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Wyświetlanie 21-40 z 8198
Tytuł:
Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A.
Autorzy:
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134, Verona, Italy. .
Dal Cortivo G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134, Verona, Italy.
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 20105. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Signal Transduction*
Cyclic GMP/*metabolism
Guanylate Cyclase-Activating Proteins/*genetics
Retinal Dystrophies/*etiology
Retinal Dystrophies/*metabolism
Algorithms ; Animals ; Calcium/metabolism ; Guanylate Cyclase/metabolism ; Humans ; Light Signal Transduction ; Mice ; Models, Theoretical ; Receptors, Cell Surface/metabolism ; Retinal Dystrophies/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.
Autorzy:
Nelissen E; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. .
Possemis N; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Van Goethem NP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Schepers M; Neuro-Immune Connect and Repair Lab, Biomedical Research Institute, Hasselt University, 3500, Hasselt, Belgium.
Mulder-Jongen DAJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Dietz L; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, 42113, Wuppertal, Germany.
Janssen W; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, 42113, Wuppertal, Germany.
Gerisch M; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, 42113, Wuppertal, Germany.
Hüser J; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, 42113, Wuppertal, Germany.
Sandner P; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, 42113, Wuppertal, Germany.; Hannover Medical School, 30625, Hannover, Germany.
Vanmierlo T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.; Neuro-Immune Connect and Repair Lab, Biomedical Research Institute, Hasselt University, 3500, Hasselt, Belgium.
Prickaerts J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 04; Vol. 12 (1), pp. 3589. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclic GMP*/metabolism
Guanylate Cyclase*/metabolism
Animals ; Male ; Mice ; Rats ; Heme/metabolism ; Hippocampus/metabolism ; Neuronal Plasticity ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/metabolism ; Rats, Wistar ; Soluble Guanylyl Cyclase/metabolism ; Vasodilator Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.
Autorzy:
Hildebrand S; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. .
Ibrahim M; Quantitative Systems Biology, LIMES-Institute (Life and Medical Sciences Bonn), University of Bonn, Bonn, Germany.
Schlitzer A; Quantitative Systems Biology, LIMES-Institute (Life and Medical Sciences Bonn), University of Bonn, Bonn, Germany.
Maegdefessel L; Experimental Vascular Surgery and Medicine, Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar - Technical University Munich, Munich, Germany.; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Röll W; Department of Cardiac Surgery, University of Bonn, Bonn, Germany.
Pfeifer A; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. .
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Źródło:
Communications biology [Commun Biol] 2022 Mar 03; Vol. 5 (1), pp. 197. Date of Electronic Publication: 2022 Mar 03.
Typ publikacji:
Journal Article
MeSH Terms:
Guanylate Cyclase*/metabolism
Muscle, Smooth, Vascular*/metabolism
Cyclic GMP/metabolism ; Humans ; Platelet-Derived Growth Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis.
Autorzy:
Aue, Annemarie (AUTHOR)
Englert, Nils (AUTHOR)
Harrer, Leon (AUTHOR)
Schwiering, Fabian (AUTHOR)
Gaab, Annika (AUTHOR)
König, Peter (AUTHOR)
Adams, Ralf (AUTHOR)
Schmidtko, Achim (AUTHOR)
Friebe, Andreas (AUTHOR)
Groneberg, Dieter (AUTHOR)
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Źródło:
Respiratory Research. 6/22/2023, Vol. 24 Issue 1, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3.
Autorzy:
Menges, Lukas (AUTHOR)
Giesen, Jan (AUTHOR)
Yilmaz, Kerem (AUTHOR)
Mergia, Evanthia (AUTHOR)
Füchtbauer, Annette (AUTHOR)
Füchtbauer, Ernst-Martin (AUTHOR)
Koesling, Doris (AUTHOR)
Russwurm, Michael (AUTHOR)
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Źródło:
Communications Biology. 5/10/2023, Vol. 6 Issue 1, p1-12. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural Insights into Retinal Guanylate Cyclase Activator Proteins (GCAPs).
Autorzy:
Ames JB; Department of Chemistry, University of California, Davis, CA 95616, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 13; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Calcium/*metabolism
Guanylate Cyclase-Activating Proteins/*chemistry
Iron/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*chemistry
Animals ; Guanylate Cyclase-Activating Proteins/metabolism ; Hydrophobic and Hydrophilic Interactions ; Light Signal Transduction ; Models, Molecular ; Protein Conformation ; Protein Multimerization ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In Vitro Characterization of Guanylyl Cyclase BdPepR2 from Brachypodium distachyon Identified through a Motif-Based Approach.
Autorzy:
Duszyn M; Chair of Plant Physiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Lwowska St. 1, PL 87-100 Torun, Poland.
Świeżawska-Boniecka B; Chair of Plant Physiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Lwowska St. 1, PL 87-100 Torun, Poland.
Wong A; Department of Biology, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou 325060, China.; Zhejiang Bioinformatics International Science and Technology Cooperation Center, Wenzhou-Kean University, Ouhai, Wenzhou 325060, China.
Jaworski K; Chair of Plant Physiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Lwowska St. 1, PL 87-100 Torun, Poland.
Szmidt-Jaworska A; Chair of Plant Physiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Lwowska St. 1, PL 87-100 Torun, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 10; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Brachypodium/*enzymology
Cyclic GMP/*metabolism
Guanylate Cyclase/*metabolism
Plant Proteins/*metabolism
Amino Acid Motifs ; Amino Acid Sequence ; Catalytic Domain ; Guanylate Cyclase/chemistry ; Guanylate Cyclase/genetics ; In Vitro Techniques ; Mutagenesis, Site-Directed ; Phosphorylation ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Protein Binding ; Protein Conformation ; Sequence Homology ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis.
Autorzy:
Trai NN; Department of Dermatology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Van Em D; Department of Dermatology, Institute of Clinical Research and Medicine, Hanoi, Vietnam.
Van BT; Department of Dermatology, Institute of Clinical Research and Medicine, Hanoi, Vietnam.
My LH; Department of Dermatology, Hanoi Central Institute of Dermatology, Dong Da, Hanoi, Vietnam.
Van Tro C; Department of Dermatology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Hao NT; Department of Dermatology, Ho Chi Minh City Hospital of Dermato Venereology, Ho Chi Minh City, Vietnam.
Vu HA; Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Tram DB; Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Van Thuong N; Department of Dermatology, Hanoi Central Institute of Dermatology, Dong Da, Hanoi, Vietnam.
Doanh LH; Department of Dermatology, Hanoi Central Institute of Dermatology, Dong Da, Hanoi, Vietnam.
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Źródło:
Indian journal of dermatology, venereology and leprology [Indian J Dermatol Venereol Leprol] 2023 May-Jun; Vol. 89 (3), pp. 378-384.
Typ publikacji:
Journal Article
MeSH Terms:
Glossitis, Benign Migratory*
Hypoalbuminemia*
Psoriasis*/diagnosis
Psoriasis*/genetics
Psoriasis*/drug therapy
Humans ; Interleukins/genetics ; Cross-Sectional Studies ; Leukocytosis ; Mutation/genetics ; Chronic Disease ; Guanylate Cyclase/genetics ; Membrane Proteins/genetics ; CARD Signaling Adaptor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.
Autorzy:
Reiberger, Thomas (AUTHOR)
Berzigotti, Annalisa (AUTHOR)
Trebicka, Jonel (AUTHOR)
Ertle, Judith (AUTHOR)
Gashaw, Isabella (AUTHOR)
Swallow, Ros (AUTHOR)
Tomisser, Andrea (AUTHOR)
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Źródło:
Trials. 4/24/2023, Vol. 24 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1–mediated heat shock response.
Autorzy:
Miles, Jay (AUTHOR)
Townend, Sarah (AUTHOR)
Milonaitytė, Dovilė (AUTHOR)
Smith, William (AUTHOR)
Hodge, Francesca (AUTHOR)
Westhead, David R. (AUTHOR)
van Oosten-Hawle, Patricija (AUTHOR)
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Źródło:
PLoS Biology. 2/13/2023, Vol. 21 Issue 2, p1-26. 26p. 1 Diagram, 5 Graphs.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Influence of Guanine-Based Purines on the Oxidoreductive Reactions Involved in Normal or Altered Brain Functions.
Autorzy:
Zuccarini, Mariachiara (AUTHOR)
Pruccoli, Letizia (AUTHOR)
Balducci, Martina (AUTHOR)
Giuliani, Patricia (AUTHOR)
Caciagli, Francesco (AUTHOR)
Ciccarelli, Renata (AUTHOR)
Di Iorio, Patrizia (AUTHOR)
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Źródło:
Journal of Clinical Medicine. Feb2023, Vol. 12 Issue 3, p1172. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to "Locking" Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition.
Autorzy:
Abbas S; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Marino V; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.
Bielefeld L; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Koch KW; Department of Neuroscience, Division of Biochemistry, University of Oldenburg, 26111 Oldenburg, Germany.
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 23; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cone Dystrophy/*metabolism
Guanylate Cyclase/*metabolism
Guanylate Cyclase-Activating Proteins/*chemistry
Guanylate Cyclase-Activating Proteins/*metabolism
Amino Acids, Aromatic/chemistry ; Calcium/metabolism ; Cations/chemistry ; Circular Dichroism ; Cone Dystrophy/genetics ; Dynamic Light Scattering ; Guanylate Cyclase-Activating Proteins/genetics ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Mutation, Missense ; Protein Binding ; Protein Conformation ; Recombinant Proteins ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors.
Autorzy:
Turunen T; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00076, Aalto, Finland.
Koskelainen A; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00076, Aalto, Finland. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 26; Vol. 11 (1), pp. 8938. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Signaling*
Calcium/*metabolism
Cyclic GMP/*metabolism
Cyclic Nucleotide Phosphodiesterases, Type 6/*metabolism
Guanylate Cyclase-Activating Proteins/*metabolism
Retinal Rod Photoreceptor Cells/*enzymology
Animals ; Cyclic GMP/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 6/genetics ; Female ; Guanylate Cyclase-Activating Proteins/genetics ; Male ; Mice ; Mice, Knockout ; Retinal Rod Photoreceptor Cells/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists.
Autorzy:
Frees A; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Assersen KB; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Jensen M; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Hansen PBL; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Vanhoutte PM; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Madsen K; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Pathology, Odense University Hospital, Odense, Denmark.
Federlein A; Institute of Physiology, University of Regensburg, Regensburg, Germany.
Lund L; Department of Urology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Toft A; Department of Urology, Odense University Hospital, Odense, Denmark.
Jensen BL; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Mar; Vol. 231 (3), pp. e13565. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*
Guanylate Cyclase*
Animals ; Arteries ; Cyclic GMP ; Humans ; Mice ; Natriuretic Peptides/pharmacology ; Soluble Guanylyl Cyclase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 21-40 z 8198

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