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Tytuł :
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Autorzy :
Petrov PD; Experimental Hepatology Unit, Health Research Institute Hospital La Fe, Av. Fernando Abril Martorell, 106, Tower A, 46026, Valencia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
García-Mediavilla MV; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
Guzmán C; Experimental Hepatology Unit, Health Research Institute Hospital La Fe, Av. Fernando Abril Martorell, 106, Tower A, 46026, Valencia, Spain.
Porras D; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.
Nistal E; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.; Department of Gastroenterology, Complejo Asistencial Universitario de León (CAULE), Altos de Nava s/n, 24071, León, Spain.
Martínez-Flórez S; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.
Castell JV; Experimental Hepatology Unit, Health Research Institute Hospital La Fe, Av. Fernando Abril Martorell, 106, Tower A, 46026, Valencia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.; Department Biochemistry and Molecular Biology, University of Valencia, C/ Doctor Moliner 50, 46100, Burjassot, València, Spain.
González-Gallego J; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
Sánchez-Campos S; Institute of Biomedicine (IBIOMED), University of León, Campus Universitario, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
Jover R; Experimental Hepatology Unit, Health Research Institute Hospital La Fe, Av. Fernando Abril Martorell, 106, Tower A, 46026, Valencia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.; Department Biochemistry and Molecular Biology, University of Valencia, C/ Doctor Moliner 50, 46100, Burjassot, València, Spain.
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Źródło :
Molecular nutrition & food research [Mol Nutr Food Res] 2019 Oct; Vol. 63 (20), pp. e1900487. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Bile Acids and Salts/*blood
Liver/*metabolism
Non-alcoholic Fatty Liver Disease/*prevention & control
Animals ; Diet, High-Fat ; Ethanol/blood ; Male ; Mice ; Mice, Inbred C57BL ; Transcriptome
Czasopismo naukowe
Tytuł :
Beneficial effects of exercise on gut microbiota functionality and barrier integrity, and gut-liver crosstalk in an in vivo model of early obesity and non-alcoholic fatty liver disease.
Autorzy :
Carbajo-Pescador S; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.
Porras D; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.
García-Mediavilla MV; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Spain.
Martínez-Flórez S; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.
Juarez-Fernández M; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.
Cuevas MJ; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.
Mauriz JL; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Spain.
González-Gallego J; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Spain.
Nistal E; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain.; Servicio de Aparato Digestivo del Complejo Asistencial Universitario de León, 24071, León, Spain.
Sánchez-Campos S; Instituto de Biomedicina (IBIOMED), Universidad de León, 24071, León, Spain .; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Spain.
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Źródło :
Disease models & mechanisms [Dis Model Mech] 2019 Apr 30; Vol. 12 (5). Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Physical Conditioning, Animal*
Intestines/*pathology
Liver/*pathology
Non-alcoholic Fatty Liver Disease/*microbiology
Obesity/*microbiology
Animals ; Bile Acids and Salts/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Enterohepatic Circulation ; Fatty Acids/biosynthesis ; Feces ; Inflammation/pathology ; Lipid Metabolism ; Liver/injuries ; Male ; Metabolic Syndrome/complications ; Metabolome ; Oxidative Stress ; Principal Component Analysis ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Previous physical exercise alters the hepatic profile of oxidative-inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats.
Autorzy :
de Castro MRT; Programa de Pós-graduação em Educação Física.; Centro de Educação Física e Desportos, Laboratório de Bioquímica do Exercício.
Ferreira APO; Programa de Pós-Graduação em Farmacologia.
Busanello GL; Programa de Pós-graduação em Educação Física.; Centro de Educação Física e Desportos, Laboratório de Bioquímica do Exercício.
da Silva LRH; Programa de Pós-graduação em Educação Física.
da Silveira Junior MEP; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Fiorin FDS; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Arrifano G; Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
Crespo-López ME; Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, Brazil.
Barcelos RP; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Cuevas MJ; Institute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of León, León, Spain.
Bresciani G; Escuela de Educación Física, Pontificia Universidad Católica de Valparaiso (PUCV), Valparaiso, Chile.
González-Gallego J; Institute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of León, León, Spain.
Fighera MR; Programa de Pós-graduação em Educação Física.; Centro de Educação Física e Desportos, Laboratório de Bioquímica do Exercício.; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Royes LFF; Programa de Pós-graduação em Educação Física.; Centro de Educação Física e Desportos, Laboratório de Bioquímica do Exercício.; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil.
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Źródło :
The Journal of physiology [J Physiol] 2017 Sep 01; Vol. 595 (17), pp. 6023-6044. Date of Electronic Publication: 2017 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Injuries, Traumatic*/blood
Brain Injuries, Traumatic*/metabolism
Brain Injuries, Traumatic*/pathology
Brain Injuries, Traumatic*/physiopathology
Physical Conditioning, Animal*
Liver/*metabolism
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Blood Glucose/analysis ; Blood-Brain Barrier/metabolism ; Catalase/metabolism ; Citrate (si)-Synthase/metabolism ; Cyclooxygenase 2/genetics ; Cytokines/blood ; Cytokines/genetics ; Cytokines/metabolism ; Insulin Resistance ; Liver/pathology ; Male ; Membrane Potential, Mitochondrial ; Nitric Oxide Synthase Type II/genetics ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Sodium-Potassium-Exchanging ATPase ; Spatial Learning ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise.
Autorzy :
Pillon Barcelos R; a Instituto de Ciências Biológicas , Universidade de Passo Fundo , Passo Fundo , Brazil.; b Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica (PPGBTOx) , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Brazil.
Freire Royes LF; b Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica (PPGBTOx) , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Brazil.; c Laboratório de Bioquímica do Exercício, Centro de Educação Física e Desportos , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Brazil.
Gonzalez-Gallego J; d Institute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) , University of León , León , Spain.
Bresciani G; e Grupo de Investigación en Rendimiento Físico y Salud (IRyS), Escuela de Educación Física , Pontificia Universidad Católica de Valparaiso , Valparaiso , Chile.
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Źródło :
Free radical research [Free Radic Res] 2017 Feb; Vol. 51 (2), pp. 222-236. Date of Electronic Publication: 2017 Feb 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adaptation, Physiological*
Oxidative Stress*
Exercise/*physiology
Inflammation/*physiopathology
Liver/*physiology
Humans
Czasopismo naukowe
Tytuł :
Diclofenac pretreatment effects on the toll-like receptor 4/nuclear factor kappa B-mediated inflammatory response to eccentric exercise in rat liver.
Autorzy :
Barcelos RP; Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil; Institute of Biomedicine (IBIOMED) and CIBERehd, University of León, Campus Universitario, 24071 León, Spain. Electronic address: .
Bresciani G; Instituto de Actividad Física y Salud, Universidad Autónoma de Chile, Chile.
Rodriguez-Miguelez P; Division of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, USA.
Cuevas MJ; Institute of Biomedicine (IBIOMED) and CIBERehd, University of León, Campus Universitario, 24071 León, Spain.
Soares FA; Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
Barbosa NV; Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
González-Gallego J; Institute of Biomedicine (IBIOMED) and CIBERehd, University of León, Campus Universitario, 24071 León, Spain.
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Źródło :
Life sciences [Life Sci] 2016 Mar 01; Vol. 148, pp. 247-53. Date of Electronic Publication: 2016 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diclofenac/*administration & dosage
Inflammation Mediators/*metabolism
Liver/*metabolism
NF-kappa B/*metabolism
Physical Conditioning, Animal/*physiology
Toll-Like Receptor 4/*metabolism
Animals ; Inflammation Mediators/antagonists & inhibitors ; Liver/drug effects ; Male ; NF-kappa B/antagonists & inhibitors ; Rats ; Rats, Wistar ; Toll-Like Receptor 4/antagonists & inhibitors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Creatine and the Liver: Metabolism and Possible Interactions.
Autorzy :
Barcelos RP
Stefanello ST
Mauriz JL
Gonzalez-Gallego J
Soares FA; Departamento de Bioquimica e Biologia Molecular, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. .
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Źródło :
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2016; Vol. 16 (1), pp. 12-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Creatine/*metabolism
Liver/*metabolism
Humans ; Kidney/metabolism ; Liver/injuries ; Performance-Enhancing Substances
Czasopismo naukowe
Tytuł :
Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis.
Autorzy :
San-Miguel B; Institute of Biomedicine (IBIOMED), University of León, León, Spain.
Crespo I; Institute of Biomedicine (IBIOMED), University of León, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain.
Sánchez DI; Institute of Biomedicine (IBIOMED), University of León, León, Spain.
González-Fernández B; Institute of Biomedicine (IBIOMED), University of León, León, Spain.
Ortiz de Urbina JJ; Institute of Biomedicine (IBIOMED), University of León, León, Spain.
Tuñón MJ; Institute of Biomedicine (IBIOMED), University of León, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain.
González-Gallego J; Institute of Biomedicine (IBIOMED), University of León, León, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain.
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Źródło :
Journal of pineal research [J Pineal Res] 2015 Sep; Vol. 59 (2), pp. 151-62. Date of Electronic Publication: 2015 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*drug effects
Carbon Tetrachloride Poisoning/*prevention & control
Endoplasmic Reticulum Stress/*drug effects
Gene Expression Regulation/*drug effects
Liver/*metabolism
Liver Cirrhosis/*prevention & control
Animals ; Carbon Tetrachloride Poisoning/metabolism ; Carbon Tetrachloride Poisoning/pathology ; Liver/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Melatonin ; Mice
Czasopismo naukowe
Tytuł :
Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failure.
Autorzy :
Vallejo D
Crespo I
San-Miguel B
Alvarez M
Prieto J
Tuñón MJ; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain. .
González-Gallego J
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Źródło :
Veterinary research [Vet Res] 2014 Feb 04; Vol. 45, pp. 15. Date of Electronic Publication: 2014 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Liver/*physiopathology
Liver Failure, Acute/*physiopathology
Animals ; Apoptosis ; Blotting, Western ; Caliciviridae Infections/physiopathology ; Caliciviridae Infections/virology ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Caspase 3/metabolism ; Disease Models, Animal ; Endoplasmic Reticulum/physiology ; Endoplasmic Reticulum/virology ; Hemorrhagic Disease Virus, Rabbit/physiology ; Humans ; Liver/ultrastructure ; Liver/virology ; Liver Failure, Acute/virology ; Male ; Microscopy, Electron, Transmission ; Rabbits ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction
Czasopismo naukowe
Tytuł :
Evaluation of the potential protective effects of ad libitum black grape juice against liver oxidative damage in whole-body acute X-irradiated rats.
Autorzy :
Andrade ER; Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS, Brazil.
Cruz IB
Andrade VV
Piccoli JC
González-Gallego J
Barrio JP
González P
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2011 Apr; Vol. 49 (4), pp. 1026-32. Date of Electronic Publication: 2011 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Beverages*
Oxidative Stress*
Vitis*
Whole-Body Irradiation*
Liver/*diagnostic imaging
Animals ; Blotting, Western ; DNA Fragmentation ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Male ; Placebos ; Radiography ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism ; X-Rays
Czasopismo naukowe
Tytuł :
Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.
Autorzy :
Tuñón MJ; Institute of Biomedicine, University of León, León, Spain.
San Miguel B
Crespo I
Jorquera F
Santamaría E
Alvarez M
Prieto J
González-Gallego J
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Źródło :
Journal of pineal research [J Pineal Res] 2011 Jan; Vol. 50 (1), pp. 38-45. Date of Electronic Publication: 2010 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Hemorrhagic Disease Virus, Rabbit/*pathogenicity
Liver/*drug effects
Liver/*pathology
Liver Failure, Acute/*drug therapy
Liver Failure, Acute/*virology
Melatonin/*pharmacology
Melatonin/*therapeutic use
Animals ; Blotting, Western ; Caspases/metabolism ; Immunohistochemistry ; Liver/metabolism ; Liver/virology ; Liver Failure, Acute/metabolism ; Male ; Oxidative Stress/drug effects ; Rabbits
Czasopismo naukowe
Tytuł :
S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats.
Autorzy :
Vercelino R; Laboratory of Experimental Hepatology and Physiology, Porto Alegre Clinical Hospital, Federal University of Rio Grande do Sul, UFRGS, 90035-903, Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil.
Crespo I
de Souza GF
Cuevas MJ
de Oliveira MG
Marroni NP
González-Gallego J
Tuñón MJ
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Źródło :
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2010 Apr; Vol. 88 (4), pp. 401-11. Date of Electronic Publication: 2010 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcysteine/*analogs & derivatives
Fibrosis/*pathology
Liver/*metabolism
Liver Cirrhosis/*metabolism
Acetylcysteine/metabolism ; Animals ; Antioxidants/metabolism ; Immunohistochemistry/methods ; Lipid Peroxidation ; Liver Cirrhosis/therapy ; MAP Kinase Signaling System ; Male ; Nitric Oxide/chemistry ; Oxidative Stress ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Signaling pathways involved in liver injury and regeneration in rabbit hemorrhagic disease, an animal model of virally-induced fulminant hepatic failure.
Autorzy :
García-Lastra R; Department of Animal Health, University of León, León, Spain.
San-Miguel B
Crespo I
Jorquera F
Alvarez M
González-Gallego J
Tuñón MJ
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Źródło :
Veterinary research [Vet Res] 2010 Jan-Feb; Vol. 41 (1), pp. 2. Date of Electronic Publication: 2009 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemorrhagic Disease Virus, Rabbit*
Liver Regeneration*
Caliciviridae Infections/*veterinary
Liver/*metabolism
Liver Failure, Acute/*veterinary
Signal Transduction/*physiology
Animals ; Apoptosis ; Caliciviridae Infections/metabolism ; Cytokines/metabolism ; Gene Expression Regulation/physiology ; Liver/cytology ; Liver Failure, Acute/metabolism ; Liver Failure, Acute/virology ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Rabbits ; STAT Transcription Factors/metabolism ; Suppressor of Cytokine Signaling Proteins/metabolism
Czasopismo naukowe
Tytuł :
Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells.
Autorzy :
Crespo I; Ciberehd and Institute of Biomedicine, University of León, León, Spain.
García-Mediavilla MV
Almar M
González P
Tuñón MJ
Sánchez-Campos S
González-Gallego J
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2008 May; Vol. 46 (5), pp. 1555-69. Date of Electronic Publication: 2007 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*metabolism
Cytokines/*pharmacology
Flavonoids/*pharmacology
Inflammation/*metabolism
Liver/*enzymology
Reactive Nitrogen Species/*metabolism
Reactive Oxygen Species/*metabolism
Apigenin/pharmacology ; Blotting, Western ; Cell Survival/drug effects ; Flavonols/pharmacology ; Glutathione/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Humans ; Kaempferols/pharmacology ; Liver/cytology ; Liver/drug effects ; Oxidation-Reduction ; Quercetin/analogs & derivatives ; Quercetin/pharmacology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Superoxide Dismutase/biosynthesis ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Tetrazolium Salts ; Thiazoles
Czasopismo naukowe
Tytuł :
Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis.
Autorzy :
Molpeceres V; Ciberehd and Institute of Biomedicine, Department of Biomedical Sciences, University of León, 24071-León, Spain.
Mauriz JL
García-Mediavilla MV
González P
Barrio JP
González-Gallego J
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Źródło :
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2007 Jul; Vol. 62 (7), pp. 687-95.
Typ publikacji :
Journal Article
MeSH Terms :
Aging/*pathology
Apoptosis/*drug effects
Liver/*ultrastructure
Melatonin/*pharmacology
Animals ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cytochromes c/metabolism ; Glutathione/metabolism ; Male ; Melatonin/administration & dosage ; Oxidation-Reduction ; Rats ; Rats, Wistar ; Reactive Oxygen Species/pharmacology ; Signal Transduction/drug effects ; Thiobarbiturates/pharmacology
Czasopismo naukowe
Tytuł :
Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats.
Autorzy :
Mauriz JL; Institute of Biomedicine, University of León, León, Spain.
Molpeceres V
García-Mediavilla MV
González P
Barrio JP
González-Gallego J
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Źródło :
Journal of pineal research [J Pineal Res] 2007 Apr; Vol. 42 (3), pp. 222-30.
Typ publikacji :
Journal Article
MeSH Terms :
Aging/*metabolism
Antioxidants/*metabolism
Liver/*enzymology
Melatonin/*pharmacology
Oxidative Stress/*drug effects
Aging/drug effects ; Animals ; Gene Expression ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure.
Autorzy :
San-Miguel B; Department of Physiology, University of León, 24071, León, Spain.
Alvarez M
Culebras JM
González-Gallego J
Tuñón MJ
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2006 Nov; Vol. 11 (11), pp. 1945-57.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Acetylcysteine/*pharmacology
Antioxidants/*pharmacology
Hepatocytes/*pathology
Liver/*pathology
Liver Failure, Acute/*metabolism
Oxidative Stress/*drug effects
Acetylcysteine/metabolism ; Animals ; Animals, Inbred Strains ; Antioxidants/metabolism ; Caliciviridae Infections/metabolism ; Caliciviridae Infections/pathology ; Disease Models, Animal ; Hemorrhagic Disease Virus, Rabbit/physiology ; Hepatocytes/virology ; Liver/metabolism ; Liver/virology ; Liver Failure, Acute/pathology ; Rabbits
Czasopismo naukowe
Tytuł :
S-adenosylmethionine protects against intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat.
Autorzy :
Palomero J; Department of Physiology and Pharmacology, University of Salamanca, 37071 Salamanca, Spain.
Galán AI
Muñoz ME
González-Gallego J
Tuñón MJ
Jiménez R
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Źródło :
Toxicology [Toxicology] 2004 Sep 01; Vol. 201 (1-3), pp. 239-45.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclosporine/*antagonists & inhibitors
Glutathione/*metabolism
Immunosuppressive Agents/*antagonists & inhibitors
Liver/*drug effects
S-Adenosylmethionine/*therapeutic use
Animals ; Cyclosporine/adverse effects ; Immunosuppressive Agents/adverse effects ; Liver/enzymology ; Liver/metabolism ; Male ; Rats ; Rats, Wistar ; gamma-Glutamyltransferase/metabolism
Czasopismo naukowe
Tytuł :
Effects of S-adenosylmethionine on intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat.
Autorzy :
Palomero J; Department of Physiology and Pharmacology, University of Salamanca, 37071 Salamanca, Spain.
Galán AI
Muñoz ME
González-Gallego J
Tuñón MJ
Jiménez R
Pokaż więcej
Źródło :
Toxicology [Toxicology] 2004 Jul 15; Vol. 200 (1), pp. 21-7.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclosporine/*antagonists & inhibitors
Immunosuppressive Agents/*antagonists & inhibitors
Liver/*drug effects
S-Adenosylmethionine/*pharmacology
Animals ; Bile/drug effects ; Bile/metabolism ; Cyclosporine/pharmacology ; Glutathione/metabolism ; Immunosuppressive Agents/pharmacology ; Liver/metabolism ; Male ; Rats ; Rats, Wistar ; Thiobarbituric Acid Reactive Substances/metabolism
Czasopismo naukowe
Tytuł :
[Effects of glutamine on antioxidants systems and hepatic detoxification in rats: influence of formulation].
Autorzy :
Ortiz de Urbina JJ; Servicio de Farmacia, Hospital de León. />Jorquera F
Culebras J
Villares C
González-Gallego J
Tuñón MJ
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Transliterated Title :
Influencia de la formulación de la glutamina en sus efectos sobre los sistemas antioxidantes y de destoxificación hepática en la rata.
Źródło :
Nutricion hospitalaria [Nutr Hosp] 2004 Mar-Apr; Vol. 19 (2), pp. 73-82.
Typ publikacji :
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Parenteral Nutrition*
Antioxidants/*physiology
Cytochrome P-450 Enzyme System/*drug effects
Cytochrome P-450 Enzyme System/*physiology
Glutamine/*pharmacology
Liver/*drug effects
Liver/*metabolism
Oxidative Stress/*drug effects
Animals ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe

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