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    Tytuł:
    Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
    Autorzy:
    Toomey CE; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. .; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. .; The Francis Crick Institute, London, UK. .
    Heywood WE; Translational Mass Spectrometry Research Group, Genetic & Genomic Medicine, Institute of Child Health, UCL, London, UK.
    Evans JR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
    Lachica J; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
    Pressey SN; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
    Foti SC; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
    Al Shahrani M; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.; College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
    D'Sa K; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
    Hargreaves IP; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
    Heales S; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
    Orford M; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
    Troakes C; London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
    Attems J; Newcastle Brain Tissue Resource, Institute of Neuroscience and Newcastle University Institute for Ageing, Newcastle upon Tyne, UK.
    Gelpi E; Neurological Tissue Bank, University of Barcelona, Barcelona, Spain.; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
    Palkovits M; Human Brain Tissue Bank, Budapest, Semmelweis University, Budapest, Hungary.
    Lashley T; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
    Gentleman SM; Department of Brain Sciences, Imperial College London, London, UK.
    Revesz T; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
    Mills K; Translational Mass Spectrometry Research Group, Genetic & Genomic Medicine, Institute of Child Health, UCL, London, UK.
    Gandhi S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. sonia.gandhi@ucl.ac.uk.; The Francis Crick Institute, London, UK. sonia.gandhi@ucl.ac.uk.
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Sep 08; Vol. 10 (1), pp. 134. Date of Electronic Publication: 2022 Sep 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Parkinson Disease*/pathology
    alpha-Synuclein*/metabolism
    Humans ; Mitochondria/metabolism ; Proteome/metabolism ; Proteomics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
    Autorzy:
    Iljina M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Hong L; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China.
    Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
    Ludtmann MH; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
    Choi ML; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
    Hughes CD; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
    Ruggeri FS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Guilliams T; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Healx Ltd., St John's Innovation Centre, Cowley Road, Cambridge, CB4 0WS, UK.
    Buell AK; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Institute of Physical Biology, University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
    Lee JE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Gandhi S; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
    Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Bryant CE; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
    Vendruscolo M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Knowles TPJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
    De Genst E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Present address: Astra Zeneca, Innovative Medicines Discovery Sciences Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK. .
    Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
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    Źródło:
    BMC biology [BMC Biol] 2017 Jul 03; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2017 Jul 03.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Single-Domain Antibodies/*metabolism
    alpha-Synuclein/*metabolism
    Humans ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Protein Binding
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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