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Tytuł :
Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism.
Autorzy :
Wang W; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Yang L; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Song L; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Guo M; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Li C; Shimadzu (China) Co., LTD Beijing Branch, Beijing 100020, China.
Yang B; Department of Pathology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Wang M; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Kou N; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Gao J; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Qu H; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Ma Y; Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Vienna General Hospital, Medical University of Vienna, 1090, Vienna, Austria.
Xue M; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address: .
Shi D; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111165. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Panax notoginseng*/chemistry
Arachidonic Acid/*metabolism
Aspirin/*therapeutic use
Blood Platelets/*drug effects
Coronary Disease/*drug therapy
Gastric Mucosa/*drug effects
Gastritis/*drug therapy
Gastrointestinal Agents/*therapeutic use
Plant Extracts/*therapeutic use
Platelet Activation/*drug effects
Platelet Aggregation Inhibitors/*therapeutic use
Saponins/*therapeutic use
Adult ; Aged ; Animals ; Aspirin/adverse effects ; Beijing ; Blood Platelets/metabolism ; Chronic Disease ; Coronary Disease/diagnosis ; Coronary Disease/metabolism ; Cytoprotection ; Drug Synergism ; Female ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gastritis/diagnosis ; Gastritis/metabolism ; Gastrointestinal Agents/adverse effects ; Gastrointestinal Agents/isolation & purification ; Humans ; Lipidomics ; Male ; Middle Aged ; Plant Extracts/adverse effects ; Plant Extracts/isolation & purification ; Platelet Aggregation Inhibitors/adverse effects ; Rats, Wistar ; Saponins/adverse effects ; Saponins/isolation & purification ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Switching Australian patients with moderate to severe inflammatory bowel disease from originator to biosimilar infliximab: a multicentre, parallel cohort study.
Autorzy :
Haifer C; St Vincent's Hospital Sydney, Sydney, NSW.; The University of Sydney, Sydney, NSW.
Srinivasan A; Eastern Health, Melbourne, VIC.; Monash University Eastern Health Clinical School, Melbourne, VIC.
An YK; Mater Hospital Brisbane, Brisbane, QLD.; The University of Queensland, Brisbane, QLD.
Picardo S; Royal Perth Hospital, Perth, WA.
van Langenberg D; Eastern Health, Melbourne, VIC.; Monash University Eastern Health Clinical School, Melbourne, VIC.
Menon S; Royal Perth Hospital, Perth, WA.
Begun J; Mater Hospital Brisbane, Brisbane, QLD.; Mater Research Institute, University of Queensland, Brisbane, QLD.
Ghaly S; St Vincent's Hospital Sydney, Sydney, NSW.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW.
Thin L; Fiona Stanley Hospital, Perth, WA.; The University of Western Australia, Perth, WA.
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Źródło :
The Medical journal of Australia [Med J Aust] 2021 Feb; Vol. 214 (3), pp. 128-133. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Equivalence Trial; Journal Article; Multicenter Study
MeSH Terms :
Biosimilar Pharmaceuticals/*therapeutic use
Gastrointestinal Agents/*therapeutic use
Inflammatory Bowel Diseases/*drug therapy
Infliximab/*therapeutic use
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Australia ; Biosimilar Pharmaceuticals/adverse effects ; Biosimilar Pharmaceuticals/economics ; Drug Costs ; Drug Substitution ; Female ; Gastrointestinal Agents/adverse effects ; Gastrointestinal Agents/economics ; Humans ; Infliximab/adverse effects ; Infliximab/economics ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity.
Autorzy :
Chen Q; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Ren R; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Zhang Q; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Wu J; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Zhang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Xue M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.
Yin D; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, PR China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, PR China. Electronic address: .
Yang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, PR China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113542. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Coptis*/chemistry
Bacteria/*drug effects
Gastrointestinal Agents/*pharmacology
Gastrointestinal Microbiome/*drug effects
Immunity, Mucosal/*drug effects
Intestines/*drug effects
Peyer's Patches/*drug effects
Polysaccharides/*pharmacology
Animals ; Bacteria/growth & development ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Gastrointestinal Agents/isolation & purification ; Intestines/immunology ; Intestines/microbiology ; Male ; Peyer's Patches/immunology ; Peyer's Patches/microbiology ; Polysaccharides/isolation & purification ; Rats, Sprague-Dawley ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
From intravenous to subcutaneous infliximab in patients with inflammatory bowel disease: a pandemic-driven initiative.
Autorzy :
Verma AM; Department of Gastroenterology, Kettering General Hospital, Kettering NN16 8UZ, UK. Electronic address: .
Patel A; Department of Gastroenterology, Kettering General Hospital, Kettering NN16 8UZ, UK.
Subramanian S; Department of Gastroenterology and Hepatology, Liverpool University Hospitals Foundation NHS Trust, Liverpool, UK.
Smith PJ; Department of Gastroenterology and Hepatology, Liverpool University Hospitals Foundation NHS Trust, Liverpool, UK.
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Źródło :
The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2021 Feb; Vol. 6 (2), pp. 88-89.
Typ publikacji :
Letter
MeSH Terms :
Antibodies, Monoclonal/*administration & dosage
Gastrointestinal Agents/*administration & dosage
Inflammatory Bowel Diseases/*drug therapy
Infliximab/*administration & dosage
Antibodies, Monoclonal/therapeutic use ; COVID-19/prevention & control ; Gastrointestinal Agents/therapeutic use ; Humans ; Infliximab/therapeutic use ; Infusions, Intravenous ; Injections, Subcutaneous ; Self Administration ; United Kingdom
Opinia redakcyjna
Tytuł :
Investigational drugs in early phase development for primary biliary cholangitis.
Autorzy :
Gochanour EM; Liver Institute Northwest , Seattle, WA, USA.
Kowdley KV; Liver Institute Northwest , Seattle, WA, USA.
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Źródło :
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2021 Feb; Vol. 30 (2), pp. 131-141. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Drugs, Investigational/*therapeutic use
Gastrointestinal Agents/*therapeutic use
Liver Cirrhosis, Biliary/*drug therapy
Animals ; Drugs, Investigational/adverse effects ; Gastrointestinal Agents/adverse effects ; Humans ; Liver Cirrhosis, Biliary/diagnosis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Differences in In Vitro Properties of Pancreatin Preparations for Pancreatic Exocrine Insufficiency as Marketed in Russia and CIS.
Autorzy :
Maev IV; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.
Kucheryavyy YA; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.
Gubergrits NB; Donetsk National Medical University, Ministry of Health of Ukraine, Lyman, Ukraine.
Bonnacker I; Abbott Laboratories GmbH, Hannover, Germany.
Shelest EA; Abbott Laboratories, Moscow, Russia.
Janssen-van Solingen GP; Abbott Product Operations AG, Allschwil, Switzerland. .
Domínguez-Muñoz JE; Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
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Źródło :
Drugs in R&D [Drugs R D] 2020 Dec; Vol. 20 (4), pp. 369-376. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Gastrointestinal Agents/*chemistry
Gastrointestinal Agents/*metabolism
Lipase/*analysis
Lipase/*metabolism
Pancreatin/*chemistry
Pancreatin/*metabolism
Commonwealth of Independent States ; Drug Liberation ; Exocrine Pancreatic Insufficiency/drug therapy ; Gastrointestinal Agents/therapeutic use ; Humans ; Pancreatin/therapeutic use ; Particle Size ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/chemistry ; Russia
Czasopismo naukowe
Tytuł :
Montmorillonite-Enveloped Zeolitic Imidazolate Framework as a Nourishing Oral Nano-Platform for Gastrointestinal Drug Delivery.
Autorzy :
Zhao H; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Ye H; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Zhou J; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Tang G; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Hou Z; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Bai H; Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Nov 04; Vol. 12 (44), pp. 49431-49441. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Bentonite/*chemistry
Gastrointestinal Agents/*pharmacology
Gastrointestinal Tract/*drug effects
Metal-Organic Frameworks/*chemistry
Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Dextran Sulfate ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/chemistry ; Gastrointestinal Tract/metabolism ; Humans ; Imidazoles/administration & dosage ; Imidazoles/chemistry ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Metal-Organic Frameworks/administration & dosage ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Structure ; Particle Size ; Surface Properties ; Tumor Cells, Cultured ; Zeolites/administration & dosage ; Zeolites/chemistry
Czasopismo naukowe
Tytuł :
Lipi Guben decoction in treating diarrheal irritable bowel syndrome: A study protocol for a randomized controlled trial.
Autorzy :
Yang H; The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine.
Liu X; The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine.
Peng W; The Chinese People's Liberation Army 921 Hospital of the Joint Logistics Support Force.
Chen R; Guiyang Nursing Vocational College.
Chen Y; The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 22; Vol. 100 (3), pp. e23887.
Typ publikacji :
Clinical Trial Protocol; Journal Article; Randomized Controlled Trial
MeSH Terms :
Diarrhea/*drug therapy
Drugs, Chinese Herbal/*therapeutic use
Gastrointestinal Agents/*therapeutic use
Irritable Bowel Syndrome/*drug therapy
Adolescent ; Adult ; Aged ; Diarrhea/pathology ; Double-Blind Method ; Drugs, Chinese Herbal/administration & dosage ; Female ; Gastrointestinal Agents/administration & dosage ; Humans ; Irritable Bowel Syndrome/pathology ; Male ; Middle Aged ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Cost-Effectiveness of 5-Aminosalicylate Therapy in Combination With Biologics or Tofacitinib in the Treatment of Ulcerative Colitis.
Autorzy :
Shaffer SR; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.
Huang E; University of Chicago Medicine, Section of General Internal Medicine, Chicago, Illinois, USA.
Patel S; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.
Rubin DT; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.
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Źródło :
The American journal of gastroenterology [Am J Gastroenterol] 2021 Jan 01; Vol. 116 (1), pp. 125-133.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Colitis, Ulcerative/*drug therapy
Gastrointestinal Agents/*therapeutic use
Mesalamine/*therapeutic use
Piperidines/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Pyrimidines/*therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/economics ; Antibodies, Monoclonal, Humanized/economics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Biological Products/economics ; Biological Products/therapeutic use ; Colitis, Ulcerative/economics ; Colitis, Ulcerative/physiopathology ; Cost-Benefit Analysis ; Deprescriptions ; Drug Therapy, Combination ; Gastrointestinal Agents/economics ; Humans ; Infliximab/economics ; Infliximab/therapeutic use ; Markov Chains ; Mesalamine/economics ; Piperidines/economics ; Protein Kinase Inhibitors/economics ; Pyrimidines/economics ; Quality-Adjusted Life Years
Czasopismo naukowe
Tytuł :
Safety considerations when managing gastro-esophageal reflux disease in infants.
Autorzy :
Simon M; KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel , Brussels, Belgium.
Levy EI; KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel , Brussels, Belgium.
Vandenplas Y; KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel , Brussels, Belgium.
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Źródło :
Expert opinion on drug safety [Expert Opin Drug Saf] 2021 Jan; Vol. 20 (1), pp. 37-49. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Practice Guidelines as Topic*
Gastroesophageal Reflux/*therapy
Gastrointestinal Agents/*therapeutic use
Alginates/adverse effects ; Alginates/therapeutic use ; Gastrointestinal Agents/adverse effects ; Humans ; Infant
Czasopismo naukowe
Tytuł :
Sustained clinical response to infliximab in refractory Cronkhite-Canada syndrome.
Autorzy :
Jiang CD; Gastroenterology, Wellington Hospital, Wellington, New Zealand .
Myint H; Gastroenterology, Auckland City Hospital, Auckland, New Zealand.
Tie A; Department of Pathology and Molecular Medicine, University of Otago, Wellington, New Zealand.
Stace NH; Department of Medicine, University of Otago, Wellington, New Zealand.
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Źródło :
BMJ case reports [BMJ Case Rep] 2020 Dec 21; Vol. 13 (12). Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gastrointestinal Agents/*therapeutic use
Immunosuppressive Agents/*pharmacology
Infliximab/*therapeutic use
Intestinal Polyposis/*drug therapy
Azathioprine/pharmacology ; Azathioprine/therapeutic use ; Colon/diagnostic imaging ; Colon/pathology ; Colonoscopy ; Drug Resistance ; Gastrointestinal Agents/pharmacology ; Gastroscopy ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Induction Chemotherapy/methods ; Infliximab/pharmacology ; Intestinal Mucosa/diagnostic imaging ; Intestinal Mucosa/pathology ; Intestinal Polyposis/diagnosis ; Male ; Middle Aged ; Pyloric Antrum/diagnostic imaging ; Pyloric Antrum/pathology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Proton pump inhibitors for the treatment of laryngopharyngeal reflux disease: A protocol for systematic review and meta-analysis.
Autorzy :
Liu X; Gansu University of Chinese Medicine.; Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu province.
Jiang Y; Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu province.
Luo H; Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu province.
Liu H; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Dec 04; Vol. 99 (49), pp. e23297.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Gastrointestinal Agents/*therapeutic use
Laryngopharyngeal Reflux/*drug therapy
Proton Pump Inhibitors/*therapeutic use
Gastrointestinal Agents/adverse effects ; Humans ; Proton Pump Inhibitors/adverse effects ; Randomized Controlled Trials as Topic ; Research Design
Czasopismo naukowe
Tytuł :
Infliximab pharmacokinetics monitoring in inflammatory bowel disease.
Autorzy :
Svoboda P
Kupka T
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Transliterated Title :
Monitorování farmakokinetiky infliximabu u idiopatických střevních zánětů.
Źródło :
Vnitrni lekarstvi [Vnitr Lek] 2020 Winter; Vol. 66 (8), pp. 34-38.
Typ publikacji :
Journal Article
MeSH Terms :
Gastrointestinal Agents*/therapeutic use
Inflammatory Bowel Diseases*/drug therapy
Antibodies ; Drug Monitoring ; Humans ; Infliximab/therapeutic use
Czasopismo naukowe
Tytuł :
Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial.
Autorzy :
Yasukawa K; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: .
Shimizu A; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Yokoyama T; Gastroenterological Surgery, National Hospital Organization Shinshu Ueda Medical Center, Ueda, Japan.
Kubota K; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Notake T; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Seki H; Gastroenterological Surgery, Nagano Municipal Hospital, Nagano, Japan.
Kobayashi A; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Soejima Y; Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
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Źródło :
Journal of the American College of Surgeons [J Am Coll Surg] 2020 Dec; Vol. 231 (6), pp. 658-669. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Gastrointestinal Agents/*therapeutic use
Non-alcoholic Fatty Liver Disease/*prevention & control
Pancreaticoduodenectomy/*adverse effects
Aged ; Female ; Gastrointestinal Agents/administration & dosage ; Humans ; Male ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Pancreatic Extracts/administration & dosage ; Pancreatic Extracts/therapeutic use ; Pancreaticoduodenectomy/methods ; Pancreatin/administration & dosage ; Pancreatin/therapeutic use ; Postoperative Care/methods
Czasopismo naukowe
Tytuł :
Extraction, purification, and determination of the gastroprotective activity of glucomannan from Bletilla striata.
Autorzy :
Wang B; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Zhang H; Shaanxi Pharmaceutical Holding Group PAIANG Chinese Medicine Co., Xi'an, 110026, PR China.
Chen L; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Mi Z; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Xu Y; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Zhao G; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Liu S; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Lei H; Biology Department, Xinzhou Teachers University, Xinzhou, 034000, PR China.
Wang Z; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
Niu J; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Oct 15; Vol. 246, pp. 116620. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Gastric Mucosa/*drug effects
Gastrointestinal Agents/*pharmacology
Mannans/*pharmacology
Orchidaceae/*chemistry
Stomach Ulcer/*prevention & control
Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Catalase/metabolism ; Cell Line ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Ethanol/antagonists & inhibitors ; Ethanol/toxicity ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gastrointestinal Agents/chemistry ; Gastrointestinal Agents/isolation & purification ; Germ-Free Life ; Glutathione Peroxidase/metabolism ; Humans ; Male ; Malondialdehyde/antagonists & inhibitors ; Malondialdehyde/metabolism ; Mannans/chemistry ; Mannans/isolation & purification ; Mice ; Molecular Weight ; Omeprazole/pharmacology ; Solubility ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Superoxide Dismutase/metabolism ; Water/chemistry
Czasopismo naukowe
Tytuł :
Physicochemical properties and potential beneficial effects of porphyran from Porphyra haitanensis on intestinal epithelial cells.
Autorzy :
Qiu HM; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Veeraperumal S; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Lv JH; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Wu TC; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Zhang ZP; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Zeng QK; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Liu Y; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Chen XQ; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China.
Aweya JJ; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China.
Cheong KL; Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Institute of Marine Sciences, Shantou University, Shantou 515063, Guangdong, PR China. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Oct 15; Vol. 246, pp. 116626. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial Cells/*drug effects
Gastrointestinal Agents/*pharmacology
Gene Expression Regulation/*drug effects
Porphyra/*chemistry
Sepharose/*analogs & derivatives
Animals ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; Gastrointestinal Agents/chemistry ; Gastrointestinal Agents/isolation & purification ; Intestinal Mucosa/cytology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Molecular Weight ; Paxillin/genetics ; Paxillin/metabolism ; Pseudopodia/drug effects ; Pseudopodia/metabolism ; Rats ; Sepharose/chemistry ; Sepharose/isolation & purification ; Sepharose/pharmacology ; Viscosity ; cdc42 GTP-Binding Protein/genetics ; cdc42 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease.
Autorzy :
Li X; Department of Pharmacology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Lu C; Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Yang Y; Department of Pharmacology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Yu C; Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: .
Rao Y; Department of Pharmacology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Sep; Vol. 129, pp. 110486. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Carriers*
Anti-Inflammatory Agents/*administration & dosage
Colitis, Ulcerative/*drug therapy
Crohn Disease/*drug therapy
Drug Delivery Systems/*instrumentation
Gastrointestinal Agents/*administration & dosage
Animals ; Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/chemistry ; Drug Compounding ; Gastrointestinal Agents/adverse effects ; Gastrointestinal Agents/chemistry ; Humans
Czasopismo naukowe
Tytuł :
Bimodal Release Ondansetron Improves Stool Consistency and Symptomatology in Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Trial.
Autorzy :
Plasse TF; RedHill Biopharma, Tel Aviv, Israel.
Barton G; Arkansas Gastroenterology, PA, North Little Rock Arkansas, USA.
Davidson E; New Phase Research & Development, Knoxville, Tennessee, USA.
Abramson D; RedHill Biopharma, Tel Aviv, Israel.
Kalfus I; RedHill Biopharma, Tel Aviv, Israel.
Fathi R; RedHill Biopharma, Tel Aviv, Israel.
Raday G; RedHill Biopharma, Tel Aviv, Israel.
Harris MS; Middleburg Consultants, Takoma Park, Maryland, USA.
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Źródło :
The American journal of gastroenterology [Am J Gastroenterol] 2020 Sep; Vol. 115 (9), pp. 1466-1473.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Abdominal Pain/*drug therapy
Defecation/*drug effects
Diarrhea/*drug therapy
Gastrointestinal Agents/*therapeutic use
Irritable Bowel Syndrome/*drug therapy
Ondansetron/*therapeutic use
Adolescent ; Adult ; Aged ; Double-Blind Method ; Female ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/adverse effects ; Humans ; Male ; Middle Aged ; Ondansetron/administration & dosage ; Ondansetron/adverse effects ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Drug release in vivo and efficacy evaluation of a new colon targeted powder of total saponins of Pulsatilla.
Autorzy :
Chen Z; Jiangxi Province Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: .
Zhao T; Jiangxi Province Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
Zhou L; Jiangxi Province Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
Kang J; Jiangxi Province Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
Guan Y; Key Laboratory for Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China.
Yang M; Key Laboratory for Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China.
Yang S; Key Laboratory for Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China.
Liu H; Key Laboratory for Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Sep; Vol. 129, pp. 110376. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Colitis, Ulcerative/*drug therapy
Colon/*drug effects
Gastrointestinal Agents/*pharmacology
Saponins/*pharmacology
Animals ; Biological Availability ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Colon/metabolism ; Colon/pathology ; Disease Models, Animal ; Drug Compounding ; Drug Liberation ; Gastrointestinal Agents/chemistry ; Gastrointestinal Agents/pharmacokinetics ; Hydrogen-Ion Concentration ; Male ; Polymethacrylic Acids/chemistry ; Powders ; Rats, Sprague-Dawley ; Saponins/chemistry ; Saponins/pharmacokinetics ; Solubility ; Trinitrobenzenesulfonic Acid
Czasopismo naukowe
Tytuł :
Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium.
Autorzy :
Mees M; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Meurer MC; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Mariano LNB; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Boeing T; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Somensi LB; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Mariott M; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Niero R; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Cechinel-Filho V; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Andrade SF; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil; Universidade Lusófona CBIOS - Research Center for Biosciences and Health Technologies, Av Campo Grande, 376, 1749-024, Lisboa, Portugal.
Duarte LP; Departamento de Química, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil.
Sousa GF; Departamento de Química, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil.
de Souza P; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil.
Da Silva LM; Programa de Pós-Graduação Em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajai (UNIVALI) - Campus, Itajai, Santa Catarina, Rua Uruguai, 458, Centro, CEP: 88302-901, Brazil. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Oct 28; Vol. 261, pp. 113180. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Maytenus*/chemistry
Anti-Inflammatory Agents/*pharmacology
Colitis/*prevention & control
Colon/*drug effects
Gastrointestinal Agents/*pharmacology
Intestinal Mucosa/*drug effects
Liver/*drug effects
Plant Extracts/*pharmacology
Animals ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/pharmacology ; Cell Line ; Colitis/chemically induced ; Colitis/metabolism ; Colitis/pathology ; Colon/metabolism ; Colon/pathology ; Cytokines/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Female ; Gastrointestinal Agents/isolation & purification ; Gastrointestinal Motility/drug effects ; Inflammation Mediators/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Liver/metabolism ; Mice ; Oxidative Stress/drug effects ; Plant Extracts/isolation & purification ; Rats
Czasopismo naukowe

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