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Tytuł :
NINJ1, rupturing swollen membranes for cataclysmic cell lysis.
Autorzy :
Wang Y; National Institute of Biological Sciences, Beijing, P.R. China.
Shao F; National Institute of Biological Sciences, Beijing, P.R. China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1370-1371.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cell Adhesion Molecules, Neuronal*
Nerve Growth Factors*
Animals ; Cell Membrane ; Endothelial Cells ; Macrophages ; Mice
Czasopismo naukowe
Tytuł :
HBEGF: an EGF-like growth factor with FGF23-like activity?
Autorzy :
Smith ER; Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia. Electronic address: .
Hewitson TD; Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia.
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Źródło :
Kidney international [Kidney Int] 2021 Mar; Vol. 99 (3), pp. 539-542.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Epidermal Growth Factor*
Fibroblast Growth Factors*/genetics
Animals ; Heparin-binding EGF-like Growth Factor ; Kidney ; Mice ; Minerals
Czasopismo naukowe
Tytuł :
FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.
Autorzy :
Chen PC; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.; Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsueh YW; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.; Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lee YH; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Tsai HW; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tsai KJ; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.; Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chiang PM; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan. .; Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2199-2212. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Blood Vessels/*drug effects
Fibroblast Growth Factors/*pharmacology
LIM Domain Proteins/*metabolism
MAP Kinase Signaling System/*drug effects
Proto-Oncogene Proteins/*metabolism
Proto-Oncogene Proteins B-raf/*metabolism
Receptor, Fibroblast Growth Factor, Type 1/*metabolism
Transcription Factors/*metabolism
Blood Vessels/cytology ; Blood Vessels/embryology ; Cell Differentiation/drug effects ; Cell Line ; Fibroblast Growth Factors/metabolism ; Humans ; Mesoderm/cytology ; Mesoderm/drug effects ; Mesoderm/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/pharmacology
Czasopismo naukowe
Tytuł :
Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability.
Autorzy :
Niu J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Zhao J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.; Department of Pharmacy, Zhejiang Hospital, Hangzhou, 310030 Zhejiang, China.
Wu J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Qiao G; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Gu J; School of Nursing, Shandong University, Jinan, 250100 Shandong, China.
Zhou C; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Li Q; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Ying L; School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Wang D; School of Life and Environmental Science, Wenzhou University, Wenzhou, 325035 Zhejiang, China.
Lin H; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Li X; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China.
Mohammadi M; Department of Biochemistry & Molecular Pharmacology, New York University Langone Medical Center, New York, NY 10016 .
Huang Z; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035 Zhejiang, China; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 17; Vol. 117 (46), pp. 29025-29034. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblast Growth Factors/*genetics
Fibroblast Growth Factors/*metabolism
Mitogens/*metabolism
Animals ; Bile Acids and Salts/metabolism ; Diabetes Mellitus, Type 2 ; Dimerization ; Disease Models, Animal ; Fibroblast Growth Factors/chemistry ; Fibroblast Growth Factors/pharmacology ; Genetic Engineering ; Glucose/metabolism ; Hep G2 Cells ; Homeostasis ; Humans ; Male ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Obese/genetics ; Receptors, Fibroblast Growth Factor/metabolism
Czasopismo naukowe
Tytuł :
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.
Autorzy :
Suzuki Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Kuzina E; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
An SJ; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Tome F; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Mohanty J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Li W; Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06477.
Lee S; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Liu Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.; Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06477.
Lax I; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 31800-31807. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Fibroblast Growth Factors/*metabolism
Glucuronidase/*metabolism
Protein Multimerization/*physiology
Binding Sites ; Calcinosis/drug therapy ; Calcinosis/genetics ; Cell Membrane/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/therapeutic use ; HEK293 Cells ; Humans ; Hyperostosis, Cortical, Congenital/drug therapy ; Hyperostosis, Cortical, Congenital/genetics ; Hyperphosphatemia/drug therapy ; Hyperphosphatemia/genetics ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/therapeutic use ; Mutation ; Osteomalacia/drug therapy ; Osteomalacia/genetics ; Protein Binding/drug effects ; Protein Binding/physiology ; Protein Domains ; Protein Multimerization/drug effects ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/therapeutic use ; Rickets, Hypophosphatemic/drug therapy ; Rickets, Hypophosphatemic/genetics
SCR Disease Name :
Tumoral Calcinosis, Hyperphosphatemic, Familial
Czasopismo naukowe
Tytuł :
Intact and C-Terminal FGF23 Assays-Do Kidney Function, Inflammation, and Low Iron Influence Relationships With Outcomes?
Autorzy :
Sharma S; Division of Nephrology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California.; Nephrology Section, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
Katz R; University of Washington, Seattle, Washington.
Bullen AL; Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California.
Chaves PHM; Benjamin Leon Center for Geriatric Research and Education, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.
de Leeuw PW; Department of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, MD Maastricht, the Netherlands.
Kroon AA; Department of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, MD Maastricht, the Netherlands.
Houben AJHM; Department of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, MD Maastricht, the Netherlands.
Shlipak MG; Department of Medicine, University of California San Francisco.
Ix JH; Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California.; Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, California.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Dec 01; Vol. 105 (12).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anemia, Iron-Deficiency/*diagnosis
Fibroblast Growth Factors/*blood
Inflammation/*diagnosis
Kidney/*physiology
Renal Insufficiency, Chronic/*diagnosis
Aged ; Aged, 80 and over ; Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/epidemiology ; Case-Control Studies ; Cohort Studies ; Female ; Fibroblast Growth Factors/analysis ; Fibroblast Growth Factors/chemistry ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/etiology ; Humans ; Incidence ; Inflammation/blood ; Inflammation/complications ; Inflammation/epidemiology ; Iron/deficiency ; Kidney Function Tests ; Male ; Prognosis ; Protein Domains ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors
Czasopismo naukowe
Tytuł :
Mussel-Inspired Surface Immobilization of Heparin on Magnetic Nanoparticles for Enhanced Wound Repair via Sustained Release of a Growth Factor and M2 Macrophage Polarization.
Autorzy :
Wu J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P.R. China.
Zhu J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.; Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, P.R. China.
Wu Q; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
An Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Wang K; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Xuan T; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Zhang J; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P.R. China.
Song W; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P.R. China.
He H; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P.R. China.
Song L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Zheng J; Department of Chemical, Biomolecular, and Corrosion Engineering, The University of Akron, Akron, Ohio 44325, United States.
Xiao J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jan 20; Vol. 13 (2), pp. 2230-2244. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Delayed-Action Preparations/*chemistry
Dopamine/*analogs & derivatives
Fibroblast Growth Factors/*administration & dosage
Heparin/*chemistry
Magnetite Nanoparticles/*chemistry
Wound Healing/*drug effects
Animals ; Biomimetic Materials/chemistry ; Bivalvia/chemistry ; Fibroblast Growth Factors/pharmacology ; Macrophage Activation/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Surface Properties
Czasopismo naukowe
Tytuł :
Role of the fibroblast growth factor 19 in the skeletal system.
Autorzy :
Chen H; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Li J; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Zhang D; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Zhou X; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: .
Xie J; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118804. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bone Development/*physiology
Bone Diseases/*metabolism
Fibroblast Growth Factors/*metabolism
Animals ; Bone Diseases/genetics ; Bone Diseases/pathology ; Fibroblast Growth Factors/genetics ; Humans
Czasopismo naukowe
Tytuł :
Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons.
Autorzy :
Bürger S; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Meng J; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Zwanzig A; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Beck M; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Pankonin M; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Wiedemann P; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Eichler W; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Unterlauft JD; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 31; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Neuroprotection*
Eye Proteins/*metabolism
Nerve Growth Factors/*metabolism
Receptors, Laminin/*metabolism
Receptors, Neuropeptide/*metabolism
Retinal Ganglion Cells/*cytology
Retinal Neurons/*cytology
Serpins/*metabolism
Animals ; Cells, Cultured ; Eye Proteins/genetics ; Mice ; Nerve Growth Factors/genetics ; Receptors, Laminin/genetics ; Receptors, Neuropeptide/genetics ; Retinal Ganglion Cells/metabolism ; Retinal Neurons/metabolism ; Serpins/genetics
Czasopismo naukowe
Tytuł :
Post-transcriptional tuning of FGF signaling mediates neural crest induction.
Autorzy :
Copeland J; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850.
Simoes-Costa M; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 29; Vol. 117 (52), pp. 33305-33316. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/genetics
Transcription, Genetic*
Fibroblast Growth Factors/*genetics
Neural Crest/*metabolism
Animals ; Cell Lineage ; Chick Embryo ; Ectoderm/cytology ; Fibroblast Growth Factors/metabolism ; Gene Expression Regulation, Developmental ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological ; Neural Crest/cytology ; Ribonuclease III/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study.
Autorzy :
Ahmed F; Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
Paul MD; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Program in Molecular Biophysics, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
Hristova K; Department of Materials Science and Engineering, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Institute for NanoBioTechnology, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.; Program in Molecular Biophysics, Johns Hopkins University, 3400 Charles Street, Baltimore, MD 21218, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2020 Dec 11; Vol. 477 (23), pp. 4515-4526.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Multimerization*
Brain-Derived Neurotrophic Factor/*metabolism
Cell Membrane/*metabolism
Membrane Glycoproteins/*metabolism
Nerve Growth Factors/*metabolism
Neurotrophin 3/*metabolism
Receptor, trkB/*metabolism
Brain-Derived Neurotrophic Factor/genetics ; Cell Membrane/genetics ; Fluorescence Resonance Energy Transfer ; HEK293 Cells ; Humans ; Ligands ; Membrane Glycoproteins/genetics ; Nerve Growth Factors/genetics ; Neurotrophin 3/genetics ; Receptor, trkB/genetics
Czasopismo naukowe
Tytuł :
FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with Na V 1.7.
Autorzy :
Dong F; Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.; Institute of Brain-Intelligence Science and Technology, Zhangjiang Lab; Shanghai Center for Brain Science and Brain-Inspired Intelligence, Research Unit of Pain, Chinese Academy of Medical Sciences, Shanghai, 201210, China.; Shanghai Clinical Research Center, Chinese Academy of Sciences/Xu-Hui Central Hospital, Shanghai, 200031, China.
Shi H; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science/Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Yang L; Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Xue H; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science/Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Wei M; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science/Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhong YQ; Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.; Shanghai Clinical Research Center, Chinese Academy of Sciences/Xu-Hui Central Hospital, Shanghai, 200031, China.
Bao L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science/Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China .; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang X; Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China .; Institute of Brain-Intelligence Science and Technology, Zhangjiang Lab; Shanghai Center for Brain Science and Brain-Inspired Intelligence, Research Unit of Pain, Chinese Academy of Medical Sciences, Shanghai, 201210, China.; Shanghai Clinical Research Center, Chinese Academy of Sciences/Xu-Hui Central Hospital, Shanghai, 200031, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Dec 09; Vol. 40 (50), pp. 9589-9601. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblast Growth Factors/*genetics
Ganglia, Spinal/*metabolism
Histamine/*adverse effects
NAV1.7 Voltage-Gated Sodium Channel/*genetics
Neurons/*metabolism
Pruritus/*genetics
Action Potentials/physiology ; Animals ; Fibroblast Growth Factors/metabolism ; Male ; Mice ; Mice, Knockout ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Pruritus/chemically induced ; Pruritus/metabolism ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
Autorzy :
Yueh MF; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093.
He F; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093.
Chen C; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093.
Vu C; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093.
Tripathi A; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Knight R; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Karin M; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093; .
Chen S; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093.
Tukey RH; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31259-31266. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblast Growth Factors/*genetics
Non-alcoholic Fatty Liver Disease/*drug therapy
PPAR alpha/*genetics
Triclosan/*pharmacology
Animals ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Acids/biosynthesis ; Fibroblast Growth Factors/antagonists & inhibitors ; Gene Expression Regulation/drug effects ; Humans ; Liver/drug effects ; Liver/pathology ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/etiology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Mice ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/drug therapy ; Obesity/etiology ; Obesity/genetics ; Obesity/pathology
Czasopismo naukowe
Tytuł :
SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
Autorzy :
Kim JY; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. Electronic address: .
Bai Y; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Jayne LA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Abdulkader F; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Gandhi M; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Perreau T; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Parikh SV; Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Gardner DS; School of Veterinary Medicine and Science, University of Nottingham, Loughborough, Leicestershire, United Kingdom.
Davidson AJ; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Sander V; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Song MA; Division of Environmental Health Science, College of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Bajwa A; Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Pabla NS; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Nov 27; Vol. 295 (48), pp. 16328-16341. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Up-Regulation*
Acute Kidney Injury/*metabolism
Epithelial Cells/*metabolism
Kidney Tubules/*metabolism
Nerve Growth Factors/*biosynthesis
SOX9 Transcription Factor/*metabolism
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Epithelial Cells/pathology ; Kidney Tubules/pathology ; Mice ; Mice, Transgenic ; Nerve Growth Factors/genetics ; SOX9 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development.
Autorzy :
Yang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Zhu X; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui 230001, China.
Jia X; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Hou W; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Zhou G; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Ma Z; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Yu B; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Pi Y; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Zhang X; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Wang J; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Wang G; State Key Laboratory of Genetic Engineering, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11452-11467.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
MAP Kinase Signaling System*
Extremities/*embryology
Fibroblast Growth Factor 9/*metabolism
Fibroblast Growth Factors/*metabolism
MSX1 Transcription Factor/*metabolism
Animals ; CDC2 Protein Kinase/metabolism ; Cell Line ; Fibroblast Growth Factor 9/genetics ; Fibroblast Growth Factors/genetics ; MSX1 Transcription Factor/chemistry ; MSX1 Transcription Factor/genetics ; Mesenchymal Stem Cells/cytology ; Mice ; Mice, Knockout ; Myoblasts/cytology ; Myoblasts/enzymology ; Myoblasts/metabolism ; Phosphorylation ; Serine/metabolism
Czasopismo naukowe
Tytuł :
A new player in the kidney-bone axis: regulation of fibroblast growth factor-23 by renal glycerol-3-phosphate.
Autorzy :
Massy ZA; Inserm Unit 1018, Team 5, Centre de recherche en Epidémiologie et Santé des Populations (CESP), Hôpital Paul Brousse, Paris-Sud University (UPS), Villejuif, France; Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France; Department of Nephrology, Ambroise Paré University Hospital, Assistance publique-Hôpitaux de Paris (APHP), Boulogne-Billancourt/Paris, France.
Drueke TB; Inserm Unit 1018, Team 5, Centre de recherche en Epidémiologie et Santé des Populations (CESP), Hôpital Paul Brousse, Paris-Sud University (UPS), Villejuif, France; Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France. Electronic address: .
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Źródło :
Kidney international [Kidney Int] 2020 Nov; Vol. 98 (5), pp. 1074-1076. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Fibroblast Growth Factors*
Glycerol*
Bone and Bones ; Kidney ; Phosphates
Czasopismo naukowe
Tytuł :
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic.
Autorzy :
Geng L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Lam KSL; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China. .; Department of Medicine, The University of Hong Kong, Hong Kong, China. .; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China. .
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Źródło :
Nature reviews. Endocrinology [Nat Rev Endocrinol] 2020 Nov; Vol. 16 (11), pp. 654-667. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Fibroblast Growth Factors/*therapeutic use
Metabolic Diseases/*drug therapy
Animals ; Clinical Trials as Topic ; Fibroblast Growth Factors/pharmacology ; Humans ; Lipid Metabolism ; Lipidomics ; Species Specificity
Czasopismo naukowe
Tytuł :
PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.
Autorzy :
Dixit S; Section of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA.
Polato F; Section of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA.
Samardzija M; Laboratory of Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
Abu-Asab M; Histopathology Core, NEI-NIH, Bethesda, MD, USA.
Grimm C; Laboratory of Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
Crawford SE; Department of Surgery, NorthShore University Health System Research Institute, Evanston, IL, USA.
Becerra SP; Section of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2020 Sep; Vol. 198, pp. 108121. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nerve Growth Factors/*deficiency
Retinal Degeneration/*metabolism
Serpins/*deficiency
Animals ; Blotting, Western ; Disease Models, Animal ; Disease Progression ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Growth Factors/genetics ; Nerve Growth Factors/metabolism ; Photoreceptor Cells, Vertebrate/metabolism ; Photoreceptor Cells, Vertebrate/pathology ; Retinal Degeneration/pathology ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/pathology ; Serpins/genetics ; Serpins/metabolism
Czasopismo naukowe
Tytuł :
Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior.
Autorzy :
Chen YC; Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland.
Baronio D; Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland.
Semenova S; Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland.
Abdurakhmanova S; Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland.
Panula P; Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 05; Vol. 40 (32), pp. 6146-6164. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Behavior, Animal*
Dopaminergic Neurons/*metabolism
GABAergic Neurons/*metabolism
Nerve Growth Factors/*metabolism
Parkinson Disease/*metabolism
Seizures/*genetics
Zebrafish Proteins/*metabolism
Animals ; Brain/cytology ; Brain/metabolism ; Gene Deletion ; Histamine/metabolism ; Male ; Nerve Growth Factors/genetics ; Parkinson Disease/genetics ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; Zebrafish ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
Flow signal change in polyps after anti-vascular endothelial growth factor therapy.
Autorzy :
Chang CJ; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Huang YM; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsieh MH; Hoping Branch, Taipei City Hospital, Taipei, Taiwan.
Li AF; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.; National Yang-Ming University School of Medicine, Taipei, Taiwan.; Department of Ophthalmology, Cheng Hsin General Hospital, Taipei, Taiwan.
Chen SJ; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.; National Yang-Ming University School of Medicine, Taipei, Taiwan.
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Źródło :
PloS one [PLoS One] 2020 Oct 23; Vol. 15 (10), pp. e0241230. Date of Electronic Publication: 2020 Oct 23 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Regional Blood Flow*/drug effects
Signal Processing, Computer-Assisted*
Polyps/*drug therapy
Vascular Endothelial Growth Factors/*antagonists & inhibitors
Aged ; Aged, 80 and over ; Choroidal Neovascularization/diagnostic imaging ; Choroidal Neovascularization/drug therapy ; Female ; Fluorescein Angiography ; Humans ; Indocyanine Green ; Intravitreal Injections ; Male ; Middle Aged ; Polyps/diagnostic imaging ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/pharmacology ; Recombinant Fusion Proteins/therapeutic use ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factors/metabolism
Czasopismo naukowe

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