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Tytuł :
Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
Autorzy :
Wang X; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Cheng Z; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xu J; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Feng M; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhang H; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhang L; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: .
Qian L; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Department of General Medicine, Tongren Hospital of Shanghai Jiao Tong University of Medicine, Shanghai 200336, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118788. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*toxicity
Cardiotoxicity/*metabolism
Doxorubicin/*toxicity
GTPase-Activating Proteins/*biosynthesis
MicroRNAs/*biosynthesis
RNA, Circular/*biosynthesis
Animals ; Cardiotoxicity/genetics ; Cells, Cultured ; GTPase-Activating Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; RNA, Circular/genetics ; Random Allocation ; Rats
Czasopismo naukowe
Tytuł :
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.
Autorzy :
Robledo RF; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Ciciotte SL; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Graber JH; Mount Desert Island Biological Laboratory, Salisbury Cove, Maine, United States of America.
Zhao Y; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Lambert AJ; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Gwynn B; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Maki NJ; Mount Desert Island Biological Laboratory, Salisbury Cove, Maine, United States of America.
Brindley EC; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Hartman E; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Blanc L; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Peters LL; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Dec 28; Vol. 16 (12), pp. e1008857. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Background*
Hematopoiesis*
Mutation*
GTPase-Activating Proteins/*genetics
Pancytopenia/*genetics
Animals ; Cells, Cultured ; Female ; GTPase-Activating Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
TAT-RasGAP 317-326 kills cells by targeting inner-leaflet-enriched phospholipids.
Autorzy :
Serulla M; Department of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Ichim G; Center for Research on Cancer of Lyon, LabEX DEVweCAN, University of Lyon, 69008 Lyon, France.
Stojceski F; Dalle Molle Institute for Artificial Intelligence Research, Università della Svizzera italiana, Scuola Universitaria Professionale della Svizzera Italiana, 6962 Lugano-Viganello, Switzerland.
Grasso G; Dalle Molle Institute for Artificial Intelligence Research, Università della Svizzera italiana, Scuola Universitaria Professionale della Svizzera Italiana, 6962 Lugano-Viganello, Switzerland.
Afonin S; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany.
Heulot M; Department of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Schober T; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Roth R; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110.
Godefroy C; Centre de Biochimie Structurale, CNRS, INSERM, University Montpellier, 34090 Montpellier, France.
Milhiet PE; Centre de Biochimie Structurale, CNRS, INSERM, University Montpellier, 34090 Montpellier, France.
Das K; Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.
García-Sáez AJ; Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.
Danani A; Dalle Molle Institute for Artificial Intelligence Research, Università della Svizzera italiana, Scuola Universitaria Professionale della Svizzera Italiana, 6962 Lugano-Viganello, Switzerland.
Widmann C; Department of Biomedical Sciences, University of Lausanne, 1005 Lausanne, Switzerland; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 31871-31881. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Death/*drug effects
Cell Membrane/*drug effects
GTPase-Activating Proteins/*pharmacology
Peptide Fragments/*pharmacology
Phosphatidylinositol 4,5-Diphosphate/*metabolism
Phosphatidylserines/*metabolism
Animals ; CHO Cells ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cricetulus ; GTPase-Activating Proteins/therapeutic use ; HeLa Cells ; Humans ; Liposomes/metabolism ; Liposomes/ultrastructure ; Microscopy, Electron ; Molecular Dynamics Simulation ; Neoplasms/drug therapy ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/therapeutic use
Czasopismo naukowe
Tytuł :
The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.
Autorzy :
Benninghoff T; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
Espelage L; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
Eickelschulte S; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
Zeinert I; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Sinowenka I; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Müller F; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Schöndeling C; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Batchelor H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Cames S; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
Zhou Z; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Kotzka J; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
Chadt A; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany .; German Center for Diabetes Research, München-Neuherberg, Germany.
Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.
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Źródło :
Diabetes [Diabetes] 2020 Nov; Vol. 69 (11), pp. 2281-2293. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Acids/*metabolism
GTPase-Activating Proteins/*metabolism
Animals ; Biological Transport/physiology ; Cell Line ; Fatty Acid Transport Proteins ; Fatty Acids/chemistry ; GTPase-Activating Proteins/genetics ; Mice ; Muscle, Skeletal/metabolism ; Myoblasts/metabolism ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Fill the gap, get the answer: Comments on "A family-based genome-wide association study of RAS".
Autorzy :
Coletta RD; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
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Źródło :
Oral diseases [Oral Dis] 2020 Nov; Vol. 26 (8), pp. 1830-1831. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article
MeSH Terms :
GTPase-Activating Proteins*
Genome-Wide Association Study*
Czasopismo naukowe
Tytuł :
EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells.
Autorzy :
Zong X; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana.
Wang W; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana.
Ozes A; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana.
Fang F; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana.
Sandusky GE; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Nephew KP; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana. .; Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana.
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Źródło :
Cancer research [Cancer Res] 2020 Oct 15; Vol. 80 (20), pp. 4371-4385. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Enhancer of Zeste Homolog 2 Protein/*genetics
Neoplastic Stem Cells/*pathology
Ovarian Neoplasms/*pathology
ras GTPase-Activating Proteins/*genetics
Aminoquinolines/pharmacology ; Animals ; Cell Line, Tumor ; Down-Regulation ; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Humans ; Indoles/pharmacology ; Mice, SCID ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Pyridones/pharmacology ; Pyrimidines/pharmacology ; Spheroids, Cellular/pathology ; Wnt Proteins/antagonists & inhibitors ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Xenograft Model Antitumor Assays ; rac1 GTP-Binding Protein/metabolism ; ras GTPase-Activating Proteins/metabolism
Czasopismo naukowe
Tytuł :
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Autorzy :
Wang YY; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
Ke CC; PhD Program in Nutrition & Food science, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Urology, En Chu Kong Hospital, New Taipei City, Taiwan.
Chen YL; Department of Pathology, Cardinal Tien Hospital, New Taipei City, Taiwan.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Lin YH; Division of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City, Taiwan.; Department of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan.
Yu IS; Laboratory Animal Center, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ku WC; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
O'Bryan MK; School of Biological Sciences, Monash University, Melbourne, Victoria, Australia.
Lin YH; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Sep 25; Vol. 16 (9), pp. e1009020. Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTPase-Activating Proteins/*genetics
Infertility, Male/*genetics
Infertility, Male/*pathology
Microfilament Proteins/*genetics
Spermatozoa/*pathology
Spermatozoa/*physiology
Animals ; Asthenozoospermia/genetics ; Axoneme/genetics ; Axoneme/ultrastructure ; Flagella/genetics ; Flagella/pathology ; GTPase-Activating Proteins/metabolism ; Gene Expression ; Humans ; Male ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/metabolism ; Mitochondria/genetics ; Mitochondria/pathology ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Sperm Motility/genetics ; Sperm Tail/pathology ; Spermatozoa/ultrastructure ; Testis/physiology
Czasopismo naukowe
Tytuł :
GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Autorzy :
Zhu J; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: .
Zhou Q; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Xia Y; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Lin L; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
Li J; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Peng M; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China.
Zhang R; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China. Electronic address: .
Zhang M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Sep 03; Vol. 79 (5), pp. 782-796.e6. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Cell Cycle Proteins/*metabolism
GTPase-Activating Proteins/*metabolism
Rho Guanine Nucleotide Exchange Factors/*metabolism
Animals ; Cell Cycle Proteins/chemistry ; GTPase-Activating Proteins/chemistry ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; Models, Molecular ; Paxillin/metabolism ; Protein Binding ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Expression of ACAP1 Is Associated with Tumor Immune Infiltration and Clinical Outcome of Ovarian Cancer.
Autorzy :
Zhang J; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhang Q; Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
Zhang J; Department of Integrated Therapy, Shanghai Cancer Center, Fudan University, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wang Q; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2020 Sep; Vol. 39 (9), pp. 1545-1557. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*genetics
GTPase-Activating Proteins/*genetics
Ovarian Neoplasms/*genetics
Biomarkers, Tumor/metabolism ; Cell Differentiation ; Chemokines/genetics ; Chemokines/metabolism ; DNA Methylation ; Female ; GTPase-Activating Proteins/metabolism ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Neoplastic Stem Cells/metabolism ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Survival Analysis ; Tumor Microenvironment ; Up-Regulation
Czasopismo naukowe
Tytuł :
SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain.
Autorzy :
Gou G; Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Roca-Fernandez A; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
Kilinc M; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Serrano E; Biobank, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Reig-Viader R; Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Araki Y; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Huganir RL; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
de Quintana-Schmidt C; Department of Neurosurgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Rumbaugh G; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Bayés À; Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Sep; Vol. 154 (6), pp. 618-634. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*growth & development
ras GTPase-Activating Proteins/*genetics
Animals ; Cerebral Cortex/growth & development ; Cerebral Cortex/metabolism ; Computer Simulation ; Gene Expression Regulation, Developmental/genetics ; Hippocampus/growth & development ; Hippocampus/metabolism ; Humans ; Isomerism ; Mice ; Mice, Inbred C57BL ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics ; Proteomics ; Subcellular Fractions/metabolism ; ras GTPase-Activating Proteins/biosynthesis
Czasopismo naukowe
Tytuł :
PKCε-dependent H-Ras activation encompasses the recruitment of the RasGEF SOS1 and of the RasGAP neurofibromin in the lipid rafts of embryonic neurons.
Autorzy :
Karouzaki S; Basic Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou, Athens, 11527, Greece.
Peta C; Basic Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou, Athens, 11527, Greece.
Tsirimonaki E; Basic Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou, Athens, 11527, Greece.
Mangoura D; Basic Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou, Athens, 11527, Greece. Electronic address: .
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Źródło :
Neurochemistry international [Neurochem Int] 2019 Dec; Vol. 131, pp. 104582. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Microdomains/*metabolism
Neurofibromin 1/*metabolism
Neurons/*metabolism
Protein Kinase C-epsilon/*physiology
SOS1 Protein/*metabolism
ras GTPase-Activating Proteins/*genetics
ras Guanine Nucleotide Exchange Factors/*genetics
Animals ; Arachidonic Acids/pharmacology ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Chick Embryo ; Computer Simulation ; GTPase-Activating Proteins ; Guanosine Triphosphate/metabolism ; Palmitic Acid/metabolism ; Primary Cell Culture ; Receptor, Cannabinoid, CB1/agonists ; Telencephalon/drug effects ; Telencephalon/metabolism
Czasopismo naukowe
Tytuł :
DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response.
Autorzy :
Yang L; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing Y; Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang W; Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China.
Ying W; Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China.
Lin L; Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China.
Chang J; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Luo L; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kang D; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiang P; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu J; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen Q; Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Miller H; Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th St., Hamilton, MT, 59840, USA.
Herrada AA; Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Talca, Chile.
Kubo M; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Kanagawa, Japan.
Sun J; Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China. Electronic address: .
Liu C; Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Aug 20; Vol. 529 (2), pp. 296-302. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*metabolism
GTPase-Activating Proteins/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Lymphoid Enhancer-Binding Factor 1/*metabolism
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Cell Differentiation ; Cells, Cultured ; Female ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/immunology ; Gene Deletion ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Lymphoid Enhancer-Binding Factor 1/genetics ; Lymphoid Enhancer-Binding Factor 1/immunology ; Male ; Mice, Knockout ; Point Mutation ; Signal Transduction
Czasopismo naukowe
Tytuł :
StarD13: a potential star target for tumor therapeutics.
Autorzy :
Jaafar L; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran, P.O. Box 13-5053, 1102 2801, Beirut, Lebanon.
Chamseddine Z; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran, P.O. Box 13-5053, 1102 2801, Beirut, Lebanon.
El-Sibai M; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran, P.O. Box 13-5053, 1102 2801, Beirut, Lebanon. .
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Źródło :
Human cell [Hum Cell] 2020 Jul; Vol. 33 (3), pp. 437-443. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*
GTPase-Activating Proteins/*genetics
Neoplasms/*drug therapy
Neoplasms/*genetics
Tumor Suppressor Proteins/*genetics
Amino Acid Sequence ; Down-Regulation ; GTPase-Activating Proteins/chemistry ; GTPase-Activating Proteins/metabolism ; Genes, Tumor Suppressor ; Humans ; Neoplasms/pathology ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/metabolism ; rho GTP-Binding Proteins
Czasopismo naukowe
Tytuł :
The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling.
Autorzy :
Cui Y; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany. .
Groth S; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
Troutman S; Department of Molecular Medicine, the Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Carlstedt A; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
Sperka T; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
Riecken LB; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
Kissil JL; Department of Molecular Medicine, the Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Jin H; Laboratory of Cancer Biology, Key Laboratory of Biotherapy, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, 310016, China.
Morrison H; Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany. .
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Źródło :
Oncogene [Oncogene] 2019 Sep; Vol. 38 (36), pp. 6370-6381. Date of Electronic Publication: 2019 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurofibromin 2/*physiology
Proto-Oncogene Proteins p21(ras)/*metabolism
ras GTPase-Activating Proteins/*metabolism
Animals ; Cells, Cultured ; GTPase-Activating Proteins/metabolism ; Genes, Tumor Suppressor ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Neurofibromatosis 2/genetics ; Neurofibromatosis 2/metabolism ; Neurofibromin 2/metabolism ; Protein Binding ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12.
Autorzy :
Tanimura S; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Nishida M; Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
Horie T; Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan.
Kamishima T; Department of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Matsumoto H; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Morimura Y; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Nishibata Y; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Masuda S; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Nakazawa D; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tomaru U; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Atsumi T; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Ishizu A; Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2020 Aug; Vol. 115, pp. 104454. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*/drug effects
Arthritis, Experimental/*drug therapy
Arthritis, Experimental/*prevention & control
Fluvastatin/*therapeutic use
GTPase-Activating Proteins/*metabolism
Animals ; Arthritis, Experimental/diagnostic imaging ; Arthritis, Experimental/pathology ; Exosomes/drug effects ; Exosomes/genetics ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fluvastatin/pharmacology ; GTPase-Activating Proteins/genetics ; Humans ; Inflammation/pathology ; Joints/diagnostic imaging ; Joints/pathology ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Synovial Membrane/pathology
Czasopismo naukowe
Tytuł :
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset.
Autorzy :
Heide M; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. .
Haffner C; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Murayama A; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.; Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako City, Saitama 351-0198, Japan.
Kurotaki Y; Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals, Kawasaki 210-0821, Japan.
Shinohara H; Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals, Kawasaki 210-0821, Japan.
Okano H; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.; Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako City, Saitama 351-0198, Japan.
Sasaki E; Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals, Kawasaki 210-0821, Japan.
Huttner WB; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Jul 31; Vol. 369 (6503), pp. 546-550. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTPase-Activating Proteins/*metabolism
Neocortex/*embryology
Animals ; Animals, Genetically Modified ; Callithrix ; Fetus ; GTPase-Activating Proteins/genetics ; Humans ; Lateral Ventricles/embryology ; Lateral Ventricles/metabolism ; Neocortex/anatomy & histology ; Neocortex/metabolism ; Neural Stem Cells/metabolism ; Neuroglia/metabolism ; Neurons/metabolism ; Organ Size ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Epithelial cell -derived microvesicles: A safe delivery platform of CRISPR/Cas9 conferring synergistic anti-tumor effect with sorafenib.
Autorzy :
He C; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
Jaffar Ali D; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu, 210096, China.
Xu H; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
Kumaravel S; Department of Medical Physiology, College of Medicine, Texas A & M Health Science Center, College Station, TX, 77843, USA.
Si K; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
Li Y; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
Sun B; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
Ma J; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Xiao Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Jul 15; Vol. 392 (2), pp. 112040. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Carcinoma, Hepatocellular/*therapy
Cell-Derived Microparticles/*pathology
Epithelial Cells/*pathology
Liver Neoplasms/*therapy
Sorafenib/*pharmacology
ras GTPase-Activating Proteins/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Cell-Derived Microparticles/metabolism ; Combined Modality Therapy ; Epithelial Cells/metabolism ; Female ; Gene Editing ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; ras GTPase-Activating Proteins/genetics
Czasopismo naukowe
Tytuł :
Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.
Autorzy :
Rastogi D; Department of Pediatrics.; Department of Pathology, and.
Johnston AD; Department of Genetics, Albert Einstein College of Medicine, New York, New York.
Nico J; Department of Pediatrics.
Loh LN; Department of Pediatrics.
Jorge Y; Department of Pediatrics.
Suzuki M; Department of Genetics, Albert Einstein College of Medicine, New York, New York.
Macian F; Department of Pathology, and.
Greally JM; Department of Genetics, Albert Einstein College of Medicine, New York, New York.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Jul 15; Vol. 202 (2), pp. 259-274.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genomics*
Phenotype*
African Americans/*genetics
Asthma/*genetics
GTPase-Activating Proteins/*genetics
Hispanic Americans/*genetics
Pediatric Obesity/*genetics
Adolescent ; Asthma/physiopathology ; Child ; Child, Preschool ; Female ; GTPase-Activating Proteins/metabolism ; Healthy Volunteers ; Humans ; Infant ; Male
Czasopismo naukowe
Tytuł :
ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.
Autorzy :
Wang L; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shen S; Department of Anesthesiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao H; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ding F; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang M; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li G; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hu F; Department of Cardiothoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 711-721.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle*
Cell Proliferation*
Cyclin-Dependent Kinase Inhibitor p27/*metabolism
GTPase-Activating Proteins/*metabolism
Lung Neoplasms/*pathology
STAT6 Transcription Factor/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; GTPase-Activating Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; STAT6 Transcription Factor/genetics ; Tumor Cells, Cultured ; Ubiquitin-Protein Ligases/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Autorzy :
Chang L; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Yang J; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Jo CH; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.
Boland A; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.; Department of Molecular Biology, Science III, University of Geneva, Geneva, Switzerland.
Zhang Z; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
McLaughlin SH; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Abu-Thuraia A; Montreal Institute of Clinical Research (IRCM), Montréal, QC, H2W 1R7, Canada.
Killoran RC; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.
Smith MJ; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, QC, H3T 1J4, Canada.
Côté JF; Montreal Institute of Clinical Research (IRCM), Montréal, QC, H2W 1R7, Canada.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, H3C 3J7, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, H3A 0C7, Canada.
Barford D; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 10; Vol. 11 (1), pp. 3464. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
GTPase-Activating Proteins/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Calorimetry ; GTPase-Activating Proteins/genetics ; Guanine Nucleotide Exchange Factors/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Immunoblotting ; Kinetics ; Microscopy, Electron ; Phosphorylation ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism ; rho GTP-Binding Proteins/genetics ; rho GTP-Binding Proteins/metabolism
Czasopismo naukowe

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