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Tytuł :
Impaired Ca Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells.
Autorzy :
Marino V; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37129 Verona, Italy.
Dal Cortivo G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37129 Verona, Italy.
Maltese PE; MAGI'S Lab S.R.L., 38068 Rovereto, Italy.
Placidi G; Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, 00168 Rome, Italy.; Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
De Siena E; Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, 00168 Rome, Italy.; Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Falsini B; Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, 00168 Rome, Italy.; Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Bertelli M; MAGI'S Lab S.R.L., 38068 Rovereto, Italy.; MAGI Euregio, 39100 Bolzano, Italy.
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37129 Verona, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 14; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Synaptic Transmission*
Calcium/*metabolism
Cone Dystrophy/*genetics
Cone Dystrophy/*physiopathology
Guanylate Cyclase-Activating Proteins/*genetics
Mutation/*genetics
Retinal Bipolar Cells/*pathology
Retinal Rod Photoreceptor Cells/*pathology
Atrophy ; Cations ; Cone Dystrophy/diagnostic imaging ; Disease Progression ; Electroretinography ; Female ; Fundus Oculi ; Guanylate Cyclase/metabolism ; Guanylate Cyclase-Activating Proteins/chemistry ; Heterozygote ; Humans ; Hydrodynamics ; Hydrophobic and Hydrophilic Interactions ; Middle Aged ; Molecular Dynamics Simulation ; Phenotype ; Protein Aggregates ; Protein Stability ; Protein Structure, Quaternary ; Retinal Bipolar Cells/metabolism ; Retinal Pigment Epithelium/pathology ; Retinal Rod Photoreceptor Cells/metabolism ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase.
Autorzy :
Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 31; Vol. 295 (31), pp. 10781-10793. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye Proteins/*metabolism
Guanylate Cyclase/*metabolism
Receptors, Cell Surface/*metabolism
Amino Acid Substitution ; Animals ; Cattle ; Eye Proteins/genetics ; Guanylate Cyclase/genetics ; Guanylate Cyclase-Activating Proteins/genetics ; Guanylate Cyclase-Activating Proteins/metabolism ; HEK293 Cells ; Humans ; Mutation, Missense ; Protein Binding ; Receptors, Cell Surface/genetics
Czasopismo naukowe
Tytuł :
GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone-rod dystrophy but not for stationary night blindness.
Autorzy :
Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Olshevskaya EV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18301-18315. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Calcium/*metabolism
Cone-Rod Dystrophies/*genetics
Eye Proteins/*metabolism
Guanylate Cyclase/*metabolism
Night Blindness/*genetics
Receptors, Cell Surface/*metabolism
Amino Acid Substitution ; Eye Proteins/chemistry ; Eye Proteins/genetics ; Guanylate Cyclase/chemistry ; Guanylate Cyclase/genetics ; HEK293 Cells ; Humans ; Protein Conformation ; Protein Multimerization ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/genetics
Czasopismo naukowe
Tytuł :
Molecular Properties and Optogenetic Applications of Enzymerhodopsins.
Autorzy :
Tsunoda SP; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan. .; JST PRESTO, Saitama, Japan. .
Sugiura M; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.
Kandori H; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1293, pp. 153-165.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Optogenetics*
Guanylate Cyclase/*metabolism
Phosphoric Diester Hydrolases/*metabolism
Rhodopsins, Microbial/*metabolism
Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Guanylate Cyclase/genetics ; Phosphoric Diester Hydrolases/genetics ; Rhodopsins, Microbial/genetics
Czasopismo naukowe
Tytuł :
Missense mutations affecting Ca -coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties.
Autorzy :
Dal Cortivo G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy.
Marino V; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy.
Bonì F; CNR-IBF, Istituto di Biofisica, Via Celoria 26, I-20133 Milano, Italy; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133 Milano, Italy.
Milani M; CNR-IBF, Istituto di Biofisica, Via Celoria 26, I-20133 Milano, Italy; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133 Milano, Italy.
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Oct; Vol. 1867 (10), pp. 118794. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Cone-Rod Dystrophies/*genetics
Guanylate Cyclase-Activating Proteins/*chemistry
Guanylate Cyclase-Activating Proteins/*genetics
Mutation, Missense/*genetics
Dynamic Light Scattering ; Guanylate Cyclase-Activating Proteins/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Point Mutation/genetics ; Protein Aggregates ; Protein Multimerization ; Protein Stability ; Scattering, Small Angle ; Temperature ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A.
Autorzy :
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134, Verona, Italy. .
Dal Cortivo G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134, Verona, Italy.
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 20105. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Signal Transduction*
Cyclic GMP/*metabolism
Guanylate Cyclase-Activating Proteins/*genetics
Retinal Dystrophies/*etiology
Retinal Dystrophies/*metabolism
Algorithms ; Animals ; Calcium/metabolism ; Guanylate Cyclase/metabolism ; Humans ; Light Signal Transduction ; Mice ; Models, Theoretical ; Receptors, Cell Surface/metabolism ; Retinal Dystrophies/pathology
Czasopismo naukowe
Tytuł :
Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.
Autorzy :
Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027 .
Olshevskaya EV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027.
Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Sep 13; Vol. 294 (37), pp. 13729-13739. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Guanylate Cyclase/*metabolism
Nuclear Proteins/*metabolism
Receptors, Calcium-Sensing/*metabolism
Amino Acid Substitution ; Animals ; Blindness/genetics ; Calcium/metabolism ; Disease Models, Animal ; Eye Abnormalities/genetics ; Female ; Guanylate Cyclase/physiology ; Guanylate Cyclase-Activating Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation, Missense ; Nuclear Proteins/physiology ; Photoreceptor Cells, Vertebrate/metabolism ; Photoreceptor Cells, Vertebrate/physiology ; Protein Binding/genetics ; Receptors, Cell Surface/metabolism ; Retina/metabolism ; Retinal Degeneration/genetics ; Retinal Rod Photoreceptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens.
Autorzy :
Hao Y; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Zhou Y; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Yu Y; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Zheng M; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Weng K; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Kou Z; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Liang J; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.
Zhang Q; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China.
Tang X; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Xu P; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China.
Link BA; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Yao K; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China .; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou 310058, China.
Zou J; Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China .; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China.; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou 310058, China.
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Źródło :
Development (Cambridge, England) [Development] 2020 Nov 19; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adherens Junctions/*metabolism
Cell Movement/*physiology
Cell Polarity/*physiology
Guanylate Cyclase/*metabolism
Zebrafish/*embryology
Zebrafish Proteins/*metabolism
rab GTP-Binding Proteins/*metabolism
Adherens Junctions/genetics ; Animals ; Cadherins/genetics ; Cadherins/metabolism ; Epithelial Cells ; Golgi Apparatus/genetics ; Golgi Apparatus/metabolism ; Guanylate Cyclase/genetics ; Protein Transport/physiology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist.
Autorzy :
Cheng J; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittburgh, PA, USA.
Maurer LM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittburgh, PA, USA.
Kang H; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lucas PC; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
McAllister-Lucas LM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittburgh, PA, USA. Electronic address: .
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Źródło :
Cellular immunology [Cell Immunol] 2020 Sep; Vol. 355, pp. 104158. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
B-Cell CLL-Lymphoma 10 Protein/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Guanylate Cyclase/*metabolism
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis Regulatory Proteins/metabolism ; B-Cell CLL-Lymphoma 10 Protein/physiology ; B-Lymphocytes/metabolism ; CARD Signaling Adaptor Proteins/physiology ; Guanylate Cyclase/physiology ; Humans ; Lymphocyte Activation/physiology ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/physiology ; NF-kappa B/metabolism ; Protein Interaction Maps/physiology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension.
Autorzy :
Kreisel W; Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Schaffner D; Institute for Exercise and Occupational Medicine, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, 79104 Freiburg, Germany.; Department of Radiology-Medical Physics, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Lazaro A; Institute for Exercise and Occupational Medicine, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Trebicka J; Translational Hepatology, Department of Internal Medicine I, Goethe University Clinic Frankfurt, 60590 Frankfurt, Germany.
Merfort I; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, 79104 Freiburg, Germany.
Schmitt-Graeff A; Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
Deibert P; Institute for Exercise and Occupational Medicine, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 28; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cyclic Nucleotide Phosphodiesterases, Type 5/*genetics
Guanylate Cyclase/*genetics
Hypertension, Portal/*enzymology
Liver Cirrhosis/*enzymology
Cyclic GMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Guanylate Cyclase/metabolism ; Humans ; Hypertension, Portal/drug therapy ; Hypertension, Portal/etiology ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Molecular Targeted Therapy ; Nitric Oxide/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.
Autorzy :
Stinson JR; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of Health Sciences, Bethesda, MD, United States. Electronic address: .
Dorjbal B; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of Health Sciences, Bethesda, MD, United States.
McDaniel DP; Biomedical Instrumentation Center, Uniformed Services University of Health Sciences, Bethesda, MD, United States.
David L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
Wu H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, United States.
Snow AL; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of Health Sciences, Bethesda, MD, United States. Electronic address: .
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Źródło :
Cellular immunology [Cell Immunol] 2020 Jul; Vol. 353, pp. 104129. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gain of Function Mutation*
CARD Signaling Adaptor Proteins/*genetics
Cell Aggregation/*physiology
Guanylate Cyclase/*genetics
Apoptosis Regulatory Proteins/metabolism ; CARD Signaling Adaptor Proteins/metabolism ; Guanylate Cyclase/metabolism ; Humans ; I-kappa B Kinase/metabolism ; Jurkat Cells ; Lymphocyte Activation ; Lymphocytes/metabolism ; Lymphocytes/physiology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/metabolism ; NF-kappa B/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Chimeras of P4-ATPase and Guanylate Cyclase in Pathogenic Protists.
Autorzy :
Günay-Esiyok Ö; Department of Molecular Parasitology, Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany. Electronic address: .
Gupta N; Department of Molecular Parasitology, Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany. Electronic address: .
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Źródło :
Trends in parasitology [Trends Parasitol] 2020 Apr; Vol. 36 (4), pp. 382-392. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adenosine Triphosphatases*/genetics
Adenosine Triphosphatases*/metabolism
Guanylate Cyclase*/genetics
Guanylate Cyclase*/metabolism
Parasites*/enzymology
Parasites*/genetics
Protozoan Proteins*/genetics
Protozoan Proteins*/metabolism
Apicomplexa/*enzymology
Apicomplexa/*genetics
Host-Parasite Interactions/*physiology
Animals ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Distinct Pharmacological Properties of Gaseous CO and CO-Releasing Molecule in Human Platelets.
Autorzy :
Kaczara P; Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.
Przyborowski K; Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.
Mohaissen T; Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.; Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Chlopicki S; Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland.; Faculty of Medicine, Chair of Pharmacology, Jagiellonian University Medical College, Grzegorzecka 16, 31-531 Krakow, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 30; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Platelets/*drug effects
Carbon Monoxide/*pharmacology
Platelet Aggregation/*drug effects
Adult ; Animals ; Aorta/drug effects ; Aorta/metabolism ; Blood Platelets/metabolism ; Carbon Monoxide/metabolism ; Gases/metabolism ; Guanylate Cyclase/metabolism ; Healthy Volunteers ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Soluble Guanylyl Cyclase/metabolism ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
[Changes of guanylate cyclase C in colon tissues of rats with intestinal injury associated with severe acute pancreatitis].
Autorzy :
Wang B; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Huang Q; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Li S; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Wu J; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Yuan X; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Sun H; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
Tang L; School of Clinical Medicine, Southwest Jiaotong University, Chengdu 610063, China.; Center of General Surgery//Sichuan Provincial Key Laboratory of Pancreatic Injury and Repair, General Hospital of Western Theater Command, Chengdu 610083, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Mar 25; Vol. 41 (3), pp. 376-383.
Typ publikacji :
Journal Article
MeSH Terms :
Pancreatitis*/complications
Acute Disease ; Animals ; Colon ; Guanylate Cyclase ; Intestinal Mucosa ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to "Locking" Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition.
Autorzy :
Abbas S; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Marino V; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.
Bielefeld L; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Koch KW; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 23; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cone Dystrophy/*metabolism
Guanylate Cyclase/*metabolism
Guanylate Cyclase-Activating Proteins/*chemistry
Guanylate Cyclase-Activating Proteins/*metabolism
Amino Acids, Aromatic/chemistry ; Calcium/metabolism ; Cations/chemistry ; Circular Dichroism ; Cone Dystrophy/genetics ; Dynamic Light Scattering ; Guanylate Cyclase-Activating Proteins/genetics ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Mutation, Missense ; Protein Binding ; Protein Conformation ; Recombinant Proteins ; Thermodynamics
Czasopismo naukowe
Tytuł :
CO 2 /bicarbonate modulates cone photoreceptor ROS-GC1 and restores its CORD6-linked catalytic activity.
Autorzy :
Duda T; Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA, USA.
Pertzev A; Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA, USA.
Sharma RK; Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA, USA. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2018 Nov; Vol. 448 (1-2), pp. 91-105. Date of Electronic Publication: 2018 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Dioxide/*metabolism
Carbonic Anhydrase II/*metabolism
Cone-Rod Dystrophies/*enzymology
Guanylate Cyclase/*metabolism
Receptors, Cell Surface/*metabolism
Retinal Cone Photoreceptor Cells/*enzymology
Retinal Rod Photoreceptor Cells/*enzymology
Animals ; COS Cells ; Carbonic Anhydrase II/genetics ; Catalysis ; Cattle ; Chlorocebus aethiops ; Cone-Rod Dystrophies/genetics ; Cone-Rod Dystrophies/pathology ; Cyclic GMP/genetics ; Cyclic GMP/metabolism ; Guanylate Cyclase/genetics ; Guanylate Cyclase-Activating Proteins/genetics ; Guanylate Cyclase-Activating Proteins/metabolism ; Receptors, Cell Surface/genetics ; Retinal Cone Photoreceptor Cells/pathology ; Retinal Rod Photoreceptor Cells/pathology
Czasopismo naukowe
Tytuł :
C-type natriuretic peptide-induced relaxation through cGMP-dependent protein kinase and SERCA activation is impaired in two kidney-one clip rat aorta.
Autorzy :
Pernomian L; Ribeirão Preto Medical School, University of São Paulo, Department of Pharmacology, Ribeirão Preto, SP, Brazil. Electronic address: .
do Prado AF; Ribeirão Preto Medical School, University of São Paulo, Department of Pharmacology, Ribeirão Preto, SP, Brazil; Laboratory of Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Silva BR; Ribeirão Preto Medical School, University of São Paulo, Department of Pharmacology, Ribeirão Preto, SP, Brazil; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Department of Physics and Chemistry, Ribeirão Preto, SP, Brazil.
de Paula TD; Ribeirão Preto Medical School, University of São Paulo, Department of Pharmacology, Ribeirão Preto, SP, Brazil; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Department of Physics and Chemistry, Ribeirão Preto, SP, Brazil.
Grando MD; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Department of Physics and Chemistry, Ribeirão Preto, SP, Brazil.
Bendhack LM; Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Department of Physics and Chemistry, Ribeirão Preto, SP, Brazil.
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Źródło :
Life sciences [Life Sci] 2021 May 01; Vol. 272, pp. 119223. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Natriuretic Peptide, C-Type/*pharmacology
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*metabolism
Vasodilation/*drug effects
Animals ; Blood Pressure/drug effects ; Cyclic GMP/metabolism ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Endothelial Cells/metabolism ; Endothelium, Vascular/metabolism ; Guanylate Cyclase/metabolism ; Hypertension/physiopathology ; Kidney/metabolism ; Male ; Natriuretic Peptide, C-Type/metabolism ; Natriuretic Peptides/metabolism ; Natriuretic Peptides/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Rats ; Rats, Wistar ; Surgical Instruments ; Vasodilation/physiology
Czasopismo naukowe
Tytuł :
Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System.
Autorzy :
Skiba DS; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.; British Heart Foundation Centre for Excellence, Institute of Cardiovascular and Medical Sciences, University of Glasgow, University Place 126, Glasgow G12 8TA, UK.
Szczepaniak P; Department of Internal and Agricultural Medicine, Translational Medicine Laboratory, Collegium Medicum Jagiellonian University, Skarbowa 1, 31-121 Krakow, Poland.
Siedliński M; Department of Internal and Agricultural Medicine, Translational Medicine Laboratory, Collegium Medicum Jagiellonian University, Skarbowa 1, 31-121 Krakow, Poland.
Poznański P; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.
Łazarczyk M; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.
Jaskuła K; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.
Religa P; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.
Sacharczuk M; Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.; Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Banacha 1B, 02-091 Warsaw, Poland.; Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Banacha 1A, 02-091 Warsaw, Poland.
Gaciong Z; Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Banacha 1A, 02-091 Warsaw, Poland.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 17; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Pressure*
Nociception*
Aorta/*drug effects
Naloxone/*pharmacology
Narcotic Antagonists/*pharmacology
Animals ; Aorta/cytology ; Aorta/metabolism ; Endothelium, Vascular/drug effects ; Female ; Guanylate Cyclase/metabolism ; Male ; Mice ; Myocytes, Smooth Muscle/drug effects ; Vasodilation
Czasopismo naukowe

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