Autor: "Gandhi, S." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Autorzy:: Toomey CE; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. .; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. .; The Francis Crick Institute, London, UK. .
Heywood WE; Translational Mass Spectrometry Research Group, Genetic & Genomic Medicine, Institute of Child Health, UCL, London, UK.
Evans JR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
Lachica J; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Pressey SN; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Foti SC; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Al Shahrani M; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.; College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
D'Sa K; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
Hargreaves IP; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
Heales S; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
Orford M; National Hospital for Neurology and Neurosurgery & Neurometabolic Unit, UCL Great Ormond Street Institute of Child Health, London, UK.
Troakes C; London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Attems J; Newcastle Brain Tissue Resource, Institute of Neuroscience and Newcastle University Institute for Ageing, Newcastle upon Tyne, UK.
Gelpi E; Neurological Tissue Bank, University of Barcelona, Barcelona, Spain.; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Palkovits M; Human Brain Tissue Bank, Budapest, Semmelweis University, Budapest, Hungary.
Lashley T; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Gentleman SM; Department of Brain Sciences, Imperial College London, London, UK.
Revesz T; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Mills K; Translational Mass Spectrometry Research Group, Genetic & Genomic Medicine, Institute of Child Health, UCL, London, UK.
Gandhi S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. sonia.gandhi@ucl.ac.uk.; The Francis Crick Institute, London, UK. sonia.gandhi@ucl.ac.uk.; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Sep 08; Vol. 10 (1), pp. 134. Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Parkinson Disease*/pathology
alpha-Synuclein*/metabolism
Humans ; Mitochondria/metabolism ; Proteome/metabolism ; Proteomics

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Skocz do pozycji: 2.

Tytuł:: Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.
Autorzy:: Choi ML; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.
Gandhi S; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2018 Oct; Vol. 285 (19), pp. 3631-3644. Date of Electronic Publication: 2018 Aug 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Protein Aggregates*
Alzheimer Disease/*physiopathology
Amyloid beta-Peptides/*metabolism
Parkinson Disease/*physiopathology
alpha-Synuclein/*metabolism
tau Proteins/*metabolism
Amyloid beta-Peptides/chemistry ; Animals ; Humans ; Protein Conformation ; alpha-Synuclein/chemistry ; tau Proteins/chemistry

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Skocz do pozycji: 3.

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Skocz do pozycji: 4.

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Skocz do pozycji: 5.

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Skocz do pozycji: 6.

Tytuł:: Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Autorzy:: Iljina M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Hong L; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China.
Horrocks MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
Ludtmann MH; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Choi ML; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Hughes CD; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Ruggeri FS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Guilliams T; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Healx Ltd., St John's Innovation Centre, Cowley Road, Cambridge, CB4 0WS, UK.
Buell AK; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Present address: Institute of Physical Biology, University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Lee JE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Gandhi S; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Bryant CE; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Vendruscolo M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Knowles TPJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .
De Genst E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Present address: Astra Zeneca, Innovative Medicines Discovery Sciences Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK. .
Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. .; Pokaż więcej
Źródło:: BMC biology [BMC Biol] 2017 Jul 03; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2017 Jul 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Single-Domain Antibodies/*metabolism
alpha-Synuclein/*metabolism
Humans ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Protein Binding

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Skocz do pozycji: 7.

Tytuł:: Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.
Autorzy:: Tufi R; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
de Castro IP; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Lehmann S; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Angelova PR; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Dinsdale D; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Deas E; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Plun-Favreau H; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Nicotera P; German Centre for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
Abramov AY; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Willis AE; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Mallucci GR; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Loh SH; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Martins LM; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.; Pokaż więcej
Źródło:: Nature cell biology [Nat Cell Biol] 2014 Feb; Vol. 16 (2), pp. 157-66. Date of Electronic Publication: 2014 Jan 19.
Typ publikacji:: Journal Article
MeSH Terms:: Disease Models, Animal*
Mutation*
Drosophila Proteins/*physiology
Mitochondria/*physiology
Nucleotides/*metabolism
Parkinson Disease/*physiopathology
Protein Serine-Threonine Kinases/*physiology
Animals ; DNA, Mitochondrial/biosynthesis ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Protein Serine-Threonine Kinases/genetics