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Wyszukujesz frazę ""Gandhi, S."" wg kryterium: Autor


Tytuł :
LRRK2 deficiency induced mitochondrial Ca exchanger upregulation.
Autorzy :
Ludtmann MHR; Royal Veterinary College, 4 Royal College St, Kings Cross, London, NW1 0TU, UK. .; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK. .
Kostic M; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
Horne A; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Gandhi S; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK.
Sekler I; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
Abramov AY; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Mar 19; Vol. 10 (4), pp. 265. Date of Electronic Publication: 2019 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*metabolism
Mitochondria/*metabolism
Parkinson Disease/*metabolism
Sodium-Calcium Exchanger/*metabolism
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Biological Transport ; Cell Death/drug effects ; Cell Death/genetics ; Cell Death/physiology ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Lithium/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Membrane Potential, Mitochondrial/physiology ; Mice ; Mice, Knockout ; Mitochondria/chemistry ; Mitochondria/drug effects ; Mitochondria/genetics ; Neuroglia ; Neurons/drug effects ; Neurons/metabolism ; Parkinson Disease/genetics ; Rats ; Rats, Sprague-Dawley ; Sodium/metabolism ; Sodium-Calcium Exchanger/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.
Autorzy :
Little D; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom. .
Luft C; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Mosaku O; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Lorvellec M; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Yao Z; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, United Kingdom.
Paillusson S; Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, United Kingdom.
Kriston-Vizi J; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, United Kingdom.
Abramov AY; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, United Kingdom.
Ketteler R; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom. .; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom. .
Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, United Kingdom.
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Źródło :
Scientific reports [Sci Rep] 2018 Jun 13; Vol. 8 (1), pp. 9033. Date of Electronic Publication: 2018 Jun 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Dopaminergic Neurons/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Mitochondria/*metabolism
Single-Cell Analysis/*methods
alpha-Synuclein/*metabolism
Benzimidazoles ; Cell Differentiation/genetics ; Cell Survival/genetics ; Cells, Cultured ; Humans ; Membrane Potential, Mitochondrial/genetics ; Microscopy, Confocal ; Mitochondria/genetics ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Rhodamines ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Autorzy :
Ludtmann MHR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.; Royal Veterinary College, 4 Royal College St, Kings Cross, London, NW1 0TU, UK.
Angelova PR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Choi ML; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK.
Rodrigues M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Baev AY; Educational-Experimental Centre of High Technologies, Laboratory of Biophysics and Biochemistry, Tashkent, Uzbekistan.
Berezhnov AV; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia.
Yao Z; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK.
Little D; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Banushi B; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Al-Menhali AS; Toxicology and Multipurpose Department, Anti-Doping Lab Qatar, Sport City Road, PO Box 27775, Doha, Qatar.
Ranasinghe RT; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Whiten DR; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Yapom R; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Dolt KS; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Kunath T; MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.
Jaganjac M; Toxicology and Multipurpose Department, Anti-Doping Lab Qatar, Sport City Road, PO Box 27775, Doha, Qatar.
Pavlov EV; Department of Basic Sciences, New York University College of Dentistry, NY, 10010, USA.
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
Abramov AY; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK. .
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk.; The Francis Crick Institute, 1 Midland Road, King's Cross, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.
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Źródło :
Nature communications [Nat Commun] 2018 Jun 12; Vol. 9 (1), pp. 2293. Date of Electronic Publication: 2018 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Membrane Transport Proteins*
Induced Pluripotent Stem Cells/*metabolism
Mitochondria/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
Animals ; Coculture Techniques ; Embryonic Stem Cells/metabolism ; Humans ; Lipid Peroxidation ; Mitochondrial Permeability Transition Pore ; Oxidation-Reduction ; Patch-Clamp Techniques ; Permeability ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation.
Autorzy :
Angelova PR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Barilani M; Unit of Regenerative Medicine - Cell Factory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Lovejoy C; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Dossena M; Unit of Regenerative Medicine - Cell Factory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Viganò M; Unit of Regenerative Medicine - Cell Factory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Seresini A; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy; Medical Genetics Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Piga D; Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT); University of Milan, Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Gandhi S; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Pezzoli G; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy.
Abramov AY; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. Electronic address: .
Lazzari L; Unit of Regenerative Medicine - Cell Factory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
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Źródło :
Redox biology [Redox Biol] 2018 Apr; Vol. 14, pp. 474-484. Date of Electronic Publication: 2017 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*pathology
Mitochondria/*pathology
Parkinsonian Disorders/*pathology
Supranuclear Palsy, Progressive/*pathology
Cell Differentiation ; Cells, Cultured ; Humans ; Membrane Potential, Mitochondrial ; Mesenchymal Stem Cells/metabolism ; Mitochondria/metabolism ; Mitophagy ; NAD/metabolism ; Oxidative Stress ; Parkinsonian Disorders/metabolism ; Reactive Oxygen Species/metabolism ; Supranuclear Palsy, Progressive/metabolism
Czasopismo naukowe
Tytuł :
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.
Autorzy :
Tufi R; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
de Castro IP; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Lehmann S; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Angelova PR; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Dinsdale D; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Deas E; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Plun-Favreau H; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Nicotera P; German Centre for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
Abramov AY; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Willis AE; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Mallucci GR; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Loh SH; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Martins LM; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
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Źródło :
Nature cell biology [Nat Cell Biol] 2014 Feb; Vol. 16 (2), pp. 157-66. Date of Electronic Publication: 2014 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Drosophila Proteins/*physiology
Mitochondria/*physiology
Nucleotides/*metabolism
Parkinson Disease/*physiopathology
Protein-Serine-Threonine Kinases/*physiology
Animals ; DNA, Mitochondrial/biosynthesis ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Protein-Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
Autorzy :
Deas E; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. />Plun-Favreau H
Gandhi S
Desmond H
Kjaer S
Loh SH
Renton AE
Harvey RJ
Whitworth AJ
Martins LM
Abramov AY
Wood NW
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Źródło :
Human molecular genetics [Hum Mol Genet] 2011 Mar 01; Vol. 20 (5), pp. 867-79. Date of Electronic Publication: 2010 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metalloproteases/*metabolism
Mitochondria/*enzymology
Mitochondrial Proteins/*metabolism
Protein Kinases/*chemistry
Protein Kinases/*metabolism
Amino Acid Sequence ; Cell Line ; Humans ; Metalloproteases/genetics ; Mitochondria/chemistry ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Molecular Sequence Data ; Mutation ; Parkinson Disease/enzymology ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinsonian Disorders ; Protein Binding ; Protein Kinases/genetics ; Protein Processing, Post-Translational ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.
Autorzy :
Burchell VS; UCL Institute of Neurology, Department of Molecular Neuroscience, Queen Square, London WC1N 3BG, UK.
Gandhi S
Deas E
Wood NW
Abramov AY
Plun-Favreau H
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Źródło :
Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2010 May; Vol. 14 (5), pp. 497-511.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitochondria/*physiology
Neurodegenerative Diseases/*physiopathology
Humans
Czasopismo naukowe
Tytuł :
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.
Autorzy :
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK.
Wood-Kaczmar A
Yao Z
Plun-Favreau H
Deas E
Klupsch K
Downward J
Latchman DS
Tabrizi SJ
Wood NW
Duchen MR
Abramov AY
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Źródło :
Molecular cell [Mol Cell] 2009 Mar 13; Vol. 33 (5), pp. 627-38.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
Calcium/*metabolism
Fetal Stem Cells/*enzymology
Mitochondria/*enzymology
Neurons/*enzymology
Parkinsonian Disorders/*enzymology
Protein Kinases/*metabolism
Animals ; Cell Line, Tumor ; Cells, Cultured ; Cytosol/metabolism ; Energy Metabolism ; Fetal Stem Cells/drug effects ; Fetal Stem Cells/pathology ; Fetal Stem Cells/radiation effects ; Glucose Transport Proteins, Facilitative/metabolism ; Homeostasis ; Humans ; Membrane Potential, Mitochondrial ; Mesencephalon/embryology ; Mesencephalon/enzymology ; Mice ; Mice, Knockout ; Mitochondria/drug effects ; Mitochondria/pathology ; Mitochondria/radiation effects ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Permeability Transition Pore ; NADPH Oxidases/metabolism ; Neurons/drug effects ; Neurons/pathology ; Neurons/radiation effects ; Oxidation-Reduction ; Oxidative Stress ; Parkinsonian Disorders/genetics ; Parkinsonian Disorders/pathology ; Protein Kinases/deficiency ; Protein Kinases/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/metabolism ; Sodium-Calcium Exchanger/metabolism ; Time Factors ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease?
Autorzy :
Plun-Favreau H; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK. />Gandhi S
Wood-Kaczmar A
Deas E
Yao Z
Wood NW
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2008 Dec; Vol. 1147, pp. 30-6.
Typ publikacji :
Journal Article
MeSH Terms :
Mitochondria/*physiology
Mitochondrial Proteins/*genetics
Parkinson Disease/*physiopathology
Protein Kinases/*genetics
Serine Endopeptidases/*genetics
High-Temperature Requirement A Serine Peptidase 2 ; Humans ; Mitochondrial Proteins/metabolism ; Mutation ; Parkinson Disease/genetics ; Phosphorylation ; Protein Kinases/metabolism ; Serine Endopeptidases/metabolism
Czasopismo naukowe
Tytuł :
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.
Autorzy :
Wood-Kaczmar A; Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom.
Gandhi S
Yao Z
Abramov AY
Miljan EA
Keen G
Stanyer L
Hargreaves I
Klupsch K
Deas E
Downward J
Mansfield L
Jat P
Taylor J
Heales S
Duchen MR
Latchman D
Tabrizi SJ
Wood NW
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Źródło :
PloS one [PLoS One] 2008 Jun 18; Vol. 3 (6), pp. e2455. Date of Electronic Publication: 2008 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Survival/*physiology
Dopamine/*metabolism
Mitochondria/*physiology
Neurons/*physiology
Protein Kinases/*physiology
Animals ; Blotting, Western ; Cells, Cultured ; DNA, Complementary ; Electrophoresis, Polyacrylamide Gel ; Humans ; Mice ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Neurons/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Mitochondria in Parkinson disease: back in fashion with a little help from genetics.
Autorzy :
Muqit MM; Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, England.
Gandhi S
Wood NW
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Źródło :
Archives of neurology [Arch Neurol] 2006 May; Vol. 63 (5), pp. 649-54.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Diseases*/complications
Mitochondrial Diseases*/genetics
Mitochondrial Diseases*/pathology
Mitochondria/*pathology
Parkinson Disease/*pathology
Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mitochondria/genetics ; Models, Biological ; Oncogene Proteins/genetics ; Parkinson Disease/etiology ; Parkinson Disease/genetics ; Protein Deglycase DJ-1 ; Protein Kinases/genetics
Czasopismo naukowe
Tytuł :
Molecular pathogenesis of Parkinson's disease.
Autorzy :
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK.
Wood NW
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Źródło :
Human molecular genetics [Hum Mol Genet] 2005 Sep 15; Vol. 14 (18), pp. 2749-55. Date of Electronic Publication: 2005 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Models, Biological*
Mitochondria/*pathology
Oxidative Stress/*physiology
Parkinson Disease/*genetics
Parkinson Disease/*metabolism
Parkinson Disease/*physiopathology
Signal Transduction/*physiology
Humans ; Phosphotransferases/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitins/metabolism ; alpha-Synuclein/metabolism
Czasopismo naukowe

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