6-Phosphate ; Insulin/metabolism ; Mice ; Mutation ; Uridine Diphosphate Glucose
SCR Disease Name:
Maturity-Onset Diabetes of the Young, Type 2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FpOGT is required for fungal growth, stress response, and virulence of Fusarium proliferatum by affecting the expression of glucokinase and other glucose metabolism-related genes.
Autorzy:
Gao, Yizhou (AUTHOR)
Wang, Yitong (AUTHOR)
He, Siming (AUTHOR)
Li, Haibo (AUTHOR)
Wang, Yuqing (AUTHOR)
Wu, Zhihong (AUTHOR)
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Źródło:
Phytopathology Research. 1/11/2024, Vol. 6 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of Fungal Morphogenesis and Pathogenicity of Aspergillus flavus by Hexokinase AfHxk1 through Its Domain Hexokinase_2.
Autorzy:
Huang, Zongting (AUTHOR)
Wu, Dandan (AUTHOR)
Yang, Sile (AUTHOR)
Fu, Wangzhuo (AUTHOR)
Ma, Dongmei (AUTHOR)
Yao, Yanfang (AUTHOR)
Lin, Hong (AUTHOR)
Yuan, Jun (AUTHOR)
Yang, Yanling (AUTHOR)
Zhuang, Zhenhong (AUTHOR)
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Źródło:
Journal of Fungi. Nov2023, Vol. 9 Issue 11, p1077. 19p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients.
Autorzy:
Cho J; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Horikawa Y; Departments of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Oiwa Y; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Hosomichi K; Laboratory of Computational Genomics, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.
Yabe D; Departments of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.; Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Imai T; Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 31; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Uridine Diphosphate Glucose*
Humans ; Fasting ; Glucokinase/genetics ; Glucokinase/metabolism ; Glucose/metabolism ; Insulin/metabolism ; Mutation
SCR Disease Name:
Mason-Type Diabetes; Maturity-Onset Diabetes of the Young, Type 2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control.
Autorzy:
Liu J; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fu H; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kang F; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ning G; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Sino-French Research Center for Life Sciences and Genomics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ni Q; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang W; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang Q; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Sino-French Research Center for Life Sciences and Genomics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło:
Journal of diabetes [J Diabetes] 2023 May; Vol. 15 (5), pp. 409-418. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Humans ; Glucokinase/genetics ; Glucokinase/metabolism ; Blood Glucose ; Glycemic Control ; Glucose/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight.
Autorzy:
Onikanni, Sunday Amos (AUTHOR)
Lawal, Bashir (AUTHOR)
Munyembaraga, Valens (AUTHOR)
Bakare, Oluwafemi Shittu (AUTHOR)
Taher, Muhammad (AUTHOR)
Khotib, Junaidi (AUTHOR)
Susanti, Deny (AUTHOR)
Oyinloye, Babatunji Emmanuel (AUTHOR)
Noriega, Lloyd (AUTHOR)
Famuti, Ayodeji (AUTHOR)
Fadaka, Adewale Oluwaseun (AUTHOR)
Ajiboye, Basiru Olaitan (AUTHOR)
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Źródło:
Molecules. Aug2023, Vol. 28 Issue 15, p5752. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Advances in the Properties of Incomptine A: Cytotoxic Activity and Downregulation of Hexokinase II in Breast Cancer Cell Lines.
Autorzy:
Arietta-García, Angel Giovanni (AUTHOR)
Calzada, Fernando (AUTHOR)
Ramírez-Sánchez, Israel (AUTHOR)
Bautista, Elihú (AUTHOR)
García-Hernandez, Normand (AUTHOR)
Ordoñez-Razo, Rosa María (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p12406. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association between glucokinase regulator gene polymorphisms and serum uric acid levels in Taiwanese adolescents.
Autorzy:
Ho LJ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
Lu CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
Su RY; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.; Department of Pathology and Laboratory Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, ROC.
Lin FH; School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Su SC; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
Kuo FC; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
Chu NF; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.; School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Hung YJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
Liu JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC. .
Hsieh CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 01; Vol. 12 (1), pp. 5519. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
Glucokinase*/genetics
Uric Acid*
Adolescent ; Child ; Female ; Genome-Wide Association Study ; Humans ; Male ; Polymorphism, Single Nucleotide ; Triglycerides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator.
Autorzy:
Tsumura Y; Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Tsushima Y; Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Tamura A; Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Kato H; Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Kobayashi T; Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2022 Mar 21; Vol. 17 (3), pp. e0265761. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/metabolism
Glucokinase*/metabolism
Animals ; Blood Glucose/metabolism ; Enzyme Activators/pharmacology ; Enzyme Activators/therapeutic use ; Glucose/metabolism ; Glycated Hemoglobin/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Liver/metabolism ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach.
Autorzy:
Faloye KO; Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Bekono BD; Department of Physics, Ecole Normale Supérieure, University of Yaoundé 1, Yaoundé BP 812, Cameroon.; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität, 79104 Freiburg, Germany.
Fakola EG; Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Ayoola MD; Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Bello OI; Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Olajubutu OG; Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Owoseeni OD; Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Mahmud S; Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi 6205, Bangladesh.
Alqarni M; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Al Awadh AA; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia.
Alshahrani MM; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia.
Obaidullah AJ; Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 28; Vol. 26 (23). Date of Electronic Publication: 2021 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Activators/*pharmacology
Flavonoids/*pharmacology
Glucokinase/*metabolism
Catalytic Domain/drug effects ; Enzyme Activators/chemistry ; Flavonoids/chemistry ; Glucokinase/chemistry ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dissecting the role of the two Streptomyces peucetius var. caesius glucokinases in the sensitivity to carbon catabolite repression.
Autorzy:
Diana RM; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
Monserrat MR; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
Alba RR; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
Beatriz RV; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
Romina RS; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
Sergio SE; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, CDMX 04510, México.
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Źródło:
Journal of industrial microbiology & biotechnology [J Ind Microbiol Biotechnol] 2021 Dec 23; Vol. 48 (9-10).
Typ publikacji:
Journal Article
MeSH Terms:
Catabolite Repression*
Glucokinase*/metabolism
Carbohydrate Metabolism ; Carbon/metabolism ; Glucose ; Streptomyces
SCR Organism:
Streptomyces peucetius
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae.
Autorzy:
Lesko, Mitchell A. (AUTHOR)
Chandrashekarappa, Dakshayini G. (AUTHOR)
Jordahl, Eric M. (AUTHOR)
Oppenheimer, Katherine G. (AUTHOR)
Bowman II, Ray W. (AUTHOR)
Shang, Chaowei (AUTHOR)
Durrant, Jacob D. (AUTHOR)
Schmidt, Martin C. (AUTHOR)
O'Donnell, Allyson F. (AUTHOR)
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Źródło:
PLoS Genetics. 5/17/2023, Vol. 19 Issue 5, p1-43. 43p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
تأثیر عصاره هیدروالکلی میوه گیاه کور بر آنزیمهاي کلیدي مسیرهاي متابولیسم گلوکز در سلولهاي کبدي موشهاي صحرایی دیابتی: یک مطالعه تجربی
Autorzy:
Noroozi-Karimabad, Mojgan
Nazari, Mahmoud
Chahardoli, Mehdi
Hajizadeh, Mohammad Reza
Mirzaei, Mohammad Reza
Assadollahi, Zahra
Mahmoodi, Mehdi
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Alternatywny tytuł:
The Effect of Hydroalcoholic Extract of Capparis Spinosa Fruit on Key Enzymes of Glucose Metabolism Pathways in the Liver Cells of Diabetic Rats: An Experimental Study.
Źródło:
Journal of Rafsanjan University of Medical Sciences. 2023, Vol. 22 Issue 2, p161-174. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insights from basic adjunctive examinations of GCK-MODY, HNF1A-MODY, and type 2 diabetes: A systemic review and meta-analysis.
Autorzy:
Liu J; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Xiao X; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhang Q; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Yu M; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
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Źródło:
Journal of diabetes [J Diabetes] 2023 Jun; Vol. 15 (6), pp. 519-531. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:
Diabetes Mellitus, Type 2*/diagnosis
Diabetes Mellitus, Type 2*/genetics
Female ; Humans ; Pregnancy ; C-Reactive Protein ; Glucokinase/genetics ; Glucose ; Glycated Hemoglobin ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Mutation ; Triglycerides
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
Autorzy:
Pusec CM; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Ilievski V; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
De Jesus A; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Farooq Z; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Zapater JL; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.; Jesse Brown VA Medical Center, Chicago, IL, USA.
Sweis N; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Ismail H; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Khan MW; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Ardehali H; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Cordoba-Chacon J; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Layden BT; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA. .; Jesse Brown VA Medical Center, Chicago, IL, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 17; Vol. 13 (1), pp. 8034. Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Hexokinase*/genetics
Hexokinase*/metabolism
Non-alcoholic Fatty Liver Disease*/metabolism
Animals ; Male ; Mice ; Glucokinase/metabolism ; Glucose/metabolism ; Hepatocytes/metabolism ; Liver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity.
Autorzy:
Guzmán TJ; Departamento de Biología Molecular y Genómica, Instituto Transdisciplinar de Investigación e Innovación en Salud/Instituto de Investigación en Enfermedades Crónico-Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
Gurrola-Díaz CM; Departamento de Biología Molecular y Genómica, Instituto Transdisciplinar de Investigación e Innovación en Salud/Instituto de Investigación en Enfermedades Crónico-Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
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Źródło:
Archives of physiology and biochemistry [Arch Physiol Biochem] 2021 Apr; Vol. 127 (2), pp. 182-193. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Dietary Supplements*
Diabetes Mellitus/*drug therapy
Gene Expression Regulation, Enzymologic/*drug effects
Glucokinase/*metabolism
Hypoglycemic Agents/*pharmacology
Phytochemicals/*pharmacology
Animals ; Diabetes Mellitus/enzymology ; Enzyme Activation ; Glucokinase/genetics ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes.
Autorzy:
Xie Z; Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Xie T; Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.; Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Liu J; Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.; Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhang Q; Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Xiao X; Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 21; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 1*/complications
Diabetes Mellitus, Type 2*/genetics
Humans ; Fatty Acids ; Glucokinase/metabolism ; Hepatocytes/metabolism ; Inflammation/complications ; Lipid Metabolism ; Mutation ; Triglycerides
SCR Disease Name:
Mason-Type Diabetes; Maturity-Onset Diabetes of the Young, Type 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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