Autor: "Gandhi, S." - OpacWWW

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Tytuł:: Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Autorzy:: Iljina M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Hong L; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
Ludtmann MH; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Choi ML; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Hughes CD; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Ruggeri FS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Guilliams T; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Healx Ltd., St John's Innovation Centre, Cowley Road, Cambridge, CB4 0WS, UK.
Buell AK; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Institute of Physical Biology, University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Lee JE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Gandhi S; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Bryant CE; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Vendruscolo M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Knowles TPJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
De Genst E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Present address: Astra Zeneca, Innovative Medicines Discovery Sciences Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK. .
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Pokaż więcej
Źródło:: BMC biology [BMC Biol] 2017 Jul 03; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2017 Jul 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Single-Domain Antibodies/*metabolism
alpha-Synuclein/*metabolism
Humans ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Protein Binding

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