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Wyszukujesz frazę ""Gandhi, S."" wg kryterium: Autor


Tytuł :
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
Autorzy :
Hughes CD; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Choi ML; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Ryten M; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.
Hopkins L; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
Drews A; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany.
Botía JA; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, 30100, Murcia, Spain.
Iljina M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; Weizmann Institute of Science, Perlman Chemical Sciences Building, Room 601, 76100, Rehovot, Israel.
Rodrigues M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Gagliano SA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Gandhi S; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk.
Bryant C; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. .
Klenerman D; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. .; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK. .
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Źródło :
Acta neuropathologica [Acta Neuropathol] 2019 Jan; Vol. 137 (1), pp. 103-120. Date of Electronic Publication: 2018 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Microglia/*metabolism
Parkinson Disease/*metabolism
Toll-Like Receptor 4/*metabolism
alpha-Synuclein/*metabolism
Animals ; Astrocytes/pathology ; Brain/metabolism ; Brain/pathology ; Cell Death ; Cytokines/metabolism ; Humans ; Inflammation/pathology ; Microglia/pathology ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/pathology ; Substantia Nigra/pathology
Czasopismo naukowe
Tytuł :
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Autorzy :
Whiten DR; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Zuo Y; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Calo L; Department of Clinical Neurosciences, University of Cambridge, Hills Road, Cambridge, CB2 0AH, UK.
Choi ML; UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
De S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Flagmeier P; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Wirthensohn DC; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Kundel F; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Ranasinghe RT; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Sanchez SE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Athauda D; UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Gandhi S; UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Spillantini MG; Department of Clinical Neurosciences, University of Cambridge, Hills Road, Cambridge, CB2 0AH, UK.
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present addresses: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2018 Oct 04; Vol. 19 (19), pp. 2033-2038. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*chemistry
Neurons/*pathology
Parkinson Disease/*pathology
alpha-Synuclein/*chemistry
Amyloid beta-Peptides/metabolism ; Aptamers, Peptide/chemistry ; Humans ; Protein Aggregation, Pathological ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.
Autorzy :
Choi ML; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
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Źródło :
The FEBS journal [FEBS J] 2018 Oct; Vol. 285 (19), pp. 3631-3644. Date of Electronic Publication: 2018 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Aggregates*
Alzheimer Disease/*physiopathology
Amyloid beta-Peptides/*metabolism
Parkinson Disease/*physiopathology
alpha-Synuclein/*metabolism
tau Proteins/*metabolism
Amyloid beta-Peptides/chemistry ; Animals ; Humans ; Protein Conformation ; alpha-Synuclein/chemistry ; tau Proteins/chemistry
Czasopismo naukowe
Tytuł :
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.
Autorzy :
Little D; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom. .
Luft C; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Mosaku O; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Lorvellec M; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Yao Z; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, United Kingdom.
Paillusson S; Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, United Kingdom.
Kriston-Vizi J; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, United Kingdom.
Abramov AY; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, United Kingdom.
Ketteler R; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom. .; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom. .
Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
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Źródło :
Scientific reports [Sci Rep] 2018 Jun 13; Vol. 8 (1), pp. 9033. Date of Electronic Publication: 2018 Jun 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Dopaminergic Neurons/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Mitochondria/*metabolism
Single-Cell Analysis/*methods
alpha-Synuclein/*metabolism
Benzimidazoles ; Cell Differentiation/genetics ; Cell Survival/genetics ; Cells, Cultured ; Humans ; Membrane Potential, Mitochondrial/genetics ; Microscopy, Confocal ; Mitochondria/genetics ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Rhodamines ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Autorzy :
Ludtmann MHR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.; Royal Veterinary College, 4 Royal College St, Kings Cross, London, NW1 0TU, UK.
Angelova PR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Choi ML; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK.
Rodrigues M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Baev AY; Educational-Experimental Centre of High Technologies, Laboratory of Biophysics and Biochemistry, Tashkent, Uzbekistan.
Berezhnov AV; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia.
Yao Z; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK.
Little D; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Banushi B; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Al-Menhali AS; Toxicology and Multipurpose Department, Anti-Doping Lab Qatar, Sport City Road, PO Box 27775, Doha, Qatar.
Ranasinghe RT; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Whiten DR; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Yapom R; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Dolt KS; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Kunath T; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Jaganjac M; Toxicology and Multipurpose Department, Anti-Doping Lab Qatar, Sport City Road, PO Box 27775, Doha, Qatar.
Pavlov EV; Department of Basic Sciences, New York University College of Dentistry, NY, 10010, USA.
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
Abramov AY; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK. .
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.
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Źródło :
Nature communications [Nat Commun] 2018 Jun 12; Vol. 9 (1), pp. 2293. Date of Electronic Publication: 2018 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Membrane Transport Proteins*
Induced Pluripotent Stem Cells/*metabolism
Mitochondria/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
Animals ; Coculture Techniques ; Embryonic Stem Cells/metabolism ; Humans ; Lipid Peroxidation ; Mitochondrial Permeability Transition Pore ; Oxidation-Reduction ; Patch-Clamp Techniques ; Permeability ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Autorzy :
Varela JA; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Rodrigues M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
De S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Flagmeier P; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Apr 23; Vol. 57 (18), pp. 4886-4890. Date of Electronic Publication: 2018 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Optical Imaging*
alpha-Synuclein/*analysis
alpha-Synuclein/*chemistry
Humans ; Protein Aggregates ; Protein Conformation
Czasopismo naukowe
Tytuł :
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Autorzy :
Iljina M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Hong L; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
Ludtmann MH; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Choi ML; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Hughes CD; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Ruggeri FS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Guilliams T; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Healx Ltd., St John's Innovation Centre, Cowley Road, Cambridge, CB4 0WS, UK.
Buell AK; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Institute of Physical Biology, University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Lee JE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Gandhi S; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Bryant CE; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Vendruscolo M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Knowles TPJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
De Genst E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Present address: Astra Zeneca, Innovative Medicines Discovery Sciences Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK. .
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
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Źródło :
BMC biology [BMC Biol] 2017 Jul 03; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2017 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Domain Antibodies/*metabolism
alpha-Synuclein/*metabolism
Humans ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Protein Binding
Czasopismo naukowe
Tytuł :
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
Autorzy :
Ludtmann MH; Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and.
Angelova PR; Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and.
Ninkina NN; School of Biosciences, University of Cardiff, Cardiff CF10 3AX, United Kingdom.
Gandhi S; Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and.
Buchman VL; School of Biosciences, University of Cardiff, Cardiff CF10 3AX, United Kingdom .
Abramov AY; Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2016 Oct 12; Vol. 36 (41), pp. 10510-10521.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*enzymology
Mitochondrial Proton-Translocating ATPases/*metabolism
alpha-Synuclein/*physiology
Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/enzymology ; Astrocytes/metabolism ; Cells, Cultured ; Energy Metabolism/genetics ; Energy Metabolism/physiology ; Membrane Potential, Mitochondrial ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; NAD/metabolism ; Oxygen Consumption/physiology ; Unfolded Protein Response/genetics ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.
Autorzy :
Angelova PR; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Ludtmann MH; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Horrocks MH; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Negoda A; Department of Physiology and Biophysics, Dalhousie University, Halifax B3H 4R2, Canada.
Cremades N; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Klenerman D; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Wood NW; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Pavlov EV; Department of Physiology and Biophysics, Dalhousie University, Halifax B3H 4R2, Canada College of Dentistry, New York University, New York 10010, USA.
Gandhi S; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK .gandhi@ucl.ac.uk.
Abramov AY; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK .gandhi@ucl.ac.uk.
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Źródło :
Journal of cell science [J Cell Sci] 2016 May 01; Vol. 129 (9), pp. 1792-801. Date of Electronic Publication: 2016 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Mutation, Missense*
Protein Folding*
Astrocytes/*metabolism
Calcium/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
Amino Acid Substitution ; Animals ; Astrocytes/pathology ; Cell Death ; Cells, Cultured ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Protein Multimerization/genetics ; Rats ; Rats, Sprague-Dawley ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Autorzy :
Iljina M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Garcia GA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Horrocks MH; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Tosatto L; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 38123 Trento, Italy;
Choi ML; Department of Molecular Neuroscience, University College London, Institute of Neurology, London WC1N 3BG, United Kingdom.
Ganzinger KA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Abramov AY; Department of Molecular Neuroscience, University College London, Institute of Neurology, London WC1N 3BG, United Kingdom.
Gandhi S; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 38123 Trento, Italy;
Wood NW; Department of Molecular Neuroscience, University College London, Institute of Neurology, London WC1N 3BG, United Kingdom.
Cremades N; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Dobson CM; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
Knowles TP; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; .
Klenerman D; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Mar 01; Vol. 113 (9), pp. E1206-15. Date of Electronic Publication: 2016 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Prions/*metabolism
alpha-Synuclein/*metabolism
Fluorescence Resonance Energy Transfer ; Kinetics ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
Autorzy :
Deas E; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Cremades N; 2 Department of Chemistry, Lensfield Road, University of Cambridge , Cambridge, United Kingdom .
Angelova PR; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Ludtmann MH; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Yao Z; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .; 3 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Chen S; 2 Department of Chemistry, Lensfield Road, University of Cambridge , Cambridge, United Kingdom .
Horrocks MH; 2 Department of Chemistry, Lensfield Road, University of Cambridge , Cambridge, United Kingdom .
Banushi B; 4 MRC Laboratory for Molecular Cell Biology, UCL , London, United Kingdom .
Little D; 4 MRC Laboratory for Molecular Cell Biology, UCL , London, United Kingdom .
Devine MJ; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Gissen P; 4 MRC Laboratory for Molecular Cell Biology, UCL , London, United Kingdom .
Klenerman D; 2 Department of Chemistry, Lensfield Road, University of Cambridge , Cambridge, United Kingdom .
Dobson CM; 2 Department of Chemistry, Lensfield Road, University of Cambridge , Cambridge, United Kingdom .
Wood NW; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Gandhi S; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .; 3 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology , Queen Square, London, United Kingdom .
Abramov AY; 1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .
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Źródło :
Antioxidants & redox signaling [Antioxid Redox Signal] 2016 Mar 01; Vol. 24 (7), pp. 376-91. Date of Electronic Publication: 2016 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxidative Stress*
Protein Multimerization*
Ions/*metabolism
Metals/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Apoptosis ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Differentiation ; Enzyme Activation ; Gene Duplication ; Glutathione/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Neurons/cytology ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Protein Aggregation, Pathological ; Protein Conformation ; Rats ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; alpha-Synuclein/chemistry ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.
Autorzy :
Reeve AK; Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK.
Ludtmann MH; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Angelova PR; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Simcox EM; Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Turnbull DM; Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK.
Abramov AY; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
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Źródło :
Cell death & disease [Cell Death Dis] 2015 Jul 16; Vol. 6, pp. e1820. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurons/*metabolism
Oxidative Stress/*genetics
Parkinson Disease/*genetics
alpha-Synuclein/*genetics
Animals ; Electron Transport Complex I/deficiency ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Humans ; Membrane Potential, Mitochondrial ; Mice ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/pathology ; Mutation ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Protein Aggregation, Pathological/genetics ; Reactive Oxygen Species/metabolism ; alpha-Synuclein/metabolism
SCR Disease Name :
Mitochondrial complex I deficiency
Czasopismo naukowe
Tytuł :
Lipid peroxidation is essential for α-synuclein-induced cell death.
Autorzy :
Angelova PR; UCL Institute of Neurology, Queen Square, London, UK.
Horrocks MH
Klenerman D
Gandhi S
Abramov AY
Shchepinov MS
Pokaż więcej
Źródło :
Journal of neurochemistry [J Neurochem] 2015 May; Vol. 133 (4), pp. 582-9. Date of Electronic Publication: 2015 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Peroxidation/*drug effects
Neurons/*drug effects
alpha-Synuclein/*metabolism
alpha-Synuclein/*pharmacology
Animals ; Animals, Newborn ; Astrocytes/drug effects ; Cell Death/drug effects ; Cells, Cultured ; Cerebral Cortex/cytology ; Coculture Techniques ; Ethidium/analogs & derivatives ; Ethidium/pharmacology ; Fatty Acids, Unsaturated/metabolism ; Female ; Male ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Understanding the molecular causes of Parkinson's disease.
Autorzy :
Wood-Kaczmar A; Department of Molecular Neuroscience, Institute of Neurology, and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Gandhi S
Wood NW
Pokaż więcej
Źródło :
Trends in molecular medicine [Trends Mol Med] 2006 Nov; Vol. 12 (11), pp. 521-8. Date of Electronic Publication: 2006 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Parkinson Disease/*genetics
Protein Kinases/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Ubiquitin-Protein Ligases/*genetics
alpha-Synuclein/*metabolism
Adult ; Animals ; Cell Death ; Chromosome Aberrations ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Middle Aged ; Models, Biological ; Mutation ; Oxidative Stress ; Parkinson Disease/metabolism ; Phosphorylation ; Protein Kinases/genetics ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/physiology ; Ubiquitin-Protein Ligases/metabolism ; alpha-Synuclein/physiology
Czasopismo naukowe

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