Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.
Autorzy:
Tsebriy O; Independent researcher, Ternopil, Ukraine. Khomiak A; Independent researcher, Ternopil, Ukraine. Miguel-Blanco C; Global Health Medicines R&D., GlaxoSmithKline, Madrid, Spain. Sparkes PC; Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. Gioli M; SOAS University of London, London, United Kingdom. Santelli M; Independent researcher, Ternopil, Ukraine. Whitley E; Department of Management, London School of Economics and Political Science, London, United Kingdom. GamoFJ; Global Health Medicines R&D., GlaxoSmithKline, Madrid, Spain. Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
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PLoS pathogens [PLoS Pathog] 2023 Oct 06; Vol. 19 (10), pp. e1011711. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
Autorzy:
Walz A; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4001 Basel, Switzerland. Duffey M; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Aljayyoussi G; Medicines for Malaria Venture, 1215 Geneva, Switzerland.; Liverpool School of Tropical Medicine, Centre for Drugs and Diagnostics, Liverpool L3 5QA, UK. Sax S; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4001 Basel, Switzerland. Leroy D; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Besson D; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Burrows JN; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Cherkaoui-Rbati MH; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Gobeau N; Medicines for Malaria Venture, 1215 Geneva, Switzerland. Westwood MA; Swiss BioQuant, 4153 Reinach, Switzerland. Siethoff C; Swiss BioQuant, 4153 Reinach, Switzerland. GamoFJ; Global Health Medicines, GlaxoSmithKline I+D, 28760 Madrid, Spain. Mäser P; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4001 Basel, Switzerland. Wittlin S; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4001 Basel, Switzerland.
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957.
Autorzy:
Miguel-Blanco C; Global Health, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Murithi JM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA. Benavente ED; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Angrisano F; Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK. Sala KA; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK. van Schalkwyk DA; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Vanaerschot M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA. Schwach F; Parasites and Microbes Programme, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK. Fuchter MJ; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, Wood Lane, London, W12 OBZ, UK. Billker O; Parasites and Microbes Programme, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, 901 87, Umeå, Sweden. Sutherland CJ; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Campino SG; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Clark TG; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Blagborough AM; Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK.; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK. Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA. Herreros E; Global Health, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.; Medicines for Malaria Venture, 20 Route de Pré-Bois, 1215, Geneva 15, Switzerland. GamoFJ; Global Health, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Baum J; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK. Delves MJ; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. .
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Scientific reports [Sci Rep] 2021 Jan 21; Vol. 11 (1), pp. 1888. Date of Electronic Publication: 2021 Jan 21.
A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.
Autorzy:
Peric M; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Center for Translational and Clinical Research, Department for Intercellular Communication, University of Zagreb School of Medicine, Zagreb, Croatia. Pešić D; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Alihodžić S; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Fajdetić A; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Herreros E; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain.; Medicines for Malaria Venture, Geneva 15, Switzerland. GamoFJ; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain. Angulo-Barturen I; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain.; The Art of Discovery, Bizkaia, Basque Country, Spain. Jiménez-Díaz MB; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain.; The Art of Discovery, Bizkaia, Basque Country, Spain. Ferrer-Bazaga S; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain. Martínez MS; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain. Gargallo-Viola D; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain.; ABAC Therapeutics, Barcelona, Spain. Mathis A; GlaxoSmithKline, Research Triangle Park, North Carolina, USA.; BioCryst Pharmaceuticals, Durham, North Carolina, USA. Kessler A; GlaxoSmithKline, Tres Cantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos (Madrid), Spain. Banjanac M; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Padovan J; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Bencetić Mihaljević V; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Munic Kos V; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Bukvić M; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Eraković Haber V; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Fidelta Ltd., Zagreb, Croatia. Spaventi R; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia.; Triadelta Partners Ltd, Zagreb, Croatia.
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British journal of pharmacology [Br J Pharmacol] 2021 Jan; Vol. 178 (2), pp. 363-377. Date of Electronic Publication: 2020 Dec 16.
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.
Autorzy:
Clark RD; Simulations Plus, Inc., 42505 10th Street West, Lancaster, CA, 93534-7059, USA. . Morris DN; Cognigen Corporation, a Simulations Plus Company, Buffalo, NY, USA. Chinigo G; Kalexsyn, Inc., Kalamazoo, MI, USA.; Pfizer Inc., Groton, CT, USA. Lawless MS; Simulations Plus, Inc., 42505 10th Street West, Lancaster, CA, 93534-7059, USA. Prudhomme J; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA. Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA. Lafuente MJ; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain. Ferrer S; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain. GamoFJ; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain. Gadwood R; Kalexsyn, Inc., Kalamazoo, MI, USA. Woltosz WS; Simulations Plus, Inc., 42505 10th Street West, Lancaster, CA, 93534-7059, USA.
Validation of the protein kinase Pf CLK3 as a multistage cross-species malarial drug target.
Autorzy:
Alam MM; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Sanchez-Azqueta A; Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK. Janha O; Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK. Flannery EL; Novartis Institute for Biomedical Research, Emeryville, CA 94608, USA. Mahindra A; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Mapesa K; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Char AB; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow G12 8QQ, UK. Sriranganadane D; Structural Genomics Consortium, Universidade Estadual de Campinas, Campinas, São Paulo 13083-886, Brazil. Brancucci NMB; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland. Antonova-Koch Y; Skaggs School of Pharmaceutical Sciences, UC Health Sciences Center for Immunology, Infection and Inflammation, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA. Crouch K; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Simwela NV; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Millar SB; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Akinwale J; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK. Mitcheson D; Department of Molecular Cell Biology, University of Leicester, Leicester LE1 9HN, UK. Solyakov L; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK. Dudek K; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK. Jones C; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK. Zapatero C; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Doerig C; Biomedical Science Cluster, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia. Nwakanma DC; MRC Unit the Gambia, Fajara, Banjul, The Gambia. Vázquez MJ; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Colmenarejo G; Biostatistics and Bioinformatics Unit, IMDEA Food Institute, 28049 Madrid, Spain. Lafuente-Monasterio MJ; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Leon ML; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Godoi PHC; Structural Genomics Consortium, Universidade Estadual de Campinas, Campinas, São Paulo 13083-886, Brazil. Elkins JM; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK. Waters AP; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Jamieson AG; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Álvaro EF; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Ranford-Cartwright LC; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow G12 8QQ, UK. Marti M; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK. Winzeler EA; Skaggs School of Pharmaceutical Sciences, UC Health Sciences Center for Immunology, Infection and Inflammation, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA. GamoFJ; Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. Tobin AB; Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK. .
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Autorzy:
Antonova-Koch Y; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Meister S; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Abraham M; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Luth MR; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Ottilie S; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Lukens AK; Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.; The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Sakata-Kato T; The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Vanaerschot M; Division of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Owen E; Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA. Jado JC; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Maher SP; Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.; Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA. Calla J; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Plouffe D; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Zhong Y; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Chen K; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Chaumeau V; Shoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Conway AJ; Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.; Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA. McNamara CW; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Ibanez M; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Gagaring K; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Serrano FN; Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Eribez K; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Taggard CM; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Cheung AL; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Lincoln C; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Ambachew B; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. Rouillier M; Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland. Siegel D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA. Nosten F; Shoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Kyle DE; Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.; Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA. GamoFJ; Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland. Zhou Y; The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Llinás M; Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry and Center for Infectious Diseases Dynamics, Pennsylvania State University, University Park, PA 16802, USA. Fidock DA; Division of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Wirth DF; Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.; The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Burrows J; Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland. Campo B; Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland. Winzeler EA; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. .; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA.
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Autorzy:
Cowell AN; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Istvan ES; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Lukens AK; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.; Infectious Disease Program, The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Gomez-Lorenzo MG; Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Vanaerschot M; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Sakata-Kato T; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. Flannery EL; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Magistrado P; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. Owen E; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA. Abraham M; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. LaMonte G; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Painter HJ; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA. Williams RM; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Franco V; Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Linares M; Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Arriaga I; Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Bopp S; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. Corey VC; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Gnädig NF; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Coburn-Flynn O; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Reimer C; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Gupta P; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Murithi JM; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Moura PA; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Fuchs O; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Sasaki E; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Kim SW; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Teng CH; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Wang LT; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Akidil A; Malaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Adjalley S; Malaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Willis PA; Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland. Siegel D; Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA. Tanaseichuk O; Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Zhong Y; Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Zhou Y; Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA. Llinás M; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA. Ottilie S; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. GamoFJ; Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Lee MCS; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.; Malaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Goldberg DE; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Fidock DA; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.; Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Wirth DF; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.; Infectious Disease Program, The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Winzeler EA; School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. .; Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
Autorzy:
Van Voorhis WC; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America. Adams JH; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Adelfio R; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. Ahyong V; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America. Akabas MH; Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine, New York, New York, United States of America. Alano P; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia. Alday A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain. Alemán Resto Y; Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America. Alsibaee A; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Alzualde A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain. Andrews KT; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia. Avery SV; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom. Avery VM; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Ayong L; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea. Baker M; Clinical Pharmacology, Novartis Consumer Health, Nyon, Switzerland. Baker S; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, Oxford University, Oxford, England, United Kingdom.; The London School of Hygiene and Tropical Medicine, London, England, United Kingdom. Ben Mamoun C; Internal Medicine, Yale University, New Haven, Connecticut, United States of America. Bhatia S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. Bickle Q; Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom. Bounaadja L; Museum of National History, Sorbonne Universities, Paris, France. Bowling T; SCYNEXIS, Inc., Durham, North Carolina, United States of America. Bosch J; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America. Boucher LE; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America. Boyom FF; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon. Brea J; CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Brennan M; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Burton A; SCYNEXIS, Inc., Durham, North Carolina, United States of America. Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America. Camarda G; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia. Carrasquilla M; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America. Carter D; School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia. Belen Cassera M; Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America. Chih-Chien Cheng K; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America. Chindaudomsate W; Department of Biochemistry, Mahidol University, Bangkok, Thailand. Chubb A; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Colon BL; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America. Colón-López DD; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America. Corbett Y; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy. Crowther GJ; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America. Cowan N; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. D'Alessandro S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy. Le Dang N; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America. Delves M; Department of Life Sciences, Imperial College London, London, England, United Kingdom. DeRisi JL; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America. Du AY; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America. Duffy S; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Abd El-Salam El-Sayed S; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.; Department of Biochemistry and Chemistry of nutrition, Mansoura University, Mansoura City, Egypt. Ferdig MT; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame Indiana, United States of America. Fernández Robledo JA; Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America. Fidock DA; Department of Microbiology & Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America. Florent I; Museum of National History, Sorbonne Universities, Paris, France. Fokou PV; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon. Galstian A; Broad Institute, Cambridge, Massachusetts, United States of America. GamoFJ; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain. Gokool S; Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom. Gold B; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America. Golub T; Broad Institute, Cambridge, Massachusetts, United States of America. Goldgof GM; Medical Scientist Training Program, University of California, San Diego, San Diego, California, United States of America. Guha R; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America. Guiguemde WA; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America. Gural N; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. Guy RK; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America. Hansen MA; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea. Hanson KK; Dept. of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, San Antonio, Texas, United States of America.; Instituto de Medicina Molecular, Lisboa, Portugal. Hemphill A; Institute of Parasitology, University of Berne, Bern, Switzerland. Hooft van Huijsduijnen R; Medicines for Malaria Venture, Geneva, Switzerland. Horii T; Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan. Horrocks P; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom. Hughes TB; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America. Huston C; Department of Medicine, College of Medicine, University of Vermont, Burlington, Vermont, United States of America. Igarashi I; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan. Ingram-Sieber K; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. Itoe MA; Instituto de Medicina Molecular, Lisboa, Portugal. Jadhav A; National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America. Naranuntarat Jensen A; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok Thailand. Jensen LT; Department of Biochemistry, Mahidol University, Bangkok, Thailand. Jiang RH; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Kaiser A; Medical Research Centre, Institute for Pharmacogenetics, Essen, Germany. Keiser J; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. Ketas T; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America. Kicka S; Department of Biochemistry, University of Geneva, Geneva, Switzerland. Kim S; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America. Kirk K; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia. Kumar VP; Internal Medicine, Yale University, New Haven, Connecticut, United States of America. Kyle DE; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Lafuente MJ; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain. Landfear S; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America. Lee N; Medicines for Malaria Venture, Geneva, Switzerland. Lee S; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea. Lehane AM; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia. Li F; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America. Little D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America. Liu L; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America. Llinás M; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America. Loza MI; CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Lubar A; Department of Medicine, University of California San Diego, San Diego, California, United States of America. Lucantoni L; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Lucet I; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. Maes L; University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium. Mancama D; Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa. Mansour NR; Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom. March S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. McGowan S; Department of Microbiology, Monash University, Clayton, Australia. Medina Vera I; Instituto de Medicina Molecular, Lisboa, Portugal. Meister S; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America. Mercer L; SCYNEXIS, Inc., Durham, North Carolina, United States of America. Mestres J; Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain. Mfopa AN; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon. Misra RN; Division of Cancer Therapeutics and Diagnosis, Drug Synthesis and Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Moon S; Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea. Moore JP; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America. Morais Rodrigues da Costa F; Graduate Program in Bioinformatics, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Müller J; Institute of Parasitology, University of Berne, Bern, Switzerland. Muriana A; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain. Nakazawa Hewitt S; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America. Nare B; SCYNEXIS, Inc., Durham, North Carolina, United States of America. Nathan C; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America. Narraidoo N; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom. Nawaratna S; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia. Ojo KK; Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America. Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America. Panic G; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland. Papadatos G; ChEMBL group, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, United Kingdom. Parapini S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy. Patra K; Department of Medicine, University of California San Diego, San Diego, California, United States of America. Pham N; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Prats S; Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain. Plouffe DM; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America. Poulsen SA; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Pradhan A; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Quevedo C; BBD BioPhenix SL-BIOBIDE, Donostia, Gipuzkoa, Spain. Quinn RJ; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Rice CA; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Abdo Rizk M; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura City, Egypt. Ruecker A; Department of Life Sciences, Imperial College London, London, England, United Kingdom. St Onge R; Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America. Salgado Ferreira R; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Samra J; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America. Robinett NG; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America.; Laboratoire de Chimie Moléculaire, CNRS,-UMR 7509, COB-IRJBD, Mulhouse Cedex, France. Schlecht U; Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America. Schmitt M; Laboratoire de Chimie Moléculaire, CNRS,-UMR 7509, COB-IRJBD, Mulhouse Cedex, France. Silva Villela F; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Silvestrini F; Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia. Sinden R; The Jenner Institute, University of Oxford, Oxford, England, United Kingdom. Smith DA; Department of Chemistry, University of Capetown, Capetown, South Africa. Soldati T; Department of Biochemistry, University of Geneva, Geneva, Switzerland. Spitzmüller A; Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain. Stamm SM; Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America. Sullivan DJ; H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America. Sullivan W; Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America. Suresh S; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Suzuki BM; Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America. Suzuki Y; Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, La Jolla, California, United States of America. Swamidass SJ; Department of Life Sciences, Imperial College London, London, England, United Kingdom. Taramelli D; Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America. Tchokouaha LR; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon. Theron A; Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa. Thomas D; Broad Institute, Cambridge, Massachusetts, United States of America. Tonissen KF; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.; School of Natural Sciences, Griffith University, Nathan, Queensland, Australia. Townson S; Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom. Tripathi AK; H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America. Trofimov V; Department of Biochemistry, University of Geneva, Geneva, Switzerland. Udenze KO; Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America. Ullah I; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom. Vallieres C; School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom. Vigil E; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America. Vinetz JM; Department of Medicine, University of California San Diego, San Diego, California, United States of America. Voong Vinh P; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Vu H; Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia. Watanabe NA; Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan. Weatherby K; School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia. White PM; Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America. Wilks AF; Hudson Institute of Medical Research; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; SYNthesis Research, Parkville, Victoria, Australia. Winzeler EA; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America. Wojcik E; Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America. Wree M; Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America. Wu W; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America. Yokoyama N; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan. Zollo PH; Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon. Abla N; Medicines for Malaria Venture, Geneva, Switzerland. Blasco B; Medicines for Malaria Venture, Geneva, Switzerland. Burrows J; Medicines for Malaria Venture, Geneva, Switzerland. Laleu B; Medicines for Malaria Venture, Geneva, Switzerland. Leroy D; Medicines for Malaria Venture, Geneva, Switzerland. Spangenberg T; Medicines for Malaria Venture, Geneva, Switzerland. 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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Jul 28; Vol. 12 (7), pp. e1005763. Date of Electronic Publication: 2016 Jul 28 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents.
Autorzy:
Bahamontes-Rosa N; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. . Gomez-Lorenzo MG; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Lelièvre J; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Rodriguez Alejandre A; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Almela MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Lozano S; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. Herreros E; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain. GamoFJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
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Źródło:
Malaria journal [Malar J] 2016 Jul 22; Vol. 15 (1), pp. 385. Date of Electronic Publication: 2016 Jul 22.
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay.
Autorzy:
Linares M; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Viera S; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Crespo B; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Franco V; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Gómez-Lorenzo MG; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Jiménez-Díaz MB; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Angulo-Barturen Í; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . Sanz LM; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. . GamoFJ; R&D Alternative Discovery and Development, Diseases of the Developing World, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain. .
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Źródło:
Malaria journal [Malar J] 2015 Nov 05; Vol. 14, pp. 441. Date of Electronic Publication: 2015 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Autorzy:
Baragaña B; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Hallyburton I; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Lee MC; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. Norcross NR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Grimaldi R; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Otto TD; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK. Proto WR; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK. Blagborough AM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Meister S; University of California, San Diego, School of Medicine, 9500 Gilman Drive 0760, La Jolla, California 92093, USA. Wirjanata G; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia. Ruecker A; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Upton LM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Abraham TS; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. Almeida MJ; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. Pradhan A; Department of Global Health, College of Public Health University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA. Porzelle A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Luksch Martínez MS; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Luksch T Bolscher JM; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands. Woodland A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Norval S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Thomas J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Simeons F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Stojanovski L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Osuna-Cabello M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Brock PM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Churcher TS; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Sala KA; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Zakutansky SE; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Jiménez-Díaz MB; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Sanz LM; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Basak R; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. Campbell M; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Avery VM; Eskitis Institute, Brisbane Innovation Park, Nathan Campus, Griffith University, Queensland 4111, Australia. Sauerwein RW; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands. Dechering KJ; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands. Noviyanti R; Malaria Pathogenesis Laboratory, Eijkman Institute for Molecular Biology, Jalan Diponegoro 69, 10430 Jakarta, Indonesia. Campo B; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Frearson JA; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Angulo-Barturen I; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Ferrer-Bazaga S; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. GamoFJ; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain. Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Leroy D; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Siegl P; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Delves MJ; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Kyle DE; Department of Global Health, College of Public Health University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA. Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland. Marfurt J; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia. Price RN; 1] Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia [2] Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK. Sinden RE; Department of Life Sciences, Imperial College, London SW7 2AZ, UK. Winzeler EA; University of California, San Diego, School of Medicine, 9500 Gilman Drive 0760, La Jolla, California 92093, USA. Charman SA; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Bebrevska L; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Gray DW; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Campbell S; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Fairlamb AH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Willis PA; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland. Rayner JC; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK. Fidock DA; 1] Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA [2] Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Gilbert IH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
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Źródło:
Nature [Nature] 2015 Jun 18; Vol. 522 (7556), pp. 315-20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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