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Tytuł:
SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
Autorzy:
Araki Y; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Rajkovich KE; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gerber EE; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gamache TR; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johnson RC; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tran THN; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Liu B; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhu Q; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hong I; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kirkwood A; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Huganir R; Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar; Vol. 383 (6686), pp. eadk1291. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cognition*
Neuronal Plasticity*/genetics
ras GTPase-Activating Proteins*/genetics
ras GTPase-Activating Proteins*/metabolism
Animals ; Humans ; Mice ; Autistic Disorder/genetics ; GTPase-Activating Proteins/genetics ; Learning ; Mice, Knockout ; Catalysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.
Autorzy:
Rosenberg EM Jr; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Jian X; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Soubias O; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Jackson RA; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Gladu E; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Andersen E; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Esser L; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
Sodt AJ; Unit of Membrane Chemical Physics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States of America.
Xia D; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
Byrd RA; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Apr 04; Vol. 19 (4), pp. e0295103. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
GTPase-Activating Proteins*/metabolism
Myristates*
Point Mutation ; Myristic Acid ; ADP-Ribosylation Factor 1/genetics ; ADP-Ribosylation Factor 1/metabolism ; ADP-Ribosylation Factors/genetics ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GRAF1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes.
Autorzy:
Zhu Q; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Combs ME; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Bowles DE; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Gross RT; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Mendiola Pla M; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Mack CP; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
Taylor JM; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
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Źródło:
Cells [Cells] 2024 Mar 04; Vol. 13 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
GTPase-Activating Proteins*/metabolism
Mitophagy*/physiology
Myocytes, Cardiac*/metabolism
Phosphatidylinositol Phosphates*
Ubiquitin-Protein Ligases*/metabolism
Animals ; Humans ; Mice ; Actins ; Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain.
Autorzy:
Mosaddeghzadeh N; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Pudewell S; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Bazgir F; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Kazemein Jasemi NS; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Krumbach OHF; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Gremer L; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Willbold D; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Dvorsky R; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Center for Interdisciplinary Biosciences, P. J. Šafárik University, Jesenná 5, 040 01 Košice, Slovakia.
Ahmadian MR; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 09; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
cdc42 GTP-Binding Protein*/genetics
cdc42 GTP-Binding Protein*/metabolism
ras GTPase-Activating Proteins*/genetics
ras GTPase-Activating Proteins*/metabolism
Binding Sites ; GTPase-Activating Proteins/metabolism ; Guanosine Triphosphate/metabolism ; Nucleotides/metabolism ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neurofibromin 1 mediates sleep depth in Drosophila.
Autorzy:
Brown EB; Department of Biology, Texas A&M University, College Station, Texas, United States of America.; Department of Biological Sciences, Florida State University, Tallahassee, Florida, United States of America.
Zhang J; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
Lloyd E; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
Lanzon E; Jupiter Life Science Initiative, Florida Atlantic University, Jupiter, Florida, United States of America.
Botero V; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.
Tomchik S; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.
Keene AC; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Dec 13; Vol. 19 (12), pp. e1011049. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Nerve Tissue Proteins*/genetics
Nerve Tissue Proteins*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
ras GTPase-Activating Proteins*/genetics
ras GTPase-Activating Proteins*/metabolism
Sleep ; Animals ; Drosophila melanogaster ; Sleep Duration ; Male ; Brain/metabolism ; Intestines/metabolism ; Diet
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C9orf72 Toxic Species Affect ArfGAP-1 Function.
Autorzy:
Rossi S; Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.; Fondazione Santa Lucia IRCCS, c/o CERC, 00143 Rome, Italy.
Di Salvio M; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), 00185 Rome, Italy.
Balì M; Department of Biology and Biotechnology, University of Rome 'La Sapienza', 00185 Rome, Italy.
De Simone A; Department of Biology and Biotechnology, University of Rome 'La Sapienza', 00185 Rome, Italy.
Apolloni S; Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy.
D'Ambrosi N; Fondazione Santa Lucia IRCCS, c/o CERC, 00143 Rome, Italy.; Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy.
Arisi I; Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.; European Brain Research Institute 'Rita Levi-Montalcini', 00161 Rome, Italy.
Cipressa F; Department of Ecological and Biological Science, University of Tuscia, 01100 Viterbo, Italy.
Cozzolino M; Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.
Cestra G; Fondazione Santa Lucia IRCCS, c/o CERC, 00143 Rome, Italy.; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), 00185 Rome, Italy.; Department of Biology and Biotechnology, University of Rome 'La Sapienza', 00185 Rome, Italy.
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Źródło:
Cells [Cells] 2023 Aug 05; Vol. 12 (15). Date of Electronic Publication: 2023 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
C9orf72 Protein*/genetics
C9orf72 Protein*/metabolism
GTPase-Activating Proteins*/genetics
GTPase-Activating Proteins*/metabolism
Animals ; Humans ; Mice ; ADP-Ribosylation Factor 1/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; RNA/metabolism ; RNA, Messenger/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.
Autorzy:
Højgaard K; Translational Neuropsychiatry Unit, Department of Clinical medicine, Aarhus University, Aarhus N, DK8200, Denmark.; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, DK8000, Denmark.
Szöllősi B; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, DK8000, Denmark.
Henningsen K; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, DK8000, Denmark.
Minami N; Neuroscience Research Unit, Mitsubishi Tanabe Pharma Corporation, Kanagawa, 227-0033, Japan.
Nakanishi N; Data Science Department, Mitsubishi Tanabe Pharma Corporation, Kanagawa, 227-0033, Japan.
Kaadt E; Translational Neuropsychiatry Unit, Department of Clinical medicine, Aarhus University, Aarhus N, DK8200, Denmark.
Tamura M; Neuroscience Research Unit, Mitsubishi Tanabe Pharma Corporation, Kanagawa, 227-0033, Japan.; NeuroDiscovery Lab, Mitsubishi Tanabe Pharma Holdings America Inc, Cambridge, MA, 02139, USA.
Morris RGM; Laboratory for Cognitive Neuroscience, Edinburgh Neuroscience, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Takeuchi T; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, DK8000, Denmark. .; Center for Proteins in Memory - PROMEMO, Department of Biomedicine, Danish National Research Foundation, Aarhus University, Aarhus C, DK8000, Denmark. .; Gftd DeSci, Gftd DAO, Tokyo, 162-0044, Japan. .
Elfving B; Translational Neuropsychiatry Unit, Department of Clinical medicine, Aarhus University, Aarhus N, DK8200, Denmark. .
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Źródło:
Molecular brain [Mol Brain] 2023 Sep 25; Vol. 16 (1), pp. 69. Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Memory Consolidation*
GTPase-Activating Proteins*
Animals ; Mice ; Rats ; Dopamine ; Glutamic Acid ; Hippocampus ; Locus Coeruleus ; Receptors, AMPA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Ras GTPase-activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens.
Autorzy:
Cao H; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Gong H; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yu M; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Pan X; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Song T; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yu J; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Qi Z; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Du Y; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Zhang R; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Liu Y; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
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Źródło:
Molecular plant pathology [Mol Plant Pathol] 2024 Mar; Vol. 25 (3), pp. e13448.
Typ publikacji:
Journal Article
MeSH Terms:
Oryza*/microbiology
Hypocreales*
GTPase-Activating Proteins/genetics ; ras GTPase-Activating Proteins ; Plant Diseases/microbiology
SCR Organism:
Ustilaginoidea virens
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin.
Autorzy:
Géci I; Department of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04011 Košice, Slovakia.
Bober P; Department of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04011 Košice, Slovakia.
Filová E; Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 142 00 Prague, Czech Republic.
Amler E; Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 142 00 Prague, Czech Republic.
Sabo J; Department of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04011 Košice, Slovakia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 12; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
GTPase-Activating Proteins*/metabolism
rho GTP-Binding Proteins*/metabolism
Female ; Humans ; cdc42 GTP-Binding Protein/metabolism ; Doxorubicin/pharmacology ; MCF-7 Cells ; Proteomics ; rac1 GTP-Binding Protein/metabolism ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers.
Autorzy:
Hsieh MJ; Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 500, Taiwan.; Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung, 402, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan.
Lo YS; Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 500, Taiwan.
Tsai YJ; Department of Surgical Pathology, Changhua Christian Hospital, Changhua, 500, Taiwan.; Translational Pathology Core Laboratory, Changhua Christian Hospital, Changhua, 500, Taiwan.
Ho HY; Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 500, Taiwan.
Lin CC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 500, Taiwan.
Chuang YC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 500, Taiwan.
Lin SH; Department of Surgical Pathology, Changhua Christian Hospital, Changhua, 500, Taiwan.; Translational Pathology Core Laboratory, Changhua Christian Hospital, Changhua, 500, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, 406, Taiwan.
Chen MK; Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No.135, Nanxiao St., Changhua City, Changhua County, 500, Taiwan. .; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, 402, Taiwan. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Jun 30; Vol. 23 (1), pp. 607. Date of Electronic Publication: 2023 Jun 30.
Typ publikacji:
Journal Article
MeSH Terms:
GTPase-Activating Proteins*/genetics
Mouth Neoplasms*/genetics
Alcohol Drinking*/adverse effects
Humans ; Disease Progression ; Genes, Regulator ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DEPDC1B is involved in the proliferation, metastasis, cell cycle arrest and apoptosis of colon cancer cells by regulating NUP37.
Autorzy:
Xiong H; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Li Y; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Liu M; Department of General Surgery, The First Affiliated Hospital of Nanchang University Jing'an County People's Hospital, Jing'an, Shanghai 330600, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2023 Jun; Vol. 27 (6). Date of Electronic Publication: 2023 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*/genetics
Colorectal Neoplasms*/pathology
GTPase-Activating Proteins*/genetics
Nuclear Pore Complex Proteins*/genetics
Animals ; Apoptosis/genetics ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Autorzy:
Lv M; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Li X; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yin Z; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yang H; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Zhou B; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
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Źródło:
PloS one [PLoS One] 2024 Apr 02; Vol. 19 (4), pp. e0294227. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnosis
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/diagnosis
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Epstein-Barr Virus Infections*
Humans ; Herpesvirus 4, Human/metabolism ; Signal Transduction ; Neoplasm Proteins/genetics ; GTPase-Activating Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integration analysis of lncRNA and mRNA expression data identifies DOCK4 as a potential biomarker for elderly osteoporosis.
Autorzy:
Wu C; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Wang C; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Xiao B; Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Li S; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Sheng Y; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Wang Q; Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China.
Tao J; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Zhang Y; Department of Molecular Orthopaedics, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Jiang X; Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2024 Mar 05; Vol. 17 (1), pp. 70. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
MicroRNAs*
Osteoporosis*/genetics
Aged ; Humans ; Biomarkers ; Databases, Factual ; GTPase-Activating Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigation of a novel TBC1D24 variation causing autosomal dominant non-syndromic hearing loss.
Autorzy:
Lei P; Department of Otolaryngology Head & Neck Surgery, The Second Hospital of Hebei Medical University, Heping West Road No. 215, Shijiazhuang, 050000, Hebei, China.; Department of Otolaryngology Head & Neck Surgery, The Third Hospital of Shijiazhuang, Tiyu South Street No.15, Shijiazhuang, 050011, Hebei, China.
Zhu Q; Department of Otolaryngology Head & Neck Surgery, The Second Hospital of Hebei Medical University, Heping West Road No. 215, Shijiazhuang, 050000, Hebei, China. .
Dong W; Department of Otolaryngology Head & Neck Surgery, The Third Hospital of Shijiazhuang, Tiyu South Street No.15, Shijiazhuang, 050011, Hebei, China.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 27; Vol. 14 (1), pp. 4734. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Deafness*/genetics
Hearing Loss, Sensorineural*/genetics
Hearing Loss*/genetics
Humans ; Amino Acid Sequence ; Mutation ; Pedigree ; GTPase-Activating Proteins/genetics
SCR Disease Name:
Nonsyndromic Deafness; Nonsyndromic sensorineural hearing loss
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance.
Autorzy:
Belnap C; Department of Advanced Education in Orthodontic Dentistry, School of Dental Medicine, University of Nevada-Las Vegas, 1700 W. Charleston Boulevard, Las Vegas, NV 89106, USA.
Divis T; Department of Clinical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, 1700 W. Charleston Boulevard, Las Vegas, NV 89106, USA.
Kingsley K; Department of Biomedical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, 1001 Shadow Lane, Las Vegas, NV 89106, USA.
Howard KM; Department of Biomedical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, 1001 Shadow Lane, Las Vegas, NV 89106, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 10; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell*/drug therapy
Carcinoma, Squamous Cell*/genetics
Carcinoma, Squamous Cell*/metabolism
Mouth Neoplasms*/drug therapy
Mouth Neoplasms*/genetics
Mouth Neoplasms*/metabolism
MicroRNAs*/metabolism
Head and Neck Neoplasms*/genetics
Chromosomal Proteins, Non-Histone*
Humans ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Cisplatin/therapeutic use ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; GTPase-Activating Proteins/metabolism ; Carrier Proteins/metabolism ; Microfilament Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Autorzy:
Muller M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Bélanger J; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Hadj-Aissa I; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Zhang C; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Epilepsy*
Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction ; GTPase-Activating Proteins/metabolism ; Mutation ; Phosphatidylinositol 3-Kinase/metabolism ; Amino Acids/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Nitrogen/metabolism
Czasopismo naukowe
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Tytuł:
AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle.
Autorzy:
Peifer-Weiß L; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Medical Faculty, 40225 Düsseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, 85764 Neuherberg, Germany.
Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Medical Faculty, 40225 Düsseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, 85764 Neuherberg, Germany.
Chadt A; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Medical Faculty, 40225 Düsseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, 85764 Neuherberg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Insulin Resistance*
Diabetes Mellitus, Type 2*/metabolism
Humans ; GTPase-Activating Proteins/metabolism ; AMP-Activated Protein Kinases/metabolism ; Muscle, Skeletal/metabolism ; Glucose/metabolism ; Insulin/metabolism ; Phosphorylation ; Insulin, Regular, Human ; Glucose Transporter Type 4/metabolism ; Muscle Contraction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis.
Autorzy:
Chen W; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhou M; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guan B; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie B; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
He J; Department of General Surgery, DongTai People's Hospital, Dongtai, Jiangsu, China.
Zhao J; Department of General Surgery, DongTai People's Hospital, Dongtai, Jiangsu, China.
Zhao Q; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan D; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2024 Feb; Vol. 14 (2), pp. e1591.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*
Extracellular Vesicles*
Humans ; Proto-Oncogene Proteins c-akt ; Tumor-Associated Macrophages ; Cholesterol ; rac1 GTP-Binding Protein/genetics ; Guanine Nucleotide Exchange Factors ; GTPase-Activating Proteins ; ATP Binding Cassette Transporter 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury.
Autorzy:
Li S; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Chen S; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Wang Y; Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Shunde, 528300, China.
Hu X; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Wang Y; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Wu Z; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Huang S; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
He J; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Deng F; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Zhao B; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Ma G; Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Shunde, 528300, China. .
Li Y; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. .; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. .; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2023 Mar 07; Vol. 22 (1), pp. 34. Date of Electronic Publication: 2023 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Injuries*
Ischemic Stroke*
MicroRNAs*/genetics
Reperfusion Injury*/genetics
GTPase-Activating Proteins*/genetics
Animals ; Rats ; Cytokinesis ; Glucose ; Hypoxia ; Neurons ; Oxygen
Czasopismo naukowe
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Tytuł:
IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins.
Autorzy:
Thines L; Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Li Z; Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Sacks DB; Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło:
Cells [Cells] 2023 Feb 02; Vol. 12 (3). Date of Electronic Publication: 2023 Feb 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
ras GTPase-Activating Proteins*
Receptor Protein-Tyrosine Kinases*
Phosphotyrosine ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1950

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